Saturday, 21 July 2018

The Herb That Cure Type I Diabetes In Vivo and Vitro, Scientists Found

Kyle J. Norton

Scientist who work for the big pharmaceutical companies have tried mimicked and replace the effectiveness of herbal phytochemical single ingredient by their synthetic version, which can be patent for commercial profits.

Even they know exactly the discovery in treatment of certain diseases may induce serious side effect.

Therefore, if you are taking any conventional medicne, please discuss the adverse effects with your doctor.

Recent study suggested that Cat's Claw may be effective to cure of type 1 diabetes induced by Th1/Th2 (T cell) cytokine production.

Unlike type 2 diabetes which is caused by Insulin resistance due unhealthy diet, genetics,.... and lifestyle, type 1 diabetes is a chronic disease characterized by inability of the pancreas in produced insulin. a hormone with function in normalized the level of glucose caused by the immune system mistakenly attacks and destroys the beta cells in pancreas.

Researchers do not know why the immune system produces autoantibodies.to attack the pancreas beta cells? 

Patients with type 1 diabetes are associated to classical symptoms of frequent urination, increased thirst, increased hunger,..... and weight loss.

Some scientists in differentiation of the difference of type 1 and type 2 diabetes found that the symptoms of type 2 diabetes are developed over the a long period of time in compared to short period of time in type 1 patients.

According to the statistic in 2015, over 30 million Americans, or 9.4% of the population, had diabetes, including 125 million of children and adults who had developed type 1 diabetes.

Patient with type 1 diabetes must inject insulin for survival, however healthy diet and life style are also the must to improve quality of life and reduce risk of diabetic complications.

If Untreated or poor management, type 1 diabetes can cause long term complications of heart disease, stroke, kidney failure, foot ulcers,...... and eyes damage

Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

The chemical constituents of Cat's claw include, ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

In vivo, immunotoxicity testing, BALB/c male mice treated once a day with 125, 500 or 1250 mg/kg of U. tomentosa extract for 28 days, increased the number of T helper lymphocytes and B lymphocytes.

The whole herb medicine also significantly exerted a large stimulatory effect on lymphocyte(a form of small white blood cell) viability.

Other study involved C57BL/6 male mice injected with MLDS (40 mg/kg) orally treated with UT at 10-400mg/kg during 21 days, showed to express a significant protection against the loss of insulin-secreting presented β-cells, through modulated the production of two helper T cell classes, known as Th1 and Th2, with increased levels of type-2 T helper cells and mast cells, known as IL-5 and the protein regulated activities of white blood cells known as IL-2.

Further linking Interleukin-2 effected on type I diabetes, the study of Interleukin-2 and type 1 diabetes and several autoimmune diseases suggested that depended on interleukin-2 (IL-2) in proliferating and controlling the T effector cells (Teff) reaction, low dose IL-2 treatment at the initial time of diabetes can rescue insulin secretion by restoring proteins expression.

Dr. Rosenzwajg M, the lead author said, " Regulatory T cells (Tregs) play a major role in controlling effector T cells (Teffs) responding to self-antigens, which cause autoimmune diseases.,....and expanding/activating Tregs with low-dose interleukin-2 (IL-2) could provide immunoregulation without immunosuppression"

Cat's Claw may be effective in protein regulated activities of white blood cells, known as IL-2 through improvement of immune function in induced immunosuppression cause of Type I diabetes, but the quantity intake should only be prescribed by professional herbalist to prevent toxicity.

However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its anti type 1 diabetes possibilities.

And intake of Cat's claw supplement and phytochemical should be taken with care, as acute liver toxicity caused by over doses had been reported in numbers of case.



Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both? by Domingues A1, Sartori A, Golim MA, Valente LM, da Rosa LC, Ishikawa LL, Siani AC, Viero RM.(PubMed)
(2) Uncaria tomentosa aqueous-ethanol extract triggers an immunomodulation toward a Th2 cytokine profile by Domingues A1, Sartori A, Valente LM, Golim MA, Siani AC, Viero RM.(PubMed)
(3) Interleukin-2 and type 1 diabetes: new therapeutic perspectives by Hartemann A1, Bourron O.(PubMed)
(4) Interleukin 2 in the pathogenesis and therapy of type 1 diabetes by Rosenzwajg M1, Churlaud G, Hartemann A, Klatzmann D.(PubMed)

11 Fruits That Inhibit Prostate Cancer Cells, Scientist Suggested


Kyle J. Norton

In South East Asian, prostate cancer is considered a disease of aging male, now has become major concerns of governments and scientific community, because of its tendency to affect even younger age population.

Some researchers that the disease is the result of over consumption of bad fats accompanied with unhealthy diet and  life style, linking directly to the economic prosperity over 3 decades.

Some people who  have made a lot of money.in that region in past 3 decades are Western diet followers. Therefore, they are also susceptible to the diseases of Western world.

Dr. Salinas CA, the lead author at the joint studies led by the University of Michigan Medical School, said, "Prostate cancer is considered a disease of older men (aged >65 years), but today over 10% of new diagnoses in the USA occur in young men aged ≤55 years"(1).

Most of the younger age patients who have prostate cancer are diagnosed with low-risk of the disease. Although early diagnosis may increase chance of survival but these people may expose to long-term effects of treatment-related morbidities and risk of disease progression that can lead to death from prostate cancer(1).

Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue. At the later state, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.

Besides inherited genes such as RNASEL and BRCA1 and BRCA2 that increase risk of prostate cancer, researchers do not know what causes prostate cancer. Howevover, there are numbers of risk factor which may increase risk of prostate cancer onset, including age, family history, obesity,...unhealthy diet.

Most prostate cancers are slow growing. Enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

According to statistic in Canada, prostate cancer is a 3rd leading cause of death from cancer in men. in Canada.
In 2017(2)
 * 21,300 men were diagnosed with prostate cancer. This represents 21% of all new cancer cases in men in 2017.
 * 4,100 men died from prostate cancer. This represents 10% of all cancer deaths in men in 2017.
 * On average, 58 Canadian men were diagnosed with prostate cancer every day.
* On average, 11 Canadian men died from prostate cancer every day.

People in the early stage of prostate cancer may experience no symptoms. However, as the cancer progress, patient may encounter problems of urinating, blood in the urine or semen, trouble getting an erection (erectile dysfunction or ED), pain in the hips, back (spine), chest (ribs), or other areas from cancer that has spread to bones.... and numbness in the legs or feet(3)

In some serious cases, patient may also loss bladder or bowel control if the tumor is pressing on the spinal cord.

If you have suffered from some of the above symptoms, please check with your doctor right the way.


11 Fruits that Kills Prostate cancer Cells include
1. Mangosteen fruit
Mangosteen fruit, a tropical fruit growth in South East Asia is an evergreen tree originated in the Sunda Islands and the Moluccas of Indonesia.

In 22Rv1, LNCaP, and prostate epithelial cells (PrECs), standardized mangosteen fruit extract (MFE), suppressed tumor growth in a xenograft tumor model without causing damage to non-tumorigenic prostate epithelial cell through induction of toxicity(46).

Polyphenols, the main chemical constituent of the fruit extract also targeted multiple signaling pathways involved cell cycle arrest and apoptosis in prostate cancer(47).
rate
α-Mangostin, a xanthone derived from Polyphenols of mangosteen fruit, demonstrated a significant effect in exhibited cell cycle-related proteins involved in prostate carcinogenesis(48).

2. Long Pepper or Indian long pepper
Used as a spice and seasoning, Long Pepper or Indian long pepper is a flowering vine in the family Piperaceae.

Piperlongumine (PL), a natural alkaloid presented in the fruit inhibited prostate cancer through downregulation of Akt downstream signaling of cell proliferation, resulting in decrease mTORC1 (nutrient/energy)activity and autophagy (cell degradation)stimulation(49).

Application of PL also induced rapid depletion of the Androgen receptor (AR) in prostate cancer (PC) cells which is an early indication of prostate cancer(50).

In human prostate cancer DU145, PC-3 and LNCaP cells, piperine, another an alkaloid from black and longpeppers, also exhibited anti-proliferative effect in human prostate cancer cells by inducing cell cycle arrest and autophagy(51).

3. Pomegranate
Pomegranates is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran, cultivated in Asian since ancient time.

POMx, a omegranate (PE) formula currently approved for clinical trials, effectively inhibited survivin (baculoviral inhibitor), induced apoptosis, retarded the rate of tumor growth in skeleton(52).

Polyphenols, main chemical compounds from pomegranate fruit extracts (PFEs), slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 (expression usually seen in invasive and highly tumorigenic cancers) from prostate cancer cell lines(53).

Other polyphenol derivative, ellagic acid (EA) converted from Ellagitannins (ETs) from pomegranate juice (PJ), significantly decreased cell proliferation by exhibiting synergism in PC-3 cells(54).

4. Strawberry
Strawberries is a genius of Fragaria × ananassa belongings to the family Roseaceae, grown all over the world with suitable climate for commercial profits and for health benefits.

Application of berry juice study, including strawberry, inhibited prostate cancer cell proliferation, not involve caspase-dependent apoptosis, but in cell-cycle arrest, by down-regulation of the expression of cdk4, cdk6, cyclin D1 and cyclin D3(Decrease the proliferative activity (55).

In fact, major classes of berry phenolics, including anthocyanins, flavonols, flavanols, ellagitannins, gallotannins, proanthocyanidins, and phenolic acids are found to be effective in attenuated growth of many human cancer cell lines, including prostate (LNCaP) tumor cell lines at concentrations ranging from 25 to 200 micro g/mL.(56).

Crude extracts (250 microg/mL) from strawberry and its pure compounds (100 microg/mL) also induced apoptosis of prostate (LNCaP, DU145) cancer cells(57).

5. Grapes
Grape is a woody vines of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey.

Fisetin, a chemical compound found in grape inhibited prostate cancer cell lines through downregulation of the PI3K/Akt (anti-apoptosis and increased cell proliferation)and the mTOR(energy sources) pathways(58).

Another chemical constituent pterostilbene, in dose-dependent ameliorated cellular proliferation, through activation of expression of AMPK(cellular energy homeostasis) and the p53(antigens).

But in p53 positive LNCaP cells, pterostilbene blocked the progression of cell cycle at G1 phase by inducing p53 expression and further up-regulating p21 expression and in p53 negative, induced apoptosis in PC3 cells(59).

