Saturday, 23 March 2019

Turmeric, the Hepatoprotective Functional Remedy

By Kyle J. Norton


Hepatoprotection is the action including the use of a substance such as herbal remedy to protect the liver against damage and injury.

Antihepatotoxicity is the ability that protects the liver against toxins.

Acute liver diseases in most cases are caused by drugs and long-term intake of certain medication. Most acute liver disease can be cured if the cause is found.

Chronic liver diseases (CLD) are any liver diseases that last more than 6 months. Most chronic liver diseases are caused by a genetic preposition or a variety of factors that damage the liver, including viruses and alcohol use.

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the world affecting 25% of the general population most of them in the Western world.

Some researchers suggested that the use of substances to protect the liver may involve several mechanisms, including strengthening the liver, gastrointestinal and immune system.

Dr. C. Girish, the lead scientists in the discussion of hepatoprotective effect, wrote, " The regulation of gastrointestinal system may improve the general well-being of the patients, as well as improvement of the constipation, may prevent the absorption of harmful substances and indirectly decrease ascites (Langmead and Rampton, 2001). The protection of liver cells against toxic materials including drugs, lipid peroxidation, and free radical injury may decrease inflammation, improve liver blood flow, and ultimately help in reduction of ascites and blood pressure (Yang et al., 2000)".

In other words, herbal medicine expressed liver protection not only by improving the blood flow to the liver but also through regating the gastrointestinal system against the building up toxins in the induction of free radicals and suppressing the normal function of the liver and improving the immune system against inflammation induced the lipid oxidation.

Herbal Bilberry, Protects your Lung Against Mycobacterium tuberculosis

By Kyle J. Norton


Mycobacterium avium complex (MAC) is a group of bacteria that cause tuberculosis through infection. Most cases Mycobacterium tuberculosis are found in the lungs.

Mycobacterium tuberculosis is pathogens that can cause tuberculosis (TB) in humans discovered in 1882 by Robert Koch.

According to statistics, 8 million new cases of TB were diagnosed annually. The disease causes the death of 2 million people worldwide, mostly in the third world.

Most people infected by MAC are asymptomatic as the bacteria remaining in your body in the inactive state. Latent TB is not contagious.

In the active stage, TB can induce symptoms of persistent coughing, unintentional weight loss, and fatigue.

In severe cases, TB can cause or pain with breathing or coughing, coughing up blood and chest pain.

Active TB is very contagious, it can spread through tiny droplets released into the air via coughs and sneezes.

All cases of active tuberculosis are treated with antibiotics that lasts six to nine months.

However, the length of treatment is totally depending on patients age and overall health, the infected location.

Some researchers suggested People with a weakened immune system are prone to the infection of Mycobacterium tuberculosis.

Dr. S H E Kaufmann said, "Mycobacterium tuberculosis. Of these, fewer than 10% ever develop the disease, although the pathogen is not eradicated but rather contained in discrete lesions. Hence, the immune system is highly effective in containing the pathogen but fails to eradicate it".

And, "Disease typically develops through reactivation once the immune system is weakened"

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In the urgency to find a natural source for the treatment of Mycobacterium aurum tuberculosis for the third world countries, where the Western medications are scarce, researchers examined the efficacy of Vaccinium myrtillus (MIC = 8 microg/mL) extract.

Compared to the ethanol extracts of Xerocomus badius, Chalciporus piperatus, Suillus luteus and of endophytes isolated from C. vulgaris, E. nigrum, Vaccinium Vitis-idaea, V. myrtillus respectively at  90 to 96% inhibition at 100 microg/mL exerted a potent antitubercular activity.

Compared to herbal C. arbuscula, Empetrum nigrum, J. communis roots, Calluna vulgaris aerial parts, Myrica gale the roots and stems at 93 to 99% inhibition at 100 microg/mL V. myrtillus showed a lesser efficacy.

These results provided some scientific basis for the traditional use of V. myrtillus for the treatment of tuberculosis.

