Sunday, 30 September 2018

Cruciferous Vegetables, The Natural Chemopreventive Veggies Protect Our Body Against Cancers Caused by Chemical Toxins, Scientists Reveal

By Kyle J. Norton, Master of Nutrients

Cruciferous vegetables, rich of phytochemcals may be considered as the functional food for prevention of  cancers caused by chemical carcinogens some studies suggested.

Chemical carcinogens, types of chemical toxins, can induce cellular and chromosomes change and DNA damage, causing mutation of healthy cells, the initial stage of cancer development.

According to the National Toxicology Program 14th Report on Carcinogens “Known to be human carcinogens”provided by the American Cancer Society, there are many different types of chemical carcinogens, including
* Lifestyle factors (nutrition, tobacco use, physical activity, etc.) 

* Naturally occurring exposures (ultraviolet light, radon gas, infectious agents, etc.) 

* Medical treatments (radiation and medicines including chemotherapy, hormone drugs, drugs that suppress the immune system, etc.) 

* Workplace exposures 

* Household exposures 

* Pollution
Cancers are class of medical diseases characterized by cell multiply disorderly and uncontrollably.

At the advance stage, most cancers can travel a distance away from the site of origin to infect other healthy cells and tissue via lymph and blood.

According to the Universidade Federal de Ouro Preto, sulforaphane (SFN),the isothiocyanate (ITC) group of organosulfur compounds found in cruciferous vegetable expressed chemopreventive properties involved detoxification processes of chemical carcinogens.

Dr. de Figueiredo SM, the lead author said, " In a dose dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells and present antiinflammatory effect acting during the initial of uncontrolled cell proliferation."

The chemoprotective activity of the cruciferous vegetable was attributed to significant expression of the antioxidants in cell cycle arrest and apoptosis of cancer cells.

Furthermore, its phytochemicals also can act as the post-initiation stages of carcinogenesis, 'suppressing' agent involving the ability to modulate the Nrf2 which is a protein with unique function of regulating expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.

In fact, besides using as chemopreventive agent against chemical carcinogenesis, sulforaphane (SFN), the major chemical constituent of cruciferous vegetables also inhibited the drug-metabolizing enzymes that cause activation/neutralization of carcinogenic metabolites and protected normal healthy cells from environmental toxin inducing of cancers.

Moreover, the phytochemical exhibited the molecular mechanisms responsible for the overall chemopreventive effects on selective cytotoxicity, the unique function of inhibiting oxidate stress, free radicals produced by lipid peroxidation in cells.

Additionally, in tobacco smoke carcinogens induced chemical tumors, cruciferous vegetable consumption has shown to inversely associate the development of cancer.

 In animal experiments. the chemopreventive effects of isothiocyanates, another compound found cruciferous vegetable, inhibited the metabolic activation of carcinogens by cytochrome P450s, enzymes with function of metabolized potentially toxic compounds.

Taking together, intake of cruciferous vegetables have a potential health benefits against environment toxins that initiates early onset of cancers. But due to small size of the sample, further studies are necessary to address the veggies anti cancers possibility.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Chemoprotection by sulforaphane: keep one eye beyond Keap1 by Myzak MC1, Dashwood RH.(PubMed)
(2) The antioxidant properties of organosulfur compounds (sulforaphane) by de Figueiredo SM1, Binda NS, Nogueira-Machado JA, Vieira-Filho SA, Caligiorne RB.(PubMed)
(3) Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane by Sharma R1, Sharma A, Chaudhary P, Sahu M, Jaiswal S, Awasthi S, Awasthi YC.(PubMed)

Alternative Therapy: Yoga Improves All Aspects in Patients with Osteoporosis

By Kyle J. Norton, Master of Nutrition

Yoga participated may benefit to individuals with osteoporosis by reducing complications of fractures, some studies suggested.

Osteoporosis is a Musculoskeletal disorders (MSDs) medical condition, characterized by decreased bone density.

The exact causes of osteoporosis are unknown. Neither researchers understood that people with the same health conditions, some are imbalance between new bone formation and bone resorption while others do not.

However, researchers do know that certain risk factors such as a lid to increase lifelong calcium deficient diet, age, female, family history,.... bone structure and over weight are associate to early onset of osteoporosis.

Furthermore, long term intake of certain medicine such as prednisone and medical condition such as rheumatoid arthritis are also the osteoporosis prevalent risk factors

According to the statistic, 1 in 3 women and 1 in 5 men older than 50 will suffer from an osteoporosis fracture, worldwide.


Yoga, the ancient practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been well known to people in Western world and some parts in Asia.

Some of yoga health benefits were reported by various respectable institutes' research and supported by health advocates.

In the review of literature published in PubMed, Medline, and Cochrane databases between 1966 and 2011 about topics related to osteoporosis and spinal movement. researchers found that
*Yoga, as a moderate form of exercise showed to strengthen the muscles supporting the spinal column, promote balance, improve posture, and enhance quality of life.

* Yoga attendees may also benefit from varied spinal movement in preserving the health and strength of the vertebral bodies.

* Yoga exercise modified by experts may be helpful in reduced risk fracture depending to risk of vertebral fractures of attendees

After adjusting to other risk factors, Dr, Smith EN the led author said, "Yoga therapists are cautioned to not apply a one-size-fits-all approach when working with this population".
Furthermore, the study also concerned that more studies are needed to further evaluate yoga poses presence which provide the least risk and greatest benefit to individuals with osteoporosis.

Physically, yoga postures and exercise exert a significant effect of stimulating bone metabolism and enhance physical function. As impact of moderate exercises are recognized as beneficial for the stimulation of bone tissue, muscle strength, type of muscle contraction are associated to changes in bone metabolism.

Additionally, in the support of the above differentiation, researchers at the Istanbul University conducted a review of literature posted in databases with 26 postmenopausal osteoporotic women over 55 years of age satisfied the criteria selected found that* Yoga may used as form of exercise in the field of osteoporosis rehabilitation.

* Yoga lessons expressed a positive influence on balance, posture, flexibility, and life quality.

* Yoga education has a positive effect on pain, physical functions, social functions, general, particularly in post postmenopausal osteoporotic women.

However, according to the reports from the Mayo Clinic in the examine 3 patients with osteopenia, but in good health and pain-free, and started yoga exercises to improve their musculoskeletal health, researchers warned,  yoga class without tailoring to individual students needed may induce pain and complications with some flexion yoga positions in the patients with osteopenia of that can lead to concern that fracture risk and increased even further in osteoporosis.

Dr. Sinaki M, said, "Although exercise has been shown to be effective for improving bonemineral density and decreasing fracture risk, our subjects had development of VCFs and neck and back pain with yoga exercises. This finding suggests that factors other than bone mass should be considered for exercise counseling in patients with bone loss. The increased torque pressure applied to vertebral bodies during SFEs may be a risk".

Furthermore, the study also advise that even though yoga exercise prescribed for patients with vertebral bone loss, is effective and important for treatment of osteopenia and osteoporosis and should be, instructors should need to know some positions can contribute to extreme strain on spines with bone loss.

