Monday, 21 January 2019

Sinigrin May Be The Potential Anti Atherosclerosis Chemical Compound, According to Sutdies

By Kyle J. Norton

Sinigrin may be used as a bioactive ingredient for the prevention and treatment of atherosclerosis, according to studies.

Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.

Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.

Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.

According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.

Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes,  being overweight or obese, unhealthy diet,  family history of heart disease and physical inactivity, particularly smoking.

Some researchers suggested that since cholesterol make up a big part in the plaque, an unhealthy diet with a high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.

In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis. 

Dr. Meifang Wang, the lead researcher in the study of "Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice" said, "....lowered circulating IGF-1 increases atherosclerosis progression in atherosclerosis-prone apolipoprotein E-deficient mice (ApoE−/−) while increased circulating IGF-1 downregulates vascular pro-inflammatory cytokine gene expression, reduces systemic and vascular oxidant stress, vascular cytokine expression, and decreases atherosclerosis progression".

And, "the pro-inflammatory phenotype that is enhanced by WD in ApoE−/− mice is further enhanced by specific IGF1R deficiency in monocytes/macrophages, and may consequently increase atherosclerosis progression".

The results suggested that the Western diet-induced atherosclerosis progression through the increase of production of pro-inflammatory cytokines and decrease of the function of insulin-like growth factor-1 (IGF-1) as a mediator of anabolic responses in many cells and tissues.


Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Scientists on finding a natural bioactive compound for the treatment of atherosclerosis examined the effect of sinigrin against plaque accumulation on the arterial walls.

On atherosclerosis in ApoE-/- mice, injection sinigrin exerted a significant effect in the inhibition of the serum concentrations of lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), calcium (Ca2+), and pro-inflammatory cytokines associated with plaque accumulated on the wall of the arteries.

Furthermore, oral administration of sinigrin attenuated the mRNA expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), which form a part of immunoglobulin superfamily in inflammatory and immune responses. 

Moreover, injection also reduced the expression of genes C-C motif chemokine ligand 2 (CCL2), and CCL5 on aorta tissues associated with the risk of atherosclerosis.

The expression of low-density lipoprotein was also reduced by the injection of sinigrin observed by some keys regulators of cholesterol such as sterol regulatory element-binding protein-2 (SREBP-2).

Interestingly, increased the concentration of sinigrin at the dose up to 100 μg/ml also significantly suppressed the levels of Tumor necrosis factor (TNF-α) and nuclear translocation of NF-κB, cell signaling protein (cytokine) involved in systemic inflammation.

Additionally, at a contraction ut to 100 μg/ml, sinigrin inhibited the c-Jun-NH (2)-terminal kinase (JNK) signaling pathway which plays a critical role in regulating cellular differentiation.

The findings strongly suggested that sinigrin inhibited the onset of atherosclerosis through lowering the low-density lipoproteins and mechanisms associated with inflammatory induction of plaque accumulation on the arterial wall.

Dr. Jang YJ, the lead scientist wrote, "sinigrin decreases the TNF-α-stimulated VCAM-1 expression through the suppression of NF-κB and MAP kinases signaling pathways, Overall, sinigrin has the potential to be used in reducing the risks of atherosclerosis".

Taken altogether, sinigrin may be considered a supplement for the prevention and combined with the primary therapy for the treatment of atherosclerosis, pending to the confirmation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression by Jang YJ1, Park B1, Lee HW1, Park HJ1, Koo HJ2, Kim BO3, Sohn EH4, Um SH5, Pyo S. (PubMed)
(2) Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice by Meifang Wang, Yusuke Higashi, Derek Wang, Ronald Korthuis, and Patrice Delafontaine. (FASEB Journal)

Phytochemical Sulforaphane (Dithiolthiones) Inhibits the Onset of Prostate cancer

By Kyle J. Norton

Scientists may have found a bioactive compound which processes a potential for the prevention and treatment of prostate cancer, with no side effects, according to studies.

