Wednesday, 20 June 2018

Infectious Disease: Beware Of Some Life Threatening And Chronic Complications Associated To Over Growth of Candida

By Kyle J. Norton

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

 In many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and over expression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.

According to the article of Health Line, the cause of over growth of candida include over use of antibiotics in the vagina,  pregnancy, uncontrolled diabetes. weak immune system,....... and lack of sleep.


Some life threatening and chronic implications of candida overgrowth
1. Toxic shock syndrome(TSS)
Candida overgrowth can cause toxic shock syndrome (TSS)(157), a potentially fatal illness by producing toxins to suppress the immune system(158)(159), leading to infectious cause of high fever, accompanied by confusion, extreme fatigue and weakness, headache, severe diarrhea, sore throat, vomiting, widespread red rash, coma(161), and multiple organ failure(160).

2. Scalded skin syndrome (SSS)
Scalded skin syndrome is defined as a condition of skin infection inducing damage to the skin with marked shedding due to toxins(162) released by candida in suppressing the immune system(162).

Depending on severity, it can causes bloodstream infection(163) and electrolyte imbalance, involved in regulate myocardial and neurological function(164), fluid balance(165), oxygen delivery, etc., resulting in high morbidity and mortality(166).

3. Candida and chronic diseases
a. Irritable Bowel Syndrome (IBS)(167)(168)
As the condition worsen, candida takes advantage of weakness immune system and imbalances in the digestive system, allowing fungus to overrun the digestive tracts(169), leading to gases which irritate the intestinal and stomach linings(171) and initiated pain(170)(172).

b. Chronic Sinusitis(173)
As candida growth occurs in the sinus cavities(173), it causes fungal serious infections, with symptoms of nasal congestion, facial pain, pressure, congestion, or fullness, reduced or absent sense of smell. Both chronic and acute fungal sinusitis require immediate treatment(174).

c. Fibromyalgia
Fibromyalgia syndrome is a chronic condition that causes intense pain in various places around the body, including muscles, connective tissues and joints, as well as a host of other symptoms, as a result of production of mycotoxins by overgrowth candida(175), causing autoimmune diseases(143)(144)(136) by triggering inflammation in the intestinal tract(151).

Fibromyalgia syndrome affects more than 6 million people in the United States.

d. Chronic Fatigue Syndrome
Chronic fatigue syndrome (CFS) is defined as a health condition of persistent fatigue unrelated to exertion, it interferes with the patient daily activity, causing trouble staying on top of their responsibilities at home and on the job, etc.(176) due to production of mycotoxins by overgrowth candida(177)(178), triggering inflammation(179) in the intestinal tract.

Symptoms of chronic fatigue syndrome include headache, tender lymph nodes, fatigue, weakness, muscle, joint aches, inability to concentrate,(180) etc.

e. Thrush
Thrush is defined as condition of infection of the mouth caused by over growth candida fungus(181)(182).

f. Eczema, or Atopic Dermatitis
Eczema is a general term for many types of skin inflammation (dermatitis). The most common form of eczema is atopic dermatitis in some cases caused by over growth of candida(183)(184) as a result of immune suppressive factors(185).


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References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(157)Effect of strain of Staphylococcus aureus on synergism with Candidaalbicans resulting in mouse mortality and morbidity. Carlson E.(PubMed)
(158)Lesson of the month 2: toxic shock syndrome.
Shalaby T1, Anandappa S2, Pocock NJ2, Keough A2, Turner A2.(PubMed)
(159)Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. Kulhankova K1, King J, Salgado-Pabón W.(PubMed)

(157)Effect of strain of Staphylococcus aureus on synergism with Candidaalbicans resulting in mouse mortality and morbidity. Carlson E.(PubMed)(158)Lesson of the month 2: toxic shock syndrome. Shalaby T1, Anandappa S2, Pocock NJ2, Keough A2, Turner A2.(PubMed)(159)Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. Kulhankova K1, King J, Salgado-Pabón W.(PubMed)
(160) Toxic Shock Syndrome, C health(161)Group A streptococcal toxic shock syndrome with extremely aggressive course in the third trimester. Sugiyama T1, Kobayashi T, Nagao K, Hatada T, Wada H, Sagawa N.(PubMed).
(162) Scalded skin syndrome, the university of Maryland medical center(163)Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Kett DH1, Azoulay E, Echeverria PM, Vincent JL; Extended Prevalence of Infectionin ICU Study (EPIC II) Group of Investigators.(PubMed)
(164) [Infectious and metabolic nervous system complications of systemic cancer].[Article in Spanish]Ortiz N1.(PubMed)
(165) [Voriconazole compromises renal function in an elderly CDK patient with Candida albicans infection].[Article in Italian] Anastasio P1,.(PubMed)
(166)Endogenous thrombospondin-1 regulates leukocyte recr Marcarelli F, Bilancio G, Mele AA, De Santo NGuitment and activation and accelerates death from systemic candidiasis. Martin-Manso G1, Navarathna DH, Galli S, Soto-Pantoja DR, Kuznetsova SA, Tsokos M, Roberts DD.(PubMed)
(167) [Life-threatening complications of Crohn's disease and ulcerative colitis: a systematic analysis of admissions to an ICU during 18 years]. [Article in German] Huber W1, Herrmann G, Schuster T, Phillip V, Saugel B, Schultheiss C, Hoellthaler J, Gaa J, Hartel M, Schmid RM, Reindl W.(PubMed)
(168)The role of Candida albicans in the pathogenesis of food-intolerant irritable bowel syndrome. Shepherd C.(PubMed)
(169) Yeasts in the gut: from commensals to infectious agents. Schulze J1, Sonnenborn U.(PubMed)
(170) Treatment of abdominal pain in irritable bowel syndrome. Vanuytsel T1, Tack JF, Boeckxstaens GE.(PubMed)
(171) Current gut-directed therapies for irritable bowel syndrome. Chang HY1, Kelly EC, Lembo AJ.(PubMed)
(172) Abdominal pain in Irritable Bowel Syndrome: a review of putative psychological, neural and neuro-immune mechanisms.Elsenbruch S1.(PubMed)
(173) [Changes of etiology of chronic sinusitis].[Article in Chinese] Deng Q1, Peng P.(PubMed)
(174)Invasive fungal sinusitis of the sphenoid sinus. Lee DH1, Yoon TM1, Lee JK1, Joo YE2, Park KH3, Lim SC1.(PubMed)
(175) Occurrence of killer yeasts in isolates of clinical origin. Robledo-Leal E1, Villarreal-Treviño L, González GM.(PubMed)
(176)Experiences of daily activity in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and their implications for rehabilitation programmes. Pemberton S1, Cox DL.(PubMed)
(177) Chronic illness associated with mold and mycotoxins: is naso-sinus fungal biofilm the culprit? Brewer JH1, Thrasher JD, Hooper D.(PubMed)
(178) Detection of mycotoxins in patients with chronic fatigue syndrome.Brewer JH1, Thrasher JD, Straus DC, Madison RA, Hooper D.(PubMed)
(179) Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression.Taranu I1, Braicu C2, Marin DE3, Pistol GC3, Motiu M3, Balacescu L2, Beridan Neagoe I2, Burlacu R4.(PubMed)
(180)Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome.
Forsyth LM1, Preuss HG, MacDowell AL, Chiazze L Jr, Birkmayer GD, Bellanti JA.(PubMed)
(181) Identification of Candida albicans genes induced during thrush offers insight into pathogenesis. Cheng S1, Clancy CJ, Checkley MA, Handfield M, Hillman JD, Progulske-Fox A, Lewin AS, Fidel PL, Nguyen MH.(PubMed)
(182) Is endometrial infection with Candida albicans a cause of recurrent vaginal thrush?Smith JR1, Wells C, Jolly M, Shah P, Savage M, Reginald P, Kitchen VS.(PubMed)
(183) Candida albicans-specific lymphoproliferative and cytokine (IL-4 and IFN-gamma) responses in atopic eczema dermatitis syndrome. Evidence of CD4/CD8 and CD3/CD16+CD56 ratio elevations in vitro. Kosonen J1, Luhtala M, Viander M, Kalimo K, Terho EO, Savolainen J.(PubMed)
(184) Candida albicans mannan- and protein-induced humoral, cellular and cytokine responses in atopic dermatitis patients. Savolainen J1, Kosonen J, Lintu P, Viander M, Pène J, Kalimo K, Terho EO, Bousquet J.(PubMed)
(185) Guidelines for treatment of atopic eczema (atopic dermatitis) Part II.
Ring J1, Alomar A, Bieber T, Deleuran M, Fink-Wagner A, Gelmetti C, Gieler U, Lipozencic J, Luger T, Oranje AP, Schäfer T, Schwennesen T, Seidenari S, Simon D, Ständer S, Stingl G, Szalai S, Szepietowski JC, Taïeb A, Werfel T, Wollenberg A, Darsow U; European Dermatology Forum; European Academy of Dermatology and Venereology; European Task Force on Atopic Dermatitis; European Federation of Allergy; European Society of Pediatric Dermatology; Global Allergy and Asthma European Network.(PubMed)