Taking altogether, yoga may be considered as an integrated form of exercise in all ages, but in older population with osteoporosis, yoga instructors should select a applicable lesson which provide the least risk and greatest benefit to individuals with osteoporosis.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton (Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Yoga, vertebral fractures, and osteoporosis: research and recommendations by Smith EN, Boser A.(PubMed)
(2) Yoga spinal flexion positions and vertebral compression fracture in osteopenia or osteoporosis of spine: case series by Sinaki M1.(PubMed)
(3) Yoga might be an alternative training for the quality of life and balance in postmenopausal osteoporosis by Tüzün S1, Aktas I, Akarirmak U, Sipahi S, Tüzün F.(PubMed)

Infectious Diseases: Green tea, The Beverage Kills Bacterial Staphylococcus and Streptococcus That Cause Cellulitis

Kyle J. Norton 

Green tea may have a therapeutic and positive effect of reducing risk and treatment of cellulitis, some scientists suggested.

The results of the investigation were evaluated by numbers of respectable institutes, including the University of Indonesia and Mashhad University of Medical Sciences and published online in some medical literature databases including PubMed.

Cellulitis is a common and serious bacterial skin infection that affects the deep layer of skin, caused mostly by Staphylococcus and Streptococcus bacteria, inducing symptoms of a red, swollen skin rash (usually on the lower legs or arms) that feels tender and hot.

The skin infectious disease can appear anywhere in the body, however, in most cases, it affects the skin of the lower legs.

Some researchers suggested that people with a weakened immune system such as age population and intake of immune suppressive drugs and obesity are most likely to develop cellulitis.

As always, most cases of cellulitis are treated with antibiotics in a period of 5-10 days. Please make sure that you discuss the side effects of the medicine with your doctor.

Although it is rare, some people with severe cellulitis that experience severe symptoms of high fever or vomiting and fails to respond to treatment.

Recurrences of cellulitis may require antibiotics that are given by IV.

Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.

In the searching of natural antibiotics against skin infection such as cellulitis, by reviewing some plants for the treatment of skin diseases taken place during the past 17 year using the of plants is as old as the mankind, researchers found that green tea with abundant polyphenols, epigallocatechin gallate exerts a strong effect as antioxidants to reduce the risk of skin diseases, including tumors, herpes, and cellulitis. 

According to the National Center for Complementary and Alternative Medicine, application of EGCG also demonstrated a potential in rejuvenated old skin cells.

Further analysis of green tea catechins, the major green tea polyphenols, exhibited antimicrobial activity against resistant pathogens in induction of skin infection, including cellulitis, researchers at the Mashhad University of Medical Sciences conducted a study to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values of different agents against bacterial strains, through assessing the interactions of green tea extract, epigallate catechin, epigallocatechin gallate, two types of methylxanthine, caffeine, and theophylline with gentamicin against standard and clinical isolates of Staphylococcus aureus (S. aureus) and the standard strain of Pseudomonas aeruginosa (P. aeruginosa).

According to the final phase of the experiment, researchers indicated that
*The MICs of gentamicin against bacterial strains were in the range of 0.312 - 320 μg/mL and the MIC values of both types of catechins were 62.5 - 250 μg/ mL.

* Green tea extract showed insufficient antibacterial activity when used alone 

* Methylxanthines had no intrinsic inhibitory activity against any of the bacterial strains tested.

* When green tea extract and catechins were combined with gentamicin, the MIC values of gentamicin against the standard strains and a clinical isolate were reduced, and synergistic activities were observed (FICI < 1). 

* A combination of caffeine with gentamicin did not alter the MIC values of gentamicin.

The results of all comparison after taking into account of other co and confounders revealed that green tea extract and catechins potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and standard P. aeruginosa strains",  Dr. Fazly Bazzaz BS, the lead author said.

Moreover, the evaluate the antibacterial activity of the Indonesian water soluble green tea extract, Camellia sinensis, against clinical isolates of methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA) and multi-drug resistant Pseudomonas aeruginosa (MDR-P. aeruginosa) also lends a support of the above differentiation.

According to the University of Indonesia,
* The inhibition zone diameter of green tea extracts for S. aureus ATCC 25923 and MRSA were (18.970 ± 0.287) mm, and (19.130 ± 0.250) mm respectively. 

* While the inhibition zone diameter for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa were (17.550 ± 0.393) mm and (17.670 ± 0.398) mm respectively. 

* The MIC of green tea extracts against S. aureus ATCC 25923 and MRSA were 400 µg/mL and 400 µg/mL, respectively.

* Finally, the MIC for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa were 800 µg/mL, and 800 µg/mL, respectively.

Taken together, green tea and its bioactive compounds may be considered as a functional food for reduced risk and treatment of cellulitis caused by Staphylococcus and Streptococcus bacterial infection.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Plants used to treat skin diseases by Nahida Tabassum and Mariya Hamdani(PMC)
(2) Effect of Catechins, Green tea Extract, and Methylxanthines in Combination with Gentamicin Against Staphylococcus aureus and Pseudomonas aeruginosa: - Combination therapy against resistant bacteria by Fazly Bazzaz BS1, Sarabandi S2, Khameneh B3, Hosseinzadeh H4.(PubMed)
(3) Antimicrobial activity of green tea extract against isolates of methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa by Radji M1, Agustama RA, Elya B, Tjampakasari CR.(PubMed)

Alternative Therapy: Yoga Intervention Can Alleviate Pain and Treat Rheumatic Diseases, Researchers Suggest.

By Kyle J. Norton (Master of Nutrients, All right reserved)

Yoga intervention may have a profound effect to alleviate pain and treat rheumatic diseases, some studies suggested.

Rheumatic diseases is a condition of Musculoskeletal disorders, affecting the joints and muscles.

Yoga, the accident technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia.

In a study to compare the effect of Tai Chi and yoga therapies in treatments for rheumatologicand musculoskeletal diseases, researchers filed the following report
* Both therapy displays a significant effect of Tai Chi and yoga in the management of rheumatologic diseases, particularly in osteoarthritis of the knee, hip and hand, and rheumatoid arthritic pain.

* Tai Chi and yoga are safe, expressed a reduction of pain and improvement of physical function and quality of life in patients with rheumatic diseases.

By the information collected, Uhlig T, the led authors said, "Recommendations for Tai Chi in knee osteoarthritis have recently been issued by the American College of Rheumatology. To allow broader recommendations for the use of Tai Chi and yoga in rheumatic diseases".

The study from McGill University, Montreal suggested that yoga lessons not only improve stress and anxiety and promote a sense of calmness, general well-being, and quality of life but also reduced inflammatory mediators including C-reactive protein and interleukin-6 in over expression pain in participant with rheumatic disease.

Truly, regular yoga practice can increase muscle strength and endurance, proprioception, the sense  equilibrium and balance, depending on the notion of force and balance, with emphasis on movement through a full range of motion to increase flexibility and mobility, thus reducing physical symptoms in patients with rheumatic diseases.

Some researchers suggested that regular yoga practice
* can improve stress management and can have a feedback effect on improving chronic pain, through affecting the response to pain, decreasing the level of perceived suffering.

