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Sunday, 17 December 2017

Herbal Therapy: Green Tea EGCG, A Potent Iron Chelator in Regulation of Progression of Parkinson's disease

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)


Green tea may be considered as a functional food and iron chelator in reduced risk and progression of Parkinson's disease, some scientists suggested

Iron chelation therapy is a primary and standard treatment for patients with iron overload.

Green tea, is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Parkinson's disease (PD) is a progressive neurodegenerative disease, causing severe depletion of glutamatergic and dopaminergic inputs in the striatum.

Investigation of the green tea EGCG effect in risk and progression of PD has been found to associate to many mechanisms involved numbers of aspects.

Application of metal chelation was found to ameliorated the expression of ROS in induction of oxidative stress through a chain of reaction and precipitation of aggregation of alpha-synuclein and beta-amyloid peptides deposit in the brain, main leading causes to the onset of  PD.

In iron abnormality PD subjects,  oxidopamine, also known as 6-hydroxydopamine or 2,4,5-trihydroxyphenethylamine(6-OHD), a neurotoxic synthetic organic compound was found to disrupt iron metabolism, leading to over expression of the iron induction of dyshomeostasis cause of iron toxicity and oxidative damage in dopaminergic neurons.

Green tea major polyphenol, (−)-epigallocatechin-3-gallate used in metal chelation, ameliorated iron dependent free radicals located in the subcellular compartments and cellular membranes, through the effect in inhibited iron input and exhibited iron output in brain areas where it preferentially accumulates in neurodegenerative diseases, particularly Parkinsons' disease.

Further analysis of the neurotoxin 6-OHDA causes of iron unstable equilibrium, green extract GECG administration improved the function of hepcidin, a liver-derived hormone in regulated iron dyshomeostasis and gene expression of the iron metabolism through expressions of iron regulatory proteins (IRP1 and IRP2)  in regulated the RNA level,  between the transcription and the translation of the gene in expression of the iron homeostasis. 

Indeed, In the differentiation of neurotoxin 6-OHDA induced iron dyshomeostasis has shown to increase oxidative stress in damage to neuron cells, green extract GECG effects demonstrated a significant inhibition of free radical and iron free radical expression in the cellular membranes through the antioxidant activities and anti-inflammatory system and expression of nuclear factor-like 2(Nrf2) in stimulated production of antioxidant in protection against oxidative damage during injury and inflammation; heme oxygenase-1(HO-1) in increased production of superoxide dismutase and catalase against ROS and peroxisome proliferator-activated receptor gamma (PPARγ) in regulated production of pro and anti inflammatory cytokines and mytokines..

By reducing the over expression of oxidative damage to neuron cells through regulation of iron related factors as mentioned above, iron chelator EGCG can counteract these adverse effects and prevent onset of PD.

Further study of the mechanism on disruption of iron metabolism by 6-OHDA in PD cell line N27, discovered that application of the iron chelator EGCG also disrupts the iron dyshomeostasis in N27 cells (dopaminergic neural cell line) induced by 6-OHDA through regulating iron transporters and regulators expression, such as DMT1 with function in mediation of the entry of dietary iron into these mucosal cells and TfR, a carrier protein for transferrin with function in import iron into the cell and regulated response to intracellular iron concentration and hepcidin, a central regulator in maintain iron homeostasis.

Dysregulation of hepcidin production results in a variety of iron disorders.

Additionally, in 6-OHDA induced neurotoxicity to cause PD, administration of green tea GECG also reduced the intracellular iron retention by decreasing the iron importers and increasing iron exporters, through regulation of the function of iron-regulated transporters, such as ferroportin.

Interestingly, there was a report suggested that intervention of 3 cups of green tea daily for 3 months improved the antioxidant status and reduced oxidative damage in early PD patients without affecting their iron status.