Piceatannol found in grape, exhibited potential anticancer properties by suppressing proliferation of a wide variety of tumor cells, through cell-cycle arrest, upregulation of antibody antigens and apoptotic activity and down-regulation of cancer cell proliferation(60).

6. Apple
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae, cultivated tree fruits. The tree is originated in Central Asia.

Apple peel extract (APE), exerted its anti cancer effects by significant decrease growth and enhanced clonogenic survival of human prostate carcinoma CWR22Rnu1 and DU145 cells, through a G0-G1(Cell cycle) phase arrest(61).

In the study of Does an apple a day keep the oncologist away? showed an inverse association of apple intake and incidence of cancer(62).

7. Papaya
Papaya is a species of Carica Papaya, belongings to the family Caricaceae and native to the tropics of the Americas, first cultivated in Mexico and several centuries.

Benzylisothiocyanate (BITC), a solvent of papaya fruit inhibited cancer cell line through induced apoptosis by converging two major pathways: the death receptor mediated extrinsic and the mitochondrial intrinsic pathway(63).

In the role of diet, papaya is effectively (more than 22.7 g/d (50th percentile) reduced prostate cancer risk by 7.4 (Adjusted OR 7.4 (95% CI 1.17-46.8)(64).

Lycopene, a major chemical constituent in tomato, also in papaya, in prospective and retrospective epidemiological studies showed an inverse relationship between lycopene intake and prostate cancer risk in vitro and in vivo(65).

8. Apricot
Apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongings to the family Rosaceae.

Ethanolic extracts (30%) of apricot inhibited the growth of PC-3 and LNCaP (Prostate cancer cell lines) cells through induction of apoptosis via down regulating ERalpha (estrogen receptor α), ) and PKC-alpha(interaction with the cell membrane) protein, and binding of both mouse uterine estrogen receptors and LNCaP human androgen receptors(66).

9. Avocado
Avocado, a commercially valuable fruit cultivated in tropical climates throughout the world is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America.

Whole-blood fatty acids testing indicated that higher intakes of dietary MUFA(monounsaturated fatty) with principal source of dietary avocadointake was inversely related to prostate cancer(67).

Acetone extract of avocado, containing carotenoids and tocopherols decreased growth of both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines in vitro.

Incubation of PC-3 cells with the avocado extract led to G(2)/M cell cycle arrest accompanied by an increase in p27(cell cycle inhibitor) protein expression(68).

10. Citrus fruits
The fruit is the genus Citrus, native to southern and southeast Asia, include grapefruit, lemon, orange, etc.

Study of incidence of prostate caner in North India compared to South India, showed a positive decreased risk of prostate cancer in increasing dietary consumption of tea, citrus fruits and melon(69).

Citrus consumption is associated with reduced all-cancer incidences, according to the study of cancer incidence among 42,470 Japanese adults in the Ohsaki National Health Insurance Cohort(70).

Oral administration of Gold Lotion (GL), an extract of multiple varieties of citrus peels containing abundant flavonoid, showed the deduction of both the weights (57%-100% inhibition) and volumes (78%-94% inhibition) of the tumors without inducing any adverse toxicity, accompanied by mechanistic down-regulation of the protein levels of inflammatory enzymes (inducible nitric oxide synthase, iNOS and cyclooxygenase-2, COX-2), metastasis (matrix metallopeptidase-2, MMP-2 and MMP-9), angiogenesis (vascular endothelial growth factor, VEGF), and proliferative molecules, as well as inducing apoptosis in prostate tumors(71).

Unfortunately, some studies did not show an association between intake of citrus fruits and risk of prostate cancer(72).

11. Bitter melon
Bitter melon, a extremely bitter fruit, is a tropical and subtropical vine belongings to the family Cucurbitaceae, native in Asia, Africa, and the Caribbean.

Treatment of bitter melon extract (BME) in prostate cancer, enhanced Bax expression(involved in p53-mediated apoptosis) and induced PARP(a nuclear protein implicated in DNA repair) cleavage(during apoptosis), delayed the progression to high-grade prostatic intraepithelial neoplasia (precede the development of prostate adenocarcinoma) and displayed approximately 51% reduction of proliferating cell nuclear antigen expression in mice(73).

MCP30, from bitter melon seeds induced apoptosis in PIN and PCa cell lines in vitro and suppressed PC-3 growth in vivo with no effect on normal prostate cells(74).

Bitter melon leaf extract (BMLE) inhibited the secretion of MMP-2, MMP-9(metastasis) and urokinase plasminogen activator (uPA)(invasion and metastasis) from rat prostate cancer cell line (PLS10)(75).