* can improve movement of joints, as motion and  muscles stretching of  can decrease the intensity of  pain or relieve your pain completely in some patients.


Furthermore, yoga breathing and medication also were found to reduce chronic pain through calming the nervous system to block respond to pain messages, reduce inflammatory chemicals from communicating with nerves and increase release of natural pain-relieving chemicals called endorphins.

However, in the review of randomized controlled trials (RCTs)  by comparing yoga with control interventions in patients with rheumatic diseases by searching database of Medline/PubMed, Scopus, the Cochrane Library and IndMED through February 2013, eight RCTs selected met the guideline with a total of 559 subjects with two RCTs with a low risk of bias, researchers found that all studies expressed a very low evidence for effects on pain and disability, in patients with rheumatic diseases participated in yoga classes, long and short terms.


Taking altogether, yoga practice may have a profound effect to alleviate pain and treat rheumatic diseases, however, larger randomized controlled trials. are necessary to reaffirm these possibilities


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299

Sources
(1) Yoga for rheumatic diseases: a systematic review by Cramer H1, Lauche R, Langhorst J, Dobos G.(PubMed)
(2) Yoga in rheumatic diseases by Bartlett SJ1, Moonaz SH, Mill C, Bernatsky S, Bingham CO 3rd.(PubMed)
(3) Tai Chi and yoga as complementary therapies in rheumatologic conditions by Uhlig T1.(PubMed)

Dried Peas Delay and Decrease Postprandial Plasma Glucose and Insulin Concentrations Effectively In Type 2 Diabetes, Scientists Find

By Kyle J. Norton, Master of Nutrition

Scientists may have found a whole food with a potential effect of management of type 2 diabetes, some studies suggested.

Types 2 Diabetes is a chronic and medical condition characterized insufficient insulin entering the bloodstream to neutralize the levels of glucose.

Types 2 Diabetes is caused either by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.

In some cases, diabetes can also be caused by allergic reactions of cells in the immune system.

The exact causes of type 2 diabetes are unknown as researchers do not know why? people with same
health condition, some are susceptible to early onset of type 2 diabetes, while others do not.

However, some researchers suggested there are some major risk factors such as genetics and lifestyle associated with early onset of insulin resistance.

Epidemiological studies also suggested that conditions such as overweight, obesity, physical inactivity, family history, race, age, and high blood pressure are some prevalent risk factors of type 2 diabetes, especially, in women with polycystic ovary syndrome and previous gestational diabetes.

According to the World Health Organization, the number of people with diabetes has risen from 108 million in 1980 to 422 million in 2014.

The global prevalence of diabetes among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014.

Diabetes prevalence has been rising more rapidly in middle- and low-income countries.

Sadly, untreated or improperly managed diabetes are leading causes of kidney failure, lower-limb amputations, and adult-onset blindness.

Dried peas are a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae.

Fried peas also healthy sources of protein, fiber, vitamins and minerals that are good for everyone diet.

The Nutrients and Chemical constituents
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Vitamin A ( Beta-carotene, lutein, and zeaxanthin)
6. B vitamins
7. Vitamin C
8. Calcium
9. Iron
10. Magnesium
11. Phosphorus
12. Potassium
13. Zinc Beside it main component of Polyphenolic compounds, it also contains saponin pisatin, L-pipecolic acid, glycoside-Pisatoside, tocopherols,.... and cerebroside.

To understand more of low-glycemic response versus a high glycemic response breakfast meal on postprandial serum glucose, insulin and free fatty acid (FFA) responses after consumption of a standardized mid-day meal in adult individuals with Type 2 diabetes mellitus (DM), researchers launched a randomized crossover intervention using control and test meals was conducted over a 3-week-period following an overnight fast of 8-10 h.

Patients included in the study were given either Breakfast (A), a high glycemic load breakfast meal consist of farina (kJ 1833; carbohydrate (CHO) 78 g and psyllium soluble fiber 0 g) or breakfast (B) a low-glycemic load breakfast meal consists of a fiber-loop cereal (kJ 1515; CHO 62 g and psyllium soluble fiber 6.6 g) randomly.

Forty-five Type 2 DM subjects included in the study have completed the requirements. By observation of post-breakfast analyses experiment, researchers found that

* Breakfast B had a significantly lower area under the curve (AUC) values for plasma glucose and insulin compared to Breakfast A (P<0.05).

* Post-lunch analyses indicated similar glucose responses for the two breakfast types.

* Insulin AUC values for Breakfasts B were significantly lower than Breakfast A (P<0.05) (95% confidence level).

These result suggested that psyllium soluble fiber have a strong effect to reduce fasting glucose compared to a meal without. However, intake of psyllium soluble fiber showed insignificant improvement postprandially in the glycemic, insulinemic and FFA responses after the consumption of the lunch meal.

Dr. Clark CA, the lead researcher also indicated, "These data revealed no residual postprandial effect of the psyllium soluble fiber breakfast meal beyond the second meal consumed".

Additionally, in the study to evaluate the glycemic and insulinemic effects of dried peas compared to potatoes researchers at the University of Göttingen conducted a study, using 3 different meals based on dried peas, potatoes, or both in patients with type 2 diabetes undergoing dietary treatment.

The tested meals were prepared according to local recipes and consumed at weekly intervals in random order at lunchtime, contained comparable amounts of carbohydrate, fat, protein, and water. The carbohydrate source of the meals differed and was supplied from either dried peas (meal 1), potatoes (meal 3), or a combination thereof (meal 2). Peripheral and venous blood was sampled over 180 min.

In the final report, researchers wrote,
* The increases in postprandial plasma glucose and insulin concentrations were delayed and significantly smaller after the peameal than after the potato meal.

* The areas under the glucose curve were 164, 257 and 381 mmol x 180 min/L for meals 1, 2, and 3, respectively (P < 0.01).

* The areas under the insulin curve were 13.8, 15.4 and 31.2 nmol x 180 min/L, respectively.

These results further reaffirm the effect of dried peas in delay and lower postprandial plasma glucose and insulin concentrations compared to potatoes.

Interestingly, researchers also strongly suggested, "..... carbohydrates in dried peas may be largely disregarded in carbohydrate counting and that type 2 diabetic patients should probably increase their consumption of low-glycemic, high-fiber foods at the expense of high-glycemic, low-fiber foods".


Taken together, dried peas may be considered as functional food for diabetes management by reducing postprandial plasma glucose and insulin concentrations in patients with type 2 diabetes.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299

References
(1) Effects of breakfast meal composition on second meal metabolic responses in adults with Type 2 diabetes mellitus by Clark CA, Gardiner J, McBurney MI, Anderson S, Weatherspoon LJ, Henry DN, Hord NG. (PubMed)
(2) Comparison of the effects of dried peas with those of potatoes in mixed meals on postprandial glucose and insulin concentrations in patients with type 2 diabetes by Schäfer G, Schenk U, Ritzel U, Ramadori G, Leonhardt U.(PubMed)

Saturday, 29 September 2018

Green Tea, The Beverage Which Blocks The Onset of Ulcerative Colitis, Researchers Find

Kyle J. Norton 


Green tea may have a therapeutic and positive effect for prevention and treatment of Ulcerative Colitis, some scientists suggested.