The findings evidences revealed that green tea bioactive polyphenol, (−)-epigallocatechin-3-gallate may be considered as iron chelator in regulation of PD progression.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson's Disease by Bitu Pinto N1, da Silva Alexandre B2, Neves KR3, Silva AH3, Leal LK3, Viana GS1.(PubMed)
(2) Green tea polyphenols prevent Parkinson's disease: in vitro and in vivo studies Dan Chen by  Iowa State University

Saturday, 16 December 2017

Herbal Therapy: Green Tea in Ameliorated Risk and Treatment of Lifestyle-Related Diseases

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)


Green tea is found to consist a therapeutic and sustainable effect in reduced risk and progression life style diseases, some scientists postulated

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Lifestyle diseases are a class of diseases associated with the way a person or group of people lives, including atherosclerosis, heart disease, and stroke; obesity and type 2 diabetes....and diseases precipitated by smoking and alcohol and drug abuse.

Epidemiological studies suggested that lifestyle-related diseases may be preventable with the change of lifestyle accompanied with intake of some nontoxic agents.

Differentiation of the effect of green tea in attenuated risk and treatment of lifestyle related diseases was found to associate to some mechanisms involving numbers of aspect, particularly, in gene facilitation.

In animal model, green tea administration inhibited risk and symptoms and progression of chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis, through regulation of tumor necrosis factor (TNF-alpha) gene in expression of  inflammatory cytokines in promoted systematic inflammation in the acute phase of infection caused by damage and injure tissues, in modulated the activation of  NF-kappaB signalling pathway related to cellular response in induction of anti and pro inflammatory stimulation and transcription factor complex (AP-1) in initiation of inflammation against foreign invasion.

The inhibition of inflammatory cytokines expression reduced symptoms of pain, reddish skin, swelling without limiting the protective effect of the immune system to prevent damage tissues against invasion of foreign substances.

Further analysis of chronic inflammatory diseases, in transgenic mice model with human idiopathic pulmonary fibrosis suggested that injection of green tea in 4 months demonstrated a significant activity in ameliorated over expression of TNF-alpha in stimulated production of pro inflammatory cytokines and interleukin (IL)-6 in initiated inflammatory expression in cellular defense in response to infections and tissue injuries in the lung.

In life style related diseases of cardiovascular disease, intake of green tea beverage or extract expressed a significant reductions in serum total cholesterol and LDL-cholesterol concentrations, without effecting the levels of HDL-cholesterol.

Additionally, in patients with type 2 diabetes mellitus, green tea extract catechin injection improved fasting glucose levels without affecting the hemoglobin A1c (HbA1c) level, which is an predictor of type 2 diabetes onset  and  green tea consumed 5 or more cups per day was associated to a strongly and positively inverse association to risk of type 2 diabetes mellitus.
.
More amazingly, after taking into account of other con founders, Dr. Sueoka E, the lead scientist suggested that intake of  green tea, containing catechins and caffeine, 5 or more cups per day exhibited a potential and therapeutic effect for body weight management, without going into details.

According to the prospective cohort study in Saitama Prefecture, Japan, green tea injection of over 10 cups per day, displayed a substantial effect in decreased relative risk of death from all causes in patients with cardiovascular disease, particularly, in stroke mortality.

Take together, there is no doubt that green tea with abundantly bioactive phytochemicals may be considered as a function food to reduced risk, progression and treatment of lifestyle related disease, but change of lifestyle is always recommended.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Human clinical studies of tea polyphenols in allergy or life style-related diseases by Maeda-Yamamoto M1.(PubMed)
(2) A new function of green tea: prevention of lifestyle-related diseases by Sueoka N1, Suganuma M, Sueoka E, Okabe S, Matsuyama S, Imai K, Nakachi K, Fujiki H.(PubMed)

Food Therapy: Chick (Garden) Peas Inhibited Platelet Aggregation in Ameliorated Risk of Cardiovascular Disease

Kyle J. Norton

Methanolic extract of Chick (Garden) Peas may have a potential effect in decreased platelet aggregation and inhibited thrombus formation, thus improving blood circulation for prevention of cardiovascular disease, some scientists suggested.

Garbanzo beans also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetable, native to Middle East.

Inflammation is a natural process of immune defense against infection caused by injure through removal of  injurious agents, necrosed cells and tissues.

Evaluation of pea family effects in  reduced platelet aggregation for prevention of cardiovascular disease have been found to associated to numbers of mechanisms involved many aspects.

