Saturday, 20 January 2018

Food Therapy: Eggplant and Its Bioactive Glycoalkaloids in Ameliorated Risk of Melanoma

Kyle J. Norton 

Eggplant may have a potential and substantial effect in reduced risk and treatment of melanoma, some scientists suggested.

Eggplant is a species of S. melongena with deeply purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

Melanoma is a type of skin cancer characterized by irregular cell growth in the pigment-containing cell. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

According to statistic, approximately 87,110 new cases of invasive melanoma will be diagnosed in the U.S. in 2017.

The evaluation of eggplant  bioactive glycoalkaloids in reduced risk and treatment of melanoma was confirmed to associate to many differentiation, involving numbers of implication.

 In the evaluation of the effect of lycoalkaloids, the nitrogen-containing secondary plant metabolites found in numerous Solanaceous plants including eggplants in numbers of cancer cell lines, researchers showed that the phytochemicals express a significant effect in inhibition of the process of early stage of various types of cancer occurrence through induction of cancer cells apoptosis.

Further analysis, glycoalkaloids efficacy was attributed to the derived phytochemical compound solamargine in activation of antioxidant activity against formation of skin cancer through expression several biomarkers and signaling pathways.

In primary melanoma cell lines WM239 and WM115, application of solamargine with half inhibitory concentration IC50 demonstrated a profound effect in inhibited the growth of metastatic cancer cells and  initiated apoptosis, through over expression of  lysosomal membrane permeabilization induced by leaky lysosomes during cell death, detected by lysosomalgalectin puncta assay, without causing damage to normal and benign skin cells, namely, WM35.

Observation of the cellular necrosis also indicated that solamargine anti skin cancer effect was confirmed by over expression of cathepsin B which is considered as a biomaker in malignant lesions and various cancers by triggering extrinsic mitochondrial death pathway function in activated cellular apoptosis through the release of cytochrome c from mitochondria during the early stages of apoptosis and apoptotic tumor necrosis factor receptor-1(TNFR1).

Moreover, injection of the derivative solamargine also disrupted the intrinsic apoptosis pathway
through reduced expression of hILP/XIAP in blocking apoptosis through an interaction with an unknown TNF receptor associated factors (TRAF) in activated caspase-3 in mediated cleavage, increasing expression of proteins Bcl-xL, and Bcl2 in regulated anti- apoptosis, anti-cell cycle arrest and decreasing levels of apoptotic protease activating factor 1 (Apaf-1) and Bax in suppression of tumor growth.

Unlike other phytochemicals such as green tea EGCG inhibited apoptosis through both intrinsic and extrinsic apoptosis pathways, eggplant derivative solamargine selectively triggered melanoma cancer cells death through only death receptors.

After taking account of other con founders, Dr, Sana S. said, " Solamargine showed high efficacy in vitro particularly against the vertical growth phase (forming a true tumor) melanoma cells".

Taken together, eggplant with abundant glycoalkaloids may be considered as a functional food to ameliorated risk, progression and treatment of melanoma. Intake of eggplant supplement should be taken with special care and only prescribed by experts.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1(PubMed)
(1) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A. Eltayeb, Brenda L. Coomber, and Sirin A. Adham(PMC)
(3) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A Eltayeb, Brenda L. Coomber and Sirin A. Adham(Cancer cell international)
(4) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications by Brahma N. Singh,1 Sharmila Shankar,2 and Rakesh K. Srivastava*(PMC)

Food Therapy: Lentils in Reduced Risk and Treatment of Hypertension

Kyle J. Norton

Intake of lentils regularly and daily may have a profound and therapeutic effect in reduced risk and treatment of high blood pressure, some scientists postulated

Lentil, a type of pulse and tiny legumes that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens belongings to the Fabaceaefamily, native to Middle East.

Hypertension is a chronic medical condition characterized by abnormal high blood pressure.