Thes results also strongly indicated that fungal endophytes recovered from Scottish plants are a source of antimycobacterial agents

Taken altogether, bilberry may be considered a function remedy for the treatment of TB, pending to the validation of larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis by Gordien AY1, Gray AI, Ingleby K, Franzblau SG, Seidel V. (PubMed)
(2) Protection against tuberculosis: cytokines, T cells, and macrophages by S H E Kaufmann. (BMJ Journal)

Herbal Artichoke Health Benefit

By Kyle J. Norton


Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Fructooligosaccharides (FOS), are oligosaccharide, a molecule made up of a small group of these sugar,

Due to its nature as a natural source of sugar and low in calories,  FOS may be used as an alternative sweetener as intake of FOS does not cause a spike in blood sugar.

FOS are considered prebiotics. Intake of FOS can increase the levels of good bacteria in the intestine, leading to a healthy ratio of gut microbiota.

Digestively, FOS contains high levels of soluble fiber which has been found to improve bowel function. Consumption of FOS also increased fecal bolus and the frequency of depositions, while a dose of 4-15 g/day given to healthy subjects has been found to reduce constipation.

According to the study, FOS also showed anti toxicity, carcinogenicity, and genotoxic effects.

FOS improved mineral absorption by decreasing levels of  pH in the colon, thus facilitating the absorption of mineral ions from the intestine, mainly calcium and magnesium 

Furthermore, FOS also found in studies decrease levels of serum cholesterol, triacylglycerols, the lead causes of cardiovascular diseases.

By modulating the levels of phospholipids, FOS lower the risk of coronary heart disease, inflammation or cancer, particularly in colon cancer.

In foods, FOS are increasingly included in food products and infant formulas for their prebiotic effect in stimulating the growth of nonpathogenic intestinal microflora.

In the examined the effects of chronic ingestion of short-chain fructooligosaccharides (FOS), an indigestible carbohydrate, on hepatic glucose production, insulin-mediated glucose metabolism, erythrocyte insulin binding, and blood lipids in 12 healthy volunteers selected received either 20 g FOS/d or sucrose for 4 wk in a double-blind crossover design, researchers found that the mean (+/- SEM) basal hepatic glucose production was lower after FOS than after sucrose consumption, through the effects on insulin-stimulated glucose metabolism in healthy subjects.

Taken altogether, artichoke processed many health benefits may be used as a functional remedy for diseases prevention in healthy subjects, pending to the validation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Dietary fructooligosaccharides and potential benefits on health by Sabater-Molina M1, Larqué E, Torrella F, Zamora S. (PubMed)
(2) Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism by Luo J1, Rizkalla SW, Alamowitch C, Boussairi A, Blayo A, Barry JL, Laffitte A, Guyon F, Bornet FR, Slama G. (PubMed)
(3) Fructooligosaccharides: a review by Fishbein L1, Kaplan M, Gough M. (PubMed)
(4) Fructooligosaccharides: Applications and Health benefits- a review by SHUBHANGI S. KHANVILKAR, Shalini S. Arya*

Herbal Ginger, the Natural Treatment of Gastric/Stomach Ulcers

By Kyle J. Norton


Gastric ulcers or stomach ulcers are conditions characterized by the painful sores in the stomach lining. Unlike the gastric ulcers, peptic ulcers are sores found in the stomach and small intestines.


The exact causes of gastric ulcer are not clearly identified. However, according to the epidemiological studies, a bacterial infection caused by the H. pylori infection has been found in the range of 30 to 50% of people with stomach ulcers. 

Gastric ulcers caused by H. pylori infection are more likely to develop in patients over 40 in the US

Other risk factors associated with gastric ulcer include long-term use of certain medications, such as NSAID which has been found to cause more than 50% of peptic ulcers and stress.

Treatment of gastric ulcers is depended totally on the underlying causes, including antacids for the reduced acid in the stomach, and antibiotics for the elimination of Helicobacter pylori.

