Friday, 14 December 2018

Apricot, the Most Prominent Fruit for the Prevention and Treatment of Pancreatic Cancer


By Kyle J. Norton, Master of Nutrition

Apricot may have a potential for the cure of pancreatic cancer without inducing any side effects, some scientists suggested.

Pancreatic cancer is a chronic condition caused by irregular cell growth in the tissue of the pancreas.

Most primary pancreatic cancer starts with the alternated DNA cells on the surface of the inner lining of the pancreas organ.

At the advanced stage, the malignant cells in the pancreas can travel a distance way to infect other tissue and organ through lymph and blood.

Including all the stages, the 5 years survival rate of pancreatic cancer is 7% and it is considered the most rapidly fatal cancer.
Most people at the early stage of pancreatic cancer do not experience any symptoms. However, at the later stage, as the tumor has grown large enough, it can suppress the nearby tissue and nerve cells, leading to localized symptoms and severe pain.

The exact causes of pancreatic cancer are unknown. Age, gender, race, family history. and inherited genetic syndromes were found to associate to the risk factor of the onset of the disease, epidemiologically.

Some researchers suggested that the most common risk factors that cause the development of pancreatic cancer are found in patients associated with a history of tobacco use and obesity.

Dr. Alguacil J in the study to examine the association between noncigarette tobacco use (i.e., cigars, pipes, smokeless tobacco) and pancreatic cancer risk among nonsmokers of cigarettes, said, "Cigarette smoking is an important and well-established cause of pancreatic cancer." and "Long-term use of smokeless tobacco (i.e., >20 years) was also associated with a nonsignificant increased risk" and "heavy use of smokeless tobacco, and to a lesser extent, cigar smoking may increase the risk of pancreatic cancer among nonsmokers of cigarettes".

These result suggested cigarettes and noncigarette smoking are associated with the increased risk of pancreatic cancer in a type-dependent manner.

In the obesity front, Dr, Michaud DS in the study "Obesity and Pancreatic Cancer" said, "obesity early in adulthood is strongly associated with future risk of pancreatic cancer and that abdominal obesity is an independent risk factor. There is increasing evidence suggesting long-standing diabetes type 2 and insulin resistance are important etiological factors of this disease, providing a strong mechanistic link to obesity".

The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae.

Apricot is classified with the family of the plum and has yellow to orange, often tinged red on the side which is exposed to the sun.

The chemical constituents of apricot include
Oleic acid, linoleic acid, palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides.

The research team on cancer program at the Shimane University showed that MK615 produced from Japanese apricot and contains several cyclic triterpenes, such as oleanolic and ursolic acids may have an effect in the inhibition of pancreatic cancer.

The experiments were performed on several human cancer cell lines exposed to MK615 for 7 days and in vivo growth of human pancreatic cancer MIAPaCa-2 cells.

Application of MK615 inhibited the growth of several human cancer cell lines in a concentration-dependent way.

Pancreatic cancer MIAPaCa-2 cells were highly sensitive to the growth-inhibiting effects of MK615. 

Treatment with MK615 preferentially induced cell death in human cancer cells without causing harm to the nearby cells such as human umbilical vein endothelial cells (HUVEC) and mouse bone marrow cells.

MIAPaCa-2 cells incubated with MK615 in the presence of antioxidant, growth-inhibition was significantly reduced.

MK615 induced the accumulation of reactive oxygen species in the exertion of cytotoxicity to the cancer cells but not in HUVEC. 

Finally, researchers also found that MK615, in both the presence and absence of gemcitabine, significantly inhibited the growth of human pancreatic cancer cells as xenografts without apparent adverse effects.

The findings suggested that MK615, a supplement produced from Japanese apricot, processes a potential and therapeutic value in treating pancreatic cancers through a reactive oxygen species-dependent mechanism.

The study was published on the National Institutes of Health

Taken altogether, Apricot with abundant bioactive compounds such as oleanolic and ursolic acids may be considered a functional fruit for the prevention and an adjunct therapy combined with primary medicine for the treatment of pancreatic cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



(1) Antitumor effect of Japanese apricot extract (MK615) on human cancercells in vitro and in vivo through a reactive oxygen species-dependent mechanism by Hattori M1, Kawakami K, Akimoto M, Takenaga K, Suzumiya J, Honma Y. (PubMed)
(2) Smokeless and other noncigarette tobacco use and pancreatic cancer: a case-control study based on direct interviews by Alguacil J1, Silverman DT. (PubMed)
(3) Obesity and Pancreatic Cancer by Michaud DS. (PubMed)

Beetroot, The Potent Function Food In Normalizing Your High Blood Pressure with No Side Effects

By Kyle J. Norton, Master of Nutrition

Beet juice with high in NO may be coaidered an therapy for prevention and treatment of high blood pressure with no side effects, some studies found.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

High blood pressure means raising the pressure in your heart. If it stays high over time it can damage the body in many ways.

The causes of high blood pressure are associated with some factors, including unhealthy lifestyle choices, lack of physical activity and poor diet.

Dr. Beilin LJ, in the update of on lifestyle and hypertension control, wrote, "lifestyle and blood pressure control will focus on complex dietary patterns, issues related to obesity, hypertension and dietary sodium, meta-analyses on exercise, alcohol, coffee consumption, and magnesium and some recent data on antioxidant vitamins".

Therefore, if you currently have high blood pressure, you can manage and treat the condition easily by the change of diet that recommends the high intake of fruits and vegetables and whole grain and reduces intake of saturated and trans fat and limits intake of red meats, and process foods, accompanied with limiting the use of alcohol, and salt intake.


Some researchers suggested that environmental factors such as long-term exposure to chronic stress are also the prevalent risk to the syndrome onset.

Dr. Tanya M. Spruill, at the Columbia University Medical Center, in the study of the connection between chronic psychological stress and hypertension, said, "Laboratory studies have provided convincing preliminary evidence that thinking about stressful events, in addition to experiencing them directly, can delay BP recovery, (leading to the persistent onset of hypertension)."

In the explanation of psychosocial factors that inflict the onset of hypertension. If your hypertension is a result of long-term psychological stress, biofeedback, progressive muscle relaxation, stress management training, and transcendental meditation, can be helpful.

Beet is best known as the beetroot or garden beet and belong to the amaranth family. It is a perennial plant with leafy stems growing to 1–2 m tall.

Besides the major chemical constituents betalains and phenolics, it also contains a lesser amount of isobetanin, probetanin, neobetanin, indicaxanthin, vulgaxanthins, etc.