The study to evaluate the lentil intake activity and risk of hypertension in spontaneously hypertensive rats (SHRs) model by feeding semi-purified diet prepared with powder (30 %, w/w) from cooked whole pulses or a pulse-free control diet (n = 8/group) for 4 weeks showed that urine samples collected from rats fed with lentil pulse group reveal 27 different metabolites in compared only 7 in control diet rat group.

According to the differentiate assays, metabolites citrulline found in pulse group exerted a significant effect in blood pressure regulation via production of the vasodilator nitric oxide (NO) whose bioavailability, is an important risk factor for reduced hypertension through arterial dilation by relaxings narrowed blood vessels and increasing oxygen and blood flow.

Further analysis, also discovered that several arginine-related compounds of NO synthase substrates and NO synthase arginine-based inhibitors with the same function in reduced high blood pressure expression were also detected in lentils but not in rat fed with control diet or other pulse powders.

Dr. Hanson M, the lead author, after taking into account of other con founders said, "Consumption of lentils increases the availability of arginine and several related compounds that could potentially elevate production of NO and contribute to the blood pressure-lowering effects of lentil-rich diets".

Additionally examination of the effect of lentils on arterial function in relation to arterial stiffness, lipid biochemistry and activation of select aortic proteins on 17-week-old male SHRs randomly assigned to groups (n=10/group) fed (a) 30% w/w green lentils, (b) 30% red lentils, (c) 30% mixed lentils (red and green) or (d) no lentils for 8 weeks with normotensive Wistar Kyoto (WKY) groups (n=10/group) received either the mixed lentil or no lentil diet found that group fed with red lentils expressed a greatest effect in lowering low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in compared to WKY mixed lentil groups compared to their controls.

The lentil diets group exhibited a reduced the media:lumen ratio of in SHRs which is one of the indication for detecting hypertension in compared control-fed SHRs but not on WKYs and the red and green lentils reduced arterial stiffness of SHRs but not WKYs.

SHR lentil groups also suppressed the aortic p38 mitogen-activated protein kinase (p38MAPK) phosphorylation function in regulated vasoconstriction, thus inducing vaso-relaxation and attenuated hypertension.

Taken together, lentils with different color may be considered as a functional food in reduced risk and  treatment high blood pressure without inducing any intolerant side effects. People with high risk of hypertension may consider to add a portion of lentil into their diet for preventive measure.


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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Lentil-based diets attenuate hypertension and large-artery remodelling in spontaneously hypertensive rats by Hanson MG1, Zahradka P1, Taylor CG1.(PubMed)
(2) Lentil consumption reduces resistance artery remodeling and restores arterial compliance in the spontaneously hypertensive rats by Hanson MG1, Taylor CG2, Wu Y3, Anderson HD4, Zahradka P5.(PubMed)
(3) Identification of urinary metabolites with potential blood pressure-lowering effects in lentil-fed spontaneously hypertensive rats by Hanson M1,2, Zahradka P1,3,2, Taylor CG1,3,2, Aliani M4,5.(PubMed)

Friday, 19 January 2018

Herbal Therapy: Herbal Catnip in Reduced Risk and Treatment of Breast Cancer

Kyle J. Norton 

Herbal catnip may have a potential and substantial effect in reduced risk and treatment of breast cancer, some scientists suggested.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belongings to the family of Lamiaceae, native to Europe and Asia, use in herbal medicine as insect repellent and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

Ingredients
Beside the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..

Breast cancer is medical condition characterized by irregular cell growth in the issue of breast.  At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

According to statistic, approximately 1 in 8 U.S. women (about 12.4%) will develop invasive breast cancer over the course of her lifetime.

In comparison of breast cancer cell lines (MCF-7, MDA-MB-231)  to non-cancer line (MCF-10A) to evaluate the cytotoxic and apoptogenic activity of EtOH 70%, hexane and aqueous extracts isolated from the herbal plant catnip, researchers showed that catnip inhibited growth of malignant cells in a time and dose-dependent manner.

The hexane extract induced greater cytotoxicity in precipitated cancer cell apoptosis in compared to other extracts.

