Sunday, 17 June 2018

How To Detox And Nourish Your Liver For Optimal Health

American diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables.

These types of harmful substances are toxic and induced a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation(10).

Some researchers suggested that escalating consumption of fat and sugar in Western countries are associated parallelly in increased incidence of CD during the latter 20th century.

Our body's detoxifying functions try to get rid of them everyday. when they fail, the toxins can cause a disruption of hormone production, damage of our body's detoxification organs and  immune system, leading to hormone imbalance and development of chronic illness.

Natural Remedies Detox And Nourish Your Liver include
1. Milk thistle
Milk thistle, a flower plant of the daisy family have been traditionally claimed in treating chronic liver disease. 

The herbal medicine contains silymarin with impressive functions in protected liver function and  expelled liver toxins.

In a study to compared Cirsium japonicum DC's flavonoids, liver protection against liver toxicity using carbon tetrachloride (CCl4) with silymarin as a positive control, researchers after taking into account of other co and founders found that silymarin exerts a clear hepatoprotective effects similar to those of Cirsium japonicum DC's flavonoids aginst toxins caused by injection of carbon tetrachloride (CCl4)(1)


Dr. Ma Q, the lead scientist said, "The results indicated that the pretreatment with C. japonicum flavonoids could significantly reverse CCl4-induced L02 cell viability decrease similarly to silymarin".

Silymarin is a mixture of flavonoids from Silybum marianum(milk thistle), a traditional European food plant with clear hepatoprotective effects.


2. Licorice
Licorice is a legume plant and and native southern Europe and parts of Asia.

The herbal medicine contains a bioactive compound glycyrrhizin, which demonstrated a significantly liver protective effect against liver toxins through suppression of hepatic stellate cell in activation of  liver fibrosis in some studies(3).

According to the even-day intraperitoneal administration of glycyrrhizin (400 mg/kg/day) to 2- to 3-month-old male C57BL/6N mice (mean weight 27 g) against acetaminophen-induced liver damage observed by activity of alanine transaminase and aspartate aminotransferase, application of glycyrrhizin significantly reversed the increased levels of long-chain acylcarnitines in induction of liver damage and toxicity(2).

Further differentiation of the this metabolomic assay, suggested that glycyrrhizin exertd a significant protection effect against acetaminophen-induced liver damage induced by toxic acetaminophen through reversing fatty acid metabolism(2).


3. Tabebuia heptaphylla
Tabebuia heptaphylla is the botanical name:of Pau d'Arco
The herbal plant contains alkaloids, flavonoids, sulfur and essential oils which have a strong effect in enhanced helping to support the immune activity(4).

The herb displayed a strong hepaprotective effect against liver damage and toxicity, probably due to a major bioactive compound  flavonoids(4).

4. Stilingia root
Stilinga root not only strengthens the immune cells but also prevent and treating food allergies and eczema by stimulating the removal of toxins accumulation in the liver caused by long term eating of preservatives, canned foods, fast foods and excessive alcohol drinking. 

According to the Scovill's compound syrup of sarsaparilla and stillingia, or, Blood and liver syrup : for the cure of scrofula and all diseases of the blood and liver by A.L. Scovill & Co, stillingia root processes a strong hepaprotective effect against liver disease and liver toxins.


5. Prickly ash
Prickly ash is also known as toothache tree. It has been used traditionally as a digestive aid and to strengthen the nervous system. Prickly ash is considered as a tonic and stimulant herb for the liver and gallbladder.

As a holistic cleanser, Prickly ash eliminates toxins, including to liver toxicity(5).

6. St. John wort
St. John wort is also known as tipton weed or klamath weed. 

The herb has been used popular for its effect in ameliorated depression.

Major bioactive flavonoids and 3-O-coumaroylquinic acid process anti-inflammation and antioxidant effects in stimulated the immune system in fighting allergies and in protected liver against  toxins(6).
.
Dr. Aydin A and colleagues in the study of the effects of St. John wort on hepatic ischemia suggested that application of H. perforatum on rat model exerts a strong liver protection against hepatic ischemia locally and systemically(6),

Its chromone glycosides also showed moderate hepatoprotective activity with EC(50) values of 160.2 microM and 217.7 microM, respectively, against tacrine-induced cytotoxicity in HepG2 cells(7).


7. Fennel 
Fennel contains anethole, polymers and essential oil with function in improved liver and pancreas in the metabolism of fats and sugars.

The herbal  medicine also has a strong effect in dissolved fat deposits of the body and restored damaged liver cells that cause jaundice, hepatitis and other liver disorders(8)(9).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Sources
(1) Hepatoprotective effect of flavonoids from Cirsium japonicum DC on hepatotoxicity in comparison with silymarin by Ma Q1, Wang LH, Jiang JG(PubMed)
(2) Targeted metabolomic study indicating glycyrrhizin’s protection against acetaminophen-induced liver damage through reversing fatty acid metabolism by Yu J, Jiang YS, Jiang Y, Peng YF, Sun Z, Dai XN, Cao QT, Sun YM, Han JC, Gao YJ(PubMed)
(3) Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis by Florent Duval, Jorge E Moreno-Cuevas, María Teresa González-Garza,Carlos Rodríguez-Montalvo, and Delia Elva Cruz-Vega(PMC)
(4) Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids by Chin-Lin Hsu*†, Gow-Chin Yen‡§1, in The Enzymes, 2014(Science Direct)
(5) Facts and benefits of Prickly Ash(Health Benefits Times)
(6) The effects of Hypericum perforatum on hepatic ischemia- -reperfusion injury in rats by Aydin A, Sakrak O, Yilmaz TU, Kerem M(PubMed)
(7) Chromone glycosides and hepatoprotective constituents of Hypericum erectum by An RB1, Jeong GS, Beom JS, Sohn DH, Kim YC(PubMed)
(8) Protective effect of anethol dithiolthione against acetaminophen hepatotoxicity in mice by Warnet JM1, Christen MO, Thevenin M, Biard D, Jacqueson A, Claude JR(PubMed)
(9) Protective mechanism of anethole on hepatic ischemia/reperfusion injury in mice by Cho HI1, Kim KM, Kwak JH, Lee SK, Lee SM(PubMed)
(10)Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation by Agus A1, Denizot J1, Thévenot J1,2, Martinez-Medina M1, Massier S1, Sauvanet P1,3, Bernalier-Donadille A4, Denis S2, Hofman P5, Bonnet R1,6, Billard E1,7, Barnich N(PubMed)

Beware of Serious Complications Caused By Over Growth of Candida

By Kyle J. Norton

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.