Ulcerative Colitis is a digestive condition characterized by inflammatory bowel disease (IBD) that induces chronic inflammation and ulcers (sores) in the digestive tract.

According to statistic, approximately, between 250,000 and 500,000 people are infected by ulcerative colitis in the United States. The risk of ulcerative colitis onset is between 2 to 7 per 100,000 persons.

Most common symptoms are abdominal pain and diarrhea. However, some patients may also experience symptoms of fatigue or tiredness, loss of appetite, dehydration feeling the urge to empty the bowels constantly,.... and weight loss.

If you have some of the symptoms of above, please check with your doctor to rule out the possibility of ulcerative colitis.

Researchers do not know the exact cause of Ulcerative Colitis.

Neither they know why ulcerative colitis induces chronic inflammation and ulcers (sores) in the digestive tract.

However, they do know that certain risk factors are associated to the development of the disease, including genetic mutation of a certain gene, environmental toxins, overreaction of the immune system,.... and long-term high levels of linoleic acid intake.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

As yin in nature, long-term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Mild to moderate ulcerative colitis (UC) patients, 15 received 400 mg or 800 mg of total Polyphenon E daily, administered in split doses or and 4 in placebo in a double-blinded, placebo-controlled pilot study, researchers at the end of the experiential indicated that oral administration of the extracts  exerts a potential effect of reduced levels of inflammation through the improvement of the reading of the mean UC disease activity index score compared to the entry score.

After 56 days of therapy, Polyphenon E  treatment group exhibited strong improvement of over response rate of 66.7% (10 of 15) and remission rate of 53.3% (8/15) compared to 0% (0/4) in both response rate and remission rate in the placebo group.

Dr. Dryden GW, the lead author, after taking into account of other co-founder said, "Administration of Polyphenon E resulted in a therapeutic benefit for(ulcerative colitis (UC)) patients who were refractory to 5-aminosalicylic and/or azathioprine".

Polyphenon E is a high-quality tea catechin extracted from natural tea leaves.

Further analysis of green tea bioactive polyphenols, epigallocatechin gallate (EGCG) on dextran sulfate sodium- (DSS-) induced ulcerative colitis in rats and to explore the roles of TLR4/MyD88/NF-κB signaling pathway, indicated that application of the extract significantly improves the intestinal mucosal injury in rats though inhibited production of inflammatory factors which were overexpression during the acute phase of injuring and damage to induced further damage to the tissue.

Moreover, green tea bioactive polyphenols, epigallocatechin gallate (EGCG) also reduced chronic inflammation and maintained the balance of the ratio of Th1/Th2 T-helper (Th) lymphocytes that prevent alterations in cellular immunity in patients with ulcerative colitis.

Imbalance of Th1/Th2 was found to associate to the occurrence and development of ulcerative colitis.

Additionally, injection of green tea EGCG also reduced the levels of TLR4 signaling in activated the intracellular signaling pathway NF-κB and inflammatory cytokine production to imitate inflammation.

Amazingly, researchers also found that injection of TLR4 antagonism not only shows a significantly reduced the protective effect of EGCG on intestinal mucosal injury colitis but also increased the expressions of inflammatory factors in the production of pro-inflammatory cytokines.

Moreover, in the examine the antioxidant activity of green tea catechins in model of colitis induced by 2.4.6 trinitrobenzene sulfonic acid (TNBS) using 35 young adult Sprague-Dawley rats which are divided into four groups: normal control (n=5), catechins (n=9), TNBS (n=9) and 2.4.6 trinitrobenzene sulfonic acid (TNBS) plus catechins (n=12), at the end of the experiment researchers at the Joint study, American University of Beirut, found that groups with TNBS and catechin express strong anti-inflammatory and anti-oxidant effects of amelioration of symptoms and expression of ulcerative colitis through stabilizing the mast cells production, induced by injection of TNBS in compared to TNBS treated group.

Dr. the lead authors in the joint study suggested that the study depicted a significant amelioration in the TNBS- and EGCG-treated rats compared to the non-treated animals in similar to histological data, as the mechanism of action occurred basically through the NF-kB pathway and possibly through a crosstalk with other pathways.

Taken together, green tea and its bioactive polyphenols may be considered as functional foods for the prevention and treatment of ulcerative colitis through the expression of antioxidant and anti-inflammatory activity.

Intake of green tea extract should be taken with extreme care as acute toxicity has been reported in some cases.

https://kylejnorton.blogspot.com/2018/09/green-tea-beverage-which-blocks-onset.html


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299


Sources
(1) A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis by Dryden GW1, Lam A, Beatty K, Qazzaz HH, McClain CJ. (PubMed)
(2) Tea catechins induce crosstalk between signaling pathways and stabilize mast cells in ulcerative colitis by Gerges Geagea A1,2, Rizzo M2, Eid A1, Hajj Hussein I3, Zgheib Z1, Zeenny MN1, Jurjus R4, Uzzo ML5, Spatola GF5, Bonaventura G5, Leone A5, Massaad-Massade L6,7,8, Jurjus A1.(PubMed)
(3) EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats by TNBS,1 Liu Xuelei,2 Dong Wanwei,3 Liang Linlang,1 and Chen Keyan3(Hindawi)

Alternative Therapy: Long Term Yoga Practice Improves Cognitive Function of Patients with Schizophrenia

By Kyle J. Norton (Master of Nutrients, All right reserved)

Epidemiological studies do agree that yoga lesson may reduce symptoms and complications  expression in patients with Schizophrenia, a renowned university study suggested.

Schizophrenia is a mental disorder induced inconsistent or contradictory elements such as breakdown of certain relation in thought, emotion, and behavior, leading to faulty perception, inappropriate actions,.... and feelings.

The exact causes of schizophrenia are unknown. However, National Health service suggested that certain risk factors involving physical, genetic, psychological and environmental circumstances are associated to the likeliness of a person to develop the condition.

Sadly, researchers do not know, why people with same health condition, some are susceptible to Schizophrenia development the while other do not.
 
Furthermore, stressful or emotional life event might trigger a psychotic episode in patient with Schizophrenia.
Yoga, the accident technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been well known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In the clinically stable, adult outpatients with SZ (n=286) completed baseline assessments randomized to treatment as usual (TAU), supervised yoga training with TAU (YT) or supervised physical exercise training with TAU (PE) researchers at the joint study led by the University of Pittsburgh filed the following results
* After six months and follow up, yoga showed a significant improvement of speed index of attention domain compared to control groups.

* In cognitive domains, yoga group demonstrated a significant improvement compared to PE and with TAU alone, respectively

Further assessment also suggested that both YT and PE improved attention and additional cognitive domains well past the training period, but only the YT group showed beneficial effect of on speed index of attention domain.

These results of improvement may be attribute to repeated practice of attentional focus and redirecting attention may be a possible active ingredient for developing greater attentional control

Moreover, the physical and cognitive benefits associated with yoga and mindfulness may be due to mechanisms that activated parasympathetic nervous system through meditative or contemplative practices.

Some researchers also suggested long term yoga practice increases body perception, stronger functional connectivity within the basal ganglia and increased activation of grey matter volume and amygdala with regional enlargement.