Unfortunately, people with gastric ulcer infected by the Helicobacter pylori treated with antibiotics have a higher risk of recurrence. In severe cases, surgery may be necessary.

Untreated or uncovered stomach ulcers may induce some complications, including stomach bleeding penetration,  and cancer.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a potential ingredient for the treatment of gastric ulcers with no side effects, researchers examined the possible mechanism of the protective effect of ginger on the aspirin-induced gastric ulcer.

The study included 40 adult male albino rats randomized divided  into four groups (10 animal per each group) and orally received the followings once daily for 5 days:

Group I: 3 ml of 1% carboxymethyl cellulose; 

Group II: ginger powder (200 mg/kg body weight) suspended in 3 mL of 1% carboxymethylcellulose; 

Group III: aspirin (400 mg/kg body weight) suspended in 3 ml of 1% carboxymethylcellulose in water. 

Group IV: ginger and 30 minutes later, received aspirin suspended in 1% carboxymethylcellulose, in similar doses as received in groups II and III.

Before treatment of ginger, Aspirin-induced a significant increase of the macroscopic ulcer score, and gastric damage observed by the shed and disrupted epithelium, mucosal hemorrhage, submucosal edema and leukocyte infiltration, loss of the mucus of the mucosal surface.

Furthermore, in the proteins perspective, Aspirin significantly increased expression of apoptosis regulator Bax, inducible nitric oxide synthase (iNOS) associated with the production of proinflammatory cytokines and heat shock protein 70 (HSP70) involved stress response.

Injection of ginger protected the gastric integrity by restoring all damage caused by aspirin in the induction of gastric ulcer.

Dr. Salah Khalil M, said, "Ginger ameliorated the histological changes by reducing Bax and iNOS and increasing HSP70 expressions".

In other words, the overexpression of proteins associated with the onset of gastric ulcer also was significantly reduced by the ginger administration.

Take all together, ginger may be considered a functional alternative for the treatment of gastric ulcers, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: Histological and immunohistochemical studies by Salah Khalil M. (PubMed)
(2) Synbiotic (probiotic and ginger extract) loaded floating beads: a novel therapeutic option in an experimental paradigm of gastric ulcer by Singh PK1, Kaur IP. (PubMed)

Friday, 22 March 2019

Herbal Bilberry Protects the Nerve System against Neurotoxicity

By Kyle J. Norton


Neurotoxicity refers to the destruction of nerve tissue caused by toxins that have entered central and/or peripheral nervous system.

In other words, neurotoxicity is a result of any substance including a biological, chemical, or physical agent that causes an adverse effect on the nerve system.

Central nerve system comprised the brain and spinal cord is the complex of nerve tissues that control the activities of the body through the message transmitted by the neurons.

Most common causes of neurotoxicity are exposure to natural or man-made toxic substances, including drug, and medication. Long-term exposure to those toxins has been found to alter the activity of the nervous system.

Most common symptoms of neurotoxicity are a headache, altered sensation, tingling and numbness in the limbs.

In severe cases, neurotoxicity can induce vission loss, loss of memory and cognitive function and change behavior, psychological problems and sexual dysfunction.

Therefore, if you are taking medication and experience some of the aforementioned symptoms, please check with your doctor to rule out the possibility of a medication overdose.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers with an aim to discover a natural compound which protects the neurons damage induced neurotransmitter dopamine (DA) by a neurotoxic metabolite, 6-hydroxy DA, through increased expression of ROS examined the effects the antioxidant activities of anthocyanin-rich preparations of Vaccinium species (Vaccinium myrtillus, Vaccinium corymbosum, and Vaccinium oxycoccus).

V. myrtillus preparation: 50% inhibition with 7 microM of total anthocyanins were the most potent inhibition of oxidation and 1.5-4 times higher than that for the other preparations or for the purified anthocyanin.

According to the components analysis, antioxidant activity in the assay correlated strongly with the Vaccinium content of anthocyanins and total cyanidins, but not quercetin or myricetin.

