Wednesday, 19 September 2018

Yoga Intervention Improves Overall Conditions of Patients With Coronary Heart Disease

Kyle J. Norton (Master of Nutrients, All right reserved)

Yoga may have a profound and positive impact on secondary prevention and improvement on overall conditions in individuals with coronary heart disease, some studies suggested.

Coronary artery disease is a medical condition caused by accumulation of plaques that block arteries in supply blood nutrients and oxygen to the heart. Most cases of the disease is associated to atherosclerosis, the condition of hardening of the arteries.

According to statistic, coronary artery disease is the most common type of heart disease that cause death of over  370,000 people every years, representing 28% of all death in the United States.

Sadly, according to the Centers For Disease Control and Prevention, approximately, 735,000 Americans have a heart attack each year.

What cause plaques building up on the arterial are debatable. However, researchers suggested that Western diet is associated to significantly increased risk of coronary artery disease.

Dr. Venegas-Pino DE in the classification of the effect of diet on heart diseases said," the western-diet-fed male ApoE-/-:Ins2+/Akita mouse, with profound cardiovascular disease involving extensive atherosclerosis, coronary artery disease and myocardial infarct resulting in shortened lifespan(4)".

Most common symptoms of coronary artery disease is angina, the condition characterized by chest pain or discomfort and shortness of breath as a result of weakening of heart muscle which can not pump enough blood to the body needs.

Over time, prolonged weakened heart muscle can lead to complications of heart failure, irregular heartbeat, or arrhythmia.

Yoga, the ancient practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been well known for people in Western world and some parts in Asia.

In a total of 80 stable CAD patients below 65 years of age of both sexes selected and randomized into two groups of 40 each. yoga Group I with for 3 months yoga lessons consisted yogic postures, pranayama breathing exercises, dietary modification, and holistic teaching along with their conventional medicine while Group II treated only on conventional medicine after 3 months, researchers found that,

*Groups attended yoga lessons expresses statistically significant improvements slow vital capacity, forced vital capacity, peak expiratory flow rate, maximum voluntary ventilation, and diffusion factor/ transfer factor of lung for carbon monoxide in compared to group II.

* The lung function in forced respiratory volume in 1(st) sec (FEV1), and FEV1 % also shows a trend toward improvement although not statistically significant in also compared to conventional treatment group.

Dr, Yadav A, the led authors after the experiment said, "Yoga regimen was found to improve lung functions and diffusion capacity in CAD patients besides improving cardiovascular functions".

These results suggested that yoga postures and meditation have a profound effect in relaxed arterial muscle to allow more blood to flow through by reduced stress which causes the muscle wall  tightening.

Furthermore, yoga posture and breathing technique also improved the lung muscle in absorption of more oxygen for the blood.

In support of the above analysis, Dr. Pal A, and colleagues conducted a study of 258 patients from the Department of Cardiology in Chhatrapati Shahuji Maharaj Medical University diagnosed with coronary artery disease randomly divided into 2 groups, the yoga group and the non-yoga group with 129 in each group, yoga attendees after 35-40 min/day, 5 days a week over a period of 18 months displayed a statistically significant reduction in body mass index, waist circumference, systolic and diastolic blood pressure, and heart rate (P < 0.05).

The relaxation to allow more blood to provide nutrients and oxygen to the body needs may also result in reduced the blood pressure, thus lowering the heart rate.

After taking into account of other risk factors, researchers suggested that yoga therapy expressed a significant effect on secondary prevention of mortality and morbidity and health-related quality of life of individuals with coronary heart disease,


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of yoga regimen on lung functions including diffusion capacity in coronary artery diseasepatients: A randomized controlled study by Yadav A1, Singh S2, Singh K2, Pai P1.(PubMed)
(2) Effect of yogic intervention on the autonomic nervous system in the patients with coronary artery disease: a randomized controlled trial by Pal A, Srivastava N, Narain VS, Agrawal GG, Rani M.(PubMed)
(3) Yoga for secondary prevention of coronary heart disease by Lau HL1, Kwong JS, Yeung F, Chau PH, Woo J.(PubMed)
(4) Evidence of extensive atherosclerosis, coronary artery disease and myocardial infarction in the ApoE-/-:Ins2+/Akita mouse fed a western diet by Venegas-Pino DE1, Lagrotteria A2, Wang PW3, Morphet J3, Clapdorp C3, Shi Y3, Werstuck GH(PubMed)

Carrot, The Functional Food Which Reduces Gastric/Stomach Cancer Risk By 26%

Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk, progression and treatment of gastric cancer, some scientists suggested.

Gastric cancer is a slowly developed condition characterized by cell growth uncontrollably and disorderly in the stomach tissue. At he later stage, the cancerous cells may travel a distance away to infect other healthy cells of the tissue and organs.

According to the US cancer society, approximately over 26000 new cases of gastric cancer are diagnosed in 2018 inducing death of over 10,000 patients.

The risk that a man and woman will develop gastric cancer in their lifetime is 1 in 95 and 1 in 154 respectively.

The exact causes of gastric cancer are unknown, some researchers suggested that older people, male, heavy smokers, people who with family history of gastric cancer and certain ethnic groups such as
Asian (especially Korean or Japanese), South American, or Belarusian descent are at increased prevalent risk of gastric cancer.

Interestingly, during past several decades, the numbers of common gastric cancer are showed a tendency of receding, however, at the same time, cancer at the area where the top part of the stomach  meets the lower end of the swallowing tube (esophagus) has increased rapidly.