Public Beware: Environment Toxins Increased Substantially Risk Of Early Onset Of Dementia As We Age


According to the research of Alzheimer's Research UK, 1 in 3 people born in the UK this year will develop dementia in their lifetime.

Approximately, over 850,000 people with dementia in the UK and these numbers will increase by over 1 million by year of 2025.

The  prevalent risk of dementia have escalated substantially in the East due to economic prosperity over last 30 years in increased living standard of population over a billion.

As a large percentage of these population are followers of Western diet as they have made a lots of money in compared to others and the past.

Dementia is the loss of mental ability that is severe enough to interfere with people's every day quality of life.

And, Alzheimer's disease is the most common type of dementia in aging people.

Western diet process high amount of saturated and trans fat, artificial ingredients with less fruits and vegetable can lead to dementia and other kinds of chronic ailment.

Certain environment toxins produced as a result of industrialization or naturally have been linked to cognitive degenerative diseases.

Researchers at the University of British Columbia in the investigation of Novel environmental toxins: steryl glycosides as a potential etiological factor for age-related neurodegenerative diseases, showed that mice fed washed cycad flour show signs that mimic amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS-PDC), including progressive deficits in motor, cognitive, and olfactory functions associated with neuron loss in the spinal cord, nigrostriatal system, cortex, hippocampus, and olfactory bulb.

Through a series of chemical extractions of washed cycad flour, researchers identified steryl glycoside molecules as bioactive molecules that are neurotoxic in culture and in mice.

A detailed review of this class of molecule revealed that the molecules are abundant in the environment, particularly in plants and bacteria.

 Lipid analysis showed that some bacteria that are associated with some forms of neurodegenerative disorders have the capacity to synthesize steryl glycosides.

Furthermore, certain steryl glycosides have been found to be a cell stress mediator and may have some immunomodulary effects.(1).

Others researchers suggested that Parkinson disease (PD) and Alzheimer disease (AD), are of purely genetic origin in a minority of cases and appear in most instances to arise through interactions among genetic and environmental factors and early environmental origins of neurodegenerative disease in later life(2).

1. Polychlorinated biphenyls (PCB)
Polychlorinated biphenyls (PCB) are industrial chemicals used commercially 1929 and ended in the United States in the 1970s for the manufacturing of electrical equipment, heat exchangers, hydraulic systems, etc.

Researchers at the Emory University in sex-specific analyses revealed that women had an excess of amyotrophic lateral sclerosis after exposing to the toxic chemicals,

Furthermore, women highly exposed to the chemicals at work are associated to an excessive risk of Parkinson disease and dementia(3).

Other study suggested chronic inhalation of low chlorinated PCBs that involved elevated blood levels was associated with a subtle attenuation of emotional well-being and attentional function.

Extended research is needed to replicate the potential long-term low PCB effects in a larger sample.(4)

2. Pesticides
Pesticides is the substances used in preventing, destroying, repelling or mitigating any pest.

 In the study to exposure to pesticides in related to central nervous system disorders of a prospective cohort study of 1,507 French elderly (1992-1998), researchers suggested neurologic impairments are highly presented in elderly persons who were exposed occupationally to pesticides in compared to general population(5).

Other study of 917 subjects interviewed from February 1997 to August 1998, 528 who were directly exposed to pesticides through mixing and/or spraying (mean exposure duration: 22 years), 173 were indirectly exposed through contact with treated plants, and 216 were never exposed, scientist strongly agreed that long-term cognitive effects also found in people with low-level exposure to pesticides in occupational conditions(6).

3. Cyanobacterial toxins
Cyanobacterial toxins produced by bacteria cyanobacteria have been linked to neurodegemerative disorders.