Dr. Coles LT, the lead scientist in the research team of the heart and diabetes program at the Baker IDI Heart & Diabetes Institute, Melbourne showed that consumption of beetroot juice on a low nitrate diet may lower blood pressure (BP)the major risk factor of cardiovascular events.

The results was based on a total of 50 women and 15 men participated in a double-blind, randomized, placebo-controlled, crossover study.

Particpants were randomized to receive 500 g of beetroot and apple juice (BJ) or a placebo juice (PL).

Volunteers also had BP measured at baseline and at least hourly for 24-h following juice consumption using an ambulatory blood pressure monitor (ABPM).

Volunteers remained at the clinic for 1-h before resuming normal non-strenuous daily activities and The identical procedure was repeated 2-wk later with the drink (BJ or PL) not consumed on the first visit.

At the end of the final phase, researchers discovered that there was a trend (P=0.064) to lower systolic blood pressure (SBP) at 6-h after drinking BJ relative to PL.

Analysis in men only (n=13) after adjustment for baseline differences demonstrated a significant (P<0.05) reduction in SBP of 4 - 5 mmHg at 6-h after drinking BJ.

These results indicated, beetroot juice will lower BP when consumed as part of a normal diet in free-living healthy adults.

Additionally, in the examining of the impact of beetroot on lower blood pressure, researchers conducted an experiment to investigate the acute effects of beetroot bread (BB) on microvascular vasodilation, arterial stiffness, and BP in healthy participants.

The acute, randomized, open-label, controlled crossover trial. included 23 healthy men received 200 g bread containing 100 g beetroot (1.1 mmol nitrate) or 200 g control white bread (CB; 0 g beetroot, 0.01 mmol nitrate).

The incremental area under the curve (0-6 h after ingestion of bread) for endothelium-independent vasodilation was greater and lower for diastolic BP (DBP; P = 0.032) but not systolic (P = 0.99) BP after BB compared with CB.

The above effects occurred in conjunction with increases in plasma and urinary nitrate (P < 0.000 1) and nitrite.

BB acutely increased endothelium-independent vasodilation and decreased DBP,

These results suggested beetroot bread (BB) lower the blood pressure by widening the micro blood vessels and decreasing the levels of  DBP, without affecting the SBP.

Dr. Hobbs DA, the lead scientists said, after taking into of co and confounders " enriching bread with beetroot may be a suitable vehicle to increase intakes of cardioprotective beetroot in the diet and may provide new therapeutic perspectives in the management of hypertension".


taken altogether, beetroot may be considered a functional food for the prevention and therapeutic agent for the treatment of hypertension without inducing any side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial by Coles LT, Clifton PM.(PubMed)
(2) Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial by Hobbs DA, Goulding MG, Nguyen A, Malaver T, Walker CF, George TW, Methven L, Lovegrove JA. (PubMed)
(3) Update on lifestyle and hypertension control by Beilin LJ. (PubMed)
(4) Chronic Psychosocial Stress and Hypertension by Tanya M. Spruill. (PubMed)

White Button Mushroom, the Potential Anti Breast Cancer Functional Foods, According to the Studies

By Kyle J. Norton, Master of Nutrition

Mushroom may be the next generation of vegetable processing pharmaceutical value for the finding of single ingredients that process anti-breast cancer potency, some studies suggested.

Breast cancer is a primary medical and chronic condition that starts with the irregular cells growth due to DNA alternation on the surface the inner lining of the breast tissue.

At the advanced stage, breast cancer cells can travel a distance away to infect other healthy tissue and organ.

According to the statistic, the risk of a woman to develop breast cancer in her lifetime is 12.4%.

In 2018, approximately over 260,000 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with over 63,000 new cases of non-invasive (in situ) breast cancer.
The exact causes of breast cancer are unknown, Women who carry the mutated gene BRAC1 and 2 are associated with the increased risk of the disease.

In the concerns of breast cancer risk among women in both developed and less-developed countries and the increasing rates of breast cancer worldwide, particularly in postmenopausal and estrogen receptor-positive cases, researchers at the University Hospital of South Manchester NHS Foundation Trust, launched an investigation to evaluate whether diet and lifestyle can prevent breast cancer.

At the final report, they discovered, "successful lifestyle changes could prevent 25% to 30% of cases of breast cancer" and "breast cancer) reductions will only be achieved if we can implement targeted prevention programs for high-risk women and women in population-based breast screening programs during childhood, adolescence, and early adulthood when the rapidly developing breast is particularly susceptible to carcinogenesis".

"Adherence to a healthy dietary pattern does not have specific effects on breast cancer risk but remains important as it reduces the risk for other common diseases, such as cardiovascular disease (CVD), diabetes, and dementia".

In menopausal women, researchers said, "Weight control throughout life appears to prevent cases (of breast cancer) after menopause".

These results clearly suggested that maintaining the healthy weight and active changing the unhealthy lifestyle and having mammograms taken every year in high-risk women are the best approaches to prevent the onset of breast cancer.




Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source,

The vegetable is a genus A. Muscaria and belonging to the family Amanitaceae and cultivated in many cultures all over the world for foods and health benefits.

Chemical constituents of white button mushroom include astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).

In the assessment of white button mushroom (WBM), widely consumed in most countries intake in the protection of breast cancer, researchers launched an investigation to examine mushroom polysaccharides for their immunomodulating and antitumor properties.

Two polysaccharide fractions, ABP-1 and ABP-2, exerted a potential antitumor activity through inhibiting the production of proinflammatory cytokines such as nitric oxide, interleukin-6, and tumor necrosis factor-α. via modulation of macrophage, (the immune first line of defense) function by that is mediated in part through activation of nuclear factor-κB in the induction of tumor cell apoptosis.

In compared to other cancer cell lines, ABP-1 and ABP-2 demonstrated the ability to inhibit the growth of human breast cancer MCF-7 cells.
Particularly, when murine Sarcoma 180 cells exposed ABP-1 or ABP-2 were implanted subcutaneously into mice, two polysaccharide fractions reduce tumor growth substantially compared to those of control mice.

These result suggested that white button mushroom may exhibit the antitumor effect through stimulating the function of immune macrophages.

Additionally, PAP-3, an acidic polysaccharide fraction in the testing against breast cancer cell line MCF-7 cancer cells with an IC50 of 193 µg/mL, displays a strong apoptotic activity through inducing the loss of mitochondrial membrane and increase of Bax/Bcl-2 ratio via cytotoxicity.

PAP-3 also exhibited the pro-apoptotic function of p53, and cell cycle arrest at the S phase.

Antioxidants produced by the incubation of MCF-7 cells such as superoxide dismutase (SOD) and N-acetylcysteine (NAC) was significantly attenuated by the ROS generation and apoptosis by PAP-3.