Complications Caused By Over Growth of Candida
When Candida growth are uncontrolled and becomes fungus, its metabolites and/or toxins(117)(118) interfere with the functioning of nutrient-uptake(107)(108) and penetrate into the bloodstream, causing
1. Neuro effects
Candida produces toxins(acetaldehyde and ethanol)(112)(113) in large quantity that affect our brain and interfere with our biochemical processes, leading to upset levels of hormones and many key chemicals(109), resulting in symptoms of fatigue, aggression, depression and toxicity and schizophrenia(110)(111).

2. Permeability
As the innermost membrane of the four coats of the intestinal wall becomes permeable due to fungus(114)(115), partially digested foods, toxins produced by fungus and chemical molecules can enter the bloodstream and reach organs that suppress their normal functions, causing immune dysfunction(116)(117) in a long run and many kinds of chronic illness(118)(119).

3. Reproductive dysfunction
Overgrowth candida can cause the reproductive tract infection(120). For female, it leads to infections of the upper reproductive tract (fallopian tubes, ovary and uterus)(123), and/or the lower reproductive tract(124) (vagina, cervix and vulva)(121)(122). For male, it is at the penis(127), testicles, urethra(128) or the sperm tube(125), causing reproductive dysfunction, including infertility(126).

4. Premenstrual syndrome
As over growth candida binding to hormones(130), it alters the pathways and their shapes by preventing them entering the target receptor sites, that make certain hormones inactive, leading to estrogen and progesterone effected cell growth, morphology and virulence(131), in regulating blood sugar(132) and endocrine disruptor causes of premenstrual syndrome(129).

5. Autoimmune disorders
5.1. After entering blood stream, it causes allergies reaction of the immune system(133)(134), but some of antigens' molecules are similar to molecules of human tissue(135), resulting of immune system attacking both the antigens and the body's healthy tissues, leading to autoimmune disorders(136).

5. 2. The main target of candida target
The main target of candida is to evade the body's immune system for their forever survival in the host body by targeting the immune system response in fighting against invading organism(137) as they change the receptors of foreign organism or theirs' form which are displaying(138), making them difficult for the body's immune cells to react appropriately(19)(140).

5.3. Digestive track colonization
The main purpose of Candida is trying to invade the intestinal wall by suppressing immune system responds(142) with inflammation(141), leading to prolong inflammation, (the prolonged inflammation is called ulceration colitis if it occurs in the large intestine(143)(144) and called Crohn's disease if it occurs in the small intestine(145)(146)(147)) that can cause digestive track colonization of the host body.

5.4. The mind and emotion
If candida overgrowth, it produces toxins (canditoxin and ethanol) to affect our brain in released metabolites that interfere with our biochemical processes in hormone production(109), leading to fatigue, aggression, depression and toxicity(110)(111).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(107) Oral candidiasis and nutritional deficiencies in elderly hospitalised patients. Paillaud E1, Merlier I, Dupeyron C, Scherman E, Poupon J, Bories PN.(PubMed)
(108) Nutritional factors and oral candidosis. Samaranayake LP (PubMed)
(109) Relative risk of vaginal candidiasis after use of antibiotics compared with antidepressants in women: postmarketing surveillance data in England. Wilton L1, Kollarova M, Heeley E, Shakir S.(PubMed)
(110) Effect of antibiotics on vulvovaginal candidiasis: a MetroNet study.Xu J1, Schwartz K, Bartoces M, Monsur J, Severson RK, Sobel JD.(PubMed)
(111) Quantifying effect of combined oral contraceptive pill on functional ovarian reserve as measured by serum anti-Müllerian hormone and small antral follicle count using three-dimensional ultrasound. Deb S1, Campbell BK, Pincott-Allen C, Clewes JS, Cumberpatch G, Raine-Fenning NJ.(PubMed)
(112)[Oral contraception and carbohydrate metabolism--the physiopathological explanation].[Article in French], Hilal M.(PubMed)

(113) PPARγ ligands switched high fat diet-induced macrophage M2b polarization toward M2a thereby improving intestinal Candida elimination. Lefèvre L1, Galès A, Olagnier D, Bernad J, Perez L, Burcelin R, Valentin A, Auwerx J, Pipy B, Coste A.(PubMed)
(114) The epidemiology of vaginal colonisation with group B streptococci in a sexually transmitted disease clinic.Honig E1, Mouton JW, van der Meijden WI.(PubMed)
(115)Risk factors for Salmonella infection. Loss of gastric acid linked to candidiasis. Larner AJ.(PubMed)
(116)Influence of gastric colonization with Candida albicans on ulcer healing in rats: effect of ranitidine, aspirin and probiotic therapy. Brzozowski T1, Zwolinska-Wcislo M, Konturek PC, Kwiecien S, Drozdowicz D, Konturek SJ, Stachura J, Budak A, Bogdal J, Pawlik WW, Hahn EG.(PubMed)
(117) Growth limitation in Candida lipolytica cultures and supersynthesis of metabolites]. [Article in Russian] Lozinov AB, Finogenova TV, Glazunova LM, Illarionova VI.(PubMed)
(118) Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. Brosnahan AJ1, Merriman JA, Salgado-Pabón W, Ford B, Schlievert PM.(PubMed)
(119) The Toxic Effects of Yeast OvergrowthPosted by SoundHealth, in Disease
(110) Mercury Poisoning, Candida Yeast, Or Is It Both?
(111) Relation of blood acetaldehyde level to clinical symptoms in the disulfiram-alcohol reaction. RABY K.(PubMed)(112)Biofuels. Engineering alcohol tolerance in yeast. Lam FH1, Ghaderi A2, Fink GR3, Stephanopoulos G4.(PubMed)
(113 Cytotoxicity and metabolic stress induced by acetaldehyde in human intestinal LS174T goblet-like cells. Elamin E1, Masclee A2, Troost F2, Dekker J3, Jonkers D2.(PubMed)
(114) Effect of corilagin on membrane permeability of Escherichia coli, Staphylococcus aureus and Candida albicans. Li N1, Luo M, Fu YJ, Zu YG, Wang W, Zhang L, Yao LP, Zhao CJ, Sun Y.(PubMed)
(115)A new look at the antibiotic amphotericin B effect on Candidaalbicans plasma membrane permeability and cell viability functions. Chudzik B1, Koselski M, Czuryło A, Trębacz K, Gagoś M.(PubMed)
(116) New insights into innate immune control of systemic candidiasis. Lionakis MS(PubMed)
(117) Growth limitation in Candida lipolytica cultures and supersynthesis of metabolites]. [Article in Russian] Lozinov AB, Finogenova TV, Glazunova LM, Illarionova VI.(PubMed)
(118) Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. Brosnahan AJ1, Merriman JA, Salgado-Pabón W, Ford B, Schlievert PM.(PubMed)
(119) The Toxic Effects of Yeast OvergrowthPosted by SoundHealth, in Disease
(120) Mercury Poisoning, Candida Yeast, Or Is It Both?