Prostate cancer is a chronic condition characterized by abnormal cell growth in the tissue of the prostate gland. It is a slow growth disease which takes years to develop and prostate cancer may be detected during the physical (rectum) exams.

The cause of prostate cancer is a result of the alternation of DNA of the cells on the surface of the inner lining of the prostate. Researchers do not know what causes the change of cell DNA and they can not explain why people with the same health conditions, ethnicity and family history, some are susceptible to the disease onset while others do not.

However, researchers do know that the increase in age, especially after age 50, as more than 80% of prostate cancers diagnosed in men who are 65 or older, is one of the major factors associated with the disease.

Other risk factors of prostate cancer include high fat, high processed carbohydrate diet, and lifestyle. And, men who are overweight or obese are at greater risk of ultimately developing an aggressive form of prostate cancer.

However, most people with some of the risk factors have never developed prostate cancer. Some researchers suggested that men who have a history of an enlarged prostate may be at the increased risk of prostate cancer.

Dr. Saiful Miah, the lead scientist in the examining the risk of developing prostate cancer of men suffering BPH wrote "BPH and PCa can be linked together at a molecular and cellular level on genetic, hormonal, and inflammatory platforms suggesting that these prostatic diseases have common pathophysiological driving factors. Epidemiological studies are weighted towards the presence of BPH having a greater risk for a man to develop PCa in his lifetime".

Most common symptoms of late stage of prostate cancer include, burning sensation or painful urination,  difficulty urinating, or trouble starting and stopping while urinating, more frequent urges to urinate at night, decreased the flow of urine stream, particularly, blood in urine (hematuria) if the tumor break the nearby blood vessel, loss of bladder control if the tumor has affected the bladder tissue and localized pain, if the tumor has pressed on the nearby nerve cells.

If you have some of the above symptoms, please check with your doctor to rule out the possibility of prostate cancer.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

On finding a natural compound or whole food for the treatment of prostate cancer, researchers in the cancer team at the University of Pittsburgh Cancer Institute and School of Medicine investigated the anti-prostate cancer effect of sulforaphane (SFN).

Injection of sulforaphane (SFN) showed to decrease the incidence or burden of early-stage prostate cancer. In other words, the chemical compound protected the prostate gland against cell alternation to initiate the disease onset.

SFN treatment exerted a cytoprotective autophagy in cultured human prostate cancer cells.  A used combination with chloroquine (CQ), the compound reduced the weight of the prostate compared to control. The average size of the metastatic lymph node was also lower by about 42% in the SFN + CQ group than in control.

Interestingly, the SFN + CQ combination was not superior to SFN alone. Furthermore, the SFN + CQ combination injection not only showed prevention of prostate cancer and metastasis but also decreased cell proliferation, increased apoptosis and cancer cell degradation.

In advanced androgen-independent prostate cancer (AIPC) represented by the DU145 and PC3 cell lines, compared the effect of TNF-related apoptosis-inducing ligand (TRAIL) and sulforaphane (SFN), researchers showed that sulforaphane exerted similar effect on apoptosis-resistant cancer stem cells (CSCs) properties compared to TRAIL, though the agents acted synergistically when applied in combination.

In vivo, tumor engraftment and tumor growth were strongly inhibited by sulforaphane (SFN),, without inducing any side effects.

In the comparison of the effect of sulforaphane(SFN) and 3,3'-diindolylmethane(DIM) in normal prostate epithelial cells and prostate cancer cells, researchers at the Oregon State University found that SFN and DIM reverse many of the cancer-associated methylation alterations, including aberrantly methylated genes that are dysregulated or highly involved in cancer progression.