Polysaccharides from the white button mushroom, especially acidic PAP-3, not only are very important nutritional ingredients, but also at least in part, exerts anti-cancer health benefits through the ROS-mediated mitochondrial apoptotic pathway.

Interestingly, in the study to investigate the evidence of consumption of dietary mushrooms can protect against breast cancer, researchers found that MCF-7 cellular proliferation was significantly (P < 0.05) reduces up to 33% by all mushrooms and Hot water extracts (MT) from white button mushroom significantly increases apoptosis, or programmed cell death.

The results strongly indicated mushrooms processes significantly suppressed cellular proliferation property, with MT further significantly inducing apoptosis and cytotoxicity in human breast cancer cells.

Taken all together, white button mushroom may be considered a functional food for the prevention and combined with the primary therapy for the treatment of breast cancer., depending on the confirmation of further data collection from the large example size and multi-center studies in human.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Macrophage immunomodulating and antitumor activities of polysaccharides isolated from Agaricus bisporus white button mushrooms by Jeong SC1, Koyyalamudi SR, Jeong YT, Song CH, Pang G.(PubMed)
(2) ROS-dependent mitochondria molecular mechanisms underlying antitumor activity of Pleurotus abalonus acidic polysaccharides in human breast cancer MCF-7 cells by Shi X1, Zhao Y, Jiao Y, Shi T, Yang X.(PubMed)
(2) Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7 human breast cancer cells by Martin KR1, Brophy SK.(PubMed)
(3) Can diet and lifestyle prevent breast cancer: what is the evidence? by Harvie M1, Howell A1, Evans DG. (PubMed)

Thursday, 13 December 2018

Phytochemical Piperine, A Potent Anti Allergy Bioactive Ingredient, Researchers Say

By Kyle J. Norton

Scientists may have found a bioactive compound in the prevention and treatment of allergy with no side effects, according to studies.

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.

Allergies are the result of the abnormally immune systematic response to typically harmless substances in the environment, leading to the symptoms and reaction in the nose, lungs, throat, sinuses, ears, lining of the stomach or on the skin.

Believe or not, the diseases associated with the hyperactivity of the immune system include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis.

According to the Centers for Disease Control and Prevention (CDC), Over 20 million Americans 18 and older and more than 6.1 million children were diagnosed with allergic rhinitis, commonly known as hay fever, in 2015. Another 20 million Americans were diagnosed with respiratory, food, or skin allergies.

In the comparison the allergic effect in the school today and the past, it often feels like food allergies are far more common today than in their youth, the incidence rarely happened in the past school days.

What contributes to the hyperactivity of the immune system in triggering the food allergy today compared to the past. No one knows.

However, researchers do know that certain risk factors including children, adults younger than 18 years old, family history of allergy and having asthma, particularly in people with a genetic preposition are associated to the onset of allergy.

Dr. Romina A. Ortiz, the lead scientist in the immunity team at the The Johns Hopkins Asthma & Allergy Center, said, " Genome-wide association studies (GWAS) has been widely employed in the field of allergic disease, and to date significant associations have been published for nearly 100 asthma genes/loci, in addition to multiple genes/loci for AD, AR and IgE levels".

And, " Molecular genetics has undergone a technological revolution, leading to next-generation sequencing (NGS) strategies that are increasingly employed to hone in on the causal variants associated with allergic diseases".

These result clearly indicated that people inherited the mutated gene from the parent that causes over-reactivity of the immune system are at the increased risk of allergy

On finding a natural constituent or wholefood for the prevention and treatment of allergy with no side effect, researchers at the Kinki University investigated the anti-allergy effect of the extract of the Piper nigrum leaf.

The extracts at a different dose of 50, 200 and 500 mg/kg exerted a significant activity in inhibiting the cutaneous reaction at the early phase and later phase in dinitrofluorobenzene (DNFB) induced allergic mice.

Allergic effect of ear swelling also was inhibited by the PN-ext (50, 200 and 500 mg/kg, per os (p.o.)). But this effect on very late phase response (vLPR) in the model mice was significant but weaker than that on IPR.

At day 7, administration of PN-ext (50, 200 and 500 mg/kg for 7 d) completely inhibited picryl chloride (PC)-induced ear swelling in PC sensitized mice.

The results were attributed to the extract inhibitory effect on compound 48/80-induced histamine release from rat peritoneal mast cells.

The in-depth analysis of the result suggested that 2 Two lignans of PN-ext, (-)-cubebin (1) and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), from the piperine found in the extract, were identified as major active principles having histamine release-inhibitory activity.

Additional evaluation of the piperine antiallergic effect, researchers launched a study of Balb/c mice to test the effect of piperine on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes.

The Balb/c mice were induced asthma by ovalbumin sensitization and inhalation. Piperine (4.5 and 2.25 mg/kg) was orally administered 5 times a week for 8 weeks.

Piperine-treated groups showed a strongly suppressed eosinophil infiltration, allergic airway inflammation, and airway hyperresponsiveness by inhibiting the proinflammatory cytokines and levels of immunoglobulin E and histamine.

In other words, the therapeutic mechanism by which piperine effectively treats asthma is based on a reduction of Th2 cytokines associated with the promotion of IgE and eosinophilic responses.

Taken altogether, piperine, a major bioactive compound found in black pepper may be used for the prevention and treatment of allergy caused by immune overreaction.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Histamine release inhibitory activity of Piper nigrum leaf by Hirata N, Naruto S, Inaba K, Itoh K, Tokunaga M, Iinuma M, Matsuda H.(PubMed)
(2) Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model by Kim SH, Lee YC. (PubMed)
(3) Genetics of Allergic Diseases by Romina A. Ortiz, MS, and Kathleen C. Barnes, Ph.D. (PubMed)

Phytochemical Polysulfides, a Plant Base Anti Bacterial and Fungal Infection Alternative

By Kyle J. Norton

Scientists may have found a natural antibiotic for the prevention and treatment of bacterial infection, according to the study.

Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belongings to the group ofOrganosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

How the immune system protects against infection. As soon as sensing the physical injury in the body, the white blood cells of the immune first line of defense not only activates the protein associated with the coagulation to cover the wound but also stimulates the production of pro-inflammatory cytokines to kill off the foreign invaders.

However, in most cases, overexpression of proinflammatory cytokines can cause death and damage to nearby health, leading to abnormal tissue healing with the formation of scars.

For example overexpression of proinflammatory cytokines produced during the hepatitis infection can induce irreversible liver scars, leading to chronic liver disease, such as cirrhosis.