(11=21) Relation of blood acetaldehyde level to clinical symptoms in the disulfiram-alcohol reaction.

RABY K.(PubMed)

(122) Biofuels. Engineering alcohol tolerance in yeast. Lam FH1, Ghaderi A2, Fink GR3, Stephanopoulos G4.(PubMed)
(123 Cytotoxicity and metabolic stress induced by acetaldehyde in human intestinal LS174T goblet-like cells. Elamin E1, Masclee A2, Troost F2, Dekker J3, Jonkers D2.(PubMed)
(124) Effect of corilagin on membrane permeability of Escherichia coli, Staphylococcus aureus and Candida albicans. Li N1, Luo M, Fu YJ, Zu YG, Wang W, Zhang L, Yao LP, Zhao CJ, Sun Y.(PubMed)
(125)A new look at the antibiotic amphotericin B effect on Candidaalbicans plasma membrane permeability and cell viability functions. Chudzik B1, Koselski M, Czuryło A, Trębacz K, Gagoś M.(PubMed)
(126) New insights into innate immune control of systemic candidiasis. Lionakis MS(PubMed)
(127 )Immunogenetics of type 1 diabetes mellitus. Morran MP1, Vonberg A1, Khadra A2, Pietropaolo M3.(PubMed)
(128) Burden of Fungal Disease - Ireland. Dorgan E1, Denning DW2, McMullan R3.(PubMed)
(129) Burden of serious fungal infections in Spain.
Rodriguez-Tudela JL1, Alastruey-Izquierdo A2, Gago S3, Cuenca-Estrella M2, León C4, Miro JM5, Nuñez Boluda A6, Ruiz Camps I7, Sole A8, Denning DW9; University of Manchester in association with the LIFE program at. Electronic address: http://www.LIFE-worldwide.org.(PubMed)
(130) Prevalence study of genital tract infections in pregnant women referred to health centers in Iran.Mobasheri M, Saeedi Varnamkhast N, Karimi A, Banaeiyan S.(PubMed)
(131)Vaginal infections among pregnant women at Omdurman Maternity Hospital in Khartoum, Sudan Abdelaziz ZA1, Ibrahim ME, Bilal NE, Hamid ME.(PubMed)
(132) Reproductive tract infections among married women in Upper Egypt. Sullam SA1, Mahfouz AA, Dabbous NI, el-Barrawy M, el-Said MM.(PubMed)
(133) Characterization of low molecular weight antimicrobial peptide from human female reproductive tract. Sharma S1, Sethi S, Prasad R, Samanta P, Rajwanshi A, Malhotra S, Sharma M.(PubMed)
(134) Lower genital tract infections in infertile Nigerian women compared with controls.Okonofua FE1, Ako-Nai KA, Dighitoghi MD.(PubMed)
(135) ion of oocyte fertilization by assisted reproductive techniques and increased sperm DNA fragmentation in the presence of Candida albicans: a case report. Burrello N1, Calogero AE, Perdichizzi A, Salmeri M, D'Agata R, Vicari E.(PubMed)
(136) Studies on the significance of positive bacterial semen cultures in male fertility in Nigeria.Onemu SO1, Ibeh IN.(PubMed)
(137) Mycetomatoid infection of the penis by Candida albicans. Mastrolorenzo A1, Giomi B, Cipollini EM, Tammaro R, Decarli N, Cammelli D, Fabiani Tropeano F, Tiradritti L, Difonzo EM, Zuccati G.(PubMed)
(138) Candida albicans epididymo-orchitis and fungemia in a patient with chronic myelogenous leukemia Mark Pimentel, MD, Lindsay E Nicolle, MD FRCPC, and Salman Qureshi, MD FRCPC(PubMed)
(139) Normocalcemic tetany and candidiasis. Galland L.(PubMed)
(140) Interaction of Candida albicans with genital mucosa: effect of sex hormones on adherence of yeasts in vitro. Kalo A1, Segal E.(PubMed)
(141) Response of pathogenic and non-pathogenic yeasts to steroids. Prasad R1, Devaux F, Dhamgaye S, Banerjee D.(PubMed)
(142)Evaluation of the influence of blood glucose level on oral candidal colonization in complete denture wearers with Type-II Diabetes Mellitus: An in vivo Study. Ganapathy DM1, Joseph S, Ariga P, Selvaraj A.(PubMed)
(143)Role of L3T4+ lymphocytes in protective immunity to systemic Candida albicans infection in mice. Cenci E1, Romani L, Vecchiarelli A, Puccetti P, Bistoni F.(PubMed)
(144)[Squamous epithelial carcinoma in a 27-year-old patient with cellular immune defect].[Article in German] Kübler A1, Ziegler C, Barth T, Zöller J.(PubvMed)
(145)Immune thrombocytopaenic purpura: an autoimmune cross-link between infections and vaccines. Rinaldi M1, Perricone C, Ortega-Hernandez OD, Perricone R, Shoenfeld Y.(PubMed)
(146)Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006-2007 and 2012-2013.Kamikawa Y1, Mori Y, Nagayama T, Fujisaki J, Hirabayashi D, Sakamoto R, Hamada T, Sugihara K.(PubMed)
(147)Oxidative and nitrosative stress on phagocytes' function: from effective defense to immunity evasion mechanisms. Ferrari CK1, Souto PC, França EL, Honorio-França AC.(PubMed)

9 Natural Remedies with Potential to Cure Non-Alcoholic Fatty Liver Disease (NALFD)

Kyle J. Norton

Non-alcoholic Fatty Liver Disease is a liver disease characterized by fat accumulated in the liver, not caused by abusive alcohol consumption.

The disease is also manifested by steatosis, steatohepatitis, cirrhosis.

Nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition in US due to increase obesity in adult population.


Obesity is associated linearly to the prevalent risk of nonalcoholic fatty liver disease (NAFLD).

In conventional medicine, treatments of NAFLD are mainly focus on weight loss accompanied to pharmacologic therapy in control of insulin resistance and dyslipidemia.


As of today, there are no effective pharmacologic therapy approved specifically and directly for treatment of nonalcoholic fatty liver disease (NAFLD).

Finding the natural treatments for less or no side effects have become an urgency in many scientific communities, including researchers at the Universities.

Alternative medicines for the treatment of NAFLD have been expressed in numbers of successful histories.

1. Turmeric
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

Turmeric has long been used in herbal medicine in treating numbers of disease.

Today, its curcuminoid, curcumin has attracted interests from researchers in many parts of the world.