According to the Laboratoire de Neurobiologie Cellulaire et Moléculaire, cyanobacterial massive proliferation is a public concern regarding the capacity of certain cyanobacterial strains to produce hepatotoxic and neurotoxic compounds, such as beta-N-methylamino-l-alanine(BMAA) that can affect public health, human activities and wild and stock animals.

BMAA is associated to various forms of neurodegenerative disorder.

4. Mixtures of organic solvents
In the study to assess the applicability of the World Health Organization (WHO) Neurobehavioral Core Test Battery (NCTB) of 53 male and 29 female Venezuelan workers exposed to mixtures of organic solvents in an adhesive factory, incompared to 56 male and 11 female workers unexposed to any type of neurotoxic chemical, research team at University of Carabobo found that compared to the nonexposed, the exposed subjects demonstrated an increased frequency of subjective symptoms of fatigue, difficulties with memory, confusion, abnormal sensation in upper and lower extremities, and sleep disturbances(8)


5. Dioxins and heavy metals
In the study to evaluate the roles of dioxins and heavy metals in cancer and neurological diseases, researchers suggested that dioxins exert toxic actions by deceasing action of antioxidant enzymes such as superoxide dismutase, and glutathione peroxidase in protect cells integrity against cancer and neuronal dysfunction.

Heavy metals manifest cytotoxic effects in various cells and tissues.

Tight regulation of metals is essential to the health to general public.

Cadmium modulates gene expression and signals transduction and reduces activities of proteins involved in antioxidant defense, interfering with DNA repair and modifying cancer development and brain function.

Cobalt promotes generation of reactive oxygen species in induction of DNA damage in cells and brain tissues, altering abnormal cells proliferation and differentiation and causing healthy cells apoptosis.

Copper is a key metal in cell division processes in both normal and tumor cells.

Copper also has been shown to have an positively important role in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis.(9)

6. Asbestos
There are report that Asbestos has been kinked to Alzheimer disease. 10 cases in which an asbestos-related disease (malignant pleural mesothelioma or asbestosis) was associated with severe Alzheimer type lesions in the brain(10).

Although toxic substances have been banned over last 10 years, the environment ejected from these substances are stills a major concern in inflicted public health issues.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/17149752
(2) http://www.ncbi.nlm.nih.gov/pubmed/16140633
(3) http://www.ncbi.nlm.nih.gov/pubmed/16357589
(4) http://www.ncbi.nlm.nih.gov/pubmed/16236166
(5) http://www.ncbi.nlm.nih.gov/pubmed/12615605
(6) http://www.ncbi.nlm.nih.gov/pubmed/11564621
(7) http://www.ncbi.nlm.nih.gov/pubmed/19660486
(8) http://www.ncbi.nlm.nih.gov/pubmed/7900732
(9) http://www.ncbi.nlm.nih.gov/pubmed/20696237
(10) http://www.ncbi.nlm.nih.gov/pubmed/3957626

Tuesday, 19 June 2018

Herbal Andrographis Paniculata, Optimizes Gastrointestinal Performance By Augmented Functions of Digestive Antioxidant and Enzymes

By Kyle J. Norton

 Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Andrographis paniculata may have potential and profound effects in improved the gastric tone and prevented gastric dysfunction through the protection of its antioxidants and activation of digestive enzymes, some scientists suggested.

Andrographis paniculata is also known as andrographis is a herbaceous plant, genus Andrographis, belongings to the family Acanthaceae, native to India and Sri Lanka.

The forgotten herb has been used in traditional Siddha and Ayurvedic for treating common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, ....

Gastroprotective effect is a condition involved enhancing the function of digestive system against the harmful organisms in induced chronic digestive disorder..

People with digestive problem may experience certain stomach discomfort, including bloating. constipation. diarrhea. heartburn, nausea and vomiting,.......and belly pain.

Untreated digestive problems over a long term can induce serious ailments of chronic illnesses, as the digestive system no longer performs it's function in provided nutrients and fluids to the needs of body's cells and tissue..

The results of malnutriments over a long period of time can lead to weakened immune defense and reduced levels of antioxidants produced by tissue of the body in fighting against pathogens, 

Most common chronic illness associated to malnutriments are gastroenteritis, arthritis, asthma, cancer, COPD, diabetes and some viral diseases such as hepatitis C and HIV/AIDS infections,

The David M and Lynda K Underwood Center for Digestive Disorders, suggested "experiments in animal models have revealed the extent to which the gut microbiota sustains health and how its disruption might contribute to disease pathogenes".

As digestive problem has altered the balance of the gut microbiome in the gastrointestinal tract.

Dr. Matthew J. Bull, the lead scientist in the discuss of  The Human Gut Microbiome in Health and Disease suggested, "Imbalance of the normal gut microbiota have been linked with gastrointestinal conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and wider systemic manifestations of disease, such as obesity, type 2 diabetes, and atopy".

Although, genetic mutation of certain genes, such as MyD88 gene, Dectin-1 gene, NLRP12 Gene and NOD2 gene (Readers who want to know more of gene implication on digestive disorders may search in PubMed with key word, "gene mutation and digestive disorder") are association with non-specific digestive disorder, the cause of digestive problem in some cases are not restrict to digestive tract but symptoms of a wider systemic problem.

Some researchers suggested the physical causes of digestive disorder including food allergies and food intolerance, unhealthy diet, Viral or bacterial infection, certain digestive diseases,...... and Inflammation and auto-immune diseases.

Further more, ageing also has a strong impact on digestive problem, as we age, the production of saliva decreases that can affect the taste, worsen acid reflux and increase risk of digestive diseases.
 

In the study of gastric ulcer induced by ethanol, aspirin, pylorus ligation and cold restraint stress models in rats, researchers at the  the Bharathi Women's College.found that  rats treated or pretreated with hydroalcoholic extract HAEAP (100,200,500mg/kg b. wt for 30 days) of andrographis paniculata demonstrate a significant ulcer reduction, in dose dependent manner.

The ulcer preventing effect of HAEAP may be a result of its bioactive compound in regulating the gastric hydrogen potassium ATPase, also known as H+/K+ ATPase, an enzyme with functions to acidify the stomach activity and stimulating mucosal defensive system at the mucosal surface of the gastrointestinal tract..

Additional analysis of the results, researchers found that the flavonoids present in the HAEAP might be responsible for the gastroprotective action probably by maintaining the antioxidants and thiol status in the gastrointestinal tract.