Some researchers in the examine the immune evolution history, suggested that the immune system must kill off the invaders with 3 to 8 weeks during the acute phase of infection, otherwise, it will adapt to the change, causing low-grade inflammation, such as type 1 diabetes mellitus, coeliac disease, inflammatory bowel disease, and rheumatoid arthritis.

According to the study by the Memorial University of Newfoundland, in the micronutrients perspectively, zinc; selenium; iron; copper; vitamins A, C, E, and B-6; and folic acid have important influences on immune responses" and "Overnutrition and obesity also reduce immunity and protein-energy malnutrition is associated with a significant impairment of cell-mediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations, and cytokine production".

These results indicated beside foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

In order to understand the range of sulfur-containing natural products from plants in the inhibition of fungi, bacteria infection, researchers investigated the biological activity of these compounds that affect human immunity.

Polysulfides, one of the bioactive compound from the group, exerted a significant redox-activity through increasing the expression of antioxidants (catalysis, metal binding) enzymes in inhibiting the radical generation and protecting the integrity of DNA and cellular membranes.

Furthermore, in order to exert the maximum effect in immunity, the biological activity of polysulfides depends on initial antioxidant-enzymatic activation to be generated with high target selectivity.

Moreover, in examing the polysulfides activity against the increase in the number of systemic fungal diseases, researchers showed that polysulfides found in the garlic extracts or essential oils demonstrated a clinically significant effect in fungal infection. the bioactive compound was considered an alternative way of protection of foodstuffs from contamination.

In vitro and in vivo, polysulfide derivatives isolated by chemical reaction also exhibited a potent antifungal acti.vity against candidosis in the tested mice.

Taken altogether, Polysulfides isolated from garlic may have a therapeutic effect in improving the immune activity against the bacterial and fungal infection with no side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms by Jacob C.(PubMed)
(2) [Pharmaceutical significance of Allium sativum L. 4. Antifungal effects].[Article in Czech]by Sovová M1, Sova P.(PubMed)
(3) Optically active antifungal azoles. II. Synthesis and antifungal activity of polysulfide derivatives of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H- 1,2,4-triazol-1-yl)-2-butanol by Tasaka A1, Tamura N, Matsushita Y, Hayashi R, Okonogi K, Itoh K.(PubMed)
(4) Nutrition and the immune system: an introduction by Chandra RK. (PubMed)

Bioactive Sulforaphane (Isothiocyanates), the Anti-Obesity Plant Based Compound

Kyle J. Norton

Dithiolthiones, a bioactive ingredient found in cruciferous vegetables may have an effect on reducing the risk of obesity in chronic consumption, some scientists suggested.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Obesity is a medical condition caused by the excess body fat accumulated over time.

And,  overweight is a condition of excess body weight relative to the height.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.

According to the statistic, 68% of the American population is either overweight or obese.

Some researchers suggested that the prevalent and widespread of obesity in the Western world not only increased the burden of health care and economic cost but also induce a reduced quality of life of adults due to chronic ailments.

In the comparison of the obesity rate today and 50 years ago, the Centers for Disease Control statistic showed that the obesity rate has skyrocketed by more than 185 percent among American adults over the last 50 years, and the rate of extreme obesity among children have tripled during the same time period.

These results clearly suggested that the adults today must have something different in their daily activity that contributes these significant change.

Some researchers suggested that lack of exercise may be one the most prevalent risk factor which induces the onset of obesity.

Dr. Petri, the lead scientist in the examine the role of physical activity and exercise in obesity and weight said, "obesity is caused by a consistent decline in daily energy expenditure is not supported either by objective measures of energy expenditure or physiological theory of weight gain alone. However, since voluntary exercise is the most important discretionary component of total daily energy expenditure, it can affect energy balance".

This conclusion indicated that lack of exercise and over nutrient consumption work together to facilitate the onset of overweight and obesity.

In the concern of obesity widespread in the American population, researchers examine the anti-obesity effect of sulforaphane in the animal model. C57BL/6N mice in the study. were fed a normal diet (ND), HFD or HFD plus 0.1% sulforaphane (SFN) for 6 weeks.

According to the food efficiency ratios compared to untreated control, the sulforaphane treatment group showed a lower body weight. SFN attenuated HFD-induced visceral adiposity, adipocyte hypertrophy associated with increasing the store of fat within the abdominal cavity and fat accumulation in the liver.

Futhermore, Serum total cholesterol and leptin, and liver triglyceride levels were lower in HFD-SFN-fed mice than in HFD-fed mice.

The efficacy of SFN in the anti-fat deposit was attributed to the decreased expression of a protein which plays a critical in reducing triglyceride level and regulating the energy homeostasis and increased adiponectin expression in the modulation of glucose and fatty acid oxidation.
Taking foods containing sulforaphane may be effective in managing weight loss for obese patients accompanied by a change of lifestyle with more vegetables and fruits into a diet.

Futhermore, in a highly palatable (HP) diet male Wistar rats, injection of sulforaphane (SFN, 1 mg kg⁻¹, 4 months treatment)exerted some beneficial effects on obesity and insulin resistance.

Moreover, glucose tolerance was lower in the HP diet groups, especially in the HP group treated with SFN. Except for the liver triacylglycerols. 

Moreover, SFN at the specific dose was found to accentuate glucose intolerance and affect the GLUT3 protein in facilitating the transport of glucose across the plasma membranes of mammalian cells in the cerebral cortex and hypothalamus in the HP diet group treated with SFN.
 Taken altogether, plant base sulforaphane may be considered a bioactive compound for the prevention and treatment of obesity with no side effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Choi KM1, Lee YS1, Kim W1, Kim SJ2, Shin KO1, Yu JY3, Lee MK1, Lee YM1, Hong JT1, Yun YP1, Yoo HS4. (PubMed)
(2) Chronic sulforaphane oral treatment accentuates blood glucose impairment and may affect GLUT3 expression in the cerebral cortex and hypothalamus of rats fed with a highly palatable diet by Souza CG1, Riboldi BP, Hansen F, Moreira JD, Souza DG, de Assis AM, Brum LM, Perry ML, Souza DO. (PubMed)
(3) Sulforaphane induced adipolysis via hormone-sensitive lipase activation, regulated by AMPK signaling pathway by Lee JH1, Moon MH, Jeong JK, Park YG, Lee YJ, Seol JW, Park SY. (PubMed)
(4) The role of physical activity and exercise in obesity and weight management: Time for critical appraisal by PetriWiklund. (Research Gate)

Wednesday, 12 December 2018

Phytochemical Sulforaphane (Dithiolthiones), the Potent Anti-Liver Disease Bioactive Compound, According to Studies

By Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of liver disease with no side effects, according to studies.