Additionally, in the review literature published in the databases of MEDLINE, PubMed, Embase, CINAHL, BIOSS, AMED, PsychINFO involved randomised controlled trials (RCTs) including people with schizophrenia comparing yoga as a package of care with standard-care control, researchers found only 3 studies with all outcomes were short term (less than eight weeks) with non of them displayed a significant change of yoga group in compared to control.

The findings indicated that short term yoga practice may have a little effect of improvement of cognitive function.

More importantly, in patients perspective,  a study of total of 100 schizophrenia patients (male: female = 57:43; age: 35.8 ± 9.2 years) attending the psychiatry out-patient services of a tertiary neuropsychiatry hospital administered a survey questionnaire, researchers at the National Institute of Mental Health and Neuro Sciences reported the following results
* 46% participant were aware that yoga is also one of the complementary therapies useful in schizophrenia.

* 32% had tried yoga in the past for some reasons, but only 31% of them were continuing yoga with reasons of lack of motivation (31%) and inability to spare time (27.6%).

* However, the majority (88.5%) of them were willing to take up add-on yoga therapy on out-patient basis along with their regular medical follow-up.

Taking altogether, long term yoga lesson may be used as secondary and therapeutic enhancement of  cognitive function in patients with schizophrenia.

There is one unsolved question required additional differentiation.  How patients knew that yoga lesson helpful in treatment of schizophrenia are unknown.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299

Sources
(1) Yoga as part of a package of care versus standard care for schizophrenia by Broderick J1, Vancampfort D.(PubMed)
(2) A randomised controlled trial of adjunctive yoga and adjunctive physical exercise training for cognitive dysfunction in schizophrenia by Bhatia T1, Mazumdar S2, Wood J3, He F2, Gur RE4, Gur RC4, Nimgaonkar VL5, Deshpande SN6.(PubMed)
(3) Yoga for schizophrenia: Patients' perspective by Govindaraj R1, Varambally S1, Gangadhar BN1.(PubMed)
(4) Effects of weekly one-hour Hatha yoga therapy on resilience and stress levels in patients with schizophrenia-spectrum disorders: an eight-week randomized controlled trial by Ikai S1, Suzuki T, Uchida H, Saruta J, Tsukinoki K, Fujii Y, Mimura M.(PubMed)
(5) A yoga program for cognitive enhancement by (PMC)

Eggplant, The Anti Cancers Night Shade Vegetable, Scientists show

By Kyle J. Norton, Master of Nutrition

Eggplant, the night shade vegetable may be considered as functional food for prevention and treatment of cancers, some researchers suggested.

Cancers are class of chronic diseases caused alternation of DNA of healthy cells.

In other words, healthy cells become cancerous if they grow uncontrollable and disorderly out of range of a normal healthy cell population which can only divide between 40 and 60 times.

According to the Hayflick limit theory, most cells survival is totally dependent to the telomeres on the ends each chromosome. 

Every time, healthy cells undergo division, the telomeres are shorten. Once the telomeres shorten to a critical length, the cells will die off.

In advance stage, travelling through fluid and blood circulation, most invasive cancer cells can infect healthy cells or tissue a distance away from the originated site.

According to the statistic provided the Canadian health Service, In 2017, over 200,000 Canadians will be diagnosed with cancer and 80,000 will die from cancer.

Sadly, 1 in 2 Canadians will be diagnosed with cancerd during their lifetime and 1 in 4 will die from the disease.

Lung, colorectal, breast and prostate cancers are most common cancer found in Canadian, accounting for half of all cancers diagnosed.

And 60% of Canadians diagnosed with cancer will survive at least 5 years after their diagnosis.

Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India.

The plant has been cultivated in southern and eastern Asia since prehistory.

Eggplant is famous with its deeply purple and the best eggplant can be found from August through October when it is in season.

Nutritional Supplements
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Pantothenic acid (B5)
10. Vitamin B6
11. Folate (Vitamin B9)
12. Vitamin C
13. Tryptophan
14. Manganese
15. Calcium
16. Copper
17. Iron
18. Magnesium
19. Phosphorus
20. Potassium
21. Zinc


Chemical constituents
The vegetable chemical compounds containing include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin and other Polyphenolic compounds.

In the effort to find the plant-derived foods such as potatoes, eggplants, and tomatoes with potential antiproliferative activities against human colon (HT29) and liver (HepG2) cancer cells, researchers at the Yeungnam University conducted a study to evaluate series of structurally related individual compounds in these plants, using microculture tetrazolium (MTT) assay.

Glycoalkaloids solamargine and solasonine and their common aglycon solasodine; and the nonsteroidal alkaloid jervine isolated from eggplant were selected to test the anti cancers possibilities compared to other compound isolated from potatoes and tomatoes.

After taking into account of other factors, researchers found that
* Glycoalkaloids derived from eggplant exerts the most active anti cancer cells compared to others. However, its hydrolysis products are less active compared to glycoalkaloids.

* Compounds isolated from eggplant are very effective against the liver cancer cells compared to colon cancer cells.

Dr. Lee KR, the lead author on the final report said, "....safety considerations should guide the use of these compounds preventative or therapeutic treatments against carcinomas".

Furthermore, the study to investigate the inhibitory effect of eggplant (Solanum melongena var. marunasu) extract on human fibrosarcoma HT-1080 cell invasion of reconstituted basement membrane [Matrigel (MG)], researcher discovered
* Delphinidin, a flavonoid pigment contained in the peel demonstrates the most effective against human fibrosarcoma HT-1080 cell.

* Interestingly, application of eggplant extract and delphinidin did not affect tumor cell adhesion to MG or haptotactic migration to MG.

Further analysis of these effects, researchers found that the inhibition of cancer was attributed to
delphinidin of blocking the activity of Matrix metalloproteinases MMPs which are responsible for the degradation of most extracellular matrix proteins during organogenesis, growth and normal tissue turnover.

The findings suggested that frequency of intake eggplant may associate to reduce risk of cancers. However, further data collection on large example size and multi centers studies performed with human consumption of the whole food eggplant during the course of cancer will be necessary to complete the picture of eggplant and its bioactive ingredients anti cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299
References
(1) Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells by Lee KR1, Kozukue N, Han JS, Park JH, Chang EY, Baek EJ, Chang JS, Friedman M.(PubMed)
(2) Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcoma HT-1080 invasiveness in vitro by Nagase H1, Sasaki K, Kito H, Haga A, Sato T.(PubMed)

Friday, 28 September 2018

Alfalfa, The Functional Herb Which Protects Our Body Against Onset of Type 2 Diabetes, Researchers Reveal

By Kyle J. Norton, Master of Nutrition

Scientists may have found a whole herb which processes anti diabetes property, some scientists suggested.

Diabetes is a chronic condition characterized by insufficient insulin entering the bloodstream to regulate the glucose as a result of either cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.

In some cases, diabetes may also be caused by allergic reactions of cells in the immune system.

The actual causes of diabetes inflammatory condition are debatable.

Some researchers also do not know why some people without genetic mutations are susceptible to type 2 diabetes while others do not.