Taken altogether, sulforaphane(SFN) use alone may be considered a bioactive ingredient for the prevention and combined with the primary therapy for treatment of prostate cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chemoprevention of prostate cancer by d,l-sulforaphane is augmented by pharmacological inhibition of autophagy by Vyas AR1, Hahm ER, Arlotti JA, Watkins S, Stolz DB, Desai D, Amin S, Singh SV.(PubMed)
(2) Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells by Labsch S, Liu L, Bauer N, Zhang Y, Aleksandrowicz E, Gladkich J, Schönsiegel F, Herr I.(PubMed)
(3) Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells by Wong CP1, Hsu A1, Buchanan A2, Palomera-Sanchez Z1, Beaver LM1, Houseman EA2, Williams DE3, Dashwood RH3, Ho E4.(PubMed)
(4) BPH and prostate cancer risk by Saiful Miah and James Catto. (PMC)

Phytochemical Allicin, the Potent Anti Pancreatic Cancer Supplement

By Kyle J. Norton

Scientists may have found a single ingredient isolated from garlic for the prevention and treatment of pancreatic cancer with no side effects, according to studies.

Cancer of pancreas or pancreatic cancer is a medical condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably.

Most pancreatic cancers start in the ducts (an exocrine component of the pancreas) that carry pancreatic juices. Pancreatic cancers originated in the glandular tissue account for over 75 - 90% of all cases of exocrine cancers.

At the advanced stage, cancerous cells from the pancreas may travel a distance away to exhibit secondary metastasis.

In Canada, the 5-year net survival including all stages for pancreatic cancer is 8%. In other words,  92% of people diagnosed with pancreatic cancer will die after 5 years.

According to the statistic provided by the American Cancer Society, every year, approximately over an estimated 55,000 adults (29,000 men and 26,000 women) in the United States are diagnosed with pancreatic cancer. The incidence rates are 25% higher in black people, compared to white people.

Researchers do not know the causes of the disease. However, age, gender, ethnicity, smoking habit, poor diet and a certain medical condition such as diabetes are associated with the prevalent risks of pancreatic cancer.

Some researchers suggested that pancreatic cancer is also found in high numbers in obese patients and patient with family history of the disease, compared to others.

Dr. Silverman DT in the assessment of risk factors for pancreatic cancer, in a population-based case control study of pancreatic cancer diagnosed in Atlanta (GA), Detroit (MI), and ten New Jersey counties from August 1986 through April 1989, including 526 incident cases and 2,153 population controls. wrote, "elevated body mass index and caloric intake had increased risk".

And, " A three-fold risk of pancreatic cancer among first-degree relatives of affected individuals was apparent. An increased risk also was associated with a family history of colon, endometrial, ovary, and breast cancer, suggesting a possible link to hereditary non-polyposis colon cancer".

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

On finding the natural compound for the treatment of pancreatic cancer with no side effects, researchers evaluated the efficacy of combined treatment of the recombinant interleukin-2 (rIL-2) and allicin on pancreatic cancer.

The study includes a total of 60 C57/BL6 nude mice pancreatic cancer xenograft models randomized assigned into four groups of 15 mice per group: control group, allicin treatment group, rIL-2 treatment group, combined treatment with allicin and rIL-2 group. 

Mice in each group were treated with saline, rIL-2, allicin, or combination of rIL-2 and allicin by weekly i.v injection for four weeks.

Treatment with allicin and rIL-2 group significantly suppressed the xenograft growth and prolonged survival time, compared to other groups. Truly, combined therapy group exerted the most amounts of apoptotic cells.

The combined treatment group anti-pancreatic cancer efficacy was attributed to the activation of levels of CD4+T, in stimulating other immune cells, in killing cancer cells and natural killer cells.

Furthermore, allicin and rIL-2 also increased the levels of Interferon gamma (IFN-γ), a cytokine produced by a variety of cells involved in the immune response against cancer cells, compared to other groups.


Dr. the lead researcher wrote in the final paper, "Combined treatment with allicin and rIL-2 resulted in suppression of tumor growth and prolonged survival time possibly through activation of CD4+T, CD8+T and NK cell".

Taken altogether, allicin isolated from the garlic may be considered a bioactive ingredient for the prevention and combined with the primary therapy for treatment of pancreatic cancer.

