Tuesday, 22 May 2018

How to Prevent Oral Cancer, PubMed Studies Show

Kyle J. Norton


Ckickpeas lectin may have a profound effect in ameliorated risk and treatment of oral cancer, some scientists suggested.

Garbanzo beans also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to Middle East.

Oral cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the mouth region. At the later stage, the cancerous cell may travel a distance away from the original site to infect healthy tissues and organs.

Investigation of the process of chickpea lectin in reduced oral cell proliferation and tumor expansion
may involve expression of several aspects and mechanism.

According to the All India Institute of Medical Sciences, chickpeas reduced the cell proliferation of human oral carcinoma cells at the concentration of 37.5 μg/mL (IC50) and no toxic effect.


Further analysis, chickpeas anti cancer activity probably is a result the pro apoptotic effect induced by phychemical agent lectin found abundantly in the legume.


Lectin are types of protein with important function of binding to cell membranes and influence cell-cell interaction.


In oral cancer cell line, injection of lectin showed a significant effect in inhibition of the p38α MAP kinase activated under cellular stresses as well as in response to inflammatory cytokines and involved function in the control of many other aspects of the physiology of the cell, such as control of cell cycle or cytoskeleton remodelling,.. for cell survival of the cancer in presence of substrate (ATP).


By blocking the physiological expression of cancer cell, lectin reduced the cell proliferation and subsequently, shrinking the cancer site.


Further more, plytochemical lectin isolated from chickpeas also demonstrated a binding affinity with p38α in regulated the production of certain inflammatory cytokines which may have certain effect in induction of cancer growth.

The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes, including protected cell in responses to inflammation and injury,


Specifically, in the influence of the production of inflammatory cytokines by p38α, lectin regulated the potent pro-inflammatory cytokine produced by cells of the innate immune system IL-1β in induction of tumor growth and metastasis in cells under prolong period of inflammation. According to general belief, many cancers have found to arise from sites of infection, chronic irritation and inflammation.


In tumor necrosis factor alpha TNF-α, application of chemical lectin to oral cancer site suppressed the inflammatory expression of the protein in induced cell survival and proliferation and promoted the pro apoptotic function of TNF-α in program of cell death and cell cycle arrest.


Tumor necrosis factor alpha TNF-α, is cell signal protein with function in induced inflammation in the acute phrase of injure and in numbers of cellular process, including cell survival, proliferation, differentiation, and death.


Importantly, the binding of kinase p38α MAPK also activated the function of IL-6, in inhibited the factors in induced production of inflammatory cytokines which have been found to have a negative impact in oral cell oncogenesis and enhanced the expression of boosting T cell trafficking to to tumor sites to induced cytotoxic effect to cause apoptosis.


IL-6, an interleukin with duo functions in both a pro-inflammatory cytokines and an anti-inflammatory myokines,

Taken together, chickpea lectin may have a therapeutically potential in reduced risk and considered as an adjunct therapy used combination with standard chemo-drugs for treatment of oral cancer

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antifungal and antiproliferative protein from Cicer arietinum: a bioactive compound against emerging pathogens by Kumar S1, Kapoor V2, Gill K1, Singh K1, Xess I3, Das SN2, Dey S1(PubMed)
(2) Cell surface interaction of annexin A2 and galectin-3 modulates epidermal growth factor receptor signaling in Her-2 negative breast cancer cells by Shetty P1,2, Bargale A3,4, Patil BR5, Mohan R6, Dinesh US7, Vishwanatha JK8, Gai PB9, Patil VS3,4, Amsavardani TS10.(PubMed)
(3) Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms by Ochoa-Alvarez JA1, Krishnan H1, Pastorino JG1, Nevel E1, Kephart D1, Lee JJ1, Retzbach EP1, Shen Y1, Fatahzadeh M2, Baredes S3, Kalyoussef E3, Honma M4, Adelson ME5, Kaneko MK6, Kato Y6, Young MA1, Deluca-Rapone L1, Shienbaum AJ1, Yin K1, Jensen LD7, Goldberg GS1.(PubMed)

Monday, 21 May 2018

How to Prevent Onset of Stroke, Naturally and Effectively, MEDLINE Studies Suggest

Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk of stroke, some scientists suggested.

Stroke is a medical condition caused by reduced blood flow to the brain resulting in cell death due to blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).