Curcumin, as an antihyperlipidemic agent, has been found to lower the “bad cholesterol” low density lipoprotein (LDL), and increase high density lipoprotein (HDL) of which reduce the risk of fat accumulated in the tissues in the liver.

In the support of the above, the water-soluble curcumin derivative was tested for its efficacy against steatohepatitis which is an inflammation of the liver with concurrent fat accumulation in liver, researchers found that the derivative not only significantly alleviates fibrosis but also decreases the grade of liver steatosis.

2. Hawthorn
Hawthorn is a shrubs and trees of the genus Crataegus, belongings to the family Rosaceae, native to temperate regions of the Northern Hemisphere in Europe, Asia and North America.

The herb has been used in traditional medicine to treat heart disease and symptoms of heart diseases such as irregular heartbeat, high blood pressure, chest pain, hardening of the arteries, etc., circulatory disorders and respiratory illnesses.

Out of 246 kinds of Chinese herb, hawthorn fruit is found in the list of many formulas for treatments of Nonalcoholic fatty liver disease (NAFLD).

3. Phytochemical Berberine and Resveratrol
Berberine and resveratrol, the phytochemical found abundantly in many vegetables and fruits as well as herbs and herbal formulas such as Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (, YCHD), Qushi Huayu Decoction (, QSHYD), and Danning Tablet.

According to studies, these formulas not only improved biochemical and histological change in nonalcoholic fatty liver disease, but also inhibited lipid accumulation by up regulating low-density lipoprotein receptor (LDLR) expression, alleviating lipid peroxidation, and reducing the production of inflammatory cytokines.

In such instance, Berberine and resveratrol, may be considered as a potential treatment for nonalcoholic fatty liver disease in the future.

5. Phytochemical Triterpenoid
Triterpenoid is a various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex hainanensis Merr.

In the study to test the effect of Triterpenoid-rich fraction (TP) from Ilex hainanensis Merr. on NAFLD with Male Sprague-Dawley (SD) fed with a normal diet (control) or high fat diet (NAFLD model), after 4 weeks, then orally administrated TF (250 mg/kg) for another two weeks, researchers showed that TP not only improves the symptoms of the subjects, but also decreases the levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, abnormality of lipid accumulation, levels of inflammation and infection and apoptosis response in the liver.

Of these results, TF is effective in protecting liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress.

6. Peony
Mu Dan Pi or Dan Pi (Cortex Moutan Radicis) is also known as peony.

The acrid, bitter and mild cool herb has been used in TCM as anti micro organism, anti inflammatory agent and to enhance circulation and immune system, etc., as it clears heat and cools the blood, clears fire of yin deficiency, clear blood stasis and rid of clots, etc., by enhancing the functions of heart, liver and kidney channels.

Peony, a very popular Chinese herb is emerging as in many study for its anti-inflammatory, anticoagulative, anti-microbial and cytokine modulating effects, as well as properties as treatments of arthritis and asthma.

In the study of the effects of peony in non alcoholic liver disease caused by insulin resistance with Adult SD rats fed on high-fat-sugar-salt diet for 56 days, divided randomly into nonalcoholic fatty liver model group, metformin group (0.2 g x kg(-1)) and total glucosides of peony group, scientists at end of experiment showed that oral administration of total glucosides not only inhibit hyperinsulinaemia but also decrease levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C).

Further analysis also found that peony also raises levels of high-density lipoprotein cholesterol (HDL-C)] and ameliorates the over expression of activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholinesterase (ChE) and superoxide dismutase (SOD) as well as contents of malondialdehyde (MDA).

These results suggested that paeony may consist a potential effect in protecting liver function by modulating serum lipid and decreasing oxidative stress caused by lipid peroxidation in induction of fatty liver.

7. Bay berry
Bay berry is a species of Myrica gale, genus Myrica, belongings to the family Myricaceae.

The herbal medicine contains numbers of bioactive chemical constituents, including gallic acid, quercetin hexoside, quercetin deoxyhexoside, quercetin, anthocyanins, flavonols, and elllagitannins.

In a randomized, placebo-controlled, double-blind, crossover study of 44 participants (ages 18-25 y) given 250 mL of either bayberry juice or placebo twice daily for 4 wk, researchers found that intake of bay berry juice decreases inflammation and infection, liver cell apoptosis, and death of liver tissues as well as reducing risk of steatosis progression in precipitated NALFD.

8. Green Tea

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

According to the University of Connecticut, Storrs, the efficacy of green tea for treatment of obese patients with nonalcoholic fatty liver disease is associated to its antioxidant compound polyphenolic catechins in induction of hypolipidemic, thermogenic, antioxidant, and anti-inflammatory activities.

These chemical compounds are also found to mitigate the occurrence and progression of NAFLD.

Dr. Masterjohn C(7), the lead author said, “(The phytochemical compounds are) demonstrating the hepatoprotective properties of green tea and its catechins and the proposed mechanisms by which these targeted dietary agents protect against NAFLD”.

In mice fed on a high-fat diet for 24 weeks, then injected with EGCG (10, 20 and 40 mg·kg(-1)·d(-1), ip), for 4 weeks, researchers found that treated mice show a significant improvement of body weight, grade 2 or 3 liver fatty degeneration (steatosis, lobular inflammation and ballooning), severe hyperlipidemia, hyperglycemia, hyperinsulinemia and insulin resistance caused by high-fat diet.

The phytocheimcal EGCG, in dose-dependent also enhanced insulin clearance and upregulated IDE protein expression and enzyme activity in regulated levels of glucose in the liver of treated mice.

In fact EGCG not only promoted weigh loss but also attenuated symptoms of mice with nonalcoholic fatty liver disease.

Administration of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats, not only decreased weight gain and visceral fat but also reduced fasting serum insulin, glucose and lipids levels, through ameliorated expression of hepatic TG accumulation and cytoplasmic lipid droplet as well as diminished hepatic lipogenesis and triglycerides out flux from liver.

9. Anise
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries in treatment of strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.

In the comparison the effect of anise fruit essential oil and extract and risk of nonalcoholic fatty liver disease, researchers at the Islamic Azad University conducted an study of 60 rats randomly divided into ten groups, six in each group with NAFLD induced by using choline-deficient diet for 90 days and followed by 30 days of treatment with 25, 50, 100, and 200 mg/kg/day of hydroethanolic extract (AE) as well as 0.125, 0.25, and 0.5 mg/kg/day of essential oil (AO).

At the end of the experiment, researchers found that both applications exert a significantly reverse activities in increased plasma levels of total cholesterol, low-density lipoprotein, and triacylglycerol and decreased in high-density lipoprotein level caused by choline-deficient diet in dose-dependent manner.

