Tuesday, 19 February 2019

Herbal Alfalfa, A Potent and Natural Dietary Antioxidants

By Kyle J. Norton

Herbal alfalfa may have a profound and positive effect in enhancing the expression of antioxidant in the body, some scientists suggested.

Antioxidants are stable molecules which inhibit oxidation induced by free radicals.

A free radical is a highly reactive atom with a single electron in the outer ring.

Free radicals produced in our body is a natural process derived either from essential metabolism through the processes of food intake or from external sources through directly contacting the skin or the air we breathe including exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.

Some foods are antioxidants producers such as fruits and vegetable and whole grain, while others such as processed meats, alcohol are radicals producers. Particularly, fats and oils can easily be oxidized if they are cooked in high heat.

In order to counter the overexpression of free radicals which add to the body's burden, our body produces enzymes antioxidants and metal carrier proteins to neutralize them before they can cause damage.

Depending on the degrees of free radical invasion, antioxidant enzymes can be categorized into first, second, third and even fourth line of defense.

Dr. O.M, in the examine the antioxidant defense wrote, "The role and effectiveness of the first line defense antioxidants which basically include superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) is important and indispensable in the entire defense strategy of antioxidants, especially in reference to superoxide anion radical (*O2) which is perpetually generated in normal body metabolism, particularly through the mitochondrial energy production pathway (MEPP)".

The statement clearly suggested that in healthy individual antioxidant enzymes synthesized form our body is good enough to protect the body from bombardments of free radicals.

However, for people with a weakened immune system, chronic illness, dietary sources of antioxidants may be needed.

Oxidative stress is a result of the imbalance of free radicals and antioxidants in the body. The syndrome is either caused by overexpression of free radicals or depressed levels of antioxidant or both.

Oxidative stress has been found to induce widespread damage due to a set of a chain reaction auto-catalytically by free radicals that attacks the lipid bilayers of the cell walls, induces lipid, protein damage and alternation of cell DNA, leading to the onset of chronic diseases, including cancers.

Alfalfa is a flowering plant in the genus Medicago, belongings to the family Fabaceae.

The herb has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year for the treatment of high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney, and urinary tract infection, etc.

North America aboriginal has used Alfalfa seed as food, such as making bread and mush.

In the reaffirming the herbal alfalfa antioxidant activity especially scavenging activity for hydroxyl radical and DPPH radical, researchers launched a study to determine whether a lyophilized aqueous extract of alfalfa or Medicago sativa L. could exert antioxidant activity against carbon tetrachloride-induced oxidative stress and liver injury in rats.

Before injecting the lyophilized aqueous extract of alfalfa, rats treated by CCl (4) showed a significant increase of serum of oxidative stress markers observed by the levels of transaminase, ALP, bilirubin, lipid profile. and liver MDA accompanied by the decline of antioxidant status in liver non-protein sulfhydryl (NP-SH); and total protein (TP) contents.

Pretreatment with alfalfa and silymarin for three weeks prior to the administration of CCl (4) significantly prevented the increase of oxidative markers by reducing the oxidative stress indicated by elevated NP-SH and TP concentration of the antioxidant liver enzyme. 

Futhermore, the incidence of liver lesion induced by the injection of CCL(4) also reduced by the pretreatment of alfalfa extract.

Application of alfalfa extracts also exerted a potent scavenging activity against hydroxyl radical and DPPH radical.

These results indicated that alfalfa may be considered a novel natural antioxidant. Dr.Al-Dosari MS wrote in the final report, " alfalfa extract possesses hepatoprotective and antioxidative stress properties possibly through its antioxidant phytochemical constituents and substantiates its use in various liver disorders as a hepatoprotector".

Additionally, researchers at the University of Life Sciences in Lublin, in the testing antioxidant effect of a dietary protein-xanthophylls (PX) concentrate of alfalfa on raw meat launched an evaluation by adding the concentration in turkey diet.