There is a general belief that stroke is an accumulation over along period of unhealthy diet with red meat and processed meats which are assassinated increased artery-clogging.

Some researchers suggested that increased intake of fruits and vegetables such as carrot accompanied with good fats such as salmon, tuna, and mackerel may have a substantial effect in reduced inflammation in the arteries and improved blood flow and decreased the chance of blood clots.

Sadly, stroke is one of the most common causes of death worldwide.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Nutrients
1. Carbohydrates
2. Sugars
3. Fibre
4. Fat
5. Protein
6. Vitamin A
7. Thiamine (VittaminB1)
8. Riboflavin (Vittamin B2)
9. Niacin (Vittamin B3)
10. Vitamin B6
11. Folate (Vittamin B9)
12. Vitamin C
13. Vitamin K
14. Calcium
15. Iron
16. Magnesium
17. Molybdenum
18. Phosphorus
19. Potassium
20. Sodium

In the review of literature published to understand more of the role of carotenoids as antioxidants in lowering stroke risk based on observational studies, researchers at the Isfahan University of Medical Sciences conduct a search with some important keywords, including (Carotenoids [MeSH] OR Carotenes [tiab] OR Carotene [tiab] OR "lycopene [Supplementary Concept]" [MeSH] OR lycopene [tiab] OR beta-Carotene [tiab]) AND (stroke [MeSH] OR stroke [tiab] OR "Cerebrovascular Accident" [tiab] OR "Cerebrovascular Apoplexy" [tiab] OR "Brain Vascular Accident" [tiab] OR "Cerebrovascular Stroke" [tiab]) AND ("oxidative stress" [MeSH] OR "oxidative stress"[tiab]).

The results of the searching of papers published between 2000 and 2017 suggested that

* High dietary intake of six main carotenoids (i.e., lycopene, <- and®-carotene, lutein, zeaxanthin, and astaxanthin) was associated with reduced risk of stroke due to their benefits in reduced over expression of reactive oxygen species.

* Beyond the antioxidant activities in prevented free radical in induction of chain reaction, other properties and mechanisms in ameliorated risk of stroke were not identified in studies satifified the guideline and criteria.

As these result, there is no surprise that dietary intake of six major carotenoids were promoted as stroke prevention and stroke mortality reduction.

Further in differentiation the benefits of lycopene an bioactive member incarotenoids, researchers found that intake of food containing high amount of lycopene demonstrates a substantially reduced risk of stroke in compared to non takers.

According to the assessment of pooled analysis of seven prospective studies, with 116,127 participants and 1,989 cases, frequent consumption of lycopene decreased stroke risk by 19.3%, after adjusting for confounding factors.

However, circulating lycopene, was associated with a statistically significant decrease in stroke risk in compared to not dietary lycopene, although both concentrations are inversely associated with stroke risk. 

In gender and geographic analysis, researchers also stated that lycopene exerts a strong impact in prevent onset of stroke, particularly in European, or male gender.

Dr. the lead scientist said, " Duration of follow-up had no effect on the final results. There was no evidence of publication bias" and " Lycopene, especially circulating lycopene, is negatively associated with stroke risk".

Additionally, in the examine the hypothese whether low serum levels of lycopene are associated with increased risk of acute coronary events and stroke in middle-aged men previously free of CHD and stroke , researchers launched an investigation of 725 men aged 46-64 years examined in 1991-3 in the Kuopio Ischaemic Heart Disease Risk Factor Study.

By December 1997, out of 725 patients, 41 men were found to have either a fatal or a non-fatal acute coronary event or a stroke.


According to the observation of a Cox' proportional hazard's model, after adjusting to examination years, age, systolic blood pressure and three nutritional factors (serum folate, beta-carotene and plasma vitamin C), researchers found that all 41 men are in the lowest quarter of serum lycopene levels.

These results once again suggested that daily intake of lycopene risk foods to increase the circulating lycopene plays an essential role in prevented risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke.

Truly, patients with lower levels of serum lycopene were found to had a 3.3-fold (95 % CI 1.7, 6.4, risk of acute coronary events or stroke in compared with the others.


Taken together, carrot with high ammount of bioactive carotenoids, especially lycopene may be considered as a function food in reduced the prevalent risk of stroke.

People who are at the higher quarter of stroke risk may want to add a portion of carrot into their daily diet for preventive measure.