Additional differentiation also found that AE and AO reduced the elevated levels of enzymes aspartate transaminase (AST) and alanine transaminase (ALT) which are considered as an indication of either liver injure or damage caused by the acute inflammation..

Observation of injection anise AE and AO also exerted a powerful antioxidant activity in significant lower over expression of ROS in exhibited free radical chain reaction in induction of oxidative stress to precipitated liver toxicity.

According to the histological findings, researchers concluded that both AE and AO display a substaintial effect in reduced macrovesicular steatohepatitis which is the leading cause of liver cancer.

Further analysis also addressed that both anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress indicated by elevation of plasma level of 8-isoprostane which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).

Taken together, remedies indicated may be considered as functional foods for treatment of non-alcoholic fatty liver disease (NAFLD).

However, additional data collection on clinical studies performed with human consumption on large sample size and multi canters during the course of diseases will be necessary to complete the picture of above natural remedies’ effects in complete the treatment possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal – The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author biography
Kyle J. Norton, Master of Nutritions
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Curcumin and liver disease.Vera-Ramirez L, Pérez-Lopez P, Varela-Lopez A, Ramirez-Tortosa M, Battino M, Quiles JL.(PubMed)
(2) [The effects of curcumin derivative on experimental steatohepatitis].[Article in Chinese] by Zeng CH, Zeng P, Deng YH, Shen N, Peng ML, Liu Q, Ren H.(PubMed)
(3) Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD) by Kim MS, Kung S, Grewal T, Roufogalis BD.(PubMed)
(4) Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis by Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH.(PubMed)
(5) Non-alcoholic fatty liver disease and liver transplantation: Outcomes and advances by Said A.(PubMed)
(6) The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial by Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato KI, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S.(PubMed)
(7) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(8) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
(9) Chinese Herbs – Mu Dan Pi or Dan Pi (Cortex Moutan Radicis)
(10) [Effects of total glucosides of paeony on enhancing insulin sensitivity and antagonizing nonalcoholic fatty liver in rats].[Article in Chinese] by Zheng LY, Pan JQ, Lv JH.(PubMed)
(11) Therapeutic potential of green tea in nonalcoholic fatty liver disease by Masterjohn C1, Bruno RS.(PubMed)
(12) Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice by Gan L1, Meng ZJ1, Xiong RB2, Guo JQ1, Lu XC1, Zheng ZW1, Deng YP1, Luo BD1, Zou F3, Li H1.(PubMed)
(13) Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats by Tan Y1, Kim J1, Cheng J1, Ong M1, Lao WG1, Jin XL1, Lin YG1, Xiao L1, Zhu XQ1, Qu XQ1.(PubMed)
(14) Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)

Friday, 15 June 2018

The Natural Healing For Non Alcoholic Fatty Liver Disease, Cited By PubMed Literature


Non-alcoholic Fatty Liver Disease is a  liver disease characterized by fat accumulated in the liver, not caused by abusive alcohol consumption.

The disease is also manifested by steatosis, steatohepatitis, cirrhosis.

Nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition in US due to increase obesity in adult population.

Obesity is associated linearly to the prevalent risk of nonalcoholic fatty liver disease (NAFLD).

In conventional medicine, treatments of NAFLD are mainly focus on weight loss accompanied to pharmacologic therapy in control of insulin resistance and dyslipidemia.

As of today, there are no effective pharmacologic therapy approved specifically and directly for treatment of nonalcoholic fatty liver disease (NAFLD).

Finding the natural treatments for less or no side effects have become an urgency in many scientific communities, including researchers at the Universities.

Alternative medicines for the treatment of NAFLD have been expressed in numbers of successful histories.

1. Turmeric
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

Turmeric has long been used in herbal medicine in treating numbers of disease.

Today, its curcuminoid, curcumin has attracted interests from researchers in many parts of the world.

Curcumin, as an antihyperlipidemic agent, has been found to lower the "bad cholesterol" low density lipoprotein (LDL), and increase high density lipoprotein (HDL) of which reduce the risk of fat accumulated in the tissues in the liver.

In the support of the above, the water-soluble curcumin derivative was tested for its efficacy against steatohepatitis which is an inflammation of the liver with concurrent fat accumulation in liver, researchers found that the derivative not only significantly alleviates fibrosis but also decreases the grade of liver steatosis.

2. Hawthorn
Hawthorn is a shrubs and trees of the genus Crataegus, belongings to the family Rosaceae, native to temperate regions of the Northern Hemisphere in Europe, Asia and North America.

The herb has been used in traditional medicine to treat heart disease and symptoms of heart diseases such as irregular heartbeat, high blood pressure, chest pain, hardening of the arteries, etc., circulatory disorders and respiratory illnesses.

Out of 246 kinds of Chinese herb, hawthorn fruit is found in the list of many formulas for treatments of Nonalcoholic fatty liver disease (NAFLD).


3. Phytochemical Berberine and Resveratrol
Berberine and resveratrol, the phytochemical found abundantly in many vegetables and fruits as well as herbs and herbal formulas such as Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (, YCHD), Qushi Huayu Decoction (, QSHYD), and Danning Tablet.

According to studies, these formulas not only improved biochemical and histological change in nonalcoholic fatty liver disease, but also inhibited lipid accumulation by up regulating low-density lipoprotein receptor (LDLR) expression, alleviating lipid peroxidation, and reducing the production of inflammatory cytokines.

In such instance, Berberine and resveratrol, may be considered as a potential treatment for nonalcoholic fatty liver disease in the future.


5. Phytochemical Triterpenoid
Triterpenoid is a various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex hainanensis Merr.

In the study to test the effect of Triterpenoid-rich fraction (TP) from Ilex hainanensis Merr. on NAFLD with Male Sprague-Dawley (SD) fed with a normal diet (control) or high fat diet (NAFLD model), after 4 weeks, then orally administrated TF (250 mg/kg) for another two weeks, researchers showed that TP not only improves the symptoms of the subjects, but also decreases the levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, abnormality of lipid accumulation, levels of inflammation and infection and apoptosis response in the liver.

Of these results, TF is effective in protecting liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress.


6. Peony
Mu Dan Pi or Dan Pi (Cortex Moutan Radicis) is also known as peony.

The acrid, bitter and mild cool herb has been used in TCM as anti micro organism, anti inflammatory agent and to enhance circulation and immune system, etc., as it clears heat and cools the blood, clears fire of yin deficiency, clear blood stasis and rid of clots, etc., by enhancing the functions of heart, liver and kidney channels.

Peony, a very popular Chinese herb is emerging as in many study for its anti-inflammatory, anticoagulative, anti-microbial and cytokine modulating effects, as well as properties as treatments of arthritis and asthma.

