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Monday, 27 January 2014

Phytochemical Anacardic acids and pituitary adenomas

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
Pituitary adenomas are noncancerous tumors that occur in the pituitary gland

The effects
In GH3 and MMQ, pituitary adenoma cell lines, anacardic acid  exerted its novel antiproliferative and cytotoxic effects by increasing in poly([adenosine diphosphate]-ribose) polymerase cleavage, sub-G1 arrest, and annexin V staining, to incuce apoptotic cell death, possible nonclassical apoptotic mechanism.


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Reference
(1) Anacardic acid induces caspase-independent apoptosis and radiosensitizes pituitary adenoma cells by Sukumari-Ramesh S, Singh N, Jensen MA, Dhandapani KM, Vender JR.(PubMed)