Methanolic extract isolated from garden pea  and Desi chickpea demonstrated an inhibited arachidonic acid (AA) expression in induction of  platelet aggregation (IC50 = 35 microg/mL)

Arachidonic acid, an omega-6 unsaturated fatty acid with function in growth and repair of muscle  tissue is also important as an proinflammatory and immunosupportive substance in response to actute and chronic tissue damage.

Several reports have suggested that arachidonic acid induced expression of platelet aggregation by mediators thromboxane A2 and/or prostaglandin H2 (PGH2) in signalling expression of thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor occupation.

Thromboxane A2 (TXA2) is a type of thromboxane with function in stimulation of production of new platelets to induce platelet aggregation.

Prostaglandin H2 is a type of prostaglandin acted as mediators involved in physiological processes, including platelet aggregation, muscle movement and inflammation.

Further differentiated the other effects of methanolic extract isolated from garden pea  and Desi chickpea on platelet aggregation, showed that the extract isolated from garden pea  displayed a positive inhibition of platelet activating factor (PAF)(IC50 = 38 microg/mL) in a dose dependent fashion, in induction of platelet aggregation, but this action was not found in Desi chickpea extract.

Platelet-activating factor (PAF), is a lipid mediator with function in exhibited expression of platelet aggregation, immune response and inflammation. 

Interestingly, the methanolic extract isolated from Kabuli chickpea also expressed a strong platelet aggregation  effect without activation of either arachidonic acid (AA) or latelet-activating factor (PAF) expressions.

The findings suggested that there must exist other mechanisms in reduced platelet aggregation, other than inhibition of arachidonic acid (AA) and platelet-activating factor (PAF) activities  by the testing extract isolated from the above members of pea family.

Further differentiation showed that methanolic extract isolated from the pea family also inhibited platelet aggregation through endothelial cells COX-2 lining the interior surface of blood vessels and lymphatic vessels in production of platelet PGE2 precipitated by inflammatory cytokine expression during the acute phase of tissue damage.

COX-2 is an enzyme with function in response for inflammation and pain.

Prostaglandin E2 (PGE-2) is also released by blood vessel walls with function in response to infection or inflammation.

Indeed, the extract displayed a strongly inhibited effect at dose of concentration 20 microg/mL in lower the levels of synthesis of PGE2  by 92%,  87% and 65% in extract of Garden pea, Desi chickpea and Kabuli chickpea, respectively, according to COX-2 essay. 

Taken together, peas family including Garden pea, Desi chickpea and Kabuli chickpea could be useful as natural anti-thrombotic and anti-inflammatory whole foods. People who are in high risk of CVD due to platelet effect may want to add a portion of chickpeas into their daily diet.

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpeaand Kabuli chickpea by Zia-ul-Haq M1, Khan BA, Landa P, Kutil Z, Ahmed S, Qayum M, Ahmad S.(PubMed)

Friday, 15 December 2017

Alternative Therapy: Yoga, In reduced Risk and Treatment of Sleep Disturbance

Kyle J. Norton


Yoga may be considered as a feasibility and efficacy program in improved sleep disturbance, some respectable institute studies suggested

An individual may experience sleep disturbance because of a medical condition, such as sleep apnea, restless leg syndrome, or periodic limb movement and/or psychological stress in initiated anxiety, an overactive nervous system, depression.......
Yoga, the ancient technique practice for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In the study to test the feasibility and efficacy of a shared yoga (SY) program for sleep disturbance in older adults with osteoarthritis (OA) from ages 50 to 7) with insomnia related to OA by randomizing to 12 weeks of SY (n = 9) or individual yoga (IY; n = 7), in compared to Pre-post testing result, all participants showed statistically significant improvements on the Insomnia Severity Index and Patient-Reported Outcomes Measurement System sleep disturbance scale and yoga overall feasibility of the program, both in the shared and individual formats.

After taking account of other risk factors, researchers said," efficacy data suggest that yoga program may improve sleep, but given the study limitations".