However, certain risk factors such as over weight and obesity (over expression of fatty tissue that cause insulin resistant),  physical inactivity, family history, race,,,,, and age. ... 

Women developed gestational diabetes, polycystic ovary syndrome,.... and high blood pressure are also some major risk factors associated to increase risk of type 2 diabetes.

The first line medicine used for treatment of type 2 diabetes is metformin which processes a significant effect in improving the body tissue sensitivity to insulin. In other words, metformin improves the body uses insulin more effectively.and lowers glucose production in the liver.

In the stage prediabetes, patients may not experience any symptoms. However, untreated diabetes or diabetes that do not manage properly, may increase the risk of cataracts and glaucoma, foot damage.

In advance stage, untreated diabetes can also cause nerve damage or poor blood flow to the feet which in turn, increases the risk of various foot complications.


Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding.

The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc. North America aboriginal has used Alfalfa seed as food, such as making bread and mush.

Ingredients
1. Essential amino acids
2. Calcium
3. Magnesium
4. Potassium
5. Iron
6. Phosphorus
7. Zinc
8. Beta carotene
9. vitamin C
10. vitamins D
11.Vitamin E
12. Vitamin K

It chemical constituents include flavones, isoflavones, sterols, Bichanin, Coumestrol, Diadzein, Formonetin, Genistein,.... and  coumarin derivatives.

In the study to examine the lucerne (alfalfa) effect by oral administrated the herbal extract through diet (62.5 g/kg) and drinking water (2.5 g/l) in reduced the hyperglycaemia of streptozotocin-diabetic mice, researchers found
* Application of aqueous extract of lucerne exerts a significant stimulation of insulin secretion from the pancreatic B-cell line.

* Application of aqueous extract of lucern also promotes insulin-like activity in inhibited over expression glucose.

* The sequential extraction with solvents revealed .higher insulin-releasing activity in both methanol and water fractions compared to one extract constituent.

Further analysis also suggested that activity of the extract was found to be heat stable and enhanced by exposure to acid and alkali (0.1 M-HCl and NaOH).

Dr. Gray AM, the lead author at the final report wrote, "The results demonstrate the presence of antihyperglycaemic, insulin-releasing and insulin-like activity in the traditional antidiabetic plant, Medicago sativa".

Additionally, in the study to reaffirm the effect herbal alfalfa against onset of diabetes researchers launched a study to compare alfalfa with other herbal medicine including dried leaves of agrimony (Agrimonia eupatoria), blackberry (Rubus fructicosus), celandine (Chelidonium majus), eucalyptus (Eucalyptus globulus), lady's mantle (Alchemilla vulgaris), and lily of the valley (Convallaria majalis); seeds of coriander (Coriandrum sativum); dried berries of juniper (Juniperus communis); bulbs of garlic (Allium sativum) and roots of liquorice (Glycyrhizza glabra).

In mice administrated by streptozotocin (200 mg/kg i.p.) to induce the development of hyperphagia, polydipsia, body weight loss, hyperglycaemia and hypoinsulinaemia, researchers found that

* Herbal alfalfa exerts strong effect in reduced the level of hyperglycaemia during the development of streptozotocin diabetes compared to others herbs.

* Herbal alfalfa reduced polydipsia and a reduced rate of body weight loss.

* Alfalfa initially countered the hypoinsulinaemic effect of streptozotocin, without affecting the fall in plasma insulin.

Dr. said, after taking into account of other co and confounders, " The results suggest that certain traditional plant treatments for diabetes, namely alfalfa,.......can retard the development of streptozotocin diabetes in mice".

Taking altogether, herbal alfalfa may be considered as functional herb for prevention and treatment of type 2 diabetes.

 However, additional data collection on large example size and multi centers clinical studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of garlic anti type 2 diabetes possibilities.

And long-term multiple dietary supplement consumption of a broad array of vitamin/mineral, herbal, and condition-specific dietary supplements on a daily basis should consult with their doctors or related field specialist before applying.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299
References
(1) Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne) by Gray AM, Flatt PR.(PubMed)
(2) Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. by Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR.(PubMed)
(3) Drug-induced lupus: an update by Vasoo S.(PubMed)

Anise, The Herb Which Exerts Antinociceptive Activity Against Primary Dysmenorrhea, Scientist Find

By Kyle J. Norton, Master of Nutrition

Herbal  Anise may process an antinociceptive activity in reducing the expression of primary dysmenorrhea, some scientists suggested.

Primary dysmenorrhea pain is a menstrual pain caused by sensory neurons stimulus triggered by overproduction prostaglandins, hormones that lead to uterus contract before or during menstruation.
Antinociceptive activity is an action or process of blocking the painful or injurious stimulus by sensory neurons.

Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen.

In traditional Chinese medicine, dysmenorrhea is defined as a pain in the lower abdomen that can spread over to the whole abdomen and lumbosacral region, depending on the diagnosis.

According to statistic, primary dysmenorrhea affects more than 50% of women in late adolescence and the early 20s. Most primary dysmenorrhea appears 6 to 12 months after the first period due to immature of the reproductive organs of young girls,
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region.

The popular herb has been used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic, carminative, digestive, expectorant, stimulant and tonic agent and to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract,.... and menstrual cramps.

The Chemical Ingredients
Besides the main ingredient Anethole, herbal anise also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the finding of natural ingredient treat primary dysmenorrhea without inducing side effects, Dr. Khodakrami Nahid, MSM and colleague conducted a study to examine the effect of an Iranian herbal drug in the treatment of primary dysmenorrhea.

The randomized, double-blind, placebo-controlled pilot trial among 180 female students at Isfahan University dormitory aged 18 to 27.

Participants were randomly divided into three groups: herbal drug were given 500 mg of highly purified saffron, celery seed, and anise (SCA) extracts three times a day for three days, starting from the onset of bleeding or pain,  mefenamic acid, and placebo.

After following the participants for two to three cycles from the beginning of menstruation through the three days of bleeding and the severity and duration of pain at 2 and 3 months were measured.

At the final report of the study, researchers filed,

* Women received Anise extract and mefenamic acid showed a statistically significant reduction in pain scores and pain duration scores.

*  The decrease in pain score was reflected by a significant reduction in other herbal drug use among the treatment groups compared to the placebo group but lesser compared to Anise group.

* Application of Anise extract demonstrated a  magnitude of the reduction which is significantly greater compared mefenamic acid and placebo groups.

* However, both herbal drugs and mefenamic acid effectively relieved menstrual pain as compared with the placebo.

These results suggested that herbal Anise processed strong antinociceptive activity against pain caused by primary dysmenorrhea may be considered as a functional herb for the treatment of primary dysmenorrhea.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
1. Herbal combination for primary dysmenorrhea by Tori Hudson, ND
2. The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial.

Arnica, The Herb Which Speeds Up Bruise Healing, Scientists Reveal

Herbal Arnica may process a property of speeding bruise healing without inducing adverse effects, some studies suggested.

A bruise is a condition characterized by black and blue marks on the skin due to trauma, caused by an object or force strikes the body, leading to damage to capillaries and sometimes venules that allow blood to seep, hemorrhage, or extravasate into the surrounding interstitial tissues.