Natural Medicine for Fatty Liver And Obesity ReversalThe Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Carotenoids as Potential Antioxidant Agents in Stroke Prevention: A Systematic Review by Bahonar A1, Saadatnia M1, Khorvash F1, Maracy M2, Khosravi A(PubMed)
(2) Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies by Li X1, Xu J2.(PubMed)
(3) Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study by Rissanen TH1, Voutilainen S, Nyyssönen K, Lakka TA, Sivenius J, Salonen R, Kaplan GA, Salonen JT.(PubMed)
(4) Healthy eating and stroke(Stroke Foundation)

Sunday, 20 May 2018

How to Enhnace Fat Metabolism in Prevention of Obesity Naturally, MEDLINE Studies Reveal



By Kyle J. Norton


Green tea may have a therapeutic and positive effect in improved fat metabolism, some scientists suggested.

Fat metabolism is a biological process converted lipid intake to energy for the body needs through breaking down fat into glycerol and fatty acids before being absorbed by the intestines.

Abnormal fat metabolism plays an important factors in the development of obesity and diabetes, according to the study of the University of Colorado Denver.

Green tea, a precious drink processes numbers of health benefit, known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

In the evaulation of the mechanisms of actions of green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG),on bile acid homeostasis and lipid metabolism, researchers conducted a study of male C57BL/6J mice
* Group 1:  fed with a low-fat diet,
Group 2: fed with high-fat western-style diet or
* Group 3: fed with high-fat western-style diet containing 0.32% green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG),

According to the differentiation at 17 weeks of experiment, mice group fed with EGCG exhibited a strong effect in reduced body weight gain, mesenteric fat mass, serum cholesterol and severity of fatty liver.

Additional analysis indicated that green tea reduced expression of significantly elevated the mRNA levels of cholesterol 7α-hydroxylase initiated by cholesterol through inhibition of bile acid synthesis in cholesterol metabolism, that enhanced attenuation of lipid absorption.


Injection of green tea EGCG also increased the level of HMG-CoA reductase in inhibited cholesterol synthesis, biliary lipid secretion, and elevated blood cholesterol through activation of low-density lipoprotein receptors which play an important role of limiting step in lipid synthesis.


Moreover, green tea EGCG also elevated scavenger receptor class B type 1 (SRB1), an enzyme with functions as a receptor for high-density lipoprotein in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver.

The enzyme also processes a property in modulating and regulating certain pathways and networks involved cellular lipids in biological systems.

Dr. Huang J, the lead scientist in the joint study at the State University of New Jersey, said, "The intestinal bile acid content was significantly decreased by EGCG, while fecal excretion of bile acids, cholesterol and total lipids were increased" and "EGCG decreases bile acid reabsorption, results in lower intestinal bile acid levels, which further decreased the absorption of lipids".

Further differentiation of the green tea effect by examining the lipid levels associated with obesity in C57BL/6J mice fed a normal diet (ND), HFD and HFD with GT for 12 weeks, scientists indicated that group treated with green tea extract and HFD expresses a significant alternation of levels of several lipid metabolites observed by the partial least squares discriminant analysis score plot.

Mice group fed with high fat diet demonstrated decreased levels of lysophospholipids (LPLs) (lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine) which show a negative correlation with triglyceride hydrolysis and increased fat absorption in compared to normal diet group.

These alternations were not found in mice group fed with HFD plus green tea.

Alternation of lysophospholipid was associated to substantial impact on lysophospholipid metabolism, in contribution of the onset or progression of obesity.

The restoration of lysophospholipids (LPLs) by green tea extract caused by long term high fat diet may be an indication of how green tea reduced expression of inflammation, insulin resistance, and fatty liver disease in obesity.


Interestingly, in the observation of injection of green tea extract in the regulation of hepatic fat metabolism in 36 male chickens fed GTPs at a daily dose of 0, 80 or 160 mg/kg of body weight for 4 weeks, researchers at the joint study lead by the Anhui Agricultural University, suggested that oral administration of green tea polyphenols (GTPs) significantly improves lipid metabolism through reduced hepatic lipid content and abdominal fat mass and abdominal fat mass accumulation which are correlated to onset and progression of over weight and obesity.