Indeed, yoga simple postures for beginners learned from the experience instructors may reduce tension of participants through induced relaxation and increased body-mind awareness which have been found to benefit the calming effect of  the nervous system in reduced risk of night time sleep disturbance.

A few minutes right before bed to do a yoga sequence designed particularly to calm the mind may also be helpful to give rise of.sleep easily.

Other researchers suggested that relaxing activities before bedtime, rather than stressful work tasks or intense exercise are necessary for some people with sleep disorder.

Additionally, the study of the efficacy of gentle yoga for sleep disturbance in women with osteoarthritis with all participants completed an 8-week yoga program that included 75-min weekly classes and 20 min of nightly home practice (13/14 completed the study) also indicate that
all participants expressed a significant improvement at post-intervention versus pre-intervention through observation of The Insomnia Severity Index and diary-reported sleep onset latency, sleep efficiency, and number of nights with insomnia.

Furthermore, all participants also showed improvement on mean scores at post-intervention through analyzed by Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, diary-reported total sleep time and wake after sleep onset.

In fact, the presence of sleep disturbance may be a stress related disease. As stress elevates production of  hormone cortisol in activation of the "flight or fight" response which directs blood flow to the nervous system and increased the brain tension in preparation how to respond to the stressful event.

Yoga exercise, using deep relaxation and meditation to create a state of consciousness between waking and sleeping, like the "going-to-sleep" stage with an aim to decrease sleep disturbance risk.

More importantly, in examine the effect of yoga in patients with Osteoarthritis (OA), the University of Washington suggested yoga intervention improved sleep disturbance through expression in reduced pain, sleep disturbance, and disability as well as improved musculoskeletal strengthening,
flexibility, relaxation, reduced of autonomic arousal, and enhanced cognitive patterns (distraction, mindfulness), probably as the result of yoga exercise effect in induced a state of calmness against central nervous tension caused by stress events and created a clear mind to tackle the stress in a positive way through relaxation and breathing.

Dr. Taibi DM, the led author said, ".... when evaluating the potential usefulness and safety of yoga programs: yoga style, instructor qualifications, and amount of time spent in yoga practice".

Particularly, in harmonization of the mind and body, yoga lead us to the stage existed in the present moment and connected mindful, conscious and connected way in solving stress.

Some yoga instructors suggested although yoga  may not facilitate all the physical or medical causes of sleep disturbance, the practice with breathing and meditation surely can re-balance the mind and action in response to overactive nervous system through soothing emotional stress by indirectly addressing the roots and experience of image and feeling in inducing pain, confusion, and anxiety while letting go of them or dealing with them in a positive way.

The information findings suggested that yoga may be considered as standardized evening yoga  in treatment in sleep disturbance. 


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1)Feasibility and Efficacy of a Shared Yoga Intervention for Sleep Disturbance in Older Adults With Osteoarthritis by Buchanan DT, Vitiello MV, Bennett K.(PubMed)
(2) A pilot study of gentle yoga for sleep disturbance in women with osteoarthritis by Taibi DM1, Vitiello MV.(PubMed)
(3) Yoga for osteoarthritis: nursing and research considerations by Taibi DM1, Vitiello MV.(PubMed)
(4) Yoga Nidra for Sleep Disorders by By David Procyshyn

Herbal Therapy: Green Tea Bioactive Epigallocatechin-3-Gallate (EGCG) Attenuated Risk and Treatment of Atherosclerosis

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)


Green tea may have a therapeutic and positive effect in reduced risk and treatment of atherosclerosis, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Atherosclerosis is medical condition characterized by the deposition of plaques of fatty material on the inner walls, causing to hardening of the arterial vessels.

According to statistic, mortality rate of coronary heart disease was about 60% in 2010 in compared to 30% of stroke and heart failure.