In support of the above differentiation, the review of a period of 1 year from 2014-2015, using semi-structured questionnaires from different traditional Bengali people having knowledge on medicinal plants, out of 49 plants under 46 genera belonging to 33 families, researcher indicated that andrographis paniculata is one of the most prominent plants used among the people of Southern Assam for treating digestive system disorders (DSD).

Moreover,  seed ethyl acetate, acetone and methanol extracts of andrographis paniculata (Burm.f.) Wall. ex Nees has drawn a lots of scientist attention due to the limit success of chemical anthelmintics, a group of antiparasitic drugs (levamisole, flubendazole, and thiabendazole) in reduced gastrointestinal diseases.

In animal controls, injection of ED(50), an methanol extract of A. paniculata at dose of 2.90 mg/ml, and in larval development assay at ED(50) of dose 4.26 mg/ml, showed significant effects against sheep parasites, Haemonchus contortus.

Taking altogether, there is no doubt that andrographis paniculata consists a strong gastroprotective effect against the activities of harmful organisms, including parasites and may be used as functional food in improving digestive functions.

However, additional data collection on clinical studies performed with human consumption on large sample size and multi centers during the course of diseases will be necessary to complete the picture of andrographis paniculata effects in complete the treatment possibilities.

Intake of andrographis paniculata extract in any forms should be taken with extreme care in prevention of acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) A biochemical study on the gastroprotective effect of hydroalcoholic extract ofAndrographis paniculata in rats by Panneerselvam S, Arumugam G(PubMed).
(2) Plant utilization against digestive system disorder in Southern Assam, India by Choudhury PR1, Choudhury MD1, Ningthoujam SS2, Mitra A1, Nath D3, Talukdar AD4.(PubMed)
(3) Anthelmintic activity of botanical extracts against sheep gastrointestinalnematodes, Haemonchus contortus by Kamaraj C1, Rahuman AA, Elango G, Bagavan A, Zahir AA.(PubMed)
(4) Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet by Quigley EMM(PubMed)
(5) Part 1: The Human Gut Microbiome in Health and Disease by Matthew J. Bull, BSc, PhD and Nigel T. Plummer, PhD(PubMed)

Scientists Discovered A Potent And Natural Alternative to Anti Depressants Without Inducing Any Side Effects

Kyle J. Norton, Master of Nutrition


The use of plants for healing purposes have been predated long before the existence of modern medicine.

Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......


Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness, affecting the way you eat, sleep, and the way you feel about yourself.

Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate.

According to general belief, people who suffer from depression may experience some mental and physical symptoms, observed by screen assay for depression in clinical settings.

The most common mental symptoms are feeling sad without reason and guilty, emotionally out of control, trouble concentrating or remembering, lack of motivation, having negative thoughts,...., particularly, in loss of interest in usual pleasurable activities.

And most common physical symptoms include lack of energy or fatigue, difficulty performing daily activities, changes in sexual desire, appetite,.... particularly, in change of sleep pattern or difficult to sleep.

In concern to the causes of depression, researchers do not know why some people are more susceptible to the syndrome while some don't. However, depression may associate to a lots of different factors that affect our mental health.

According to the mapping risk factors for depression across the lifespan, the development of depression may involve a complex interplay of environmental and genetic risk factors including widowhood, physical abuse during childhood, obesity, having 4-5 metabolic risk factors, sexual dysfunction, job strain and with  ino consistent evidence for the causal effects of obesity, smoking, and alcohol consumption(4).

If you are experience some of the above symptoms, you may be at the early onset of depression. Please make that you see the related field specialist immediately.

If you are taking  conventional antidepressants, such as sertraline (Zoloft), fluoxetine (Prozac, Sarafem) citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil, Pexeva, Brisdelle), fluvoxamine (Luvox), please make sure you know the adverse effects such as increased appetite, weight gain, loss of sexual desire, fatigue, drowsiness, insomnia. dry mouth, blurred vision, constipation,.....

Green tea may have a profound effect in reduced risk and treatment of depression, some scientists suggested

Green tea, a precious drink processes numbers of health benefit, known to almost everyone in Asia and Western world.

However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

In vivo, application of green tea(GT) and GABA green tea (GGT) expressed a protective activity of against post-stroke depression (PSD), a common consequence of stroke, according to joint study lead by the Pavia University.

And, in mouse model of post-stroke depression, GGT and GT enhance the activity in the modulation of depressive symptoms through decreased oxidative stress, increased antioxidant endogenous defenses, including polyphenol, theanine, glutamine, etc......

Also, according to a cross-sectional study of consumption of green tea and coffee ascertained with a validated dietary questionnaire and the amount of caffeine intake estimated from these beverages, conducted by the joint venture lead by the Fukuoka Women's University, green tea consumption is associated to reduce symptoms of depression, depending to amount of intake.

Compared amount intake,  participants consumed ≥4 cups green tea/d had a 51% significantly lower prevalence odds of having depressive symptoms than those consumed less than 1 cup/d.

The multiple-adjusted odds for depressive symptoms comparing the highest with the lowest quartile of caffeine consumption was 0·57.

These results suggested that green tea consumption have a linear effect correlated to numbers of cup intake per day without mentioning the effects of maximum cups that patients can take.

Dr. Pham NM, the lead author in the study said, "higher consumption of green tea, coffee and caffeine may confer protection against depression".

Furthermore, in the review of Embase, PubMed, and Chinese National Knowledge Infrastructure databases from their inception through August 2014, tea consumption of more than 3 cups a day showed a significant decrease the risk of depression of 37% (RR = 0.63, 95% CI: 0.55-0.71), in compared to individuals with lower tea consumption and those with higher tea consumption.

Taking together, there is no doubt, green tea may be used as a functional food in reduced symptoms and risk of depression if consumes daily.