Additionally, the application also expressed a strong effect in the phosphorylation levels of AMP-activated protein kinase α (AMPKα) which plays an important role in skeletal muscle fatty acid utilization and in regulated growth and reprogrammed metabolism, and Acetyl-CoA carboxylase 1 (ACACA) in modulation of fat cell cycle stages and cytokinesis, thus reducing fat synthesis and production of pro inflammatory cytokines.

More importantly, green tea polyphenol also altered the mRNA levels and enzymatic activities in suppressed expression of enzymes involved PUFA in the liver in stimulated lipid synthesis and fat oxidation.


Taken together, green tea containing high amount of bioactive polyphenols, such as catechins may be considered as a functional food to reduce onset and progression of over weight and obesity.

 However, intake of green tea extract should be taken with care as acute liver toxicity has been reported in some cases.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice by Huang J1,2, Feng S1,3, Liu A1, Dai Z1,4, Wang H1, Reuhl K5, Lu W6, Yang CS1,2.(PubMed)
(2) Effect of green tea on hepatic lipid metabolism in mice fed a high-fat diet by Nam M1, Choi MS2, Choi JY2, Kim N3, Kim MS3, Jung S1, Kim J1, Ryu DH4, Hwang GS5.(PubMed)
(3) Green tea polyphenols alter lipid metabolism in the livers of broiler chickens through increased phosphorylation of AMP-activated protein kinase by Huang J1,2, Zhou Y1, Wan B1, Wang Q1, Wan X1,2.(PubMed)
(4) Increase in serum and bile cholesterol and HMG-CoA reductase by lovastatin in rats by Yamauchi S1, Linscheer WG, Beach DH.(PubMed)

How to Alleviate Severity, Duration & Frequency of Chronic Headache Naturally and Effectively, Medline Studies Find

By Kyle J. Norton

Yoga therapy may have an important role in regulated central versus peripheral mechanisms in expression of chronic headache, the study by the All India Institute of Medical Sciences suggested.

Yoga, the ancient technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

According to the study to investigate the role of muscle spasm over activity in chronic tension type headache (CTTH) with 15 patients of CTTH and 7 age matched controls, randomized assigned to either yoga intervention or control, yoga group demonstrated a significant improvement in reduced overactivity of temporalis muscle in CTTH patients at rest in compared with control.


Furthermore, after examined the EMG records, researchers found that yoga group displays a strong improvement of  subjective pain scores. and a substantial decrease in the mean electromyography (EMG) amplitude of temporalis muscle during rest and mental activity in compared to other applications such as non steroidal anti inflammatory drugs, botulinum toxin injections.


EMG amplitude is medical technique used to evaluate details of the timing and magnitude of muscle activation as well as muscles in powering a variety of types of locomotion.

Truly, yoga breathing and relaxation reduced daily stress through calming the central nervous system by connecting the mind and body, restoring the endocrine system in hormone balancing, thus reducing production of stress hormone cortisol through bring back the present moment, while letting them go or dealing them in a profound way.

Further more, yoga postures and deep breathing ameliorated over expression of nerve neurons in transmitted information of sensation, stress, and suffering by creating a state of ease of the body and mind, and strengthening the flow of energy, thus enhancing relaxation in response to pain through unraveling the mind-body samskaras.

Moreover, in a study of 50 patients (aged 18-58 years) in a clinical diagnosis of CCTH, divided in 2 groups,
* Group 1 (n=30) patients were received 8 lessons and practical demonstration of Brahmakumaris spiritual based meditation known as Rajyoga meditation for relaxation therapy, in addition to routine medical treatment (analgesics and muscle relaxants) and

* Group 2 (n=20) patients were received analgesics and muscle relaxants twice a day but no relaxation therapy in the form of meditation by the Dr. Kiran, and colleagues, to support of the effect of yoga therapy in reduced symptoms and pain in tension types of headache,

After 8 weeks follow up period, scientists showed that both therapies show a highly significant reduction in headache variables but yoga group expressed a highly significant relief of severity, duration & frequency of headache by 94%, 91% and 97% in compared to group 2 of 36%, 36% and 49% respectively.

The total headache relief according to headache index was 99% in yoga group in compared to only 51% in control group.

These results indicated that yoga intervention may have an acute effect in ameliorated pain in chronic tension headache.


More promisingly, in the study to provide preliminary data on the feasibility, acceptability, and safety of alignment-based yoga for youths with chronic headaches, researchers at the joint study lead by the Medical College of Wisconsin/Children's Hospital of Wisconsin found that yoga therapy may be considered pediatric headaches treatment, indicated by positive parent and participant ratings of the yoga experience.