The study included 120 turkeys assigned randomly assigned to 3 groups (group I-control group; group II--with 1.5% supplementation of the protein-xanthophylls (PX) concentrate; group III--with 3% supplementation of the protein-xanthophylls (PX) concentrate).

The addition of protein-xanthophylls (PX) concentration of alfalfa to a turkey diet protects the deterioration of breast and thigh meat quality.

Also, by examining the changes in color, oxymyoglobin content, TBARS, and oxidation-reduction potential values, researchers said " the inclusion of the concentration to turkey diets acts as an antioxidant in the raw meat.

Taken altogether, alfalfa may be considered a natural antioxidant which improves the antioxidant profile in the body against the overexpression of free radicals in the initiation of oxidative stress.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References

(1). In vitro and in vivo antioxidant activity of alfalfa (Medicago sativa L.) on carbon tetrachloride intoxicated rats. by Al-Dosari MS (PubMed).
(2). Effect of protein-xanthophylls (PX) concentrate of alfalfa supplementation on physico-chemical properties of turkey breast and thigh muscles during ageing. by Karwowska M, Stadnik J, Dolatowski ZJ, Grela ER. (PubMed)
(3) First line defense antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defense grid by O.M.Ighodaroab, O.A.Akinloyeb. (Science Direct)

Whole Food Papaya, the Best Anti Diabetes Functional Food, Studies Found

Kyle J. Norton

Papaya may be the next generation of whole food for the prevention and treatment of type II diabetes with no side effects, some studies suggested.

Diabetes is a condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.

Most cases of type II diabetes are either caused by cells in pancreas died off or receptor sites clogged up by fat and cholesterol. 

In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Epidemiological studies suggested that obesity, family history, ethnicity, the increase in age, gestation diabetes, polycystic ovary syndrome. and high blood pressure is the most common risk factors associated with the onset of the prediabetes and type II diabetes.

Dr. Stephen S. Rich, in the article "the genetics of diabetes and Its complications", suggested that type II diabetes may be a genetically related disease. Unlike type 1 diabetes, in which there seems to be an autoimmune process, type 2 diabetes is a disease of relative rather than absolute insulin deficiency. Genes involved in type 2 diabetes, with the most promising, replicated findings on chromosomes are 1q21-q24, 2q37, 12q24 and 20.

Untreated and unmanageable type II diabetes may induce complications of the onset of cardiovascular disease, nerve damage (neuropathy). kidney damage (nephropathy), eye damage (retinopathy). foot damage and kin conditions.

Medication used for the treatment of type II diabetes is focused on alleviating the symptoms and improving quality of life and slowing down the progression of the disease.

If you currently intake medicine for treatment of diabetes, please sure you know all the side effects for the preventive measure.

Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries

Unripe pawpaw fruit (Carica papaya) not only inhibited α-amylase, α-glucosidase but also reduced lipid peroxidation in a dose-dependent manner, in rat pancreas(1).

The key enzymes of α-amylase, α-glucosidase, involved in the digestion of carbohydrates, have been linked to the onset of type 2 diabetes. Inhibition of these enzymes can significantly reduce the post-prandial increase of blood glucose and have been also used for management of blood glucose level in type 2 diabetic and borderline patients by therapists (2).

In streptozotocin-induced diabetic rats study, the aqueous extract of leaves of C. papaya administered strongly controlled blood glucose levels(3), through the prevention of hepatocyte disruption, as well as accumulation of glycogen and lipids via its hypoglycemic and antioxidant effect(4)

In a new study, conducted by the researchers at the Davis Heart and Lung Research Institute, fermented papaya preparation was tested whether it improves dermal wound healing outcomes in adult diabetic mice by preventing the risk of infections(5).

The result was astonishing, the fermentation not only up-regulated the Sp1 DNA binding activity(modulating the cellular response to DNA damage) in Peripheral blood mononuclear cells (PBMC) but also the protein and mRNA expression of Rac2(regulates a number of cellular functions)(5).