In the study of the effects of peony in non alcoholic liver disease caused by insulin resistance with Adult SD rats fed on high-fat-sugar-salt diet for 56 days, divided randomly into nonalcoholic fatty liver model group, metformin group (0.2 g x kg(-1)) and total glucosides of peony group, scientists at end of experiment showed that oral administration of total glucosides not only inhibit hyperinsulinaemia but also decrease levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C).

Further analysis also found that peony also raises levels of high-density lipoprotein cholesterol (HDL-C)] and ameliorates the over expression of activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholinesterase (ChE) and superoxide dismutase (SOD) as well as contents of malondialdehyde (MDA).

These results suggested that paeony may consist a potential effect in protecting liver function by modulating serum lipid and decreasing oxidative stress caused by lipid peroxidation in induction of fatty liver.

7. Bay berry
Bay berry is a species of Myrica gale, genus Myrica, belongings to the family Myricaceae.

The herbal medicine contains numbers of bioactive chemical constituents, including gallic acid, quercetin hexoside, quercetin deoxyhexoside, quercetin, anthocyanins, flavonols, and elllagitannins.

In a randomized, placebo-controlled, double-blind, crossover study of 44 participants (ages 18-25 y) given 250 mL of either bayberry juice or placebo twice daily for 4 wk, researchers found that intake of bay berry juice decreases inflammation and infection, liver cell apoptosis, and death of liver tissues as well as reducing risk of steatosis progression in precipitated NALFD.


8. Green Tea
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

According to the University of Connecticut, Storrs, the efficacy of green tea for treatment of obese patients with nonalcoholic fatty liver disease is associated to its antioxidant compound polyphenolic catechins in induction of hypolipidemic, thermogenic, antioxidant, and anti-inflammatory activities.

These chemical compounds are also found to mitigate the occurrence and progression of NAFLD.

Dr. Masterjohn C(7), the lead author said, "(The phytochemical compounds are) demonstrating the hepatoprotective properties of green tea and its catechins and the proposed mechanisms by which these targeted dietary agents protect against NAFLD".

In mice fed on a high-fat diet for 24 weeks, then injected with EGCG (10, 20 and 40 mg·kg(-1)·d(-1), ip), for 4 weeks, researchers found that treated mice show a significant improvement of body weight, grade 2 or 3 liver fatty degeneration (steatosis, lobular inflammation and ballooning), severe hyperlipidemia, hyperglycemia, hyperinsulinemia and insulin resistance caused by high-fat diet.

The phytocheimcal EGCG, in dose-dependent also enhanced insulin clearance and upregulated IDE protein expression and enzyme activity in regulated levels of glucose in the liver of treated mice.

In fact EGCG not only promoted weigh loss but also attenuated symptoms of mice with nonalcoholic fatty liver disease.

Administration of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats, not only decreased weight gain and  visceral fat but also reduced fasting serum insulin, glucose and lipids levels, through ameliorated expression of hepatic TG accumulation and cytoplasmic lipid droplet as well as diminished hepatic lipogenesis and triglycerides out flux from liver.


9. Anise
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries in treatment of strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.

In the comparison the effect of anise fruit essential oil and extract and risk of nonalcoholic fatty liver disease, researchers at the Islamic Azad University conducted an study of 60 rats randomly divided into ten groups, six in each group with NAFLD induced by using choline-deficient diet for 90 days and followed by 30 days of treatment with 25, 50, 100, and 200 mg/kg/day of hydroethanolic extract (AE) as well as 0.125, 0.25, and 0.5 mg/kg/day of essential oil (AO).

At the end of the experiment, researchers found that both applications exert a significantly reverse activities in increased plasma levels of total cholesterol, low-density lipoprotein, and triacylglycerol and decreased in high-density lipoprotein level caused by choline-deficient diet in dose-dependent manner.

Additional differentiation also found that AE and AO reduced the elevated levels of enzymes aspartate transaminase (AST) and alanine transaminase (ALT) which are considered as an indication of either liver injure or damage caused by the acute inflammation..

Observation of injection anise AE and AO also exerted a powerful antioxidant activity in significant lower over expression of ROS in exhibited free radical chain reaction in induction of oxidative stress to precipitated liver toxicity.

According to the histological findings, researchers concluded that both AE and AO display a substaintial effect in reduced macrovesicular steatohepatitis which is the leading cause of liver cancer.

Further analysis also addressed that both anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress indicated by elevation of plasma level of 8-isoprostane which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).

Taken together, remedies indicated may be considered as functional foods for treatment of non-alcoholic fatty liver disease (NAFLD).

However, additional data collection  on clinical studies performed with human consumption on large sample size and multi canters during the course of diseases will be necessary to complete the picture of above natural remedies' effects in complete the treatment possibilities.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author biography
Kyle J. Norton, Master of Nutritions
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Curcumin and liver disease.Vera-Ramirez L, Pérez-Lopez P, Varela-Lopez A, Ramirez-Tortosa M, Battino M, Quiles JL.(PubMed)
(2) [The effects of curcumin derivative on experimental steatohepatitis].[Article in Chinese] by Zeng CH, Zeng P, Deng YH, Shen N, Peng ML, Liu Q, Ren H.(PubMed)
(3) Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD) by Kim MS, Kung S, Grewal T, Roufogalis BD.(PubMed)
(4) Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis by Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH.(PubMed)
(5) Non-alcoholic fatty liver disease and liver transplantation: Outcomes and advances by Said A.(PubMed)
(6) The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial by Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato KI, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S.(PubMed)
(7) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(8) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)

(9) Chinese Herbs – Mu Dan Pi or Dan Pi (Cortex Moutan Radicis)
(10) [Effects of total glucosides of paeony on enhancing insulin sensitivity and antagonizing nonalcoholic fatty liver in rats].[Article in Chinese] by Zheng LY, Pan JQ, Lv JH.(PubMed)
(11) Therapeutic potential of green tea in nonalcoholic fatty liver disease by Masterjohn C1, Bruno RS.(PubMed)
(12) Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice by Gan L1, Meng ZJ1, Xiong RB2, Guo JQ1, Lu XC1, Zheng ZW1, Deng YP1, Luo BD1, Zou F3, Li H1.(PubMed)
(13) Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats by Tan Y1, Kim J1, Cheng J1, Ong M1, Lao WG1, Jin XL1, Lin YG1, Xiao L1, Zhu XQ1, Qu XQ1.(PubMed)

(14) Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)

Thursday, 14 June 2018

*9 Foods Stimulated Over Growth of Fungus Candida, You May Not Know

By Kyle J, Norton

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.
Foods stimulated over growth of fungus candida
1. Fruits and artificial ingredients
The high sugar content in fruit feeds Candida except green apples, citrus, berries and avocado(186)
and artificial ingredients can depressed immune system(187).