However, intake of allicin in a form of supplement should be taken with extreme care in the prevention of overdose toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Effect of combined treatment with recombinant interleukin-2 and allicinon pancreatic cancer by Wang CJ, Wang C, Han J, Wang YK, Tang L, Shen DW, Zhao Y, Xu RH, Zhang H.(PubMed)
(2) Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines by Kaschula CH, Hunter R, Hassan HT, Stellenboom N, Cotton J, Zhai XQ, Parker MI.(PubMed)
(3) Risk factors for pancreatic cancer: a case-control study based on direct interviews by Silverman DT1. (PubMed)

Sunday, 20 January 2019

Localized Honey, the Best for the Treatment of Allergies with No Side Effects, According to Studies

By Kyle J. Norton

Scientists may have found a natural alternative for the treatment of allergies, according to studies.

Allergies are a faulty reaction of the immune systematic responses against harmful substances that enter the body.

Symptoms and diseases associated with allergy include sinus swelling, seasonal and returning allergies, hay fever and nasal allergies.

Believe or not, Penicillin, antibiotic medicine is the most common allergy trigger in drug allergies.  10 percent of people are allergic after using the medicine.

According to the statistics, in the US, approximately, more than 50 million Americans have experienced various types of allergies each year and 15 million Americans have food allergies, including 5.9 million children under age 18.

In other words, 1 in 13 children suffers from a food allergy. About 30 percent of children with food allergies are allergic to more than one food.

The findings strongly suggested that foods are the most common and major cause of the allergic onset.

Dr. Ruchi S. Gupta and colleagues in the allergic team in examining the food allergies in children wrote, "Overall, estimated current FA prevalence was 7.6%,.The most prevalent allergens were peanut (2.2%), milk (1.9%), shellfish (1.3%), and tree nut (1.2%)".

And, "Among food-allergic children, 42.3% reported ≥1 severe FA and 39.9% reported multiple FA. Furthermore, 19.0% reported ≥1 FA-related emergency department visit in the previous year and 42.0% reported ≥1-lifetime FA-related emergency department visit, whereas 40.7% had a current epinephrine autoinjector prescription.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a natural compound for the treatment of allergies examined the honey effects in the treatment of allergic rhinitis (AR).

The prospective randomized placebo-controlled study included 40 AR patients divided equally into a case group and a control group. All the subjects received a daily dose of 10 mg of loratadine for 4 weeks.

The case group then ingested 1 g/kg body weight of honey daily in separate doses for the 4-week period. The control group ingested the same dose of honey-flavored corn syrup as a placebo.

According to the AR symptoms scored at the start, week 4, and week 8 of the study, at week 4, both groups showed progressive improvement in the symptoms, however, at week 8, only the case group showed continuous improvement in the symptom score.

The ingested honey group showed a significant improvement in individual AR symptoms after week 8 and the efficacy in reducing the symptoms persisted for a month after the cessation of the honey treatment.

The results suggested that honey processed certain chemical compounds that were not found in the corn syrup for the treatment of AR.

Some researchers suggested that long-term intake of raw honey can help to ameliorate allergy symptoms by regularly exposing to pollen, similarly to the allergy injection in desensitizing pollen-program.

If this result is true then only local honey can process the anti-AR symptoms compared to honey unlocalized pollen.

Taken altogether, honey may be considered a functional remedy for the prevention and treatment of AR symptoms, regardless of the types of honey, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ingestion of honey improves the symptoms of allergic rhinitis: evidence from a randomized placebo-controlled trial in the East coast of Peninsular Malaysia by Asha'ari ZA1, Ahmad MZ, Jihan WS, Che CM, Leman I. (PubMed)
(2) Will honey relieve my seasonal allergies? by Allergists
(3) The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States by Ruchi S. Gupta, Christopher M. Warren, Bridget M. Smith, Jesse A. Blumenstock, Jialing Jiang, Matthew M. Davis, Kari C. Nadeau. (APP News and Journals)

Bilberry May Process Anti Breast Cancer Potency with No Side Effects, According to Medical Literature

By Kyle J. Norton

Bilberry may be the next potential and therapeutic treatment of breast cancer with no side effects, according to studies.