Taken altogether, the  findings suggested that certain fruits and theirs bioactive compound may have a strong impact in reduced risk, progression and treatment. however, due to limitation of the sample, a large cohost study with larger sample size are necessary to reconfirm their viability.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrion, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) Prostate cancer in young men: an important clinical entity by Salinas CA1, Tsodikov A2, Ishak-Howard M1, Cooney KA(PubMed)
(2) Prostate cancer statistics(Canadian Cancer Society)
(3) Signs and Symptoms of Prostate Cancer(US Cancer Society)
(46) Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract by Li G1, Petiwala SM1, Pierce DR1, Nonn L2, Johnson J(PubMed)
(47) Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer by Li G, Thomas S, Johnson JJ.(PubMed)
(48) α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth by Johnson JJ, Petiwala SM, Syed DN, Rasmussen JT, Adhami VM, Siddiqui IA, Kohl AM, Mukhtar H.(PubMed)
(49) Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death by Makhov P, Golovine K, Teper E, Kutikov A, Mehrazin R, Corcoran A, Tulin A, Uzzo RG, Kolenko VM.(PubMed)
(50) Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells by Golovine KV, Makhov PB, Teper E, Kutikov A, Canter D, Uzzo RG, Kolenko VM.(PubMed)
(51) Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy by Ouyang DY, Zeng LH, Pan H, Xu LH, Wang Y, Liu KP, He XH.(PubMed)
(52) Pomegranate extract inhibits the bone metastatic growth of human prostate cancer cells and enhances the in vivo efficacy of docetaxel chemotherapy by Wang Y, Zhang S, Iqbal S, Chen Z, Wang X, Wang YA, Liu D, Bai K, Ritenour C, Kucuk O, Wu D.(PubMed)
(53) Ellagic acid inhibits migration and invasion by prostate cancer cell lines by Pitchakarn P, Chewonarin T, Ogawa K, Suzuki S, Asamoto M, Takahashi S, Shirai T, Limtrakul P.(PubMed)
(54) Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis by Vicinanza R, Zhang Y, Henning SM, Heber D.(PubMed)
(55) Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkappaB by edible berry juice by in D, Blanchette M, Barrette S, Moghrabi A, Béliveau R.(PubMed)
(56)Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(57)Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties by Zhang Y, Seeram NP, Lee R, Feng L, Heber D.(PubMed)
(58) Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management by Adhami VM, Syed DN, Khan N, Mukhtar H.(PubMed)
(59) Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancercells by Lin VC, Tsai YC, Lin JN, Fan LL, Pan MH, Ho CT, Wu JY, Way TD.(PubMed)
(60) Biological activity of piceatannol: leaving the shadow of resveratrol by Piotrowska H, Kucinska M, Murias M.(PubMed)
(61) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(62) Does an apple a day keep the oncologist away by Gallus S, Talamini R, Giacosa A, Montella M, Ramazzotti V, Franceschi S, Negri E, La Vecchia C.(PubMed)
(63) Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation by Basu A, Haldar S.(PubMed)
(64) Roles of diet, lifetime physical activity and oxidative DNA damage in the occurrence of prostate cancer among men in Klang Valley, Malaysia by Shahar S, Shafurah S, Hasan Shaari NS, Rajikan R, Rajab NF, Golkhalkhali B, Zainuddin ZM.(PubMed)
(65) Multitargeted therapy of cancer by lycopene by van Breemen RB, Pajkovic N.(PubMed)
(66) Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo by Shenouda NS, Sakla MS, Newton LG, Besch-Williford C, Greenberg NM, MacDonald RS, Lubahn DB.(PubMed)
(67)Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(68)Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances by Lu QY, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D(PubMed)
(69) A case control study on prostate cancer in Delhi by Tyagi B, Manoharan N, Raina V.(PubMed)
(70) Citrus consumption and cancer incidence: the Ohsaki cohort study by Li WQ, Kuriyama S, Li Q, Nagai M, Hozawa A, Nishino Y, Tsuji I.(PubMed)
(71) Potent anti-cancer effects of citrus peel flavonoids in human prostatexenograft tumors by Lai CS, Li S, Miyauchi Y, Suzawa M, Ho CT, Pan MH.(PubMed)
(72) Citrus fruits intake and prostate cancer risk: a quantitative systematic review by Bae JM, Lee EJ, Guyatt G.(PubMed)
(73) Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model by Ru P, Steele R, Nerurkar PV, Phillips N, Ray RB.(PubMed)
(74) Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells by Xiong SD, Yu K, Liu XH, Yin LH, Kirschenbaum A, Yao S, Narla G, DiFeo A, Wu JB, Yuan Y, Ho SM, Lam YW, Levine AC.(PubMed)
(75) Momordica charantia leaf extract suppresses rat prostate cancerprogression in vitro and in vivo by Pitchakarn P, Ogawa K, Suzuki S, Takahashi S, Asamoto M, Chewonarin T, Limtrakul P, Shirai T.(PubMed)

Friday, 20 July 2018

The Magic Bean That Processes Anti Chronic Diseases' Activities

Kyle J. Norton

The use of plants for healing purposes has been predated long before the existence of modern medicine.

Recent study suggested regular intake of kidney bean may have a potential effect in the prevention and treatment of chronic diseases.

Chronic diseases are medical conditions that last more than 3 months or more and can not be cured.

According to WHO in the article of "Noncommunicable diseases" suggested, "The four main types of noncommunicable diseases are cardiovascular diseases (like heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructed pulmonary disease and asthma) and diabetes"(4).

Some chronic conditions also are correlated to other diseases, such as  chronic conditions of high blood cholesterol and pressure are associated to increase risk of heart attack and stroke.

According to the Center for diseases control and prevention statistic, approximately, over 117 million people worldwide had one or more chronic health conditions. And 1 in 4 adults had two or more chronic health conditions(5).