A randomized controlled clinical trial conducted at the Cardiac Centre, ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of Biosciences University of Mauritius, suggested that oral administration of 6g FPP®/day for a period of 14 weeks could improve the general health status of several organs targeted by oxidative stress during diabetes and  the supplement may be used in the management the complications of diabetes such as cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress(6).

Taken altogether, unripe, fermented papaya and its' leaves may be effective in diabetic management by controlling the levels of glucose and reduced risk of complications.

Some Western researchers insisted that large sample size and multicenter studies are necessary to validate its effectiveness by identifying the ingredients which are comparable to recently pharmaceutical medicine in use because geography, environment, time of harvest, etc. may influence the concentration of the food cultivation.

In fact, herbalists have long acknowledged that the external factors (mentioned above) may alter the quality of the herbs and foods by classifying these difference either through price or formula differentiation.

Indeed, the effectiveness with little or no adverse side effects of the formula is not the concentration of individual herb and a herb itself but the interaction of all ingredients in a herb and herbs in the same formula. Extracting only one ingredient of the herb for treatment of certain diseases may be effective but enhances complicated consequences.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya) by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO.(PubMed)
(2) Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update by Tundis R1, Loizzo MR, Menichini F.(PubMed)
(3) Antihyperglycemic and hypolipidemic activities of aqueous extract of Carica papaya Linn. leaves in alloxan-induced diabetic rats by Maniyar Y, Bhixavatimath P.(PubMed)
(4) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY.(PubMed)
(5) Correction of aberrant NADPH oxidase activity in blood-derived mononuclear cells from type II diabetes mellitus patients by a naturally fermented papaya preparation by Dickerson R1, Deshpande B, Gnyawali U, Lynch D, Gordillo GM, Schuster D, Osei K, Roy S.(PubMed)
(6) Effects of a short term supplementation of a fermented papayapreparation on biomarkers of diabetes mellitus in a randomized Mauritian population by Somanah J1, Aruoma OI, Gunness TK, Kowelssur S, Dambala V, Murad F, Googoolye K, Daus D, Indelicato J, Bourdon E, Bahorun T.(PubMed)
(6) Genetics of Diabetes and Its Complications by Stephen S. Rich

Phytochemical Allicin, the Anti Colon Cancer Bioactive compound

By Kyle J. Norton


Phytochemicals may be the next potential sources of a new medicine for the treatment of diseases with little or no side effects.

Phytochemical allicin may be the next natural ingredient for the prevention and treatment of colon cancer with no side effects, some scientists suggested.

Colon is a large intestine formed part of the digestive system where water is reabsorbed and waste material is stored as feces before being removed.

Colon cancer is the medical condition characterized by the cell growth irregularly and disorderly due to change of DNA.

Most cases of colon cancer start in the cell on the surface of the inner lining of the colon. However, at the later stage, colon cancer may cause secondary metastasis, leading to cancers forming on other tissues and organs, a distance away through lymph and blood.

According to the statistics, the risk of colon cancer has been rising in younger age groups coincidently with the declining rate in older age groups.

Sadly, the proportion of cases diagnosed in individuals younger than age 50 increased from 6% in 1990 to 11% in 2013. Most of these cases (72%) occur in people who are in their 40s.

The causes of colon cancer are unknown, Some researchers suggested that the widespread colon cancer over the past few decades in the developed world probably is the result of the promotion of the Western diet that leads to obesity.

Dr. E E Frezza, the lead scientist at the Texas Tech University Health Sciences Cente, in the study to examine obesity in the risk colon cancer wrote, "Obesity is a risk factor for many diseases" and "Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer".

And, "Although WC is better established as a measure of obesity than BMI, the evidence for colon cancer risk is not secure on this point; combining BMI and WC measurements would appear, at present, to be the wisest approach for colon cancer risk assessment".

The finding strongly suggested that obesity is a major risk factor of colon cancer.