However, oral administration of large amount daily should be taken with care, particular to people with yin constituent.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Green tea and coffee consumption is inversely associated with depressivesymptoms in a Japanese working population by Pham NM1, Nanri A1, Kurotani K1, Kuwahara K1, Kume A1, Sato M2, Hayabuchi H3, Mizoue T1.(PubMed)
(2) Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression by Di Lorenzo A1, Nabavi SF2, Sureda A3, Moghaddam AH4, Khanjani S4, Arcidiaco P5, Nabavi SM2, Daglia M1.(PubMed)
(3) Effect of green tea on reward learning in healthy individuals: a randomized, double-blind, placebo-controlled pilot study by Zhang Q1, Yang H, Wang J, Li A, Zhang W, Cui X, Wang K.(PubMed)
(4) Mapping risk factors for depression across the lifespan: An umbrella review of evidence from meta-analyses and Mendelian randomization studies by Köhler CA1, Evangelou E2, Stubbs B3, Solmi M4, Veronese N5, Belbasis L6, Bortolato B7, Melo MCA1, Coelho CA1, Fernandes BS8, Olfson M9, Ioannidis JPA10, Carvalho AF(PubMed)

Monday, 18 June 2018

Beware: Poor Diet Cause Early Onset of Dementia, as We Age Revealed By Medline Studies

By Kyle J. Norton

Dementia is a condition of  neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement, chronically

Over 47 millions of worldwide population are afflicted by the diseases, mostly in the West.

The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

According to Alzheimer society of Canada, beside aging, people with diabetes, high blood pressure, obesity, smoking, depression, cognitive inactivity, and physical inactivity are susceptible to substantial risk of dementia onset.

In a prospective cohort study conducted in Caerphilly, South Wales, United Kingdom. Men aged 45-59 years, to examine whether caloric intake in mid-life is associated with later dementia or cognitive impairment not dementia (CIND) by the University of Bristol, researchers found that age adjusted odds ratios demonstrated strongest associations between average energy consumption and vascular CIND or dementia.

The results suggested aging population who follow poor diet are at increased risk dementia in compared to younger adult group, although, when adjusted for social class, the observed association between caloric intake and cognitive outcomes is modest.

Midlife characteristics of nonsmoking, body mass index (BMI) less than 25.0 kg/m(2), physically active, and having a healthy diet (based on alcohol, dairy, meat, fish, fruits, vegetables, cereals, and ratio of monounsaturated tosaturated fat) are associated to reduce risk of dementia(132).


Poor diet causes of dementia
1. Saturated fat and Trans fat(145)
Saturated fat is important for energy, hormone production, cellular membranes, especially in signalling and stabilization processes in the body, but over consumption can cause cholesterol building up in the arteries, leading to heart diseases, stroke, diabetes, etc.

A high saturated fat and cholesterol intake has shown to increase the risk of dementia, whereas fish consumption may decrease this risk(135)(145), probably due to involvement in the β-oxidation process of long-chain fatty acids, very-long-chain fatty acids, and branched-chain fatty acids of peroxisome(133)(145) in the breaks down molecules into smaller units to release energy of very long chain fatty acids(134).

 Intake of trans fat is also found to potentially increase the AD risk or cause an earlier onset of the disease due to its effects in increased production of amyloid beta (Aβ) peptides, main components of senile plaques(136).

2. Artificial sweetener
Artificial sweetener can cause obesity risk of dementia independence of diabetes and cardiovascular comorbidities(137). and induced increasing consumption of fat(138).

3. Fast Foods
Fast foods, unwholesome foods, containing high amounts of artificial ingredients, with an aim to be cooked fast and handed over to the customer in minutes may induce anxiety, tension, depression, difficulty in concentration, and memory, that can lead to onset of senile dementia(139).

4. Artificial ingredients
A standard American diet containing high amount of MSG and aspartame may induce the early onset of neurodegenerative disease(140)

5. Alcohol
Moderate alcohol drinking is associated with a reduced risk of unspecified incident dementia and AD(141)(145), however, excessive consumption of alcohol not only causes liver damage but also increases risk of neuro-degeneration, including onset of dementia due to its neurotoxic and neuroprotective effect(142).

6. Low intake of fruits and Vegetables
Nutrition plays a role in the ageing process of the brain and suboptimal nutrient.

According to The Chinese University of Hong Kong, older people with questionable dementia have lower intakes of vegetables, fruits(145) and fluid than those who were cognitively normal(143)

7. Meat
The typical American diet containing high amounts of red meat has shown to increase risk of cholesterol building up in the blood vessels and capillaries in causation of heart diseases and stroke(144) and cognitive impairment(135).


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Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299


References
(135) Dietary fat intake and the risk of incident dementia in the Rotterdam Study by Kalmijn S1, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM.(PubMed)
(136) Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP) by Grimm MO1, Rothhaar TL, Grösgen S, Burg VK, Hundsdörfer B, Haupenthal VJ, Friess P, Kins S, Grimm HS, Hartmann T.(PubMed)
(137) Can artificial sweeteners help control body weight and prevent obesity? by Benton D1.(PubMed)
(138) Central obesity and increased risk of dementia more than three decades laterby R. A. Whitmer, PhD, D. R. Gustafson, PhD, E. Barrett-Connor, MD, M. N. Haan, DrPH, E. P. Gunderson, PhD and K. Yaffe, MD(Neurology)
(139) Evaluation of diet and life style in etiopathogenesis of senile dementia: A survey study. by Chaudhuri K1, Samarakoon SM, Chandola HM, Kumar R, Ravishankar B.(PubMed)
(140) WHERE CTE, DIET, and NEURODEGENERATION MEET(Reversing disease for optimal health)
(141) Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes by
Panza F1, Capurso C, D'Introno A, Colacicco AM, Frisardi V, Lorusso M, Santamato A, Seripa D, Pilotto A, Scafato E, Vendemiale G, Capurso A, Solfrizzi V.(PubMed)
(142) Alcohol and cognition in the elderly: a review by Kim JW1, Lee DY, Lee BC, Jung MH, Kim H, Choi YS, Choi IG.(PubMed)
(143) Lower fluid and fruits/vegetable intake in questionable dementia among older Hong Kong Chinese.by Lee J1, Lam L, Woo J, Kwok T.(PubMed)
(144) Meat consumption in relation to mortality from cardiovascular disease among Japanese men and women by Nagao M1, Iso H, Yamagishi K, Date C, Tamakoshi A.(PubMed)
(145) Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective? by Panza F1, Frisardi V, Seripa D, Logroscino G, Santamato A, Imbimbo BP, Scafato E, Pilotto A, Solfrizzi V.(PubMed)

Sunday, 17 June 2018

Detoxification: How To Detox And Nourish Your Liver For Optimal Health

Western diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables.

These types of harmful substances are toxic and induced a shift in microbiota composition in enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation(10).

Some researchers suggested that escalating consumption of fat and sugar in Western countries are associated parallelly in increased incidence of cardiovascular disease during the latter 20th century(10).
Also, according to the report in The American Journal of Pathology and studied mice module, Western diet altered the bile acid profile and elevated liver inflammation(12) as well as promoted other Western-pattern diet-related diseases, including non alcohol fatty liver disease, metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis(11).