A bruise can also be induced by surgery caused by instruments which pierce into the deep layer of the skin to create an opening.

Most Bruising resolves themselves in a few days or weeks.

Some bruise may cause pain but the pain usually goes away when the color of the area fades away. 

Bruising, also known as a contusion, is defined as a condition of 

Some researchers suggested that

Most common causes of bruising are sport related. 

Sport physical activities can sometimes cause broken bones, strains and sprains, dislocations, torn tendons,..... and muscle swelling. Overuse of body muscles in sport is one of risk factor that can cause, inducing bruising.

Ice and heat therapies by Appling ice or heat immediately after the injury to reduce blood flow around the area. were found to be effective in preventing bruising.

Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.

The herb has been used in traditional medicine for centuries to treat strains, sprains, and bruises.

The chemical ingredients besides major bioactive compound helenalin, Anica also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside,..... and six dibenzylbutyrolactol derivatives.

In the assessment of the comparative utility of topical formulations in hastening the resolution of skin bruising, researchers at the Northwestern University, conducted a double (patient and rater) blinded randomized controlled trial with numbers of healthy volunteers, age range 21-65 years.

After four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). on each subject, each bruising area was injected by one topical agent, including 5% vitamin K, 1% vitamin K and 0·3% retinol, 20% arnica, or white petrolatum, twice a day for 2 weeks.

At the end of the 2 weeks experiment, researchers found that
* All four treatment score a significant improvement in the change in the rater bruising score.

* The mean improvement associated with 20% arnica was greater than with white petrolatum (P=0·003), and the mixture of 1% vitamin K and 0·3% retinol.

* However, 5% vitamin K cream processes the highest bruise healing score compared to other applications.

These results suggested that topical 20% Arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.

In  a double-blind, placebo-controlled, randomized trial with three parallel arms to reaffirm Arnica efficacy in the control of bruising, reducing swelling and promoting recovery after local trauma,  64 adults undergoing elective surgery for carpal tunnel syndrome were randomized to take three tablets daily of homeopathic Arnica 30C or 6C or placebo for seven days before surgery and fourteen days after surgery.

According to the summary of the experiment final report, researchers showed
* There were no group differences on the primary outcome measures of pain (P=0.79) and bruising (P=0.45) at day four.

* Swelling and use of analgesic medication also did not differ between arnica and placebo groups.

* Adverse events were reported by 2 patients in the arnica 6C group, 3 in the placebo group and 4 in the arnica 30C group.

These results strongly indicated that Arnica does not process analgesic property.

Moreover, in the study to assess Arnica decreases bruising and muscle pain efficacy, the Memorial Family Medicine Residency Program conducted a randomized, double-blind, placebo-controlled trial including 53 subjects.

Measurement of ankle range of motion and muscle tenderness were also recorded during Leg pain induced by calf raises.

Then, each participant received 2 tubes of cream, 1 with active Arnica and 1 with placebo.

The creams were applied to the lower legs immediately after the exercise, and again at 24 and 48 hours post-exercise according to the "RIGHT" or "LEFT" labels.

At 48 hours post-exercise, subjects had their ankle range of motion and muscle tenderness measured.

Subjects used the analog scale to rate pain in each leg at baseline, 24 hours, 48 hours, and 72 hours.

At the final day of study, by analyzing the reported returned by participants, scientists found that

* No significant differences in pain scores were seen before exercise.

* Pain scores on legs treated with Arnica were higher than scores on those receiving placebo 24 hours after exercise respectively.

* Pain scores on day 3 and day 4 were not significantly different.

* There was no difference in muscle tenderness.

* Ankle range of motion did not differ significantly on either day 1  or day 3.

Dr. Adkison JD, the lead author suggested, Arnica may increase pain in the affected area within 48 hours immediately after application.

Taking all together, herbal Arnica may be used as a therapeutic treatment for speeding up bruise healing however, patients should be aware that topical application of herbal Arnica does not process analgesic property. In some cases, it may increase pain in the affected area.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
2. Accelerated resolution of laser-induced bruising with topical 20% arnica: a rater-blinded randomized controlled trial. by Leu S, Havey J, White LE, Martin N, Yoo SS, Rademaker AW, Alam M.(PubMed)
3. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. by Stevinson C, Devaraj VS, Fountain-Barber A, Hawkins S, Ernst E.(Pubmed)
4. The effect of topical arnica on muscle pain" by Adkison JD, Bauer DW, Chang T., (PubMed).
5. Cosmetics and herbal remedies with Compositae plant extracts - are they tolerated by Compositae-allergic patients?" by Paulsen E, Chistensen LP, Andersen KE., (PubMed)
6. Contact allergy to Compositae plants in patients with atopic dermatitis. [Article in English, Serbian]" by Jovanović M, Poljacki M, Duran V, Vujanović L, Sente R, Stojanović S., (PubMed)

Alternative Therapy: Yoga In Prevention and Treatment of Neurological Disorders

Kyle J. Norton (Master of Nutrients, All right reserved)


Yoga, an integrated form of exercise may be used for reduced risk and treatment of neurological  disorders, some scientists suggested.

Neurological disorders are medical condition characterized by any disorder of the nervous system caused by structural, biochemical or electrical abnormalities.

There are many forms of neurological  disorders. The most common types of the disease include neurodegenrative disease, such as Alzheimer's disease (AD) and Parkinson's disease, epilepsy. multiple sclerosis and Migraines.

According to the Medical press, globally, the burden of neurological disorders (Alzheimer's disease, Parkinson's disease, stroke, epilepsy etc) has increased substantially over the past 25 years. These may be results of over 25 years of economic expansion that have increased living standard of billion of people in the Southeast Asian region.

Today, people who have made a lots of money in that region have abandoned traditional diet with abundant vegetables and fruits and replaced them  with Western diet which is considered as a risk factor of neurological  disorders.

A new report from the World Health Organization (WHO) showed that neurological disorders, ranging from epilepsy to Alzheimer disease, from stroke to headache, affect up to one billion people worldwide. And, An estimated 6.8 million people diet every year as a result of neurological disorders.
 
In Europe alone, neurological diseases cost the health care system an estimation of 139 billion euros in 2004.

Yoga, the ancient  technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been well known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a review of literature published online, including randomized, controlled trials with yoga as the central component of the intervention, researchers filed the following reports
*  6 selected trial expressed a significant effect of yoga lessons in reduced symptoms and treatment of neurological disorders
* 10 out 13 trials chosen indicated a positive effect in use of yoga as as an ancillary treatment of in patients with psychiatric disorders.

Researchers also note that Trials were excluded in these review if yoga was not the central component of the intervention.

These results suggested that long term participation in yoga affects the adrenal gland of central nervous system in production of hormones which have strong implications on stress and anxiety, such as serotonin, adrenaline and cortisol.

Further more, yoga meditation and posture also enhanced blood circulation to the central nervous system, thus reducing risk of neurological disorders.