Breast cancer is the chronic condition characterized by irregular cells growth in the breast tissue caused by the alternation of DNA.

The causes of breast cancer are unknown, As of today, researchers cannot explain why people with the same health conditions in the same family, some are susceptible to the onset of breast cancer while others do not.

According to the statistics, 1 in 8 U.S. women, representing 12.4 % of all women will develop invasive breast cancer over the course of her lifetime.

Believe or not, In 2018, approximately 266,120 new cases of invasive breast cancer were diagnosed in women in the U.S.

The 5 years survival rate of breast cancer diagnosis at the early stage is 100%. Therefore, women at a higher risk of breast cancer should examine their breast at least once a month for preventive measure.

Most cases of breast cancer begin in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

Women with breast cancer may experience symptoms of lump, swelling of all or part of a breast, skin irritation or dimpling, breast or nipple pain,  nipple retraction, redness, and scaliness.

If you experience some of the above symptoms, please make sure to check with your doctor as soon as possible to rule out the possibility of breast cancer.

In North America, some researchers suggested that obesity may have some strong impact on the risk of breast cancer onset.

Dr. Manuel Picon‐Ruiz, the lead scientist in the study of "Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention", wrote "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".

And, " the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".

The results clearly suggested that if you are obese, your risk of breast cancer is increased substantially, compared to non-obese individuals.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of breast cancer examined the bilberry effect on the MCF7 human breast cancer cells.

Bilberry extract inhibited cell proliferation in a concentration-dependent fashion with a 50% inhibitory concentration of 0.3-0.4 mg/mL.

At this concentration, the natural compound also concerts the induction of apoptotic cell death of the cancer cells with no apparent effect on the microtubule that provides structure and shape to the cytoplasm of eukaryotic cells or actin cytoskeletons.

In other words, bilberry extract induced cancer cell apoptosis was not through cell cycle arrest at this concentration.

However, at the higher extract concentrations (0.5-0.9 mg/mL), the extract did cause an increase in the fraction of cells at the G(2)/M phase of the cell cycle.

Further differentiation of the cell death, bilberry extract at 0.3-0.4 mg/mL did not appreciably inhibit microtubule polymerization in vitro, but significant inhibition of polymerization (approximately 30%) did occur at higher extract concentrations (0.5-1 mg/mL).

Moreover, researchers found that the efficacy of bilberry against breast cancer cell was attributed not by the expression of anthocyanins but all phytochemicals in the extracts.

Dr. Nguyen V and colleagues wrote in the final report, " (Bilberry extract) inhibits proliferation of and induces apoptosis in breast cancer cells at its lowest effective concentrations via a mechanism that does not involve action on microtubules or on mitosis.

And, "At somewhat higher concentrations the extract modifies microtubule organization in cells and causes accumulation of cells at mitosis by a direct action on microtubules".

Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of breast cancer, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells by Nguyen V1, Tang J, Oroudjev E, Lee CJ, Marasigan C, Wilson L, Ayoub G. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., Cynthia Morata‐Tarifa, Ph.D., Janeiro J. Valle‐Goffin, MD, Eitan R. Friedman, MD, and Joyce M. Slingerland, MD, Ph.D. (PMC)

Artichoke Protects Us Against Heart Disease, According to Studies

By Kyle J. Norton

Artichoke may be used as a natural and herbal remedy for the treatment of heart disease with no side effects, according to studies.

Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.

According to the statistics, heart disease is a leading cause of death in the US. Approximately 2000 people in the general population die of heart disease every day.

Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.

Most common risk factors associated with heart disease are aging, family history with heart disease, metabolic syndrome, high blood pressure and cholesterol, obesity, smoking, and stress epidemiologically.