In the study to determine the effect of green tea bioactive epigallocatechin-3-gallate (EGCG) in ameliorated Porphyromonas gingivalis -induced atherosclerosis in a murine model, after injection of the extract EGCG, the tested mice than fed high-fat diets and injected with P. gingivalis three times a week for 3 weeks, observation at weeks 15 displayed a significant reduction of atherosclerotic plaques accumulated in the branches of arteries, observed by Oil Red O staining

Further analysis also found that the polyphenol extract decreased infection of atherosclerotic lesion areas in the anatomic dilations of the ascending aorta through decreased expression of C-reactive protein, in regulated the acute phase of infection and monocyte chemoattractant protein-1 (MCP-1/CCL2) chemokines in regulated migration and infiltration of monocytes/macrophages.of immune system in induced production of cytokines to counter foreign substances.

Additional observation, also indicated that green tea bioactive epigallocatechin-3-gallate (EGCG) not also improved LDL/very LDL cholesterol but also ameliorated ROS activity via antioxidant in induced low-density lipoprotein (LDL) oxidation, a leading indication of plague accumulation.

In depth differentiation, the efficacy of green tea epigallocatechin-3-gallate (EGCG) in reduced expression of atherosclerosis due to bacterial P. gingivalis was attributed to decrease secreted proteins with functions in stimulated inflammatory effects, such as chemokines (CCL2) involved in immunoregulatory and inflammatory processes, matrix metallopeptidase 9 (MMP-9) in regulated pathological remodeling processes that involve inflammation, ICAM-1 (Intercellular Adhesion Molecule 1) involvesd inflammation of capillary vessel walls, the mitochondrial chaperonin hsp60 in induction of inflammation,......

Interestingly, in the process to prevent plague to initiation of development of atherosclerosis through above implications, green tea epigallocatechin-3-gallate (EGCG) also increased levels of antioxidant defense enzyme (heme oxygenase-1 mRNA) HO-1 mRNA levels in reduced expression of oxidative stress in induction of pathogenic inflammatory diseases.

Intrusively, continued investigated the effect of epigallocatechin-3-gallate (EGCG) in inhibit the formation and development of atherosclerosis via its anti inflammatory capability also found that EGCG restricts the function of IL6 (interleukin 6) in induced over expression of pro inflammatory cytokines and Angiotensin (Ang) II functions in stimulated and increased vascular permeability through production of vascular endothelial cell growth factor CRP in initiated the pro inflammatory process.

Interleukin 6 is an interleukin with duo functions of pro inflammatory cytokines and anti inflammatory mytokines.

Amazingly, antioxidant activities of EGCG also acted as free radical scavengers to prevent ROS to establish a chain reaction in induction of inflammatory effect in encouraging lipid accumulation in the inner wall of arteries, the leading cause of atherosclerosis.

ROS are free radical with function to mediate many pathophysiological processes, such as growth, migration, apoptosis and secretion of inflammatory cytokines,

Angiotensin is a hormone with function in regulated vasoconstriction in increased blood pressure.

Application of combined (-)-Epigallocatechin gallate (EGCG) +chitosan (CS) and aspartic acid (PAA). demonstrated a significant effect in reduced risk and treatment of atherosclerosis through ameliorated lipid deposition in tested animals.
In compared to the effects of conventional medicine simvastatin with approximately successful treatment rate of lipid deposition of 15.6%, injection of (-)-Epigallocatechin gallate (EGCG) +chitosan (CS) and aspartic acid (PAA).exhibited over all treatment rate of 16.9%.

The accounted evidences suggesting that EGCG, as a natural substance, may have a substantial and therapeutic effect in attentuated risk and treatment of atherosclerosis through anti-inflammatory and antioxidative activities..


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sourcesase
(1) Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis -induced atherosclerosis by Yu Cai Tomoko Kurita-Ochiai Tomomi Hashizume Masafumi Yamamoto(Pathogen and Disease)
https://academic.oup.com/femspd/article/67/1/76/2367414
(2) Improving the effectiveness of (-)-epigallocatechin gallate (EGCG) against rabbit atherosclerosis by EGCG-loaded nanoparticles prepared from chitosan and polyaspartic acid by Hong Z1, Xu Y, Yin JF, Jin J, Jiang Y, Du Q.(PubMed)
(3) Epigallocatechin-3-gallate inhibits interleukin-6- and angiotensin II-induced production of C-reactive protein in vascular smooth muscle cells by NingPeng, Jun-tian Liu Fang. Guo. Rui Li(Science Direct)

Thursday, 14 December 2017

Alternative Therapy: Yoga, in Reduced Risk and Treatment of Gastrointestinal Disorders

Kyle J. Norton 

Yoga, as an adjunct intervention may be combined to standard treatment in reduced symptoms and treatment of gastrointestinal disorders, some scientists suggested.