In deed, some yoga instructors suggested that the alleviation of stress by yoga exercise in reduced insomnia and swelling and constriction of the blood vessels was a result of yoga in initiated deep sleep and reduced tension of the blood vessels in the face and neck.

Additionally, these results were also associated to yoga exercise effects in enhanced  head muscles relaxation and revitalization and improved hypertension in blood circulation, particularly in people with chronic headache.


The findings suggested that yoga intervention may be used as an integrated form of exercise in provided relief in severity of headache, duration & frequency of chronic headache, particularly in tension types of headache.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Role of temporalis muscle over activity in chronic tension type headache: effect of yoga based management by Bhatia R1, Dureja GP, Tripathi M, Bhattacharjee M, Bijlani RL, Mathur R.(PubMed)
(2) Effect of rajyoga meditation on chronic tension headache by Kiran, Girgla KK, Chalana H, Singh H.(PubMed)
(3) A pilot study of yoga for chronic headaches in youth: promise amidst challenges by Hainsworth KR1, Salamon KS2, Khan KA3, Mascarenhas B4, Davies WH2, Weisman SJ3.(PubMed)
(4) Interpreting muscle function from EMG: lessons learned from direct measurements of muscle force byThomas J. Roberts1,* and Annette M. Gabaldón(PMC)

How to Block the Entry Phase of Prostate Cancer Cells Development Naturally, National Institutes of Health Studies Suggest



Kyle J. Norton


Herbal Catnip may have a potential and substantial effect in reduced risk of pre-malignant cells, caused by slowly change from normal cells to cancer-like properties in initiated prostate cancer, some scientists suggested.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belongings to the family of Lamiaceae, native to Europe and Asia'

The plant has been used in herbal medicine as insect repellent and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

Ingredients
Beside the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..

Prostate cancer is medical condition characterized by irregular cell growth in the issues of prostate.

 At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

According to statistic, based on 2012-2014 data, approximately 11.6 percent of men are diagnosed with prostate cancer at some points during their lifetime.


On PC3 and DU145 prostate cell lines, in comparison of the effective of methanol extracts, n-hexan, methylene chloride (CH2Cl2), ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O fractions and the essential oil isolated from the aerial parts of the catnip to examine the cytotoxic and apoptogenic activity, researchers found that application of ethyl acetate extract in compared to other extracts, displays a strong inhibited property in decreased prostate cancer cell viability in PC3 cell line, through cell cycle arrest in the sub-G1 area.

The ethyl acetate extract also caused lost some DNA structure in tested cell lines, in a concentration dependent manner.

Furthermore, through observation of IC 50 values, ethyl acetate (EtOAc) expressed a greater significant activity in estrogen receptor positive PC3 cells which are more sensitive to the cytotoxic effects in comparison with low hormone-receptor presenting DU-145 cells.


Interestingly, ethyl acetate (EtOAc) in inhibited PC3 cancer cell line with lesser value of IC50 and greater effect than other tested compounds,
es
The results of these efficacy were attributed to the activity of PC3 cells which process a property to change its negative androgen receptors profile to positive (PC3AR+)


The study also indicated that more cytotoxic activity of N. cataria found on PC3 cells in comparison with DU145 AR¯ cells might also be associated to different response of cells to sex hormones.

Additionally, according to the Western blotting analysis administration of ethyl acetate extract after 48 hours securely induced cancer apoptosis through activated caspase 3 cleavage  and Poly(ADP-ribose) polymerase (PARP).

Caspase 3 cleavage is an important marker associated to the progression of cancer cell’s entry point into the apoptotic signaling pathway.

Poly(ADP-ribose) polymerase (PARP) plays an essential role in execution of the cells apoptosis and is considered as an early indicator of apoptosis.

Moreover, researchers also found that the Catnip extract also increased level of Bax Protein after 48 hours of exposure in initiated cancer cell apoptosis with release of cytochrome c, an early phase of cell degradation and death.


After taking into account of other con founders, Dr. Emami SA, the lead author said, " the semi polar EtOAc extract of N. cataria induces apoptosis in pc3 cells compare to DU-145 cells and further analytical assays are suggested to identify the active phytochemicals possess cytotoxic activity".