Also in the review of article used comprehensive scientific, evidence-based studies to analyze the efficacy of various basic and applied aspects of yoga in disease prevention and health promotion, particularly in neurological disorders from various resources including PubMed, Ovid, MD-Consult, USC, and U.C.L.A. libraries, researchers at the USC, after adjusting to other co confound factors, indicated that patients who participated in the class of yoga demonstrate statistically encouraging physiological and psychological improvements in the aforementioned neurological disorders.

Additionally, in the investigate promotion of mind-body medicine for health promotion, disease prevention and as a possible treatment modality for neurological disorders, researchers at the S-VYASA University performed a comprehensive search in the PubMed/Medline found that 94 out of 700 examine demonstrated a strong improvement in patients with various neurological disorders

Martin Jones, the lead author in the article of Yoga for Neurological Health, For those with MS, Parkinson's, or Other Neurological Disorders wrote, " (Yoga) Exercises that train neuromuscular coordination, as well as draw vitality and strength to all parts of the body" and "Techniques to draw on the healing aspects of the parasympathetic (“rest and repose”) nervous system and meditation to retrain the brain and create more efficient pathways to the pre-frontal lobes, the most highly evolved part of our nervous system, where we experience our most inspired, creative thinking and elevated levels of consciousness".

Base on information collected, there is no doubt that yoga may be considered as secondary form of exercise used conjunction with standard application for reduced symptoms and treatment of neurological  disorders


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299


Sources
(1) Yoga as an ancillary treatment for neurological and psychiatric disorders: a review by Meyer HB1, Katsman A, Sones AC, Auerbach DE, Ames D, Rubin RT.(PubMed)
(2) The therapeutic value of yoga in neurological disorders by Mishra SK1, Singh P, Bunch SJ, Zhang R.(PubMed)
(3) Evidence based effects of yoga in neurological disorders by Mooventhan A1, Nivethitha L2(PubMed)
(4) Yoga for Neurological Health, For those with MS, Parkinson's, or Other Neurological Disorders, Led by Maitri Jones

Thursday, 27 September 2018

How to Protect Your Stomach Against Onset of Atrophic Gastritis and Gastric Cancer

By Kyle J. Norton, Master of Nutrition

Scientists may have found a whole food which has a unique function in protecting the stomach against the onset of atrophic gastritis and gastric cancer, some studies suggested.

Atrophic gastritis is a condition of loss of gastric glandular cells caused by long-term inflammation of the stomach mucous membrane (mucosa).

Loss of the gastric glandular cells in the long term eventually is replaced by intestinal and fibrous tissues.

Gastric cancer is a medical condition characterized by irregular and uncontrollable cell growth in the stomach lining in the beginning. At the advanced stage, the malignant cells can travel a distance away through blood and fluid circulation to infect other healthy tissue and organs.

Researchers do not know why some people with the same health condition are susceptible to the risk of gastric cancer, while others do not. The exact causes of gastric cancer are also unknown. However, some researchers suggested that Age, diet, and stomach disease, such as can increase the risk of developing gastric cancer.

Both atrophic gastritis and gastric cancer share the common symptoms of stomach pain, nausea and vomiting, loss of appetite,... and indigestion. However, common symptoms of unexpected weight loss and stomach ulcers can only be found in gastric cancer while iron deficiency anemia is found in the majority of patients with atrophic gastritis.

If you experience some of the above symptoms, please see your doctor to rule out gastric cancer possibility.

Celery is a species of Apium graveolens, belongings to the family Apiaceae, cultivated all around the globe as a vegetable.

Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

In vitro, with an aim to find the natural ingredient from food sources for treatment of atrophic gastritis and gastric cancer without inducing adverse effects, researchers conducted an experiment, including 5-8 week-old Mongolian gerbils inoculated with Helicobacter pylori for four weeks without (atrophic gastritis group) or with N'-methyl-N'-nitro-N-nitroso-guanidine (MNNG) (gastric cancer group) in drinking water, and were then rested for two weeks.

During the 7th-32th (atrophic gastritis group) or the 7th-52th (gastric cancer group) weeks were given various doses (0-60 mg/kgbw/day) of apigenin, a major bioactive compound isolated from celery.

Observation at the end of the 32th (atrophic gastritis group) or the 52th (atrophic gastritis group) week, after sacrificing, researchers found that
*Application of Apigenin at the doses range from 30-60 mg/kgbw/day effectively decreased atrophic gastritis (atrophic gastritis group) and dysplasia/gastric cancer (gastric cancer group).


* Apigenin treatment (60 mg/kgbw/day) significantly decreased Helicobacter pylori colonization and Helicobacter pylori-induced histological changes of neutrophil and monocyte infiltrations and atrophic gastritis in both atrophic gastritis and gastric cancer.

These results suggested that apigenin isolated from celery processes a remarkable ability to inhibit Helicobacter pylori-induced atrophic gastritis and gastric cancer progression as well as possessing potent anti-gastric cancer activity.

Additionally, the study in finding of natural compound which processes mechanisms of apoptosis in tumor cells for tumor therapy and cancer molecular biology and inhibits loss of cell cycle control, leading to uncontrolled proliferation in healthy cells, suggested that celery seed extract (CSE), in a dose- and time-dependent manner, exhibited anti-proliferation effect on human gastric cancer BGC-823 cells, through cell cycle arrest and apoptosis-related proteins.

Dr. Gao LL, the lead scientist said, at the end of the experiment, "The molecular determinants inhibition of cell proliferation, as well as apoptosis of CSE, may be associated with cycle arrest in the S phase".

Furthermore, Celery seed oil, in benzo[a]pyrene- (BP) induced forestomach cancer in mice, the chemical constituents. 3-n-butylphthalide and sedanolide showed to reduce tumor incidence from 68% to 30% and 11%, and 67% and 83% in tumor multiplicity, respectively.

These results suggest that phthalides, as a class of bioactive natural products occurring in edible umbelliferous plants, may be effective chemopreventive agents for cancer.

Moreover, in the differentiation of the nutritional epidemiology of gastric cancer in 293 cases and neighborhood-, age-, and sex-matched controls in communities throughout the counties of Niagara, Monroe, and Erie in western New York researcher discovered that ingestion of carotene from raw vegetables (including celery, cucumbers, carrots, green peppers, tomatoes, and onions), as well as with the increased use of low-temperature food storage exerts a significant inhibition of oxidation products that could act as carcinogens in the stomach.

Taken altogether, celery whole food and celery seed containing high amounts of bioactive Apigenin  and phthalide, respectively may be used to prevent and treat atrophic gastritis and gastric cancer without no adverse effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils by Kuo CH1, Weng BC2, Wu CC3, Yang SF4, Wu DC5, Wang YC(PubMed)
(2) Molecular mechanisms of celery seed extract induced apoptosis via s phase cell cycle arrest in the BGC-823 human stomach cancer cell line by Gao LL1, Feng L, Yao ST, Jiao P, Qin SC, Zhang W, Zhang YB, Li FR(PubMed)
(3) Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil by Zheng GQ1, Kenney PM, Zhang J, Lam LK(PubMed)
(4) Diet in the epidemiology of gastric cancer by Graham S1, Haughey B, Marshall J, Brasure J, Zielezny M, Freudenheim J, West D, Nolan J, Wilkinson G.(PubMed)