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

With an aim to find a natural ingredient for the treatment of colon cancer with no side effects, researchers at The Hebrew University of Jerusalem examined the effects of allicin on cell proliferation of colon cancer cell lines HCT-116, LS174T, HT-29, and Caco-2.

Injection of allicin preparation exerted a time- and dose-dependent cytotoxic effect on these cells at concentrations ranging from 6.2 to 310 μM.

Treatment with allicin induced HCT-116 apoptotic cell death through reducing the numbers of the chromosome in the DNA in the cancer cells, increasing the function and proteins associated with cell apoptosis and decreasing the expression of proteins involved cell proliferation and migration.

Futhermore, allicin treatment also induced cell death through cancer cell degradation.

Moreover, allicin application also activated the protein which protects the normal cell against oxidative damage triggered by injury and inflammation and reduces the function of the phytochemicals in the inhibition of the HCT-116 proliferation without affecting the cancer apoptosis.

In vivo and vitro, researchers evaluated the combined effect of allicin and CPT-11 against the human colon cancer cell line LoVo.

Allicin treatment alone inhibited the growth of LoVo cells in a dose and time-dependent manner, with an IC50 value of 32.23, 10.74, 6.58 mg x L(-1) at 24 h, 48 h, and 72 h, respectively. 

The apoptosis rate of LoVo cells increased progressively as the cells were treated with increasing concentration of allicin in 24 h, while the apoptosis rate achieved peak value when the cells were treated with allicin at the concentration of 8 mg x L(-1) in 48 h. 

These results strongly suggested that low concentrations of allicin (< 4 mg x L(-1)) leads to G2/M cell cycle arrest, and higer concentrations ( > 4 mg x L(-1)) exerts G1 + G2/M cell cycle arrest in 24 h.

Compared with a single use of CPT-11, the combined use of CPT-11 and allicin (4.0, 8.0 mg x L(-1), respectively) showed increasing cytotoxicity on the LoVo cells, with IC50 of 24 h decreasing from 47.5 to 7.4 and 7.2 mg x L(-1), respectively.

Dr. Gao Y, the lead scientist, wrote in the final report, "Allicin has significant anti-proliferation effect on human colon cancer cell line LoVo by induction of apoptosis and arrestment of the cell cycle and can enhance the cytotoxicity of CPT-11 on the colon cancer LoVo cell".

Taken altogether, phytochemical Allicin may be considered a bioactive compound for the prevention and combined with the primary medicine for the treatment of colon cancer, pending to large sample and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2 by Bat-Chen W, Golan T, Peri I, Ludmer Z, Schwartz B.(PubMed)
(2) [Allicin enhances cytotoxicity of CPT-11 to colon cancer LoVo cell in vitro]. [Article in Chinese] by Gao Y, Liu Y, Cao W, Deng Z, Liu H, Xu L, Chen X.(PubMed)
(3) Influence of obesity on the risk of developing colon cancer by E E Frezza, M S Wachtel, and M Chiriva‐Internati. (PMC)

Monday, 18 February 2019

Honey Improves the sleep Quality Naturally with No Side Effects, Scientists Say

By Kyle J. Norton

Scientists may have found a natural alternative for the improvement of sleep quality with no side effects, according to studies.

Sleep disorders are conditions can be acute or chronic. Most of us experience sleep disturbance sometimes due to some specific and unspecific events. However, chronic sleep disorders are the changes in the way that you sleep.

Most people with chronic sleep disorder experience symptoms of excessive daytime sleepiness, irregular breathing or increased movement during sleep, and difficulty falling asleep.

Sleep quality can be measured by examing the.way that you sleep, including the time period that you need to fall to sleep and how many times you have awakened and drifted back to sleep during night sleep.

According to the statistic provided by the National Sleep Foundation’s inaugural Sleep Health Index45 % of Americans have poor or insufficient sleep. that affects their daily activities at least once in the past seven days.