Based in the findings, researchers wrote in the final report, "The results provide evidence for the high potency of anthocyanins towards a potentially neurotoxic reaction, and provide a basis for in vivo testing of these flavonoids and their physiological metabolites in the context of neuro- and mitochondrial-protective effects".


In order to reveal more information about bilberry anti neurotoxic activity, researchers once against evaluated the Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) protection of retinal ganglion cells (RGCs) against neurotoxicity in the induction of retinal damage. 

The vitro study included RGC cultures (RGC-5, a rat ganglion cell-line transformed using E1A virus) and cell damage and radical activation induced by 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1, a peroxynitrite donor).

The vivo study included mice induced retinal damage by N-methyl-D-aspartic acid (NMDA)-

According to the assays, VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and radical activation in RGC-5 in vitro and in mouse forebrain homogenates.
VMA inhibited lipid peroxidation in concentration-dependent manner.

Furthermore, intravitreously injected VMA significantly inhibited the NMDA-induced morphological retinal damage and increased TUNEL-positive cells in the ganglion cell layer.

Where terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) is a method for detecting DNA fragmentation of DNA breaks generated during apoptosis.

The results suggested VMA and its bioactive comapound anthocyanidins process neuroprotective effects in vitro and in vivo models of retinal diseases.

Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a function remedy for the prevention and treatment against neurotoxicity, pending to the validation of larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity by Yao Y1, Vieira A. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. (PubMed)

Bioactive Plantbased Betanin Protects the Liver Against Injury Naturally

By Kyle J. Norton


Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.

Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of injury may be necessary.

Most cases of liver injury can lead to abdominal pain and tenderness caused by bleeding blood in the abdomen that irritates the abdominal tissue. 

The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.

According to the statistics, liver injury has been found constituting 5% of all traumas, making it the most common abdominal injury.

Liver injury can be classified by the liver injury scale, depending on the area of the damage
* Grade I <10% surface area < 1 cm in depth 
* Grade II 10–50% surface area 1–3 cm 
* Grade III >50% or >10 cm >3 cm 
* Grade IV 25–75% of a hepatic lobe \
* Grade V >75% of a hepatic lobe 
and grade VI Hepatic avulsion

In other words, based on the grade of liver injury, patients either treated with nonoperative management and observation for a full self-recovery or surgery.

Betanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a natural compound for the protection of liver against injury researchers examined protective effect of betanin against liver injury induced by carbon tetrachloride (CCl4) in common carp (Cyprinus carpio L.).

The study included fish treated with 1, 2, and 4 % betanin in fodder throughout the experiment for 20 days followed by intraperitoneally injected with 20 % (v/v in peanut oil) carbon tetrachloride (CCl4) at a volume of 0.5 mL/kg body weight.

Where carbon tetrachloride (CCl4)  is a highly toxic liquid chemical.

Injection of CCL4, after 3 days showed liver histological damages accompanied by the induced liver CYP2E1 activity associated with some degrees of steatosis and increased serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT), the indication of oxidative stress.

Furthermore, CCL4 also induced liver damage expressed by the depletion of glycogen storage.

Compared with the CCl4 control group, the betanin-treated groups reduced CYP2E1 expression, decreased malondialdehyde level, increased liver antioxidative capacity observed by the increased glutathione level and superoxide dismutase and catalase activities.

Moreover, the betanin-treated groups also increased liver glycogen storage, and reduced serum AST/ALT activities, with significant differences in the 2 and 4 % treatment groups.

These results suggested betanin processes liver protective effects against liver injury by restoring some levels of liver function through its antioxidant activity.

Dr. Han J, the lead scientist wrote in the final report, " betanin attenuates CCl4-induced liver damage in common carp. Moreover, the inhibition of CYP2E1 activity and oxidative stress may have significant roles in the protective effect of betanin".