However, most people with some of the above risk factors have never developed heart disease. Symptoms of heart disease completely depend on the infected location.

Some researchers suggested that by making a change in lifestyle accompanied by moderate physical activity such as walking, the risk of heart disease can be prevented.

The American College of Cardiology wrote in the article of Heart Disease: Lifestyle Changes to Lower Risk. "Start slowly, and go at a pace you can manage. Try to do at least 2½ hours of moderate exercise a week. One way to do this is to be active 30 minutes a day, at least 5 days a week". 

"Healthy eating starts with learning new ways to eat, such as adding more fresh fruits, vegetables, and whole grains and cutting back on foods that have a lot of saturated fat, sodium, and sugar" 

"Getting active and eating a healthy diet can help you lose extra weight and  quit smoking"

Finally, the article continued, "Even though you are taking medicine, it is always important to make lifestyle changes that keep your heart and your body healthy".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae, native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.

Finding a natural ingredient for the treatment of cardiovascular diseases has been a dream of many scientists. Researchers at the joint study led by the IRCCS San Raffaele Pisana, examined the effects of vegetables, including artichoke on CVD.

The joint study included a total of 38 subjects at risk of CVD. After, a week of the run-in period, participants were randomly assigned to one of the following 4-week interventions: low vegetable consumption (800 g of vegetables/week) or high vegetable consumption (4200 g of vegetables/week).


According to the assays that record immunological, and antioxidant markers, leukocyte and lymphocyte expression of the gut-homing β7 integrin, there were no significant changes detected in clinical, immunological, and antioxidant markers in biological samples, except for an increase in white blood cell count for the low vegetable consumption group.

Immune system's innate and adaptive immune responses play an essential role in the development and progression of cardiovascular diseases by inhibiting the pro-inflammatory expression.

Vegetable consumption group exerts a CVD protective effect in modulating markers of immune function and antioxidant status in patients with CVD. In healthy individuals, intake of vegetables does not induce a change of both antioxidant and inflammatory markers associated with immune function, particularly in nonsmoking men.

These results strongly suggested that vegetables modulate the function of the immune system according to the needs of the body.

In other to reveal more information about artichoke anti CVD activity, Dr. Rondanelli M and colleagues at the University of Pavia investigated the artichoke extracts on the cardiovascular disease on both animals and man.

Injection of artichoke not only reduced the levels of cholesterol in the bloodstream through its hypolipidemic activity but also inhibited the expression of high blood glucose and free radicals through the antioxidant and hypoglycemic activity.

The results indicated artichoke reduced the risk and progression of cardiovascular disease by improving the production of antioxidant enzymes against oxidative stress in the initiation of low-grade inflammation, a hallmark of CVD.

Futhermore, artichoke also decreases the levels of blood cholesterol and glucose, the cluster conditions associated with the risk CVD, epidemiologically.

Taken altogether, artichoke which processes anti cardiovascular diseases activity through several mechanisms may be considered a functional remedy for the prevention and treatment of cardiovascular diseases, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effects of High Consumption of Vegetables on Clinical, Immunological, and Antioxidant Markers in Subjects at Risk of Cardiovascular Diseases by Peluso I1, Raguzzini A1, Catasta G1, Cammisotto V1, Perrone A1, Tomino C2, Toti E1, Serafini M. (Hindawi)
(2) Health-promoting properties of artichoke in preventing cardiovascular disease by its lipidic and glycemic-reducing action by Rondanelli M1, Monteferrario F, Perna S, Faliva MA, Opizzi A. (PubMed)
(3) Heart Disease: Lifestyle Changes to Lower Risk by The American College of Cardiology

Saturday, 19 January 2019

3,3'-Diindolylmethane, the Potential Anti Colon Cancer Bioactive Compound, According to Researchers

By Kyle J. Norton

3,3'-Diindolylmethane or DIM may have a profound and positive effect in reducing risk and treatment of colon cancer, according to studies.

