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Sunday, 19 January 2014

Phytochemicals Phytic acid and Colorectal cancer

Phytic acid (Inositol hexaphosphate) are phytichemicasl of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.


The effects
Inositol hexaphosphate (IP6), or phytic acid is best known as a natural fighter against cancers. In the study on HT-29 Colorectal Cancer Cells, the phytochemical exerted a strong evidence for the induction of apoptotic cell death, as a result of up-regulation of Bax and down-regulation of Bcl-xl in favor of apoptosis. Other in the study of the expression changes of β-catenin and cyclooxygenase-2 (COX-2) and cell proliferation in the adenoma-carcinoma sequence after treatment with rice bran PA by immunocytochemistry also showed the similar result as phytic acid lowering the proliferating index as compared to azoxymethane (AOM) alone (p<0.05). A significant positive correlation (p=0.01) was noted between COX-2 expression and proliferation.


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References
(1) Pro-Apoptotic Effect of Rice Bran Inositol Hexaphosphate (IP6) on HT-29 Colorectal Cancer Cells by Shafie NH, Esa NM, Ithnin H, Saad N, Pandurangan AK.(PubMed)
(2) Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA) by Saad N, Esa NM, Ithnin H.(PubMed)