Further analysis, also indicated that at dose of 60 μg/ml concentration of catnip hexane extract reduced the expression of mRNA of ornithine decarboxylase 1 in response to growth-promoting stimuli and exhibited a high turnover rate of breast cancer.

 Over expressions of mRNA of tumor ornithine decarboxylase levels heterogeneity found in breast cell lines were associated to significantly increase the mean of tumor malignancy.by 4.9 and 3.6 fold of adenosine deaminase, a E2 responsive in MCF-7 human breast cancer cells and by 3.5 and 2.6 in MCF-7 cell line and MDA-MB-231 cell line, respectively and in compared to control.

Tumor ornithine decarboxylase gene is also considered as a bio marker as a prognostic factor for breast cancer. Increased serum of adenosine deaminase is found to correlate to cancer progression and malignancy.

The results indicated that application of catnip methanol hexane extract scores a high potential in modulated the expression of ornithine decarboxylase 1 and adenosine deaminase genes in breast cancer cells in inhibited malignant cancer proliferation and induced apoptosis.

Moreover, the investigation of the anticancer activities of chloroform Nepeta deflersiana extract and various sub-fractions (ND-1-ND-15) of ND against human breast cancer cells (MCF-7) by the King Saud University suggested that applications of selected sub-fractions of the chloroform extract at dose of 10-1000 μg/ml for 24 hours, displays a significant reduction of the cell viability of MCF-7 cancer cell line and altered the cellular morphology in a concentration-dependent manner.

Additional analysis indicated that N-10 isolated from catnip expressed a greater cytotoxicity in induced cancer death in compared to other other fractions according to the 
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.

According to the neutral red uptake assay, ND-1 extract did not cause any cytotoxicity in MCF-7 cells exposed for 24 h. However, the ND-10 extract was found more toxic toward breast cancer cells.

Finally, in MCF-7 cells, application at doses at 500 and 1000 μg/ml concentrations of all extracts exhibited a huge activity on in reduced the normal morphology of the cells and cell adhesion capacity in compared to the control.

And most the breast cancer cells at 1000 μg/ml concentration lost their typical morphology and appeared smaller in size and shrunken.

In compared to cancer cell line A-549 cells, MCF-7 cells were less sensitive to growth inhibition by all the extracts.

Taken together, there is no doubt that catnip and its methanol extracts may be a potential and therapeutic source of pharmacologically active molecules for the development of the chemotherapeutic drug for treatment of breast cancer.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Growth inhibition of human breast cancer cells and down-regulation of ODC1 and ADA genes by Nepeta binaloudensis by Akbar Safipour, Afshar Fatemeh Saeid Nematpour, Mahshid Meshkani, and ArezosadatKhafi(Science Direct)
(2) Anticancer Activity of Chloroform Extract and Sub-fractions of Nepeta deflersiana on Human Breast and Lung Cancer Cells: An In vitro Cytotoxicity Assessment by Al-Oqail MM1, Al-Sheddi ES1, Siddiqui MA2, Musarrat J2, Al-Khedhairy AA2, Farshori NN1.(PubMed)

Herbal Therapy: Green Tea In Prevention and Treatment of Acute and Chronic Constipation

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and treatment of acute and chronic constipation, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome", according to traditional Chinese medicine.

Constipation is a condition of hard to pass stool or not passing stool frequently, affecting 1/6 people over 12 years old in Canada.

In the examine the effects of Pu-erh tea on constipation in ICR mice induced by carbon injection  researchers found that mice in control group without administrated Pu-erh green tea expressed a significant weight loss, food and water intake in compared to experiment group.

In compared to first black stool time of normal group of 90 min, control (injection of carbon) of 221 min and bisacodyl treatment group (100 mg/kg in control group) of 118 min, mice in control group treated with green tea at doses of 200, 400 and 800 mg/kg showed an improved stool passing time of 178, 155 and 139 min, respectively.