Colon cancer is a chronic condition caused by irregular cell growth in the tissue of the colon.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon tissue. It is one of most slow-growing cancer that takes years to develop. Therefore, most patients in the early stage of cancer do not experience any symptoms.

However, at the advanced stage, cancer can cause severe rectal bleeding and persistent abdominal pain due to the larger size tumor that has pressed on the nearby nerve cells and blood vessels.

According to the statistics, the risk of CRC increases with age; the median age at diagnosis for colon cancer is 68 in men and 72 in women.

The data of colon provided by CDC showed that every year, 97,000 new cases of colon cancer are diagnosed.

Besides sharing the common symptoms with other types of cancer such as unintended weight loss, loss of appetite, persistent fatigue, and tiredness, patients with colon cancer may also experience symptoms of change of bowel movement, rectal bleeding and persistent abdominal discomforts, such as cramps, gas or pain.

If you experience some of the above symptoms, please make sure you check with your doctor to rule out the possibility.

Although there are many risk factors involved the onset of colon cancer, some researchers suggested aging may be one of the most prevalent risks.

Donna Myers on the examination of the time that needed for a polyp or growth of tissue in the lining  to cancer and the percentage of colon cancer cases in people age 50 or older, said, " By the time colorectal cancer is diagnosed, it has often been growing for several years, first as a non-cancerous polyp and later as cancer. Research indicates that by age 50, one out of four people has polyps".

The results strongly suggested that if you are at the age of 50 and a higher risk of colon cancer, you may want to have a colonoscopy done every 3 years.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

Researchers on finding the natural compounds for the treatment of colon cancer examined the two anti-cancer agents (doxycycline or 3,3'-diindolylmethane) on HCT-116 and HT-29 colon cancer cell lines.

Injection of the 2 compounds resulted in profound changes in the intracellular content of several lncRNAs (by up to 100 times secreted by tumors into the bloodstream.

The results strongly suggested that by examining the levels of lncRNAs colon cancer expression can be monitored through tumor relapse and metastasis.

In order to reveal more information about 3the Sulindac (SU; 320 ppm) effect on colon cancer, researchers examined two natural compounds, 3,3'-diindolylmethane (DIM; 250 ppm) and curcumin (CUR; 2000 ppm), with or without lower doses of SU could affect carcinogenesis.

Colon tumors were significantly reduced by SU 320 ppm (62 % reduction over Controls), by DIM and CUR without or with SU 80 and 160 ppm (50, 53 and 58 % reduction, respectively) but not by SU 80 ppm alone.

Futhermore, total tumors (colon and small intestine) were found to reduce substantially by SU (80 and 320 ppm) and by DIM and CUR.

Apoptosis in the normal mucosa was significantly increased by SU 320 ppm and slightly increased by DIM and CUR with or without SU.

The combination of SU with DIM or Cur also caused a slight reduction in Survivin-Birc5 expression observed with all the treatments compared to controls.

Where Survivin-Birc5 protein is found to inhibit caspases associated with the blocking of cancer cell death. The protein is highly expressed in most cancers associated with a poor clinical outcome.

The results strongly reaffirmed the anti-colon cancer activity of DIM and CUR combination.


Taken altogether, DIM used alone or combined with another bioactive compound may be considered a supplement for the prevention and comn=bined with primary medicine for the treatment of colon cancer, pending to the confirmation of larger sample size and multicenter human study.

Intake of DIM as o form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.


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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Treatment with anti-cancer agents results in profound changes in lncRNA expression in colon cancer cells].[Article in Russian] by Zinovieva OL1, Grineva EN1, Prokofjeva MM1, Karpov DS1, Krasnov GS1, Prassolov VS1, Mashkova TD1, Lisitsyn NA. (PubMed)
(2) Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis by Femia AP1, Soares PV2, Luceri C3, Lodovici M4, Giannini A5, Caderni G. (PubMed)
(3) The Link Between Age and Colorectal Cancer Risk by Donna Myers