Strawberry, a delicious fruit may have a profound effect in the prevention and treatment of colon cancer, some studies suggested.
Colon cancer is a chronic and medical condition characterized by abnormal cell growth which starts in the lining of colonic tissue. At the advanced stage, the cancerous cells can travel a distance away to infect other healthy tissue and organ through blood and fluids circulation.
According to to the statistic provided by the American Cancer Society, colon cancer is the third most common cancer diagnosed in both men and women in the United States. In 2018, approximately, over 97,000 new cases the cancer are diagnosed, causing about 50,630 deaths.
Early diagnosed with colon cancer have an over 90% of 5 years survival rate.
The exact causes of colon cancer are unknown. However, researchers suggested that chronic inflammation of the intestines such as ulcerative colitis and Crohn's disease and genetic mutation inherited from the parents are some prevalent major risk factors.
Furthermore, age, gender, people with polyps on the inner wall of the colon or rectum, personal and family history, poor diet, and unhealthy lifestyle are also associated to the increased risk of the onset of the disease.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
In the evaluate the recent discovery that ellagitannins (ETs), a class of hydrolyzable tannins found in some fruits and nuts, including strawberry may have beneficial effects against colon cancer, researchers at the University of Rhode Island launched an investigation to study whether, the efficacy of the ETs was a result from its function on ETs hydrolyzing the release ellagic acid (EA) and was converted by gut microbiota to urolithin A (UA; 3,8-dihydroxy-6H-dibenzopyran-6-one) type metabolites, which may persist in the colon through enterohepatic circulation.
These results suggested that strawberry with abundant bioactive compound ellagitannins (ETs) has potential against colon carcinogenesis through gut microbiota.
Taken all together, strawberry processed high levels of phenolics compound and ellagitannins (ETs) may be considered a functional food in the reduced risk and treatment of colon cancer.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Effects of fruit ellagitannin extracts, ellagic acid, and their colonicmetabolite, urolithin A, on Wnt signaling by Sharma M, Li L, Celver J, Killian C, Kovoor A, Seeram NP. (PubMed)
(2) Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro by McDougall GJ, Ross HA, Ikeji M, Stewart D.(PubMed)
(3) Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties by Zhang Y, Seeram NP, Lee R, Feng L, Heber D.(PubMed)
(4) Diet and Lifestyle in Colorectal Cancer Survivors by Junga Lee,1 Justin Jeon,1 and Jeffrey A. Meyerhardt. (PMC)