Liver disease in most cases is linked to alcohol or drugs. In fact, it can be caused by a variety of factors and affecting everyone from infants to older adults, including infected viri such as hepatitis A, B, C, and medication overloaded.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Most common symptoms of liver disease include weakness and fatigue, weight loss, nausea, vomiting, and jaundice.

If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility of liver disease.

According to the statistic provided by the Canadian Liver Foundation,  approximately, one in 10 Canadians, or more than three million people, have some form of liver disease and over a period of only eight years, the death rate from liver disease has risen nearly 30%.

This incidences of liver disease not only lead to dismiss the quality of life and life expectancy but cause a financial burden of the health care system.

Conventional treatment of liver disease depends on your diagnosis. Most cases of liver disease can be treated with lifestyle modifications, such as stopping alcohol use in alcoholic fatty liver disease or losing weight, in nonalcoholic liver disease.

Dr. Valerio Nobili, the lead scientist in the examined the role of lifestyle changes in the management of chronic liver disease, said, "several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status".

And,  "The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity".

With an aim to find a natural ingredient for the treatment of liver disease, researchers evaluated the ability of sulforaphane, an activator of Nrf2, to blunt CYP2E1-dependent, ethanol-induced steatosis in vivo and in vitro.

Where Nuclear factor (erythroid-derived 2)-like 2, (Nrf2), is a pro- antioxidant protein which plays a critical role in protecting our body against oxidative damage triggered by injury and inflammation.

And CYP2E1 is a protein involved in the metabolism of xenobiotics in the body.

Application of sulforaphane (SFN) treatment increased the levels of antioxidants by activating the levels of the Nrf2 and lowering oxidant stress observed by the decline in lipid peroxidation and increase in glutathione (GSH) levels.

SFN also decreased liver levels of triglycerides and cholesterol elevated by the injection of ethanol.

The results strongly suggested that SFN inhibited liver disease by increasing expression of antioxidant enzymes and lowing the expression of free radical as well as reducing the liver fat deposits.

Moreover, in the investigation to determine whether glucoraphanin and its breakdown product sulforaphane, are potent modulators of various phase I and phase II enzymes involved in carcinogen-metabolizing enzyme systems in vitro, researchers showed that injection of glucoraphanin at higher concentration (25 μM) decreased dealkylation of methoxyresorufin, a marker for cytochrome P4501 activity

Where cytochrome P4501 is an enzyme involved in the metabolism of endogenous substrates and drugs, as well as the activation of certain toxins and environmental pollutants.

Compared to glucoraphanin, sulforaphane is superior to its precursor in modulating carcinogen-metabolizing enzyme systems in vitro.

The University of Rhode Island, Kingston study also suggested that SF activate Nrf2 activation in inhibited lipid accumulation in white adipose tissue, suppressed adipogenesis, insulin resistance, and glucose intolerance, and hepatic steatosis in Lep(ob/ob) mice.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis by Zhou R1, Lin J, Wu D.(PubMed)
(2) Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolising enzymes in Hep G2 cells by Abdull Razis AF1, Noor NM. (PubMed)
(3) Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice by Xu J1, Kulkarni SR, Donepudi AC, More VR, Slitt AL. (PubMed)
(4) The role of lifestyle changes in the management of chronic liver disease by Valerio Nobili, Christine Carter-Kent,2 and Ariel E Feldstein. (PMC)

Eggplant, the Cardio-Protective Functional Veggie, Scientists Suggest

By Kyle J. Norton

Scientists may have found a whole fruit or vegetable with a potential to treat cardiovascular disease with no side effects, some studies found.

Cardiovascular disease is a class of conditions associated with heart and blood vessels. Anything that affects the normal heart and blood vessel functionings is considered risk factors of the disease, including heart's muscle, valves or rhythm, and blockage of blood vessels.

According to the statistics, in the US, approximately, 610,000 people die of heart disease every year that's 1 in every 4 deaths. The disease is the leading cause of death for both men and women.

The causes of cardiovascular diseases are associated with the location that affects the functioning of the heart and blood vessels, including atherosclerosis is caused by the blockade of the blood vessel due to the accumulation of plaques in the arteries and arrhythmias caused by abnormal heart rhythms.

Epidemiological studies strongly suggested that most common cardiovascular disease that affects most of the heart disease patients are coronary artery disease (CAD).

Coronary artery disease (CAD) is the most common form of heart disease caused by one or more of the coronary arteries become narrow or blocked.

Some researchers suggested that the widespread of the diagnosis of coronary artery disease (CAD) in the Western world probably is a result of the promotion of the Western diet over the last few decades.

The diet high in bad cholesterol, salts and sugar and carcinogens associated with the accumulation of plaques on the arteries have been found to be a culprit of the onset of coronary artery disease in many studies.

Dr. Oikonomou E, the lead author in the joint study led by the National and Kapodistrian University of Athens in the concerns of CAD widespread in the Western world launched an investigation to examine the independent predictive value of an unhealthy diet on the severity of coronary artery disease (CAD).

In the total of 188 symptomatic stable patients with CAD. Patients were categorized as having severe CAD or nonsevere CAD by coronary angiography.

Among several demographics and clinical characteristics, all patients were tested using a semiquantitative food frequency questionnaire.

By analysing the 8 principal components in the 8 distinct dietary patterns found in the returned questionnaire, researchers found that The Western dietary pattern (increased intake of fat, red meat, and carbohydrates and minimal consumption of fruits and green leafy vegetables) was predictive of severe CAD (area under the curve: 0.73, 95% confidence intervals: 0.64-0.83, P < .001).

These results not only suggested that the Western not only causes the onset of the disease but also increased the risk of severity of coronary artery lesions in patients with stable CAD.

The doctors in the study wrote the final report, "the findings highlight the role of dietary patterns when estimating cardiovascular risk for the management of patients with CAD".

Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India.

The plant has been cultivated in southern and eastern Asia since prehistory. It is famous for its deep purple and the best eggplant can be found from August through October when it is in season.

The chemical constituents of eggplant include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.

In the finding, a natural compound with the efficacy for the prevention and treatment of cardiovascular disease with no side effects, researchers at the University of Connecticut School of Medicine examines the role of raw and grilled eggplants on cardioprotection using an isolated perfusion heart model.

The animals were fed freeze-dried products of either raw or grilled eggplants for 30 days. After 30 days, isolated working hearts were subjected to 30 min ischemia followed by 2 h of reperfusion.

The medical assays suggested eggplants process potent cardioprotective compounds judging by their ability to increase left ventricular function, and reduce myocardial infarct size and cardiomyocyte apoptosis.