Taking altogether, Catnip and its extract may be considered as a functional food in reduced risk of Prostate cancer through blocking the entry phase of the onset of prostate cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines by Emami SA1, Asili J, Hossein Nia S, Yazdian-Robati R, Sahranavard M, Tayarani-Najaran Z. DOI:http://dx.doi.org/10.7314/APJCP.2016.17.S3.125

Saturday, 19 May 2018

How To Treat Depression Naturally, US National Library of Medicine Human and Model Studies Show

Kyle J. Norton


Anise may have a potential and substantial effect for treatment of depression, some scientists suggested.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....


Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

Depression is a condition of mood disorder. affecting the patients feel, think, and handle daily activities.

According to statistic of The National Institute of Mental Health, approximately, 16 million adults had at least one major depressive episode in 2012 in the United States, a 6.9 percent of the population.

In the evaluation of the herbal Anise aqueous and ethanol extracts antidepressant-like effect in mice with several different doses of 50, 100 and 200 mg/kg in compared to the standard medicine Fluoxetine at dose of 30mg/kg and and imipramine at dose of 20mg/kg, researchers at the joint study lead by the Azad University showed that except the dose at 50mg/kg of aqueous extract, application of other doses demonstrated a linearly significant improvement of mobility times.


Further analysis also found that all doses from Anise extract increased the swimming time dose-dependently, without any significant change in climbing time in tested mice similar to those of Fluoxetine and in compared to aqueous extract.


Moreover, Fluoxetine and imipramine expressed a strong decreased immobility time in both tests in contrast to imipramine increased climbing time without any significant change in swimming time.


The result suggested that both extracts in dose higher than 50mg/kg display antidepressant-like activity similar to that of fluoxetine through improved mobility of depressed mice as inactivity is considered as one of major symptoms in patients with depression.


As the depression progressed, patients demonstrated a behavior in making efforts to escape from society, eventually will exhibit immobility with reflection of psychological despair.


Dr. Shahamat Z the lead author said, " P. anisum possesses an antidepressant-like activity similar to that of fluoxetine, which has a potential clinical value for application in the management of depression".


Additionally, in the testing essential (volatile) oil and essential oil of Piper laetispicum antidepressant activity in compared to Fluoxetine as standard antidepressant drug and other natural remedies including Leaves-Bay, Curry, Coriander and Mint; Fruits-Star anise, Pepper, Cardamom, Caraway and Fennel; Seeds of Fenugreek, Mustard, Nutmeg and Black Cumin; and Underground stem-Onion, Garlic, Ginger and Turmeric; Miscellaneous-Clove, Cinnamon, Capsicum, Tamarind and Asafoetida, reserachers found that all participated essential oil, specially anise produced a significant reduction in immobility along with an increase in climbing behavior similar to those of fluoxetine.


The application of essential oil caused a dose -dependent reduction( probably in dose less than 50 mg/kg) in immobility which is contracted to the above study and an increase in climbing at all studied doses in compared to control group.


Further more, in the examine of the efficacy of anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome of a total of 120 randomly assigned into 3 equal groups received anise oil, Colpermin, and placebo, at the end of the study, scientists showed that application of anise group exerted a continuously improvement of the syndrome in compared to the other 2 groups with some unknown mechanisms.

Some researchers postulated that essential oil smell may have a profound effect to the brain in triggering emotional reaction in stimulating the limbic system in regulated autonomic and endocrine function, particularly, in response to emotional stimuli in expression of motivation and reinforcing behaviors.

Additionally, the application of essential oil scent also have a direct influence in calming the central nervous system in ameliorated over production of certain hormones in reacted to the unfavorably emotional behaviors.


Taken together, Anise essential oil may be used as a secondary therapy to standard medicine in treatment of depression.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice by Shahamat Z1, Abbasi-Maleki S2, Mohammadi Motamed S3.(PubMed)
(2) Effectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome. A Randomized Active and Placebo-Controlled Clinical Trial by Maryam Mosaffa-Jahromi, PharmD, PhD, Ali-Mohammad Tamaddon, PharmD, PhD, Suleiman Afsharypuor, PharmD, PhD, Alireza Salehi, MD, MPH, PhD, Seyed Hassan Seradj, PharmD, PhD, Mehdi Pasalar MD, MPH, PhD, Peyman Jafari, PhD, Kamran Bagheri Lankarani, MD (Journal of Evidence-Based Integrative Medicine)
(3) Essential oil isolation from culinary drugs and screening for antidepressant potential Mohib Abdul Jalil Khan , Imtiyaz Ansari, Amjad Ali Mohammad Iqbal Oriental College of Pharmacy, Navi Mumbai, Maharashtra- 400705, India.(INTERNATIONAL JOURNAL OF ADVANCES INPHARMACY MEDICINE AND BIOALLIED SCIENCES)
(4) The Forced Swim Test as a Model of Depressive-like Behavior by Roni Yankelevitch-Yahav, 1 , 2 Motty Franko, 2 Avrham Huly, 2 and Ravid Doron(PMC)