Our body's detoxified functions try to get rid of them everyday. When they fail, the toxins can cause a disruption of hormone production, damage of our body's detoxification organs and  immune system, leading to hormone imbalance and development of chronic ailments.

Natural Remedies Detox And Nourish Your Liver include
1. Milk thistle
Milk thistle, a flower plant of the daisy family have been traditionally claimed in treating chronic liver disease. 

The herbal medicine contains silymarin with impressive functions in protected liver function and  expelled liver toxins.

In a study to compared Cirsium japonicum DC's flavonoids, liver protection against liver toxicity using carbon tetrachloride (CCl4) with silymarin as a positive control, researchers after taking into account of other co and founders found that silymarin exerts a clear hepatoprotective effects similar to those of Cirsium japonicum DC's flavonoids aginst toxins caused by injection of carbon tetrachloride (CCl4)(1)


Dr. Ma Q, the lead scientist said, "The results indicated that the pretreatment with C. japonicum flavonoids could significantly reverse CCl4-induced L02 cell viability decrease similarly to silymarin".

Silymarin is a mixture of flavonoids from Silybum marianum(milk thistle), a traditional European food plant with clear hepatoprotective effects.


2. Licorice
Licorice is a legume plant and and native southern Europe and parts of Asia.

The herbal medicine contains a bioactive compound glycyrrhizin, which demonstrated a significantly liver protective effect against liver toxins through suppression of hepatic stellate cell in activation of  liver fibrosis in some studies(3).

According to the even-day intraperitoneal administration of glycyrrhizin (400 mg/kg/day) to 2- to 3-month-old male C57BL/6N mice (mean weight 27 g) against acetaminophen-induced liver damage observed by activity of alanine transaminase and aspartate aminotransferase, application of glycyrrhizin significantly reversed the increased levels of long-chain acylcarnitines in induction of liver damage and toxicity(2).

Further differentiation of the this metabolomic assay, suggested that glycyrrhizin exertd a significant protection effect against acetaminophen-induced liver damage induced by toxic acetaminophen through reversing fatty acid metabolism(2).


3. Tabebuia heptaphylla
Tabebuia heptaphylla is the botanical name:of Pau d'Arco
The herbal plant contains alkaloids, flavonoids, sulfur and essential oils which have a strong effect in enhanced helping to support the immune activity(4).

The herb displayed a strong hepaprotective effect against liver damage and toxicity, probably due to a major bioactive compound  flavonoids(4).

4. Stilingia root
Stilinga root not only strengthens the immune cells but also prevent and treating food allergies and eczema by stimulating the removal of toxins accumulation in the liver caused by long term eating of preservatives, canned foods, fast foods and excessive alcohol drinking. 

According to the Scovill's compound syrup of sarsaparilla and stillingia, or, Blood and liver syrup : for the cure of scrofula and all diseases of the blood and liver by A.L. Scovill & Co, stillingia root processes a strong hepaprotective effect against liver disease and liver toxins.


5. Prickly ash
Prickly ash is also known as toothache tree. It has been used traditionally as a digestive aid and to strengthen the nervous system. Prickly ash is considered as a tonic and stimulant herb for the liver and gallbladder.

As a holistic cleanser, Prickly ash eliminates toxins, including to liver toxicity(5).

6. St. John wort
St. John wort is also known as tipton weed or klamath weed. 

The herb has been used popular for its effect in ameliorated depression.

Major bioactive flavonoids and 3-O-coumaroylquinic acid process anti-inflammation and antioxidant effects in stimulated the immune system in fighting allergies and in protected liver against  toxins(6).
.
Dr. Aydin A and colleagues in the study of the effects of St. John wort on hepatic ischemia suggested that application of H. perforatum on rat model exerts a strong liver protection against hepatic ischemia locally and systemically(6),

Its chromone glycosides also showed moderate hepatoprotective activity with EC(50) values of 160.2 microM and 217.7 microM, respectively, against tacrine-induced cytotoxicity in HepG2 cells(7).


7. Fennel 
Fennel contains anethole, polymers and essential oil with function in improved liver and pancreas in the metabolism of fats and sugars.

The herbal  medicine also has a strong effect in dissolved fat deposits of the body and restored damaged liver cells that cause jaundice, hepatitis and other liver disorders(8)(9).

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Sources
(1) Hepatoprotective effect of flavonoids from Cirsium japonicum DC on hepatotoxicity in comparison with silymarin by Ma Q1, Wang LH, Jiang JG(PubMed)
(2) Targeted metabolomic study indicating glycyrrhizin’s protection against acetaminophen-induced liver damage through reversing fatty acid metabolism by Yu J, Jiang YS, Jiang Y, Peng YF, Sun Z, Dai XN, Cao QT, Sun YM, Han JC, Gao YJ(PubMed)
(3) Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis by Florent Duval, Jorge E Moreno-Cuevas, María Teresa González-Garza,Carlos Rodríguez-Montalvo, and Delia Elva Cruz-Vega(PMC)
(4) Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids by Chin-Lin Hsu*†, Gow-Chin Yen‡§1, in The Enzymes, 2014(Science Direct)
(5) Facts and benefits of Prickly Ash(Health Benefits Times)
(6) The effects of Hypericum perforatum on hepatic ischemia- -reperfusion injury in rats by Aydin A, Sakrak O, Yilmaz TU, Kerem M(PubMed)
(7) Chromone glycosides and hepatoprotective constituents of Hypericum erectum by An RB1, Jeong GS, Beom JS, Sohn DH, Kim YC(PubMed)
(8) Protective effect of anethol dithiolthione against acetaminophen hepatotoxicity in mice by Warnet JM1, Christen MO, Thevenin M, Biard D, Jacqueson A, Claude JR(PubMed)
(9) Protective mechanism of anethole on hepatic ischemia/reperfusion injury in mice by Cho HI1, Kim KM, Kwak JH, Lee SK, Lee SM(PubMed)
(10)Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation by Agus A1, Denizot J1, Thévenot J1,2, Martinez-Medina M1, Massier S1, Sauvanet P1,3, Bernalier-Donadille A4, Denis S2, Hofman P5, Bonnet R1,6, Billard E1,7, Barnich N(PubMed)
(11) Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis by Schierwagen R1, Maybüchen L1, Zimmer S2, Hittatiya K3, Bäck C4, Klein S1, Uschner FE1, Reul W1, Boor P5, Nickenig G2, Strassburg CP1, Trautwein C4, Plat J6, Lütjohann D7, Sauerbruch T1, Tacke F4, Trebicka J(PubMed)
(12) Western Diet Consumption May Increase Risk of Chronic Liver Inflammation in Men by All India | NDTV Food Desk | Updated: July 12, 2017 16:05 IST(NDTV)

Infectious Disease: Beware of Serious Complications Caused By Over Growth of Candida

By Kyle J. Norton

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.