Interestingly, researchers found no difference in cardioprotective ability between the raw and grilled products.

Based on the antioxidant vitamins classification, researchers showed that vitamin A, vitamin C, and β-carotene, were lower and some of the polyphenolic components, especially nasunin content, were higher in grilled eggplants, These result indicated that there must be some other ingredient processed by both grill and raw eggplants that exert cardiovascular diseases not found in this study.

Moreover, in the study to analyze total phenolics and antioxidant capacity in the indigenous vegetables for cardioprotective effect researchers at the Tuskegee University conducted a group analysis including collard greens, mustard greens, kale, okra, green onion, butter beans, butter peas, purple hull peas, rutabagas, and eggplant.

At a concentration of 10.0 mg dried vegetable equivalent/ml, the extract of these vegetables exerted a significant antioxidant activity by reducing 13.2-88.5% DPPH(•) radical in 30 min.

The Oxygen Radical Absorbance Capacity. (ORAC) value ranged from 2.5 to 100.7 µmoles of Trolox equivalents per gram of dried sample.

The antioxidant capacity of the vegetable samples was highly related to their total phenolic content.

The evidence suggested these indigenous vegetables are good sources of the phenolic compounds, which might provide anti-oxidative protection against free radicals in inducing chronic diseases, such as cardiovascular disease.

Taken altogether, eggplant processed abundantly bioactive antioxidants may be considered a functional vegetable for the prevention and an adjunct therapy combined with the primary medicine for the treatment of cardiovascular disease without inducing any adverse effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cardioprotective properties of raw and cooked eggplant (Solanum melongena L) by Das S1, Raychaudhuri U, Falchi M, Bertelli A, Braga PC, Das DK. (PubMed)
(2) Total phenolics and antioxidant capacity of indigenous vegetables in the southeast United States: Alabama Collaboration for CardiovascularEquality Project by Huang Z1, Wang B, Eaves DH, Shikany JM, Pace RD. (PubMed)
(3) Western Dietary Pattern Is Associated With Severe Coronary Artery Disease by Oikonomou E1, Psaltopoulou T2, Georgiopoulos G1, Siasos G1,3, Kokkou E1, Antonopoulos A1, Vogiatzi G1, Tsalamandris S1, Gennimata V1, Papanikolaou A1, Tousoulis D. (PubMed)

Phytochemical Indole-3-carbinol In the Prevention and Treatment of Breast cancer

By Kyle J. Norton

Indole-3-carbinol may be the pharmaceutical target in the searching of a chemo drug doe the treatment of breast cancer, some scientists suggested.

As a phytochemical in the class of Indoles, Indole-3-carbinol processes a unique function by the breaking down of the glucosinolate glucobrassicin found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Breast cancer is a medical and chronic condition caused by cell growth irregularly and uncontrollably in the breast tissue. At the early stage, most case breast cancer starts in the cells of the inner lining tissue of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the advanced stage, breast cancer cell caused by alternation of DNA can travel far the way from the primary site to infect other healthy tissue and organs.

Most patient at the early may have a lump when touching with no symptoms.

Patients who inherited the genetic preposition of BRCA1 and 2 are associated with over 60% of the risk of breast cancer.

However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of the breast cancer onset.

Dr. Harvie M, the lead scientist on breast cancer program team at the University Hospital of South Manchester NHS Foundation Trust, said, " The World Cancer Research Fund (WCRF) and American Cancer Society (ACS) cancer prevention guidelines recommend maintaining a healthy weight, undertaking at least 150 minutes of moderate intensity exercise per week, limiting alcohol consumption, and eating a plant-based" and "Lifestyle factors appear to modify risk among high-risk women with a family history and those with typical risk of the general population".

In Post menopause, weight control is the major factor throughout life appears to prevent breast cancer after menopause.

Daily physical activity and reduced intake alcohol throughout life are associated with reduced risk of developing pre- and postmenopausal breast cancer, however, smoking during adolescence or early adulthood increases later risk of breast cancer.

Interestingly, in the depth discussion of the diet pattern in risk of breast cancer, researchers do not find the direct link to breast cancer risk.

These results suggested by actively following the healthy lifestyle and moderate exercise, risk of breast cancer can be decreased substantially.

The team on the final report said, "Recent expert reports estimate that successful lifestyle changes could prevent 25% to 30% of cases of breast cancer".

According to the statistic, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.

Dr. the lead author in the research team of cancer program in the investigation to examine the effect of indole-3-carbinol cyclic tetrameric derivative (CTet) in breast cancer cell proliferation by endoplasmic reticulum stress and autophagy-related cell death induction conducted an experiment to evaluated the synergistic activity of CTet in combination with cisplatin and doxorubicin in triple-negative breast cancer cell lines.

In MDA included -MB-231 and BT-20 triple-negative breast cancer cells, CTet in combination with both cisplatin and doxorubicin synergistically inhibits cell viability and induces autophagy.

The efficacy of the CTet and combination exerted a strong anti-cancer effect as seen in the MAP1LC3B gene that is responsible for a normal physiological process in the body in dealing with the destruction of cells.
Pre-treated with cisplatin and doxorubicin demonstrated a strong cytotoxic activity of CTet in cells in the tested cancer cell lines.

The findings reaffirmed the potential of CTet as a chemopreventive agent or chemotherapeutic in combination with standard approaches for triple-negative breast cancer.

Furthermore, indole-3-carbinol cyclic tetrameric derivative CTet induces autophagy and inhibits breast cancer cell proliferation, researchers at the University of Urbino Carlo Bo conducted an investigation to examine the antitumoral activity of a mixture of tri- and tetrameric cyclic I3C derivatives (CTr/CTet) both in vitro (MCF-7 and MDA-MB-231 breast cancer cell lines.

Observation of the application on the tested cancer cell line suggested CTr/CTet mixture inhibit breast cancer cell proliferation (IC50 = 1.3 and 1.6 μg/ml in MCF-7 and MDAMB- 231, respectively) inducing the G0/1 cell cycle phase accumulation.

The efficacy was attributed to the mixture in activating the overexpression of p21, p27 and GADD45A, which are the cell cycle regulators, nuclear translocation of FOXO3ain the induction of cell apoptosis and inhibition of Akt activity and downregulation of estrogen receptor.in stimulating the cancer cell proliferation.

Moreover, n vivo, the tumor growth of xenotransplanted was also inhibited by reducing the function of Cyclin E and its low molecular weight that is important in the transition from G1 to S phase of the cell cycle that determines initiation of DNA duplication.