Friday, 18 May 2018

Women's Health: How to Normalize Your Menstrual Cycle Naturally, US National Library of Medicine Studies Show

Chaste Tree berry may be used as a functional food in regulated production of progesterone in balancing steriod hormone in women menstrual cycle, some scientists suggested.


Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Progesterone is a sex hormone with various mechanisms, including women menstrual cycle, pregnancy, embryogenesis......

According to the Royal Melbourne Institute of Technology-University, Vitex may have a function similar to the conventional medicine, fluoxetine, in stimulated production of increasing mid-luteal progesterone and 17β-oestradiol levels in women menstrual cycle.

In the review of data bases of 8 literature collection, Vitex extracts showed a significant effect in women's health.

In the aspect of premenstrual syndrome, the extract improve psychological symptoms such as depression, anxiety,... through progesterone regulation.

Dr. Deborah Brauser, author of the article of "Progesterone, Anxiety Affect Premenstrual Dysphoric Disorder" said, "As a gynecologist, I believe PMDD is driven by the female sex hormone progesterone," said Dr. Sundström Poromaa, adding that there is very little progesterone during the follicular phase".


Flavonoid glycosides, orientin and apigenin 3, 8-di-C-glycosides in addition to iridoid compound, aucubin isolated from the ethanolic extract of Vitex agnus-castus fruits, also displayed an increased production of progesterone hormone by observation of plasma progesterone of women with 0.6 and 1.2 g kg(-1) per body weight (b.w.) doses.

The study also addressed the hormone progesterone may have directed effect in increased uterine weight of ovariectomized rats in comparable to that of control group.

Dr. Jillian Stansbury, the researcher of the women herbs for men said, "Consumption of Vitex fruits by female chimpanzees as part of their natural diets has been found to dramatically increase progesterone levels in the urine, indicating an overall progesteronic effect.34 One hypothesis is that reduced LH allows follicle-stimulating hormone to dominate and can lead to decreased estrogen and testosterone and a relative increase in progesterone".


Furthermore, the contribution of the herb in improved concentration of progesterone in the luteal phase, may also increase the chance of pregnancy, as the total of 37 women with oligomenorrhea and 30 women with amenorrhea received 50 drops of Phyto Hypophyson L, a Vitex agnus castus-containing homeopathic preparation or placebo 3 times a day over 3 months or 3 cycles report.


Promisingly, intake of the Vitex agnus castus-containing homeopathic preparation expressed a spontaneous menstruation, improved concentration of progesterone in the luteal phase, shortening of the cycle, earlier ovulation, and pregnancy in 38 out of 67 women.

Taking together, chemical constituents found in Chaste tree berry expressed a strong activity in increased chance of pregnancy and normalized hormone aspects in women menstrual cycle with progesterone and other hormones regulation.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)
(2) Progesterone, Anxiety Affect Premenstrual Dysphoric Disorder by Deborah Brauser(Medscape)
(3) Gynecological efficacy and chemical investigation of Vitex agnus-castus L. fruitsgrowing in Egypt by Ibrahim NA1, Shalaby AS, Farag RS, Elbaroty GS, Nofal SM, Hassan EM.(PubMed)
(4) WOMEN’S HERBS” FOR MEN By Editor1 Posted November 8, 2010
In Botanical Medicine, Endocrinology, Fertility, Men's Health, Nature Cure, Oncology, Dr Jillian Stansbury
(4) [The efficacy of the complex medication Phyto-Hypophyson L in female, hormone-related sterility. A randomized, placebo-controlled clinical double-blind study].[Article in German]by Bergmann J1, Luft B, Boehmann S, Runnebaum B, Gerhard I.(PubMed)