Gastrointestinal diseases are the class of diseases of the digestive system including the diseases of  esophagus, stomach, small intestine, large intestine and rectum

Yoga, the ancient technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best  known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In comparison of the effectiveness of standard medical care (SMC) and mixture of yoga poses, meditation, and relaxation exercises given once a week in group of 69 patients, ages 8 to 18 years, with abdominal pain-related functional gastrointestinal disorders (AP-FGIDs), at the end of experiment, yoga participated group demonstrated a significant improvement of all aspects related  to abdominal pain-related functional gastrointestinal disorders (AP-FGIDs) of 58% inconpared to only 29% of non yoga group.

Subanalyses over the time period of 12 months, also expressed a significantly greater reduction of pain score by 50% in favor of YT.

In fact, the presence of abdominal pain-related functional gastrointestinal disorders (AP-FGIDs may be a stress related disease. As stress elevates hormone production of cortisol levels in activation of the "flight or fight" response which directs blood flow to the nervous system, causing the reduced blood circulation for muscle of the digestive system to perform its function optimally, thus inducing symptoms expression of digestive disorder such as abdominal pain.

According to Dr. E A Mayer in the article of The neurobiology of stress and gastrointestinal disease, "the role of stress in the modulation of the most common gastrointestinal disorders has traditionally been considered a domain of psychology, and has frequently been lumped together with the role of ..... Chronically elevated cortisol levels".

Additionally, stress also was found to associate to reduce function of immune system in fighting against viral bacterial invasion, in induced gastrointestinal infection and inflammation.

Some researchers suggested that chronic stress may induce ulcer as a result of over expression of hormone adrenaline and depressed digestive system.

Yoga exercise has been found to induce a state of calmness in reduced central nervous tension caused by stress events and create a clear mind to tackle the stress in a positive way through relaxation and breathing, particularly, in harmonization of  the mind and body, yoga lead us to the stage existed in the present moment and connected mindful, conscious and connected way in solving stress.

Dr. Korterink JJ, the led author said, "At 1-year follow-up, YT in addition to standard care was superior compared with SMC according to treatment success, PIS, and reduction of school absence".

Interestingly, yoga therapy also showed to improve gastrointestinal disorder in day time behavior problems of children with Autism Spectrum Disorder (ASD), by reduced levels of inflammation in intestinal tract, irritation bowel syndrome, bloating and other digestion related problems.

Additional analysis also suggested that child attended yoga class also expressed improved Gl problems such as chronic constipation, diarrhoea, abdominal pain, bloody stools, vomiting and flatulence.

In depth differentiation, yoga exercised by children with Autism Spectrum Disorder (ASD) exerted a significant improvement in over all aspects.

Dr. Kumar Narasingharao, the led author after taking into account of other confounders, at the conclusion said, "Yoga affects both physiological and psychological level which helps in overall development of ASD children and thus, enhancing the quality of life of children as well as family".

The information findings suggested that yoga may be used as a secondary form of therapy to assist standard intervention in reduced risk and treatment of gastrointestinal disorders


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Complementary Healthcare Practices: Stress Management for Gastrointestinal Disorders:The Use of Kundalini Yoga Meditation Techniques by Shannahoff-Khalsa, David(PubMed)
(2) Yoga Therapy for Abdominal Pain-Related Functional Gastrointestinal Disorders in Children: A Randomized Controlled Trial by Korterink JJ1, Ockeloen LE, Hilbink M, Benninga MA, Deckers-Kocken JM.(PubMed)
(3) Sleep Disorder, Gastrointestinal Problems and Behaviour Problems Seen in Autism Spectrum Disorder Children and Yoga as Therapy: A Descriptive Review by Narasingharao K1, Pradhan B2, Navaneetham J3(PubMed)
(4) Stress, Illness and the Immune System by Saul McLeod. (Published 2010).