The chronic diseases are the 7th most common causes of death in 2014(5).

Although most common causes of chronic condition are either debatable or depending to types of condition. However, some researchers suggested that physical activity, poor nutrition, tobacco use, and excessive alcohol drinking are the most common risk factors.

Chronic diseases today have become a burden of the health care system, according to CDC. In US, the conditions cost over 68% of annual health care expenditures of $2.7 trillion(5).

Depending to types of chronic condition, patients may experience some correlated symptoms
* In Patients with cardiovascular diseases, the symptoms include chest pain, chest tightness, chest pressure and chest discomfort (angina),....and shortness of breath.

* Depending to types of cancer, symptoms may including blood in the urine, hoarseness, persistent lumps or swollen glands. ... and indigestion or difficulty swallowing.

 * Patients with chronic respiratory diseases may experience shortness of breath, especially during physical activities, wheezing,... and 
chest tightness.

* Patients with diabetes may include symptoms of unusual thirst, frequent urination, weight change,........ and extreme fatigue or lack of energy.


Kidney bean is very popular because of its kidney shape, strong flavor and color of reddish brown in nature. The bean often is an excellent dietary selection with no cholesterol, but a good source of protein and minerals.

According to the University of Colorado Colorado Springs, consumption of kidney bean regularly attenuated the increased glycaemic stress (hyperglycaemia and hyperinsulinaemia) including diabetes, CVD and cancer.

Dr. Hutchins AM, the lead author said, " (The efficacy of kidney in reduced risk of chronic illness may be attributed to the) glycaemic response and the impact that relationship may have on the risk of developing diabetes, CVD and cancer".

In the study to compared two different illumination conditions during germination (12 h light/12 h dark vs 24 h dark) in lentils (Lensculinaris L.) and kidney beans (Phaseolus vulgaris L.), melatonin content exerted a significantly antioxidant activity in protection against free radicals as well as showing the use of food as preventive strategies in combating chronic diseases through the diet.

Furthermore, the investigation of phenolic rich extracts obtained from two kinds of common beans, white kidney beans (WKB) and round purple beans (RPB), extracts Phenolic acids and phenolic compounds expressed a strong antioxidants and anti inflammatory activities in reduced the incidence of several chronic diseases that share an inflammatory component.


Dr. García-Lafuente A, the lead researcher in the study said, "common bean extracts may be used as a source of anti-inflammatory agents as well as a dietary complement for health promotion".


Taking together, intake kidney beans regularly may reduce risk and progression chronic illness through the immunomodutory effects involved increased antioxidant and ameliorated inflammatory activities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV.(PubMed)
(2) Effect of illumination on the content of melatonin, phenolic compounds, and antioxidant activity during germination of lentils (Lens culinaris L.) and kidney beans (Phaseolus vulgaris L.) by Aguilera Y1, Liébana R, Herrera T, Rebollo-Hernanz M, Sanchez-Puelles C, Benítez V, Martín-Cabrejas MA.(PubMed)
(3) In vitro anti-inflammatory activity of phenolic rich extracts from white and red common beans by García-Lafuente A1, Moro C2, Manchón N2, Gonzalo-Ruiz A3, Villares A2, Guillamón E2, Rostagno M2, Mateo-Vivaracho L2.(PubMed)
(4) Noncommunicable diseases by WHO
(5) Chronic Diseases: The Leading Causes of Death and Disability in the United States(CDC)


A Beverage That Processes Anti Allergic Potency, Scientists Say

Kyle J. Norton 


Green tea may have a particular and special effect in ameliorated auto immunity in precipitation of allergic diseases, some scientists opinionated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Allergic diseases are a class of conditions characterized by over reaction of the immune system to substances which cause little or no harm to the body.

Investigation of the effect of green tea bioactive compounds in reduced abnormal immune allergic expression was found to associate to certain mechanisms.

According to the statistic, approximately 60 million Americans suffer from allergic diseases. affecting all age groups.

Most common allergic diseases include hay fever, food allergy, respiratory diseases such as asthma and eczema.

In rare case, allergies can trigger also a life-threatening anaphylaxis.

Most common symptoms include, itch, redden, Hives Itchy skin Rash Facial swelling Wheezing, sneezing Itching of the nose, eyes or roof of the mouth, runny and stuffy nose....and swelling of the lips, tongue, face or throat.

However, if you experience some the severe symptoms of a drop in blood pressure, any form of shortness of breath, skin rash, lightheadedness, .... and a rapid, weak pulse, you may already be infected by life-threatening anaphylaxis, please visit the nearest hospital right the way.

According to the Kyushu University, Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) isolated from cv. "Benifuuki" green tea expressed strong and positive activities in inhibited the mast cell production in precipitated allergic inflammatory responses and suppressed the high-affinity IgE receptor (FcεRI) function in expression of mmunoglobulin E (IgE), an antibody isotype involved allergy disorder through 67 kDa laminin receptor in mediation of the suppressive effect by epigallocatechin-3-O-gallate.


Further analysis also found that the bioactive compound binds to 67 kDa laminin receptor to attenuate allergic expression induced by mast cell by suppressing the myosin light chain phosphorylation in regulated immune response to osinophil (a type of disease-fighting white blood cell) migration in the tissue, a characteristic feature of allergic diseases and ERK1/2 phosphorylation signalling by modulation of inflammatory cytokines expression.