2. Aged cheese(188)
Candida famata found in aged cheese may induce invasive candidiasis(188).

3. Additive and preservation
Men made chemicals can disrupt the digestive track friendly bacteria and allow candida over growth(189)(190) such as citric acid. Non-organic food like meat or eggs can also contain antibiotics and steroids for faster growth(191).

4. Alcohol(192)
Alcohol can depress the liver(193) and immune system(194)(195), causing over growth candida.

5. Caffeine, sugar and sweetener
Caffeine(196)(197), sugar and sweetener(198) all harmful to the body and feed candida

6. Glutens
Gluten is a protein composite that appears in foods processed from wheat and related species
that can cause immune suppression(199)(200)(201).

7. Mushrooms
Mushroom which is the fleshy, spore-bearing fruiting body of a fungus, typically produced above ground on soil or on its food source can promotes fungus overgrowth(202).

8. Condiments(203)
Condiment which is a sauce or seasoning added to food to impact a particular flavor can depress the immune system(204), causing candida.

9. Vinegar but not apple cider vinegar
Vinegar is an acidic liquid produced from the fermentation of ethanol in a process that yields its key ingredient, acetic acid which can deplete the stomach of acids and cause inflammation(205)(206) in the digestive track, including acetic acid ulcer(205).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(187) Top 4 Most Dangerous Artificial Sweeteners(Fit day)(188) Treatment of Candida famata bloodstream infections: case series and review of the literature. Beyda ND1, Chuang SH, Alam MJ, Shah DN, Ng TM, McCaskey L, Garey KW.(PubMed)
(189) Food Additives And Preservatives(All food business)
(190) Candida Albicans andFood Additives(Candida Albicans cure)(191) Antibiotics exposure, risk factors, and outcomes with Candidaalbicans and non-Candida albicans candidemia. Results from a multi-center study. Wang H1, Wu DW, Han H, Yue JF, Zhang F, Shan TC, Guo HP, Yin M.(PubMed)
(192) Candida and Alcohol Abuse (Holistic health talk)(193) Control of state 3 respiration in liver mitochondria from rats subjected to chronic ethanol consumption. Spach PI1, Cunningham CC.(PubMed)
(194) The associations of alcohol drinking and drinking cessation to measures of the immune system in middle-aged men. Mili F1, Flanders WD, Boring JR, Annest JL, DeStefano F.(PubMed)
(195) Acute immunomodulatory effects of binge alcohol ingestion. Afshar M1, Richards S2, Mann D3, Cross A4, Smith GB5, Netzer G6, Kovacs E7, Hasday J. (PubMed) (196) Recombinagenicity of caffeine for Candida albican . Sarachek A1, Henderson LA.(PubMed)
(197) Effects of growth temperature and caffeine on genetic responses of Candida albicans to ethyl methanesulfonate, nitrous acid and ultraviolet radiation. Sarachek A, Bish JT.(PubMed)
(198) Sugar, Dairy, Artificial Sweeteners and Candida albicans Infections(Candida Diet Foods)(199) Immunomodulatory strategies for celiac disease. Rossi M1, Maurano F, Luongo D.(PubMed)
(200) The effect of diet on systemic immune responses to wheat gliadin.
Johnson RB, LaBrooy JT, Shearman DJ, Davidson GP.(PubMed)(201) In mice, gluten in maternaldiet primes systemic immune responses to gliadin in offspring.Troncone R1, Ferguson A.(PubMed)(202) [Virulence of the opportunistic pathogen mushroom Candidaglabrata].[Article in Spanish] Castaño I1, Cormack B, De Las Peñas A.(PubMed)
(203) Condiments and the Candida Diet(Jiangsu, Shihuan bioengineer company)(204) Immunomodulation of mast cells by nutrients. Hagenlocher Y1, Lorentz A2.(PubMed)
(205) Effect of hypoxia on acetic acid ulcer of the stomach in rats with or without coenzyme Q10.
Kohli Y, Suto Y, Kodama T.(PubMed)

Lifelong Use of 8 Types of Conventional Drugs May Cause Cognitive Dysfunction(Dementia and Dementia Like Symptoms) as We Age, Revealed by National Library of Medicine Studies



Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every 5 years.

Dementia is the loss of mental and physical ability that are severe enough to interfere with people's daily life and Alzheimer's disease is the most common type of dementia in aging population.

Western diet contains high amount of saturated and trans fat, artificial ingredients with less fruits and vegetable that can lead to dementia and other kind of diseases


Types of medication Can Cause Dementia or Dementia Like Symptoms
As aging, accumulation of toxins of certain medication used to treat certain diseases, such as antidepressants, sedatives, cardiovascular drugs and anti-anxiety medications may induce increased risk of cognitive dysfunction, leading to dementia and dementia-like symptoms(1).

1. Antidepressants, (selective serotonin reuptake inhibitors, antipsychotics and benzodiazepines)
An Antidepressant is a psychiatric medication used to treat mood disorders, such as major depression and dysthymia and anxiety disorders.

 In a study conducted by Johns Hopkins Bayview Medical Center of total of 230 participants  followed for a mean of 3.7 years with use of persistency index (PI)  to calculate all antidepressants, selective serotonin reuptake inhibitors (SSRIs), antipsychotics (atypical and typical), and benzodiazepines as the proportion of observed time of medication exposure, researchers found that psychotropic medication used are associated with more rapid cognitive and functional decline in AD, expressed by symptoms scale.

Clinicians may tend to prescribe psychotropic medications to AD patients at risk of poorer outcomes, but one cannot rule out the possibility of poorer outcomes being caused by psychotropic medications(2)

2. Anti-inflammatory drugs (NSAIDs)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are pain reliever, used often to treat pain caused by over expression of inflammatory cytokines, such as arthritis.

There was a weak association between any NSAIDs and the risk of cognitively impaired, no dementia (CIND)(3)

3. Cannabis
Cannabis has been used for the treatment of a number of conditions, including neuropathic pain, spasticity associated with multiple sclerosis, and chemotherapy-induced nausea, etc,.

The study conducted by University of Western Australia showed that chronic use of cannabis may impair intellectual abilities but data on this topic remain sparse and difficult to interpret.

There  are evidences that some drugs contribute to the causal pathway that leads to the development of cognitive impairment but currently available data do not support the introduction of a separate diagnostic category of drug-induced dementia (such as alcohol-related dementia)(4).

4. Hallucinogens
Hallucinogens, psychedelic drugs, used primary action to alter cognition and perception may cause distortion of sensory perception, and other psychic and somatic effects, including sweating, heart palpitations, blurring of vision, memory loss, trembling, and itching(5)

5. Corticosteroids
Corticosteroids are synthetic drugs closely resemble cortisol, a steroid hormones produced by the adrenal glands to assist the physiologic processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, behavior, etc.