Complications Caused By Over Growth of Candida
When Candida growth are uncontrolled and becomes fungus, its metabolites and/or toxins(117)(118) interfere with the functioning of nutrient-uptake(107)(108) and penetrate into the bloodstream, causing
1. Neuro effects
Candida produces toxins(acetaldehyde and ethanol)(112)(113) in large quantity that affect our brain and interfere with our biochemical processes, leading to upset levels of hormones and many key chemicals(109), resulting in symptoms of fatigue, aggression, depression and toxicity and schizophrenia(110)(111).

2. Permeability
As the innermost membrane of the four coats of the intestinal wall becomes permeable due to fungus(114)(115), partially digested foods, toxins produced by fungus and chemical molecules can enter the bloodstream and reach organs that suppress their normal functions, causing immune dysfunction(116)(117) in a long run and many kinds of chronic illness(118)(119).

3. Reproductive dysfunction
Overgrowth candida can cause the reproductive tract infection(120). For female, it leads to infections of the upper reproductive tract (fallopian tubes, ovary and uterus)(123), and/or the lower reproductive tract(124) (vagina, cervix and vulva)(121)(122). For male, it is at the penis(127), testicles, urethra(128) or the sperm tube(125), causing reproductive dysfunction, including infertility(126).

4. Premenstrual syndrome
As over growth candida binding to hormones(130), it alters the pathways and their shapes by preventing them entering the target receptor sites, that make certain hormones inactive, leading to estrogen and progesterone effected cell growth, morphology and virulence(131), in regulating blood sugar(132) and endocrine disruptor causes of premenstrual syndrome(129).

5. Autoimmune disorders
5.1. After entering blood stream, it causes allergies reaction of the immune system(133)(134), but some of antigens' molecules are similar to molecules of human tissue(135), resulting of immune system attacking both the antigens and the body's healthy tissues, leading to autoimmune disorders(136).

5. 2. The main target of candida target
The main target of candida is to evade the body's immune system for their forever survival in the host body by targeting the immune system response in fighting against invading organism(137) as they change the receptors of foreign organism or theirs' form which are displaying(138), making them difficult for the body's immune cells to react appropriately(19)(140).

5.3. Digestive track colonization
The main purpose of Candida is trying to invade the intestinal wall by suppressing immune system responds(142) with inflammation(141), leading to prolong inflammation, (the prolonged inflammation is called ulceration colitis if it occurs in the large intestine(143)(144) and called Crohn's disease if it occurs in the small intestine(145)(146)(147)) that can cause digestive track colonization of the host body.

5.4. The mind and emotion
If candida overgrowth, it produces toxins (canditoxin and ethanol) to affect our brain in released metabolites that interfere with our biochemical processes in hormone production(109), leading to fatigue, aggression, depression and toxicity(110)(111).

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(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(107) Oral candidiasis and nutritional deficiencies in elderly hospitalised patients. Paillaud E1, Merlier I, Dupeyron C, Scherman E, Poupon J, Bories PN.(PubMed)
(108) Nutritional factors and oral candidosis. Samaranayake LP (PubMed)
(109) Relative risk of vaginal candidiasis after use of antibiotics compared with antidepressants in women: postmarketing surveillance data in England. Wilton L1, Kollarova M, Heeley E, Shakir S.(PubMed)
(110) Effect of antibiotics on vulvovaginal candidiasis: a MetroNet study.Xu J1, Schwartz K, Bartoces M, Monsur J, Severson RK, Sobel JD.(PubMed)
(111) Quantifying effect of combined oral contraceptive pill on functional ovarian reserve as measured by serum anti-Müllerian hormone and small antral follicle count using three-dimensional ultrasound. Deb S1, Campbell BK, Pincott-Allen C, Clewes JS, Cumberpatch G, Raine-Fenning NJ.(PubMed)
(112)[Oral contraception and carbohydrate metabolism--the physiopathological explanation].[Article in French], Hilal M.(PubMed)

(113) PPARγ ligands switched high fat diet-induced macrophage M2b polarization toward M2a thereby improving intestinal Candida elimination. Lefèvre L1, Galès A, Olagnier D, Bernad J, Perez L, Burcelin R, Valentin A, Auwerx J, Pipy B, Coste A.(PubMed)
(114) The epidemiology of vaginal colonisation with group B streptococci in a sexually transmitted disease clinic.Honig E1, Mouton JW, van der Meijden WI.(PubMed)
(115)Risk factors for Salmonella infection. Loss of gastric acid linked to candidiasis. Larner AJ.(PubMed)
(116)Influence of gastric colonization with Candida albicans on ulcer healing in rats: effect of ranitidine, aspirin and probiotic therapy. Brzozowski T1, Zwolinska-Wcislo M, Konturek PC, Kwiecien S, Drozdowicz D, Konturek SJ, Stachura J, Budak A, Bogdal J, Pawlik WW, Hahn EG.(PubMed)
(117) Growth limitation in Candida lipolytica cultures and supersynthesis of metabolites]. [Article in Russian] Lozinov AB, Finogenova TV, Glazunova LM, Illarionova VI.(PubMed)
(118) Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. Brosnahan AJ1, Merriman JA, Salgado-Pabón W, Ford B, Schlievert PM.(PubMed)
(119) The Toxic Effects of Yeast OvergrowthPosted by SoundHealth, in Disease
(110) Mercury Poisoning, Candida Yeast, Or Is It Both?
(111) Relation of blood acetaldehyde level to clinical symptoms in the disulfiram-alcohol reaction. RABY K.(PubMed)(112)Biofuels. Engineering alcohol tolerance in yeast. Lam FH1, Ghaderi A2, Fink GR3, Stephanopoulos G4.(PubMed)
(113 Cytotoxicity and metabolic stress induced by acetaldehyde in human intestinal LS174T goblet-like cells. Elamin E1, Masclee A2, Troost F2, Dekker J3, Jonkers D2.(PubMed)
(114) Effect of corilagin on membrane permeability of Escherichia coli, Staphylococcus aureus and Candida albicans. Li N1, Luo M, Fu YJ, Zu YG, Wang W, Zhang L, Yao LP, Zhao CJ, Sun Y.(PubMed)
(115)A new look at the antibiotic amphotericin B effect on Candidaalbicans plasma membrane permeability and cell viability functions. Chudzik B1, Koselski M, Czuryło A, Trębacz K, Gagoś M.(PubMed)
(116) New insights into innate immune control of systemic candidiasis. Lionakis MS(PubMed)
(117) Growth limitation in Candida lipolytica cultures and supersynthesis of metabolites]. [Article in Russian] Lozinov AB, Finogenova TV, Glazunova LM, Illarionova VI.(PubMed)
(118) Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. Brosnahan AJ1, Merriman JA, Salgado-Pabón W, Ford B, Schlievert PM.(PubMed)
(119) The Toxic Effects of Yeast OvergrowthPosted by SoundHealth, in Disease
(120) Mercury Poisoning, Candida Yeast, Or Is It Both?