Importantly, application of green tea Pu-erh also expressed a strong increase of serum levels of
1. Motilin (MTL) in the blood steam in stimulated the contraction of the fundus and antrum and accelerated gastric emptying; 
2. Gastrin, a peptide hormone in stimulated secretion of gastric acid (HCl) by the parietal cells of the stomach in improved gastric motility; 
3. Endothelin (ET), a peptide hormone with function in contraction of rat stomach strips, rat colon, and guinea pig ileum; 
4. Acetylcholine enzyme (AchE) chemical released by motor neurons of the nervous system in order to activate muscles; 
5. Substance P (SP) a amino-acids peptide in induction of rapid contraction of the smooth muscle of the digestive tract and 
6. Vasoactive intestinal peptide (VIP), a potent vasodilator, in regulated smooth muscle activity and blood flow in the gastrointestinal tract.

And decrease of somatostatin (SS) hormone in reduced gastric acid secretion and emission of gastrointestinal hormones, such as gastrin.

Additionally, in comparison of 2 types of commonly used osmotic laxative polyethylene glycol (PEG), namely PEG with electrolytes mixed with water and PEG without electrolytes mixed with tea or other sources such as juice and coffee for taste, researchers at the Pirkanmaan Erikoislääkäripalvelu conducted a randomized, double-blind, parallel-group study at ten private assisted-living facilities or communal nursing homes in Finland. Selected patients were.required to have used isotonic PEG at a stable dose without any other treatment for constipation (except for Plantago ovata seeds) for at least 2 weeks prior to a run-in period and  randomly assigned receive hypotonic PEG or continued to receive isotonic PEG, both dissolved in water, 12 g once or twice daily or once every other day, for 4 weeks, found that the mean (SD) weekly stool frequencies are not different in both hypotonic and isotonic PEG groups, although soft or normal stool consistency of 70% was higher in the hypotonic PEG group in compared to 52% in isotonic PEG group.

Moreover, both products are considered safe without inducing stool straining or gastrointestinal symptoms, although level of sodium was statistically and significantly lower in the hypotonic PEG group at the last day of testing of the study in compared to other group.

Dr. Seinelä L, after taking into account of other co factors said, "Both treatments appear safe, well tolerated and, when dissolved in water, well accepted by the majority of the patients. When desired, switching from isotonic to hypotonic PEG can safely take place in elderly individuals without compromising efficacy".

However, a total of 1,705 female Japanese dietetic students aged 18-20 years and free of current disease studies suggested the intake of tea is associated to constipation(3) without mentioning types of tea used in the surveys.

According to the theory of traditional Chinese medicine, green tea is yin in nature with function in relieved indigestion and smoothed bowel movements through promotion of fluid production(4) and constipation is a result of over expression of yang or deficiency of yin,  therefore, we do believe, the tea mentioned in the study were red, black or herbal tea with yang sufficiency.

Taken together, green tea may be considered as a functional food for prevention and treatment of constipation. Intake of green tea extracts should be taken with exceptional care due to toxicity reported in medical literature. 


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Component analysis of Pu-erh and its anti-constipation effects by Li G1, Wang Q1, Qian Y1, Zhou Y1, Wang R1, Zhao X1.(PubMed)
(2) Comparison of polyethylene glycol with and without electrolytes in the treatment of constipation in elderly institutionalized patients: a randomized, double-blind, parallel-group study by Seinelä L1, Sairanen U, Laine T, Kurl S, Pettersson T, Happonen P.(PubMed)
(3) Dietary intake in relation to self-reported constipation among Japanese women aged 18-20 years by Murakami K1, Okubo H, Sasaki S.(PubMed)
(4) History of Green Tea by Tao de Wan

Thursday, 18 January 2018

Herbal Therapy: Herbal Anise in Ameliorated Menopausal Hot Flash Frequency and Severity

Kyle J. Norton 

Anise may have a potential and substantial effect in relief and reduced recurrence of menopausal hot flashes, some scientists suggested.

Anise
 is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....agent


Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

Hot flashes are the frequent symptoms of menopause induced sudden feelings of warmth in some parts of the body. The symptoms affect approximately 75% of all women in peri menopause in the Western world.