The National Sleep Foundation continued, "...despite sleeping within the recommended number of hours a night, 35 percent of Americans report their sleep quality as “poor” or “only fair.” Twenty percent of Americans reported that they did not wake up feeling refreshed on any of the past seven days".

What causes poor quality of sleep in American? Some researchers suggested these may be results from occupation and occupation stress.  

Dr, Eui-Joong Kim, the lead scientists, in examing the stressors' effect on sleep quality said, "It is possible that different types of stressors may bring with them different impacts on sleep" and " (a) some aspect of daily stress (such as job stress) and life events (such as divorce, bereavement), (b) experimentally imposed stressors (laboratory-based studies), and (c) traumatic stressors (such as disasters or PTSD)".

Additionally, " The first and last categories typically involve a longer duration of the stress exposure with varying levels of intensity; the experimental stressors, on the other hand, typically involve a short-term exposure to mild stress".

These results partly explained why over 20% of American suffer from poor quality of sleep.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural compound for the improvement of sleep quality, researchers compared the effects of a single nocturnal dose of 3 honey products (eucalyptus honey, citrus honey, or Labiatae honey) to placebo (silan date extract) in children with upper respiratory tract infections (URIs).

The study included 300 children aged 1 to 5 years with URIs, nocturnal cough, and illness duration of ≤ 7 days from 6 general pediatric community clinics.

Eligible children received a single dose of 10 g of eucalyptus honey, citrus honey, Labiatae honey, or placebo administered 30 minutes before bedtime. There was a significant improvement in sleep quality from the night before treatment to the night of treatment in all 3 honey products and the placebo group.

However, the improvement was greater in the honey groups.

Honey products were rated higher than the silan date extract for symptomatic relief of their children's nocturnal cough and sleep difficulty due to URI, According to the survey returned from parents.

Dr. Cohen HA the lead scientist after taking into account co and confounders, said, "Honey may be a preferable treatment for a cough and sleep difficulty associated with childhood URI".

Furthermore, in order to reveal more information of honey effects in cough and sleep difficulty, researchers compared the effects of a single nocturnal dose of buckwheat honey or honey-flavored dextromethorphan (DM) with no treatment on nocturnal cough and sleep difficulty associated with childhood upper respiratory tract infections.

The study included 105 children aged 2 to 18 years with upper respiratory tract infections, nocturnal symptoms, and illness duration of 7 days or less were given a single dose of buckwheat honey, honey-flavored DM, or no treatment administered 30 minutes prior to bedtime.

Honey treatment group demonstrated significant differences in symptom improvement between treatment groups.

In paired comparisons, honey was significantly superior to no treatment for cough frequency and the combined score. 

And, according to the survey returned by the parents, honey is most favorable for symptomatic relief of their child's nocturnal cough and sleep difficulty in children with upper respiratory tract infection.

Taken altogether, honey may be considered a functional remedy for the improvement of sleep quality, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study by Cohen HA1, Rozen J, Kristal H, Laks Y, Berkovitch M, Uziel Y, Kozer E, Pomeranz A, Efrat H. (PubMed)
(2) Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents by Paul IM1, Beiler J, McMonagle A, Shaffer ML, Duda L, Berlin CM Jr. (PubMed)
(3) The Effect of Psychosocial Stress on Sleep: A Review of Polysomnographic Evidence by Eui-Joong Kim and Joel E. Dimsdale. (PMC)
(4) LACK OF SLEEP IS AFFECTING AMERICANS, FINDS THE NATIONAL SLEEP FOUNDATION

Honey, the Natural Treatment of Anxiety Disorder with No Side Effects, According to Studies

By Kyle J. Norton

Scientists may have found a natural alternative for the treatment of anxiety disorder, according to studies.

Anxiety disorder is a class of medical conditions associated with chronic worries and fear, leading to symptoms of the fast heart rate and shakiness.

