Eggplant is a species of S. melongena with deeply purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
Melanoma is a type of skin cancer characterized by irregular cell growth in the pigment-containing cell. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistic, approximately 87,110 new cases of invasive melanoma will be diagnosed in the U.S. in 2017.
Further analysis, glycoalkaloids efficacy was attributed to the derived phytochemical compound solamargine in activation of antioxidant activity against formation of skin cancer through expression several biomarkers and signaling pathways.
through reduced expression of hILP/XIAP in blocking apoptosis through an interaction with an unknown TNF receptor associated factors (TRAF) in activated caspase-3 in mediated cleavage, increasing expression of proteins Bcl-xL, and Bcl2 in regulated anti- apoptosis, anti-cell cycle arrest and decreasing levels of apoptotic protease activating factor 1 (Apaf-1) and Bax in suppression of tumor growth.
Unlike other phytochemicals such as green tea EGCG inhibited apoptosis through both intrinsic and extrinsic apoptosis pathways, eggplant derivative solamargine selectively triggered melanoma cancer cells death through only death receptors.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1(PubMed)
(1) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A. Eltayeb, Brenda L. Coomber, and Sirin A. Adham(PMC)
(3) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A Eltayeb, Brenda L. Coomber and Sirin A. Adham(Cancer cell international)
(4) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications by Brahma N. Singh,1 Sharmila Shankar,2 and Rakesh K. Srivastava*(PMC)