In the investigation of the effect of Pimpinella anisum and symptoms of hot flash in postmenopausal women, researchers at the Shahid Beheshti Universit conducted a review of medical records at health centers of sample of 72 women with hot flashes randomly selected according to the predetermined criteria and divided into experimental group received a capsule containing 330 mg Pimpinella anisum 3 times a day and control group received 3 capsules, each containing 330 mg potato starch, over 4 weeks with pre treatment of frequency and severity of hot flashes taken in 2 weeks before administration indicated that women in anise treatment group exert a significant reduced frequency and severity of hot flashes from the pre treatment of 4.21% and 56.21% to 1.06% and 14.44% at the end of the fourth week respectively in compared to control group.

Further analysis found that women who are in the anise testing group also continue benefits from the ameliorated of the frequency and severity of hot flashes in 4 weeks follow up examination.

These results suggested that long term intake of herbal Anise may have a continued efficacy in relief and recurrence of menopausal hot flashes.

Additional illustration of the prevalence of hot flash in menopause women by reviewing the literature published on MEDLINE (1966 to January 2015), Scopus (1996 to January 2015), and Cochrane Central Register of Controlled Trials (The Cochrane Library, issue 1, 2015), researchers at joint study lead by the Mashhad University of Medical Science showed that over all studies approved the herbal effects of Anise in contribution of reduced hot flash occurrence and frequency as well as alleviating the side effects of hot flashes.

Moreover, in the double-blind clinical trial conducted to determine the effects of Anise abstract on hot flashes in women referring to rural and urban health centers of Qazvin province during 2006 by randomly assigned 72 postmenopausal women at different verities selected according to pre-determined criteria and divided into group of experimental group took a capsule containing 100 mg Anise 3 times a day and control group received 3 placebo capsules, each containing 330 mg starch over over 4 weeks experimental periods, searchers after compared to the frequency of hot flashes and the types of food they took 1 weeks before administrations found that there are significant difference in hot flash expression in these 2 groups of women

The Anise group showed a substantial decrease in frequency and severity of hot flashes from  4.21% and 56.21% before treatment and 1.06% and 14.44% at the end of the fourth week, respectively.
And women in control expressed an insignificant change of hot flash frequency and severity in compared to measurement before treatment. 

Interestingly, after taking account of other con founders, Dr. Fatemeh Nahidi, the lead author said, "  women can be taught to choose different alleviating methods, preferably".

In other words, by providing enough information, women who suffered from menopause hot flash  should be able to choose different alleviating methods in relief and recurrence of the symptoms.

 Women who do not tolerate the side effect of conventional medicine with symptoms of hot flash may want to add a portion of Anise into their diet, please consult with your herbalist before taking the herbs for preventive measure.

Due to short term of 4 weeks of study, some researchers suggested that  further studies with longer duration of treatment Anise for assessing hot flashes are necessary.

Taken together, herbal Anise may be considered as adjunct therapy used combination with standard treatment of hot flash in women in peri-menopause, menopause and post menopause. However, intake of herbal Anise supplements should be taken with extreme care in prevented toxicity.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) The Study on the Effects of Pimpinella anisum on Relief and Recurrence of Menopausal Hot Flashes by Nahidi F1, Kariman N, Simbar M, Mojab F.(PubMed)
(2) The efficacy of Iranian herbal medicines in alleviating hot flashes: A systematic review by Ghazanfarpour M1, Sadeghi R2, Abdolahian S3, Latifnejad Roudsari R4.(PubMed)
(3) Effect of anise extract on hot flush of menopause by Fatemeh Nahidi, M. Taherpour, F. Mojab, Hamid Alavi Majd(Research Gate)

Herbal Therapy: Habitual Green Tea in Ameliorated Risk of Stroke

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)


Green tea is found to consist a therapeutic and substantial effect in reduced risk and treatment of stroke, some scientists suggested

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Stroke is a medical condition of emergency caused by reduced or interrupted blood circulation to the brain, such as blocking artery induced ischemic stroke and leaking or bursting of a blood vessel precipitated hemorrhagic..