A double-blind clinical study of the green tea effect on subjects exposed to Japanese cedar pollinosis, administration of Benifuuki green tea containing O-methylated catechins showed a significantly relieved allergic symptoms induced by pollen such as nose blowing, eye itching in compared with the placebo group without effecting the normal immune responses.

More interestingly, in mouse bone marrow-derived mast cells activated by antigens, bioactive compound epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3″Me) in combination with ginger extract also demonstrated a strongly anti-delay-type allergic effect by suppressing cytokines secretion of tumor necrosis factor (TNF-α), a cell signaling protein (cytokine) in response to systemic inflammation in the acute phase infection.and macrophage Inflammatory Proteins(MIP-1α), a chemokine involved host response to invading bacteria and virus.

In compared to the dose of 5.1 times higher in EGCG, injection of 8.5 mg of EGCG3″Me exhibited a much stronger anti allergic activity than 43.5 mg of EGCG, observed by the area under curve AUC (area under the drug concentration time curve; min μg/ml) of 6.72 ± 2.87 in EGCG and 8.48 ± 2.54 in EGCG3″Me.

Taken together, green tea with abundantly bioactive Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) may be considered as a functional food for protection against auto immune response stimulated by unharmful allergens.

However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its antiallergic possibilities.

Intake of green tea extracts, such as EGCG should be taken with extreme care, as overdoses induced acute liver toxicity have been reported by some medical literature.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page, http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(*) Anti-Allergic Action of O-methylated EGCG in Green Tea Cultivar Benifuuki by MARI MAEDA-YAMAMOTO1 * AND HIROFUMI TACHIBANA2(Journal of Food and Drug Analysis, Vol. 20, Suppl. 1, 2012, Pages 313-317)
(1) Human clinical studies of tea polyphenols in allergy or life style-related diseases by Maeda-Yamamoto M1.(PubMed)(2) In vitro and in vivo anti-allergic effects of ‘benifuuki’ green tea containing O-methylated catechin and ginger extract enhancement by Mari Maeda-Yamamoto,1 Kaori Ema,1 and Ikuo Shibuichi2(PubMed)

Thursday, 19 July 2018

Beet, The Root Veggie That Inhibits Bladder Cancer Cells


By Kyle J. Norton

Intake of function food beet root regularly not only lowers the early occurrence but also provides a natural treatment of bladder cancer without inducing adverse effects.

Bladder cancer is a medical condition characterized by irregular cell growth and multiplied disorderly and uncontrollably in bladder tissues.

According to statistic, men are 4 times like to get bladder cancer in compared to women. The condition is the 9th common cancer worldwide.

Every-year, approximately 400, 000 new cases are diagnosed. The 5 years of survival rate included all stage of bladder cancer is about 77% in compared to 70% and 65% of 10 years and 15 years respectively.

The survival rate of early diagnosed of bladder cancer is at 98%.

The causes of bladder are unknown. However, some researchers suggested that smoking and tobacco used is one major cause of bladder cancer.

 Long term exposure to chemicals and irritation of the lining of bladder due to infection are associated to risk factors of the disease.

Most common symptoms of bladder cancer are blood in urine accompanied with painful urination,... and pelvic pain. You should check with your doctor right the way, you experience some of these symptoms.

Dr. Martin C. S. Wong the lead scientist at the joint study conducted by the The Chinese University of Hong Kong and other institutes said, "Many European countries experienced incidence rise. A substantial mortality reduction was observed in most countries, yet increases in mortality rates were observed in the Philippines and Iceland. These findings identified countries where more preventive actions are required"(4).

Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

According to University of Urbino 'Carlo Bo', betaxanthins and betacyanins, isolated from beet root exerted a significant anti cancer effects in testing bladder cancer cell lines, through expression of antioxidant and pro apoptotic activities.

The anti cancer property of beet root also displayed a strong anti angiogenesis by blocking the cancer cell in established new blood vessel signalling.


When used combination with Vitexin-2-O-xyloside, an apigenin flavone glucoside, betaxanthins and betacyanins also exerted a strong antiproliferative activity in bladder cancer cell lines, intrinsically and extrinsically in expression of apoptosis.

The study also indicated that these combination when used conjunction in the conventional chemotherapy not only enhance the effectiveness of treatment in bladder cancer but also overcome the adverse effect of toxicity and multidrug resistance of cancer cells.

Furthermore, in other study conducted by the same university, Betacyanins (BC) purified from beetroot (Beta vulgaris var. rubra L.) tested,alone or in combination with vitexin-2-O-xyloside (XVX) also isolated from the same vegetable enhanced the ability to reduce the proliferation rate in T24 bladder cancer cells, synergistically.by inhibition of protein of gene in promoted cell survival and enhanced cancer apoptosis.