Most people with anxiety may experience the feeling of nervousness in responding to events such as a problem at work, before taking a test, or before making an important decision.

According to the statistics, anxiety disorders are the most common mental illness in Canada and approximately 1 in every 8 Canadians is affected by the illness. In other words, over 250,000 people in Canada suffer from anxiety.

Family history, gender (women are more likely diagnosed with the condition compared to men), chronic stress, people with traumatic life experiences and the use of substances are some prevalent risk factors of anxiety.

However, some researchers suggested the widespread anxiety disorder probably is correlated with the onset of obesity over the past few decades. In fact, over 68% of American are either overweight or obese.

Dr. Lykouras L, the lead scientist in the concerns of obesity risk of anxiety disorder wrote, "
Obesity has been associated with anxiety disorders as follows: most of the studies show a positive relationship with panic disorder, mainly in women, with specific phobia and social phobia. Some authors have found a relationship with generalized anxiety disorder but a negative relationship has been also reported. Only a few studies have found the association between obesity and agoraphobia, panic attacks and posttraumatic stress disorder".

And, "Anxiety is also a common trait in personality disorders. There is no single personality type characteristic of the morbidly obese, they differ from the general population as their self-esteem and impulse control is lower. Obese patients present with passive-dependent and passive-aggressive personality traits, as well as a trend for somatization and problem denial".

The finding strongly suggested in some aspects anxiety can be a cause of obesity and vice versa.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a natural ingredient for the treatment of anxiety disorder with no side effects evaluated the antioxidant and anxiolytic-like effect of Tualang honey in stressed ovariectomized (OVX) rats. 

The study included animals divided into 6 groups, (i) nonstressed sham-operated control rats, (ii) sham-operated control rats exposed to stress, (iii) nonstressed OVX rats, (iv) OVX rats exposed to stress, (v) OVX rats exposed to stress and treated with 17 β-oestradiol (E2) (20 μg daily, sc), and (vi) OVX rats exposed to stress and treated with Tualang honey (0.2 g/kg body weight, orally).

Before treatment of Tualang honey, OVX rats showed a significant increased anxiety-like behavior due to increased stress, compared to other groups. Injection of either Tualang honey or E2  significantly decreased anxiety-like behavior.

Honey treatment rats demonstrated reduced levels of malondialdehyde (MDA) and protein carbonyl (PCO) which are biomarkers of oxidative stress.

Furthermore, the levels/activities antioxidant enzymes produced by the rats such as superoxide dismutase (SOD), glutathione S-transferases (GST), glutathione peroxidase (GPx), and glutathione reductase (GR) were significantly increased in the brain homogenates of treated stressed OVX groups compared to untreated stressed OVX.

The finding strongly supported that honey processed the anxiolytic activity in the animal model.

Dr. Badriya Al-Rahbi, the lead scientist after taking into account co and confounders said, "Tualang honey has protective effects against brain oxidative stress and may be useful alternative anxiolytic agent especially for postmenopausal women.

Taken altogether, honey, particularly Tualang honey may be considered functional remedies for the prevention and treatment of anxiety disorder, pending to the confirmation of large samp;e size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources:
(1) Protective Effects of Tualang Honey against Oxidative Stress and Anxiety-Like Behaviour in Stressed Ovariectomized Rats by Badriya Al-Rahbi, 1 Rahimah Zakaria, 2 , * Zahiruddin Othman, 3 Asma' Hassan, 4 andAsma Hayati Ahmad. (PubMed)
(2) Anxiety disorders and obesity by Lykouras L1, Michopoulos J. (PubMed)


Honey, the Best Remedy for the treatment of Asthma with No Side Effects

By Kyle J. Norton

Scientists may have found a natural alternative for the treatment of asthma, according to studies.

Asthma is a chronic inflammation of the airway of the lung with recurring symptoms. Asthma, attacks triggered by the stimuli can induce airway swollen and inflamed, leading to muscle constriction.