Taken altogether, betanin may be considered supplements for the treatment of liver injury, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin attenuates carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio L.) by Han J1, Gao C, Yang S, Wang J, Tan D. (PubMed)
(2) Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying/antioxidant enzymes in human liver cell lines by Krajka-Kuźniak V1, Paluszczak J, Szaefer H, Baer-Dubowska W. (PubMed)

Phytochemical 3,3'-Diindolylmethane Prevents the Onset of Hypoxia

By Kyle J. Norton


Hypoxia is a condition of deficiency in the amount of oxygen reaching the tissues, leading to permanent damage to the brain, liver, and other organs.

Most common symptoms of hypoxia include fast heart rate, rapid breathing, shortness of breath, slow heart rate and sweating.

Hypoxemia is a condition of the abnormally low level of oxygen in the blood.

There are many risk factors associated with the onset of hypoxemia, including reduced oxygen levels on the high altitude, damage of the lung that affects the breathing and exhaling function.

People with lung and heart disease such as asthma, poor blood circulation, and anemia are at a higher risk of hypoxemia.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

In the searching a potential compoundagainstt the onset of hypoxia, researchers examined the neuroprotective potential of 3,3'-diindolylmethane (DIM) in cellular and animal models of Parkinson's disease and lipopolysaccharide-induced inflammation.

In hypoxia-induced damage in mouse hippocampal cells in primary cultures, the 18 h of hypoxia-induced apoptotic processes in terms of the mitochondrial membrane potential, associated with the process of energy storage during oxidative phosphorylation. activation of a protein associated with cell death induced by fragmentation of cell nuclei.

Injection the DIM significantly demonstrated strong neuroprotective and anti-apoptotic actions in hippocampal cells exposed to hypoxia through decreasing the expression genes (Ahr and Arnt) involved the regulation of inflammatory signaling pathways and increasing the gene (Erβ) expression involved suppressing the inflammatory responses.

Futhermore, DIM decreased the expression of AhR-regulated CYP1A1 in stimulating the inflammatory response.

The results strongly suggested impairment of protein expression of AhR and ARNT, but not ERβ plays a key role in the neuroprotective action of DIM against hypoxia-induced cell damage.

Where aryl hydrocarbon receptor nuclear translocator (ARNT) is a component of the DNA binding form of the Ah receptor required for receptor function.

And aryl hydrocarbon receptor (AhR) is protein associated with the regulation of genes expression.

In other words, the mutation of genes aryl hydrocarbon receptor (AhR) or aryl hydrocarbon receptor nuclear translocator (ARNT) are the culprits in the induction of neuro oxygen deficiency.

Based on the findings, researchers wrote in the final report, "This study may have implication for identifying new agents that could protect neurons against hypoxia by targeting AhR/ARNT signaling".

Furthermore, in hypoxia induces oxidative damage in retinal pigment epithelial cells (RPE cells) by cobalt chloride (CoCl2, 200 µM) and/or DIM (10 and 20 µM). DIM significantly attenuated the CoCl2-induced expression of a protein (VEGF) associated with the formation of blood vessels in the ARPE-19 cells compared to the lower levels under normal condition.

Similar to those of the aforementioned characteristics, DIM deactivated the genes which play an integral role in the body's response to low oxygen concentrations (HIF-1α) and pro-apoptosis (NF-κB, p38 MAPK) induced by CoCl2.

DIM also inhibited the induction of hypoxia by CoCl2 through the inhibition of oxidative stress detected by fluorescence microplate assay.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention of hypoxia, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Selective Aryl Hydrocarbon Receptor Modulator 3,3'-Diindolylmethane Impairs AhR and ARNT Signaling and Protects Mouse Neuronal Cells Against Hypoxia by Rzemieniec J1, Litwa E1, Wnuk A1, Lason W1, Krzeptowski W2, Kajta M. (PubMed)
(2) 3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1α and NF-κB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions by Park H1, Lee DS2, Yim MJ2, Choi YH3, Park S4, Seo SK4, Choi JS5, Jang WH6, Yea SS6, Park WS7, Lee CM8, Jung WK9, Choi IW. (PubMed)