Taking together, a diet enriched with these bioactive molecules of beet root could be used as function food in prevention and treatment of human bladder cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES1.(PubMed)
(2) Betacyanins enhance vitexin-2-O-xyloside mediated inhibition of proliferation of T24 bladder cancer cells by Scarpa ES1, Emanuelli M2, Frati A1, Pozzi V2, Antonini E1, Diamantini G1, Di Ruscio G3, Sartini D3, Armeni T3, Palma F1, Ninfali P1.(PubMed)
(3) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES1.(PubMed)
(4) The global epidemiology of bladder cancer: a joinpoint regression analysis of its incidence and mortality trends and projectio by Martin C. S. Wong,1,2 Franklin D. H. Fung,1 Colette Leung,1 Wilson W. L. Cheung,1William B. Goggins,3 and C. F. Ng(PMC)

Wednesday, 18 July 2018

Believe It or Not, Fennel May Alleviate Daily Stress Automatically and Naturally, Scientists Discover

Kyle J. Norton


Fennel may have a potential and positive effect in reduced negative stress impact on daily living, some scientists suggested.

Stress in a natural response of our brain against any kinds of threat and demand. People responded to stress differently, some can cope with stress that no one else can.

However, if stress is over whelming, caused over productions of certain hormones that can induce strong implications in interfered one's daily activity.

Prolonged stress is found to exert physically, emotionally and mentally negative expression in various aspects, including sleep disturbance, digestive disorders,....

Some researchers suggested that people with chronic stress not only increases risk of heart attack and stroke, speeds up the aging process but also are susceptible to risk of metal conditions, such as anxiety, depression, and other mental health problems.

If you experience some abnormal cognitive, emotional, physical,....... and behavior symptoms, you may be in the early stage of chronic stress. Please check with your health service providers.

Causes of stress can be external and internal,
* External stress includes:  difficulty in relationship, at work stress, financial problem, loss of love one,...... and financial problems.
* Internal stress includes: pessimism, rigid thinking, lack of flexibility,........and negative thinking.

Chronic stress if untreated can lead to development of some serious ailments, including mental disorders, abnormal endocrine functions, cardiovascular disease,.......... and respiratory problems.

Some researchers suggested that people with untreated chronic stress also are likely to increase risk of infections, digestive problems and muscular pains, particularly headaches and migraine attack.

Furthermore, society and environment also have significant impacts on stress conditions.

According to the widely validated Holmes and Rahe Stress Scale, the top ten stressful life events for adults, include
Death of a spouse
Divorce
Marriage separation
Imprisonment
Death of a close family member
Injury or illness
Marriage
Job loss
Marriage reconciliation
Retirement


Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The herb or food also is used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.



In the study to evaluate the anti-stress and memory-enhancing properties of F. vulgare extract in experimentally stress rats at doses of 50, 100 and 200 mg/kg body weight administered orally with an orogastric tube, researchers found that rats treated with all doses exert significant effect in reduced stress implication linearly, observed by Urinary levels of vanillylmandelic acid (VMA) assay in 24 hours.


Further analysis of fennel rat treated group  with additional injection of ascorbic acid also found that the secretion of urinary ascorbic acid levels increased from 65.74 to 78.59, 108.41 and 125.82 μg/kg within the same period on doses of 50, 100 and 200 mg/kg body weight respectively in compared to untreated control group.

These results indicated that fennel has a stronger impact in reduced chronic stress connotation in compared to both ascorbic acid and control groups.

Moreover, treated group also displayed a reduced expression of lipid peroxidation in both rat liver and brain homogenates catalyzed by the stress in induction of ROS production and reduction of natural antioxidant defense in compared to rat group treated with ascorbic acid.

Dr. S Koppula,, the lead author, after taking into account of other con founders said, "The (Fennel) extract also exhibited potent antioxidant effect by inhibition of lipid peroxidation in both rat liver and brain homogenates to a greater extent than the standard antioxidant, ascorbic acid".


Additionally, in the review literature of number of such drugs mostly in the form of their extracts (holistic approach) or in some,of  active principles isolated from them for their antistress activity by a number of tests, researchers found that
* Fennel may have a strong effect in reduced stress in tested mice through observation of swimming endurance and hexobarbitone sleeping time in association to stress in induction of anxiety.

* Fennel inhibits the production of level stress hormone corticosterone produced in the cortex of the adrenal gland.

* Fennel increases production antioxidant and enhanced the antioxidant defense of host such as Superoxide Dismutase (SOD) and sorbitol dehydrogenase (SDH), in inhibited over expression of ROS in initiated chain reaction caused by chronic stress.

* Fennel inhibits levels of MAO in association to alternation of mood and mental conditions.

Finally, application of fennel also reduced tension of central nervous system in response to stress impact, thus reducing neurotransmitter levels in stimulated production of stress hormones in facilitated ROS production, depression, anxiety,.......


The above illustration were supported by the application of fennel oil in exerted significant anti psychiatric disorders caused by chronic stress such as depressive and anxiety in tested mice respectively treated with water, fluoxetine (0.3 mg/kg) and fennel oil (0.5 ml/day) conducted by the Aga Khan University

Repeated administration of fennel oil for 3 weeks demonstarted significant antidepressant- and anxiolytic-like effects, observed by struggling time in forced swim test (FST) and time spent in open arm in elevated plus maze (EPM) in comparable to fluoxetine treatment group.

Interestingly, rats treated group also exhibited a high levels of antioxidant in inhibited ROS in facilitated production of free radicals through lipid peroxidation.