According to statistic, in US, every year, approximately 795,000 people suffer a stroke, a leading cause of serious and long-term disability.

Evaluation of green tea effect in risk of stroke was found to associated of certain mechanism involving numbers of aspects.

The review of medical literature published online suggested that green tea with strong inhibition of high blood pressure, a primary risk factor of stroke through its antioxidant and vasodilative activities induced by phytochemical flavonoids in imporved blood circulation to the brain. Although increased acute blood pressure was found in some studies, this acute effect did not translate into significant alterations in ambulatory blood pressure during regular tea consumption.

The impact of tea or catechin consumption precipitated nitric oxide  formation, as an essential gas signal molecule to protect the brain against in facilitated ischemic stroke and hemorrhagic stroke by relaxed vascular smooth muscle cells and induced vasodilatation through regulating network of blood vessel and peripheral nerve tissues. 

Amazingly, catechin also reduced NO levels through endothelial function by increased platelets aggression in post stroke.


In fact, green tea theanine, a bioactive chemical constuents also found to process anti stroke development through stimulating NO production of the cells in the inner wall of arteries in reduced risk of vascularconstrction and promoted  blood circulation, thus decreasing risk of an artery-blocking clot, a major cause of stroke, 

Further analysis also discovered that glutamate molecule found in theanine may also play an important role in attenuated risk of stroke through neuroprotective effect by decreased middle cerebral artery occlusion and cerebral infarction caused by blocking or narrowing the arteries in supplying blood and oxygen to the brain.

According to the study of  82 369 Japanese (aged 45-74 years; without cardiovascular disease [CVD] or cancer in 1995 and 1998 for Cohort I and II, respectively) received 13 years of mean follow-up through the end of 2007. green tea consumption of green tea 2 to 3 and ≥ 4 cups/d showed a siginficant effect in reduced risk of stroke with the multivariable-adjusted hazard ratios of 0.86 (0.78-0.95) and 0.80 (0.73-0.89), respectively in compared to non drinkers. And Higher green tea consumption reduced the risks of stroke subtypes, especially in intracerebral hemorrhage.

Other researchers suggested that green tea efficacy in reduced risk of stroke may be also associated to antioxidant effect in protection of endothelial function in blood circulation by reduced high blood cholesterol induced plaque build-up in the arteries in blocking blood flow to the brain, particularly in reactive oxygen species (ROS) precipitation of lipid peroxidation.

The effect of green tea in reduced insulin resistance in healthy adults may also contribute to lower risk of stroke, according to the cohort of 1509 nondiabetic participants from the Northern Manhattan Study (mean [SD] age, 11 [10] years; 64.2% women; 58.9% Hispanics).

Dr. Arab L said, "Regardless of their country of origin, individuals consuming >or=3 cups of tea per day had a 21% lower risk of stroke than those consuming <1 cup per day (absolute risk reduction, 0.79; CI, 0.73 to 0.85). The proportion of heterogeneity not explained by chance alone was 23.8%".

The information findings suggested that habitual green tea consumption may have a therapeutic in reduced risk of stroke development in general population. 


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1)The impact of green tea and coffee consumption on the reduced risk of strokeincidence in Japanese population: the Japan public health center-based study cohort by Kokubo Y1, Iso H, Saito I, Yamagishi K, Yatsuya H, Ishihara J, Inoue M, Tsugane S.(PubMed)
(2)Coffee, tea, and cocoa and risk of stroke by Larsson SC1(PubMed)
(3) The Impact of Green Tea Consumption on the Prevention of Hemorrhagic Stroke by Lee SM1, Choi NK, Yoon BW, Park JM, Han MK, Park BJ.(PubMed)
(4) Green and Black Tea Consumption and Risk of Stroke A Meta-Analysis by Lenore Arab, PhD; Weiqing Liu, MS; David Elashoff, PhD(Stroke. 2009;40:1786-1792.)
(5) Insulin resistance and risk of ischemic stroke among nondiabetic individuals from the northern Manhattan study by Rundek T1, Gardener H, Xu Q, Goldberg RB, Wright CB, Boden-Albala B, Disla N, Paik MC, Elkind MS, Sacco RL.(PubMed)