Taken altogether, Indole-3-carbinol processed apoptotic and antiproliferative activity can be considered a functional supplement for the prevention and combined with primary medicine for treatment of breast cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the phytochemical during the course of the disease will be necessary to complete the picture of Indole-3-carbinol anti-breast cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The Indole-3-carbinol cyclic tetrameric derivative CTet synergizes with cisplatin and doxorubicin in triple-negative breast cancer cell lines by De Santi M1, Galluzzi L, Duranti A, Magnani M, Brandi G.(PubMed)
(2) Antitumoral activity of indole-3-carbinol cyclic tri- and tetrameric derivatives mixture in human breast cancer cells: in vitro and in vivo studies by Brandi G1, Fraternale A, Lucarini S, Paiardini M, De Santi M, Cervasi B, Paoletti MF, Galluzzi L, Duranti A, Magnani M.(PubMed).
(3) Can diet and lifestyle prevent breast cancer: what is the evidence? by Harvie M1, Howell A1, Evans DG. (PubMed)

Tuesday, 11 December 2018

Phytochemical Allyl isothiocyanate, the Potential Anti Brain Cancer Bioactive Compound

By Kyle J. Norton

Phytochemical Allyl isothiocyanate may be next pharmacotherapeutic target to identify the chemo drug for the treatment of brain cancer without inducing any side effects.

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color.

Brain and spinal cord make up the nervous system. Brain and Spinal Cord tumors originated are not very common.

Brain cancer is a medical and chronic condition characterized by cell growth disorderly in the brain tissue.

Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in the US are diagnosed with a brain tumor each year alone.

Most brain types of brain cancer in the older adult ages 50 to 60 are Chordomas. The cancer is a rare and slow growing, but it can invade adjacent bone and put pressure on the nearby neural tissue.

Meningiomas, the most common type of benign brain tumor of the age group 40-50s. However, a small percentage of these tumors can be malignant. 

According to the statistic provided by the Canadian cancer society, Every day about 25 Canadians is diagnosed with a brain tumor.

The 5-year survival rate of brain cancer is only 25%, compared to over 60% for cancers overall.  Most adults with a diagnosis of aggressive glioblastoma survive only 1–2 years after their diagnosis.

The exact causes of brain cancer are debatable.  Researchers di not know why people with the same health conditions, family history, some are at a higher risk to develop brain cancer while others do not.

Some researchers suggested genetic preposition and acquired gene mutation due to long-term exposure to chemical toxins may be the prevalent risk factor that causes the alternation of brain cell DNA.

Most common symptoms of brain cancer depending on the stage are persistent headaches and localized pain, gradual loss of sensation and movement, speech difficulty and persistent pain

If you are experiencing some of the above symptoms, please make sure you check with your doctor immediately to rule the brain cancer possibility.

Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.

 Most primary tumors are caused by abnormal cells growth that surrounds and support neurons, with a small number may be caused by a gene defect from exposure to radiation or toxic chemicals.

In the examining the side effects of Allyl isothiocyanate from the available data suggest that urinary concentrations of AITC equivalent are at least ten times higher than in the plasma, and tissue levels of AITC equivalent in the urinary bladder were 14-79 times higher than in other organs after oral AITC administration to rats for the treatment of cancer.

These results indicated AITC may be most effective in the bladder as a cancer chemopreventive compound, as AITC at high-dose levels exhibited a low degree of cytotoxicity and genotoxicity in animal cancer studies.

Once again, the experiment reaffirmed the effect of AITC in the exhibition of many desirable attributes of a cancer chemopreventive agent.

In the reassessment of Allyl isothiocyanate (AITC) in the reduced risk of cancer, researchers at the National Chung Hsing University conducted an experiment to examine the effects of the phytochemical in the brain cancer cells.
In compared to other cancer cell lines inhibition, AITC significantly decreased proliferation and viability of human brain malignant glioma GBM 8401 cells in a dose-dependent manner with IC50 9.25+/-0.69 microM for 24 h-treatment.  

In cell differentiated assay, AITC induced significantly G2/M arrest and sub-G1 phase (apoptotic population) in GBM 8401 cells.

AITC markedly reduced the CDK1/cyclin B activity and protein levels which are responsible for cancer cell proliferation and survival.

Furthermore, AITC-induced apoptotic cell death through enhancing the proteins associated with cells death programming.


Dr. Chen NG, the lead scientists at the final report, said, "AITC is a potent anti-human brain malignant glioma drug and it shows a remarkable action on cell cycle arrest before a commitment for apoptosis is reached".

Taken altogether, it is safe to suggest that Phytochemical Allyl isothiocyanate may be used as chemopreventive and functional phytochemical for high-risk of brain cancer individual and an adjunct therapy combined with primary medicine for the treatment of brain cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway by Chen NG, Chen KT, Lu CC, Lan YH, Lai CH, Chung YT, Yang JS, Lin YC.(PubMed)
(2) Allyl isothiocyanate as a cancer chemopreventive phytochemical by Zhang Y.(PubMed)

Eggplant, Night Shape Veggie Which Processes the Potential for the Prevention and Treatment Type 2 Diabetes

By Kyle J. Norton

Eggplant, the night shape fruit or vegetable may have a strong effect in reducing risk and treatment of type 2 diabetes, some researchers suggested.

Type 2 diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate glucose.

The condition of insulin resistance is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. 

According to the US statistic in 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. and 1.25 million American children and adults have type 1 diabetes.

Some researchers suggested that the widespread of type 2 diabetes in the US was associated with the promotion of the Western diet which has been found to complicate the risk of insulin receptor sites clogged up by fat and cholesterol, affecting the receptor in absorbing and releasing insulin from and to the body.

Dr. Merat S, the lead scientist in the study of a group of mice involved the Western diet risk of insulin resistance and hyperinsulinemia wrote, "The Western diet group had higher average glucose levels (187+/-16 versus 159+/-12 mg/dL) and 4.5-fold higher plasma insulin levels".and "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis, but also IR, potentially complicating the interpretation of results".

These results firmly suggested long-term followers of the Western diet high in saturated and trans fat, red meat, processed foods and low in fruits and vegetables are the main culprits for the onset of insulin resistance, the early stage of type 2 diabetes.

Therefore, by the change to a healthy diet that reduces the intake of total fat (saturated fatty acids in particular) and increases intake of dietary fiber by consuming more vegetables and fruits and whole grain cereal products, diabetes is preventable.

Dr. Matti Uusitupa, MD, in the article of "Lifestyles Matter in the Prevention of Type 2 Diabetes" quoted, "In a Swedish uncontrolled study shown that an increase in physical activity and moderate weight loss reduced the incidence of type 2 diabetes by 50% in middle-aged men with IGT" and

"In a Chinese study of IGT patients, 6-year interventions with diet, physical activity, and diet plus physical activity resulted in an approximate 30–40% reduction in diabetes risk in both normal weight and overweight persons".

Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

The vegetable is famous with its deep purple and the best eggplant can be found from August through October when it is in the season. While it's generally thought of as a vegetable, eggplant is actually a fruit.

Chemical constituents
The vegetable chemical compounds containing include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.

In the concerns of the wide spread of type 2 diabetes among American, researchers launched an investigation to examine the National Diabetes Education Program of NIH, Mayo Clinic and American Diabetes Association recommendation of eggplant-based diet as a choice for management of type 2 diabetes.

Therecommendation is based on the rationale is the high fiber and low soluble carbohydrate content of eggplant. 

Application of phenolic-enriched extracts of eggplant showed a moderate free radical scavenging-linked antioxidant activity and high alpha-glucosidase inhibition by preventing the glucosidase in breaking down starch and disaccharides to glucose and moderate to high angiotensin I-converting enzyme (ACE) inhibition activity in the prevention of β-cell dysfunction and apoptosis occurring in type 2diabetes.

By inhibiting these enzymes researchers suggested that intake of eggplant should provide a strong biochemical basis for management of type 2 diabetes by controlling glucose absorption.

Dr.Kwon YI, the lead author said, "phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress".

Further analysis the phenolic antioxidant in the eggplant, researchers conducted an experiment on the member chlorogenic acids (CGAs) on chronic diseases including diabetes, by searching the database of online medical literature.

* The biological properties of CGA in addition to its antioxidant and anti-inflammatory effects was found in some studies.

* CGA was found to exert pivotal roles on glucose and lipid metabolism regulation and on the related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.

* CGA demonstrated a wide range of potential health benefits, including its anti-diabetic, anti-carcinogenic, anti-inflammatory and anti-obesity impacts, may provide a non-pharmacological and non-invasive approach.

Taken altogether, eggplant processed a high amount of phenolic compound may be considered a functional vegetable in the prevention of type 2 diabetes and an adjunct therapy combined with primary medicine for the treatment of the disease.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) in outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities by Upadhyay R1, Mohan Rao LJ.(PubMed)
(3) Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet by Merat S1, Casanada F, Sutphin M, Palinski W, Reaven PD. (PubMed)
(4) Lifestyles Matter in the Prevention of Type 2 Diabetes by Matti Uusitupa, MD

White Button Mushroom, The Potential Anti Colon Cancer Functional Food, Scientists Say

By Kyle J. Norton

Scientists may have found an edible mushroom with the potential in reducing risk and treatment of colon cancer, some scientists suggested.

Primary colon cancer is a medical condition characterized the cell growth regularly that starts on the surface of the inner lining tissue of the colon.

After proliferating to the advanced stage, the cancerous cells can dispatch from the original site to infect other healthy tissue and organs far the way from the colon.

The exact causes of colon cancer are unknown. As of today, researchers still wonder, why people with the same health condition, family history, and diet, some are susceptible to the onset of the disease while others do not.

According to the statistic, colorectal cancer(cancer that starts in the colon or rectum) is the third most commonly diagnosed cancer and the second leading cause of cancer death in men and women combined in the United States. About 71% of cases arise in the colon and about 29% in the rectum.

Dr. Milly Ryan-Harshman, in the study of Diet and colorectal cancer, suggested, "Whether red meat is a culprit in causing CRC remains unanswered, although any effect it might have is likely moderate and related to processing or cooking"

 "The effect of dietary fiber on risk of CRC has also been difficult to determine because fiber intake is generally low. Evidence that folic acid, calcium, and vitamin D reduce the risk of CRC is stronger"

" In particular, recent research indicates that calcium and vitamin D might act together, rather than separately, to reduce the risk of colorectal adenomas. There might also be an interaction between low folate levels and high alcohol consumption and CRC".

These result indicated a reduced intake of red meat, increase intake of nutrients from the fruits and vegetable including folic calcium and vitamin D are associated with the substantially reduced risk of colon cancer.

However, in the study conducted by the team lead by Dr. Dana-Farber, Cancer Center oncologist Jeffrey Meyerhardt, MD appeared in the Aug. 15 issue of the Journal of the American Medical Association, the Western diet not only associate to the colon cancer risk but also elevate the risk of recurrent colon cancer in colon cancer patients.

Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source,

It is a genus A. Muscaria and belong to the family Amanitaceae and has been cultivated in many cultures all over the world for foods and health benefits.

Chemical constituents of white button mushroom include
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).

Intake of dietary supplementation with Se-enriched white button mushroom can reduce the production of antioxidant produced by the colon tumor by up-regulating the integrity of cell mRNA expression levels.
Se-enriched white button mushroom inhibited the colon cancer cell by stimulating the production of GPx-1 and 2 and anti-antioxidant enzyme activity.
Selenise white button mushroom can positively increase GPx-1 and GPx-2 gene expression and GPx-1 enzyme activity in rat colon cells in the protection of cell DNA alternation due to overexpression free radicals, Dr. Maseko T, the leader in the team at the The University of Melbourne suggested at the final report.

The study was published on United States National Library of Medicine (NLM).

Furthermore, in the reassessment of the 2 epidemiological studies that demonstrated an inverse correlation between mushroom intake and the risk of cancer, researchers launched an investigation to evaluate whether white button mushroom affects the growth of breast and colon cancer cells.

Application of white button mushroom suppressed proliferation of colon cancer (HT-29, HCT-116) cells, without affecting proliferation of epithelial mammary MCF-10A and normal colon FHC cells. 

The inhibition of cell proliferation by the mushroom was associated with the cell cycle arrest at the G0/G1 phase in HT-29 cells.

White button mushroom was also found to up-regulated expression of p21 in the induction of apoptosis and inhibited Rb phosphorylation, a tumor suppressor protein in HT-29 cells,

The finding confirmed the results from the 2 epidemiological studies that white button mushroom process anti-colon cancer possibility.

Taken all together, dietary white button mushroom intake daily and regularly may have a significant effect in the prevention colon and combined with the primary therapy in the treatment of colon cancer



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(2) Selenium-enriched Agaricus bisporus increases expression and activity of glutathione peroxidase-1 and expression of glutathione peroxidase-2 in rat colon by Maseko T1, Howell K, Dunshea FR, Ng K.(PubMed)
(3) Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway by Jedinak A1, Sliva D.(PubMed)
(4) Diet and colorectal cancer, Review of the evidence by Milly Ryan-Harshman, Ph.D. RD. (PubMed)