During the asthma attacks, patients may experience symptoms of difficult breathing, and severe wheezing in the breath and coughs that won't stop.

According to the statistic provided by the Centers for Disease Control and Prevention (CDC), 1 in 13 people in the US has asthma.

In other words, more than 26 million Americans have asthma, with half of the patients are children.

If you experience symptoms of a cough which often worse at night or early in the morning, wheezing in your breath, accompanied with chest tightness and shortness of breath, you may be at the early stage of asthma. Please check with your doctor to rule out the possibility.

Genetic and environmental factors are the most common risk factors associated with the onset of asthma. Some researchers suggested that the widespread obesity over the past few decades may also have a strong implication on the onset of the disease.

Dr. David A. Beuthe r, the lead scientist in the concern of the association of asthma and obesity  said, "Cross-sectional and prospective cohort studies of humans have shown a modest overall increase in asthma incidence and prevalence in the obese, although body mass index does not appear to be a significant modifier of asthma severity".

And, "Studying the obesity-asthma relationship in large cohorts, in which self-reports are frequently used to ascertain the diagnosis of asthma, has been complicated by alterations in pulmonary physiology caused by obesity, which may lead to dyspnea or other respiratory symptoms but do not fulfill accepted physiologic criteria for asthma".

These results strongly suggested that if you are obese, your risk of asthma is increased substantially.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Scientists on finding a natural remedy for the treatment of asthma investigated the effect of aerosolized honey on airway tissues in a rabbit model of ovalbumin (OVA)-induced asthma.

The study included 40 New Zealand white rabbits sensitized twice with a mixture of OVA and aluminum hydroxide on days 1 and 14.

Honey treatments were given from day 23 to day 25 at two different doses (25% (v/v) and 50% (v/v) of honey diluted in sterile phosphate buffer saline.

During the study, aerosolized honey treatment group restored the epithelium, mucosa, and submucosal regions of the airway infected by the application of OVA.

Futhermore, aerosolized honey treatment also found to reduce the number of airway inflammatory cells presented in bronchoalveolar lavage fluid and inhibit the goblet cell hyperplasia, an indication of airway remodeling in asthma.

The findings strongly suggested that aerosolized honey has a significant effect on the treatment and management of asthma in animal models.

Additional differentiation of the modulatory effect of honey, royal jelly, and propolis extract on peripheral blood leukocytes and lung inflammation in a mouse conalbumin-induced asthma model in mice model divided into
* The mice in group I that were not sensitized or treated; they were kept as controls.

* The mice in group II that were sensitized and challenged with conalbumin. Twenty-four hours after the first challenge with antigen.

* The mice in group III received 0.5 mg/kg of dexamethasone intraperitoneally per day for 18 consecutive days and kept as positive controls.

* The mice in groups IV, V, and VI received 650, 1000, and 30 mg/kg of honey, royal jelly, and propolis (aqueous and ethanolic extract), respectively, once per day for 18 consecutive days.

At the end of the experiment, by comparing the blood sample before and after treatment, researchers showed
* The groups treated with propolis extract exhibited considerable ameliorative effects against asthma, probably due to the expression of flavonoids and phenolics that exert antioxidative effects.

* Honey- or royal jelly-treated groups exhibited an increased incidence of asthma cascade events due to increased inflammatory cells, probably due to the antagonist to bronchial asthma cases.

The results clearly indicated that not all honey is the same. Some can be used for asthma while others can not, probably due to types of chemicals compounds found in the pollen 

Taken altogether, honey and other bee products may be considered functional remedies for the prevention and treatment of asthma, pending to the confirmation of the types of honey in a large and multicenter human study.