Wednesday, 17 January 2018

Alternative Therapy: Yoga in Reduced Blood Glucose Levels in Gestational Diabetes and Improved Pregnancy Outcome

Kyle J. Norton 

Yoga intervention may have a profound and positive impact in reduced risk and treatment on blood sugar levels among pregnant women, the Prince of Songkla University study suggested.

Yoga, the ancient technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a randomized controlled trial carried out to measure the capillary fasting plasma glucose, 2-h postprandial blood glucose, and hemoglobin A1c, among pregnant women with GDM, after accounting to other co founders, researchers indicated that fasting plasma glucose and 2-h postprandial blood glucose significantly reduced and glycosylated hemoglobin (HbA1c), accepted as an indicator for evaluation of the glucose control in diabetes mellitus (DM) patients also decreased substantially.

In deed, yoga mindfulness program created a self consciousness between body and mind, by bring back the presence and dealing the event positive way. In pregnant women the exercise induced attention of eating control such as when the stomach is full and what portion is needed. The breathing exercises relaxed the central nervous system, thus ameliorating stress expression in stimulated production of hormone epinephrine which is found to associate to blood sugar levels by converting glycogen from glucose stored in muscle cells and liver.

Prolonged stress may induce failure of the adrenal gland leading to over production of stress hormone in induction of abnormal high blood glucose.

Dr. Youngwanichsetha S, the led researcher said, "Mindfulness eating and yoga exercise had health benefits on glycemic control in pregnant women with GDM".

Additionally, in the support of the above differentiation, researchers at the SVYASA University conducted a study of 68 high-risk pregnant women recruited from two maternity hospitals in Bengaluru, India and randomized into yoga and control groups. with the yoga group (n=30) received standard care plus one-hour yoga sessions, three times a week, from the 12th to the 28th week of gestation and control group (n=38) received standard care plus conventional antenatal exercises (walking) in the same period, researchers found that yoga group expressed a significantly fewer pregnancy induced gestational diabetes (GDM) and cases in compared to control and induced  less complications in yoga group, including small for gestational age (SGA) babies and newborns with low APGAR scores.

Truly, breathing and meditation practice in yoga were found to induce a strong implication of relaxation and oxygenation to the pancreas, thus increasing the pancreas function in regulation of blood glucose through insulin secretion.

Some yoga instructors also suggested that mindfulness in yoga lesson also improved blood sugar levels by bring back the natural state of self conscientiousness of present experience of more aware of hunger and satiety cues, and emotional impact on hunger, particularly enhanced more positive relationship and feeling to food.

After examining other risk factors, the study concluded, yoga only can reduced risk of unfavorable complications, including gestational diabetes mellitus  in this group of women but also demonstrated significantly improvement of pregnancy outcome.

More importantly, in the searching of the data base from PubMed, eight studies (10 reports) satisfied the criteria included in the final analysis, researcher postulated that yoga intervention not only reduced risk of gestational diabetes mellitus, also improved pregnancy related complications, such as hypertension, and intrauterine growth restriction, particularly, decrease in perceived stress levels.

Taking altogether, Yoga therapy not only reduced risk of gestational diabetes mellitus in healthy women and improved glucose levels in women with gestational diabetes mellitus but also enhanced pregnancy outcome.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effects of mindfulness eating and yoga exercise on blood sugar levels of pregnant women with gestational diabetes mellitus by Youngwanichsetha S1, Phumdoung S2, Ingkathawornwong T3.(PubMed)
(2) The effects of yoga in prevention of pregnancy complications in high-risk pregnancies: a randomized controlled trial by Rakhshani A1, Nagarathna R, Mhaskar R, Mhaskar A, Thomas A, Gunasheela S.(PubMed)