Food therapy: Chickpeas Lectin in reduced Risk and Treatment of Oral cancer


Kyle J. Norton


Ckickpeas lectin may have a profound effect in ameliorated risk and treatment of oral cancer, some scientists suggested.

Garbanzo beans also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to Middle East.

Oral cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the mouth region. At the later stage, the cancerous cell may travel a distance away from the original site to infect healthy tissues and organs.

Investigation of the process of chickpea lectin in reduced oral cell proliferation and tumor expansion
may involve expression of several aspects and mechanism.

According to the All India Institute of Medical Sciences, chickpeas reduced the cell proliferation of human oral carcinoma cells at the concentration of 37.5 μg/mL (IC50) and no toxic effect.

Further analysis, chickpeas anti cancer activity probably is a result the pro apoptotic effect induced by  phychemical agent lectin found abundantly in the legume.

Lectin are types of protein with important function of binding to cell membranes and influence cell-cell interaction.

In oral cancer cell line, injection of lectin showed a significant effect in inhibition of the p38α MAP kinase activated under cellular stresses as well as in response to inflammatory cytokines and involved function in the control of many other aspects of the physiology of the cell, such as control of cell cycle or cytoskeleton remodelling,.. for cell survival of the cancer in presence of substrate (ATP). 


By blocking the physiological expression of cancer cell, lectin reduced the cell proliferation and subsequently, shrinking the cancer site.

Further more, plytochemical lectin isolated from chickpeas also demonstrated a binding affinity with p38α in regulated the production of certain inflammatory cytokines which may have certain effect in induction of cancer growth.

The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes including to protect cell in responses to inflammation and injury,

Specifically, in the influence of the production of inflammatory cytokines by p38α, lectin regulated the potent pro-inflammatory cytokine produced by cells of the innate immune system IL-1β in induction of tumor growth and metastasis in cells under prolong period of inflammation. According to general belief, many cancers have found to arise from sites of infection, chronic irritation and inflammation.

In tumor necrosis factor alpha TNF-α, application of chemical lectin to oral cancer site suppressed the inflammatory expression of the protein in induced cell survival and proliferation and promoted the pro apoptotic function of TNF-α in program of cell death and cell cycle arrest.

Tumor necrosis factor alpha TNF-α, is cell signal protein with function in induced inflammation in the acute phrase of injure and in numbers of cellular process, including cell survival, proliferation, differentiation, and death.

Importantly, the binding of kinase p38α MAPK also activated the function of IL-6, in inhibited the factors in induced production of inflammatory cytokines which have been found to have a negative impact in oral cell oncogenesis and enhanced the expression of boosting T cell trafficking to to tumor sites to induced cytotoxic effect to cause apoptosis.

IL-6, an interleukin with duo functions in both a pro-inflammatory cytokines and an anti-inflammatory myokines,

Taken together, chickpea lectin may have a therapeutically potential in reduced risk and considered as an adjunct therapy used combination with standard chemo-drugs for treatment of oral cancer

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antifungal and antiproliferative protein from Cicer arietinum: a bioactive compound against emerging pathogens by Kumar S1, Kapoor V2, Gill K1, Singh K1, Xess I3, Das SN2, Dey S1(PubMed)
(2) Cell surface interaction of annexin A2 and galectin-3 modulates epidermal growth factor receptor signaling in Her-2 negative breast cancer cells by Shetty P1,2, Bargale A3,4, Patil BR5, Mohan R6, Dinesh US7, Vishwanatha JK8, Gai PB9, Patil VS3,4, Amsavardani TS10.(PubMed)
(3) Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms by Ochoa-Alvarez JA1, Krishnan H1, Pastorino JG1, Nevel E1, Kephart D1, Lee JJ1, Retzbach EP1, Shen Y1, Fatahzadeh M2, Baredes S3, Kalyoussef E3, Honma M4, Adelson ME5, Kaneko MK6, Kato Y6, Young MA1, Deluca-Rapone L1, Shienbaum AJ1, Yin K1, Jensen LD7, Goldberg GS1.(PubMed)