(11=21) Relation of blood acetaldehyde level to clinical symptoms in the disulfiram-alcohol reaction.

RABY K.(PubMed)

(122) Biofuels. Engineering alcohol tolerance in yeast. Lam FH1, Ghaderi A2, Fink GR3, Stephanopoulos G4.(PubMed)
(123 Cytotoxicity and metabolic stress induced by acetaldehyde in human intestinal LS174T goblet-like cells. Elamin E1, Masclee A2, Troost F2, Dekker J3, Jonkers D2.(PubMed)
(124) Effect of corilagin on membrane permeability of Escherichia coli, Staphylococcus aureus and Candida albicans. Li N1, Luo M, Fu YJ, Zu YG, Wang W, Zhang L, Yao LP, Zhao CJ, Sun Y.(PubMed)
(125)A new look at the antibiotic amphotericin B effect on Candidaalbicans plasma membrane permeability and cell viability functions. Chudzik B1, Koselski M, Czuryło A, Trębacz K, Gagoś M.(PubMed)
(126) New insights into innate immune control of systemic candidiasis. Lionakis MS(PubMed)
(127 )Immunogenetics of type 1 diabetes mellitus. Morran MP1, Vonberg A1, Khadra A2, Pietropaolo M3.(PubMed)
(128) Burden of Fungal Disease - Ireland. Dorgan E1, Denning DW2, McMullan R3.(PubMed)
(129) Burden of serious fungal infections in Spain.
Rodriguez-Tudela JL1, Alastruey-Izquierdo A2, Gago S3, Cuenca-Estrella M2, León C4, Miro JM5, Nuñez Boluda A6, Ruiz Camps I7, Sole A8, Denning DW9; University of Manchester in association with the LIFE program at. Electronic address: http://www.LIFE-worldwide.org.(PubMed)
(130) Prevalence study of genital tract infections in pregnant women referred to health centers in Iran.Mobasheri M, Saeedi Varnamkhast N, Karimi A, Banaeiyan S.(PubMed)
(131)Vaginal infections among pregnant women at Omdurman Maternity Hospital in Khartoum, Sudan Abdelaziz ZA1, Ibrahim ME, Bilal NE, Hamid ME.(PubMed)
(132) Reproductive tract infections among married women in Upper Egypt. Sullam SA1, Mahfouz AA, Dabbous NI, el-Barrawy M, el-Said MM.(PubMed)
(133) Characterization of low molecular weight antimicrobial peptide from human female reproductive tract. Sharma S1, Sethi S, Prasad R, Samanta P, Rajwanshi A, Malhotra S, Sharma M.(PubMed)
(134) Lower genital tract infections in infertile Nigerian women compared with controls.Okonofua FE1, Ako-Nai KA, Dighitoghi MD.(PubMed)
(135) ion of oocyte fertilization by assisted reproductive techniques and increased sperm DNA fragmentation in the presence of Candida albicans: a case report. Burrello N1, Calogero AE, Perdichizzi A, Salmeri M, D'Agata R, Vicari E.(PubMed)
(136) Studies on the significance of positive bacterial semen cultures in male fertility in Nigeria.Onemu SO1, Ibeh IN.(PubMed)
(137) Mycetomatoid infection of the penis by Candida albicans. Mastrolorenzo A1, Giomi B, Cipollini EM, Tammaro R, Decarli N, Cammelli D, Fabiani Tropeano F, Tiradritti L, Difonzo EM, Zuccati G.(PubMed)
(138) Candida albicans epididymo-orchitis and fungemia in a patient with chronic myelogenous leukemia Mark Pimentel, MD, Lindsay E Nicolle, MD FRCPC, and Salman Qureshi, MD FRCPC(PubMed)
(139) Normocalcemic tetany and candidiasis. Galland L.(PubMed)
(140) Interaction of Candida albicans with genital mucosa: effect of sex hormones on adherence of yeasts in vitro. Kalo A1, Segal E.(PubMed)
(141) Response of pathogenic and non-pathogenic yeasts to steroids. Prasad R1, Devaux F, Dhamgaye S, Banerjee D.(PubMed)
(142)Evaluation of the influence of blood glucose level on oral candidal colonization in complete denture wearers with Type-II Diabetes Mellitus: An in vivo Study. Ganapathy DM1, Joseph S, Ariga P, Selvaraj A.(PubMed)
(143)Role of L3T4+ lymphocytes in protective immunity to systemic Candida albicans infection in mice. Cenci E1, Romani L, Vecchiarelli A, Puccetti P, Bistoni F.(PubMed)
(144)[Squamous epithelial carcinoma in a 27-year-old patient with cellular immune defect].[Article in German] Kübler A1, Ziegler C, Barth T, Zöller J.(PubvMed)
(145)Immune thrombocytopaenic purpura: an autoimmune cross-link between infections and vaccines. Rinaldi M1, Perricone C, Ortega-Hernandez OD, Perricone R, Shoenfeld Y.(PubMed)
(146)Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006-2007 and 2012-2013.Kamikawa Y1, Mori Y, Nagayama T, Fujisaki J, Hirabayashi D, Sakamoto R, Hamada T, Sugihara K.(PubMed)
(147)Oxidative and nitrosative stress on phagocytes' function: from effective defense to immunity evasion mechanisms. Ferrari CK1, Souto PC, França EL, Honorio-França AC.(PubMed)