An excess can cause agitation and even dementia like symptoms(6).

6. Fluoroquinolone antibiotics
Fluoroquinolone antibioticsare are medication taken to treat a variety of infections.
However,  the drugs are associated to exhibit delirium in elderly patients(7).

7. H2-receptor antagonists
H2-receptor antagonists are medicines taken to reduce the amount of acid in the stomach by blocking one important producer of histamine2. These drugs are associated  to induce delirium in elderly patients(8).

8. Anticonvulsants
Anticonvulsants are types of medication used to treat epileptic seizure act on brain through different mechanisms. Intake of anticonvulsants can precipitate drowsiness and difficulty thinking, some more commonly than others(9).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) http://www.ehow.com/how-does_5510964_prescription-drugs-cause-dementia.html
(2) http://www.ncbi.nlm.nih.gov/pubmed/22374884
(3) http://www.ncbi.nlm.nih.gov/pubmed/22546354
(4) http://www.ncbi.nlm.nih.gov/pubmed/16240487
(5) http://serendip.brynmawr.edu/exchange/node/1880
(6) https://www.ncbi.nlm.nih.gov/pubmed/15728296
(7) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541197/
(8) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115775/
(9) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229254/

The Impact of Hormones On The Onset Of Dementia

Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.

Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

American typical diet contains high amount of saturated and trans fat, artificial ingredients with less fruits and vegetable which can lead to dementia and other kind of diseases.

As we age, productions of hormone decrease gradually that can effect the cognitive function, leading to dementia.

According to Eric R. Braverman, MD in the article of Hormones Dementia, numerous studies have linked hormone supplementation as protective in the development of dementia regardless of whether or not these hormones are deficient but more so when they are deficient.

Growth hormone beginning from age 30 in both men and women, estrogen loss beginning at age 40 in women, testosterone loss beginning at age 40 in men and DHEA loss beginning in both men and women at age 50.

The loss of luteinizing and sex binding globulin hormones may also be associated with the development of dementia with age(1)

Hormone Causes of Dementia
1. Growth hormone
A report at the Universidad de Barcelona, Barcelona showed that there is a physiological decline of the growth hormone (GH)/insulin-like growthfactor-I (IGF-I) axis with ageing, and the possibility that the GH/IGF-I axis is involved in cognitive deficits has been recognized for several years.

The results of several studies addressing the deficiency of growth hormone (GH) in induction of dementia include
* Superimposable response of GH to GHRH than response of GH to GHRH in healthy individuals.

* Blunted GH to GHRH response in AD patients

* Higher GH concentrations in the morning; greater increase of GH to GHRH in AD patients than in controls(2).

Other reported that evidence favoring this idea stems from the ability of both hormones to stimulate beta amyloid release from neurons as well as by the stimulatory effect that IGF-I exerts on brain amyloid clearance.

In addition, insulin and IGF-I levels are altered in Alzheimer's patients and, probably in close association to these changes, cell sensitivity towards insulin--and possibly also IGF-I--is decreased in these patients.(3)

2. Estrogen
In the research of the association of decreased levels of estrogen and dementia, scientist at the Kings College London suggested that the positive effects of estrogen are most robust in young women and in older women who had initiated ET around the time of menopause(4).

Other study supported the hypothesis that estrogen-replacement therapy is associated with a reduced prevalence of Alzheimer's disease in postmenopausal women.

Prospective clinical trials are required to enable women and their physicians to weigh risks and benefits of estrogen-replacement therapy for the prevention of dementia(5)

3. Testosterone
In a study of a group of 28 older men with either subjective memory loss or dementia, researchers found that serum total testosterone and sex hormone binding globulin (SHBG) correlated inversely with plasma levels of amyloid beta peptide 40.
According to the Fremantle Hospital study,  lower androgen levels are associated with increased plasma Abeta40 in older men with memory loss or dementia.

These results suggested that subclinical androgen deficiency enhances the expression of Alzheimer's disease-related peptides in vivo(6).

4. DHEA
Kyushu University, in the study of a decreased concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with Alzheimer's disease (AD), found that patients with AD and patients with CVD were found to have lower concentration of serum DHEA-S and a lower DHEA-S/DHEA ration compared to normal control individuals.

Also, according to the final report, no significant difference was observed in the concentration of serum DHEA-S or the DHEA-S/DHEA ratio between patients with AD and those with CVD.

These results suggest that reduced concentrations of serum DHEA-S may not be unique to AD, but instead reflect a common phenomenon in dementing diseases(7).

Other study in the assessed plasma DHEA and DHEAS levels in AD sufferers (n=72) and compared them to age-matched controls (n=72) showed that Plasma DHEA concentrations are significantly lower in AD patients compared to control (4.24+/-0.4 ng/ml for AD; 3.38+/-0.3 ng/ml for control, p=0.027, Mann-Whitney 1-tailed)

And DHEA levels are significantly correlated to DHEAS levels in both control and AD conditions (Spearman's rho correlation coefficient=0.635 in controls and 0.467 in AD, p<or=0.01)(8).

Spearman's rho correlation coefficient is a method used to measure  the relationship between two variables using a monotonic function.
5. Sex-hormone binding globulin
There are evidence in the literature suggests that gonadotropins may be involved in processes in contribution to the etiology/pathogenesis of AD such as inflammation, cholesterol homeostasis, and insulin status.

Here we examine the potential mechanisms by which gonadotropins could influence neurodegenerative processes.(9)

6. Luteinizing hormone (LH)
Some researchers suspected that that another hormone of the hypothalamic-pituitary-gonadal axis, luteinizing hormone (LH), may be a major factor in AD pathogenesis.

In cell culture, LH increased amyloidogenic processing of amyloid-beta protein precursor, and in animal models of AD, pharmacologic suppression of LH and FSH reduced plaque formation.

Given the evidence supporting a pathogenic role for LH in AD, a trial of leuprolide acetate, which suppresses LH release, has been initiated in patients.(10)


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Sources
(1) http://www.pathmed.com/faq/?p=409
(2) http://www.ncbi.nlm.nih.gov/pubmed/18537700
(3) http://www.ncbi.nlm.nih.gov/pubmed/15094079
(4) http://www.ncbi.nlm.nih.gov/pubmed/20840280
(5) http://www.ncbi.nlm.nih.gov/pubmed/9566385
(6) http://www.ncbi.nlm.nih.gov/pubmed/14624021
(7) http://www.ncbi.nlm.nih.gov/pubmed/8732462
(8) http://www.ncbi.nlm.nih.gov/pubmed/19665809
(9) http://www.ncbi.nlm.nih.gov/pubmed/16785601