Taken together, fennel with abundant phytochemicals may be considered as a functional food in reduced stress implication in initiation of related diseases.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Foeniculum vulgare Mill (Umbelliferae) Attenuates Stress and Improves Memory in Wister Rats by S Koppula, H Kumar(Tropical Journal of Pharmaceutical Research)
(2) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(3) Untreated Stress Can Lead To Serious Problems(Aarogya)
(4) Stress Symptoms, Signs, and Causes(Help guide)

Chamomile Enhances Immune System Integrity and Immune Cells Viability

By Kyle J. Norton, Master of Nutrition


Herbalism or phytotherapy a traditional medicine used botany and plants as medical treatment, linking health benefits in prevention, management and treatment of diseases has drawn much interests in today respectable scientists.

But herbal qualities, because geographic differences, time of grown,..... and harvest, are still raised some concerns of conventional researchers.

How many conscientious scientists do believe that some days phytotherapy will replace conventional single ingredient medicine for treatment of diseases without inducing serious side effects.

Would the big pharmaceutical companies whose bottom line is nothing but profits and more profits allowed that to happen?

Immunomodulatory effect is a function that stimulates T-cell proliferation, natural killer (NK) cell cytotoxicity, production of cytokines by human peripheral blood mononuclear cells (PBMCcs),.... and nitric oxide (NO) production.

In other words, improving immune function of modulation of gene or neurohormonal system may exert a strong efficacy in protected our body against harmful agents, including micro organisms,......and immunotoxins.

Immune dysfunction can be expressed in several different ways, depending to whether the immune system is overactive or underactive.

In long term overactive immune function, patient may be experience some symptoms of chronic inflammation caused by over production of pro inflammatory cytokines. Diseases associated to these syndromes include, asthma, rheumatoid arthritis (RA), type 1 diabetes...... and Inflammatory bowel disease

Long term of underactive immune system can reduced immune function in fighting against various pathogens or toxins, leading to development of diseases. Diseases associated underactive immune function include Human immunodeficiency virus / acquired immune deficiency syndrome (HIV/AIDS),....

The causes of immune dysfunction, in joint investigation of " Immune Dysfunction as a Cause and Consequence of Malnutrition" lead by the Queen Mary University of London, suggested "Malnutrition results from disordered nutrient assimilation but is also characterized by recurrent infections and chronic inflammation, implying an underlying immune defect." and " Defects emerge before birth via modifications in the immunoepigenome of malnourished parents"(3).

Patients with chronic immune dysfunction are associated to increase risk of morbidity and mortality(4)(5).

Chamomile is also known as camomile, common name of many species daisy-like plants, belongings to the family Asteraceae, native of the Old World.

The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

Chamomile (Matricaria chamomilla), in recent study conducted by some institutions, restored the resistance against lethal infection with the predominately granulocyte-dependant Candida albicans in immunosuppressed mice.

Administration of the chamomile extract in five doses enhanced the total white blood cells count (up to 1.2 × 10(4) cells/mm(3)) and increased significantly bone marrow cellularity.

Some researchers suggested, "Changes in bone marrow cellularity can be an indicator of systemic toxicity and, therefore, bone marrow should be included in the battery of tissues examined for enhanced histopathology of the immune system"(6).

In other words, increased numbers of bone marrow cellularity has a strong effect in enhanced immune function.

Heteropolysaccharides found in Matricaria chamomilla L. also showed to normalize the developing of the immune response upon air cooling as a result of initiated immunostimulating properties of enlargement of red blood cells and activization of immunoregulation cells.

Dr. Ghonime M, the lead author, said, "immunomodulatory activity,.....Chamomile extracts may have therapeutical implications in prophylactic treatment of opportunistic infections and as supportive treatment in oncogenic cases".

There is no doubt that chamomile and its chemical ingredients have expressed a strong immunomodulatory activity in protection of our body against various diseases, but intake of large quantity should be taken with care to avoid toxicity.

However, further data collection with larger example size and multi centers performed on human consumption over a long term and during the course of the disease will be necessary to complete the picture of chamomile immunomodulatory possibilities.

Additionally, while addressing the possible advantages of chamomile's immunomodutary activities, researchers must also take into account of potential, risk such as, quality controls, dosages and dosage induced adverse effect of acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Evaluation of immunomodulatory effect of three herbal plants growing in Egypt by Ghonime M1, Eldomany R, Abdelaziz A, Soliman H.(PubMed)
(2) [The immunomodulating activity of the heteropolysaccharides from German chamomile(Matricaria chamomilla) during air and immersion cooling].[Article in Russian] by Uteshev BS1, Laskova IL, Afanas'ev VA.(PubMed)
(3) Immune Dysfunction as a Cause and Consequence of Malnutrition by Claire D. Bourke,1,⁎ James A. Berkley,2,3 and Andrew J. Prendergast(PMC)
(4) Extrahepatic morbidity and mortality of chronic hepatitis C by Negro F1, Forton D2, Craxì A3, Sulkowski MS4, Feld JJ5, Manns MP(PubMed)
(5) [Morbidity and mortality in HIV infection].[Article in German] by Stöckle M1, Elzi L, Rockstroh JK, Battegay M(PubMed)
(6) Enhanced Histopathology of the Bone Marrow by SUSAN A. ELMORE, the Society of Toxicologic Pathology