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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Inhalation of honey reduces airway inflammation and histopathological changes in a rabbit model of ovalbumin-induced chronic asthma by Kamaruzaman NA, Sulaiman SA, Kaur G, Yahaya B1.(PubMed)
(2) Evaluation of propolis, honey, and royal jelly in amelioration of peripheral blood leukocytes and lung inflammation in mouse conalbumin-induced asthma model by El-Aidy WK1, Ebeid AA1, Sallam Ael-R1, Muhammad IE2, Abbas AT3, Kamal MA4, Sohrab SS. (PubMed)
(3) Obesity and Asthma by David A. Beuther, Scott T. Weiss, and E. Rand Sutherland. (PMC)

Honey, the Best for the Treatment of Ocular Demodex and Dry-Eye with No Side Effects

By Kyle J. Norton

Scientists may have found a natural alternative for the treatment of  Ocular Demodex and Dry-Eye, according to studies.

Believe or not, the Demodex in eyelashes that cause the severity of ocular discomfort is quite common in the US. According to the US Federal Science, over 70% of American suffer from the presence of Demodex without even noticing.

The increase in age, patients with conjunctival papillary hypertrophy, are some most common Demodex risk factors.

Furthermore, methicillin-resistant Staphylococcus aureus (MRSA) was detected more often on eyelids with Demodex.

The finding strongly suggested that Demodex plays a pathogenic role in the ocular discomfort linked with aging.

Dry eye happened mostly in the older adults is a condition in which a person doesn't have enough quality tears to clean and nourish the eye, leading to a chronic vision problem.

Dry eye in most cases is caused by the inadequate amount of tears due to lower than normal amount of tear production or tears evaporate too quickly from the eyes and poor quality of tears. 

People with dry eye may experience symptoms of irritation, gritty, scratchy or burning eyes; a feeling of something in their eyes; excess watering; and blurred vision.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers with an aim to find a natural source for the treatment of vision problem compared the Manuka honey and tea tree oil against ocular Demodex.

The study included 53 viable Demodex mites acquired from the epilated eyelashes of 9 participants with blepharitis and symptomatic dry eye. Then, the viable mites were randomized to one of five treatment groups: cyclodextrin-complexed and uncomplexed Manuka Honey, 100% and 50% tea tree oil, and no treatment.

Compared to the results of four treatments, researchers found that the survival probabilities are lowest with 100% tea tree oil, and highest with cyclodextrin-complexed and uncomplexed Manuka Honey.

The finding clearly suggested that the efficacy of cyclodextrin-complexed Manuka honey was comparable with 50% tea tree oil, an established treatment for ocular Demodex.

In order to reveal more information about honey anti-dry eye effects, researchers evaluated
the effects of Manuka (Leptospermum sp.) honey eye drops (Optimel, Melcare, Australia).

The study included 24 participants aged 20 to 55 years with contact lens-related dry eye randomized to two treatment groups with 20 completed the study.

One group was received Optimel eye drops twice a day for two weeks followed by conventional lubricant (Systane Ultra, Alcon) therapy for two weeks while the other group completed the treatments in the reverse order. 

The Optimel treatment exerted an improvement of Dry eye symptoms significantly and patients with more severe symptoms at baseline showed a greater improvement in symptoms. 

Seventy-five% of contact lens wearers reported good adherence to Optimel treatment and 95% reported no issues using this product.

However, due to the short duration of treatment, there were no significant differences observed in the objective signs of a dry eye. 

Researchers at the ean of the experiment wrote in the final report, "Optimel Eye Drops reduce the symptoms of dry eye in contact lens wearers and are safe to use".

Taken altogether, honey, particularly Tualang honey may be considered functional remedies for the prevention and treatment of ocular Demodex and dry-eye, pending to the confirmation of larger sample size and multicenter human study.





Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Comparing the in vitro effects of MGO™ Manuka honey and tea tree oil on ocularDemodex viability by Frame K1, Cheung IMY2, Wang MTM2, Turnbull PR1, Watters GA2, Craig JP. (PubMed)
(2) Treatment of contact lens related dry eye with antibacterial honey by Wong D1, Albietz JM1, Tran H1, Du Toit C1, Li AH1, Yun T1, Han J1, Schmid KL. (PubMed)