Also, some medical conditions such as lymphoma, H. pylori bacterial infections,  tumors in  digestive system and stomach polyps are  associated to risk of the disease.

If you experiment of persistent feeling floated after eating, and small meal after eating, heart burn, indigestion,... and stomach pain accompanied of general symptoms of cancer such as unexplained weight loss, please check with your doctor to rule out the possibility of gastric cancer..

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the investigation the hypothesis of "eating carrots may play a major role in the prevention of gastric cancer", researchers at the joint study lead by the J Shahid Sadoughi University of Medical Sciences conducted a medical literature review selected from the data bases of including PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx, those studies satisfied the guidelines and criteria showed that risk of gastric cancer reduced by 26% with the consumption of carrots.

After taking into account of other co factors, researchers warranted that the result does not showed the possibility of a publication bias, according to the funnel graph by comprehensive meta analysis/2.0 software.

Although without mentioning the amount intake daily, these results showed an inverse relationship between the consumption of carrots and the risk of gastric cancer.

Furthermore, in the analysis of the effect of Helicobacter pylori (H. pylori) overgrowth in risk of gastric cancer, scientists found that injection of gene of UreB into carrot by Agrobacterium-mediated transformation expressed a significant effect in regenerated carrot plants the expressed UreB protein accounted for 25mug/g roots in reduced expression of H. pylori.

The same application also showed a similar effect in immune response in inhibition of infection of bacterial Helicobacter pylori in mice.

These result suggested that certain chemical compounds in carrot may consist a strong anti micro organism activity by protecting the plant against bacterial infection.

Therefore, UreB transgenic carrot can be potentially used as an edible vaccine for controlling H. pylori but also ameliorated risk of the bacteria in induction of gastric cancer.



The illustration of above differentiation were supported by the study conducted by the Graduate School of Fudan University.

According to the evaluation of the Wuxing soup containing Daikon Radish Leaves (Green element) Daikon Radish (White element) Carrots (Red color element) Burdock Root (Yellow element) Shittake Mushroom (Black element), application of the soup to the human gastric adenocarcinoma cell line (SGC-7901) expressed a huge inhibitory activity in reduced tumor cells proliferation in a time and dose dependent manner.

More importantly, Wuxing soup induced tumor cell death through apoptotic morphological changes and DNA ladder of the tested SGC-7901 cells.

Additionally, used combination with calcium inhibitor Bapta AM, an intracellular calcium chelator not only exerted a strong effect in  reduced the cancer apoptotic rate but also protected SGC-7901 cells in a dose dependent manner.

Dr. Mo F, the lead author said, "Wuxing soup has an effective inhibition on cancer cells, and can induce SGC-7901 cells to apoptosis by calcium".

Taken together, carrot may be considered as a function food in ameliorated risk and used combination with conventional standard treatment for gastric cancer.

However, further data collection on large example size and multi centers studies performed with human consumption of the whole food during the course of gastric cancer will be necessary to complete the picture of carrot's anti cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Biography

Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Effect of Carrot Intake in the Prevention of Gastric Cancer: A Meta-Analysis by Fallahzadeh H1, Jalali A2, Momayyezi M1, Bazm S3.(PubMed)
(2) Oral immunogenicity and protective efficacy in mice of a carrot-derived vaccine candidate expressing UreB subunit against Helicobacter pylori by Zhang H1, Liu M, Li Y, Zhao Y, He H, Yang G, Zheng C.(PubMed)
(3) [The anti-tumour effect of Wuxing soup and its mechanism in inducing apoptosis of tumour cells mediated by calcium].[Article in Chinese] by Mo F1, Hu JY, Gan Y, Zhao YX, Zhao XT.(PubMed)

Green Tea,The Popular Beverage Which Blocks The Entry Point of Bacterium That Cause Tuberculosis

Kyle J Norton

Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of tuberculosis (TB), some scientists suggested.

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Commonly, the bacteriium attacked the lung tissue but in some cases they also can cause major damage to other parts of the body.

The disease is very contagious, as types of bacteria that cause TB can spread from person to person through microscopic droplets released into the air.

In other words, people can be infected by TB if they can to closely contact with TB patients through tuberculosis coughs, speaks, sneezes, spits,.... and laughs.

Bacterium called Mycobacterium tuberculosis are the main culprits that cause TB. The disease is rare in the Western world, however, according to the report of WHO of the region including 36 countries in the Western Pacific Region, approximately 1.4 million notified cases of all forms of TB in 2011 (75 per 100 000 population), corresponding to 23% of the total cases notified globally.

There were 0.6 million new smear-positive cases notified in 2011 (32 per 100 000 population), corresponding to 22% of the total smear-positive cases notified globally.

Conventional medicine Isoniazid (INH) is quite effective and considered as the primary therapy for latent TB. Most patients are required to take an isoniazid antibiotic pill daily for 9 months.

It you are taking Isoniazid (INH) and experience nausea, vomiting, rash, fever, ataxia, slurring of speech, peripheral neuritis, dizziness and stupor within 30 minutes to two hours after ingestion, you should go to hospital right the way as in some cases, the symptoms may follow with complications of grand mal seizures and coma.

Please make sure you understand the risk which may be induced by the medicine.

Green tea, is a precious drink processed numbers of health benefit and known to almost everyone in Asia and Western world.

In the investigation of the effect of reactive oxygen species (ROS) in risk of tuberculosis of a total of 200 newly diagnosed cases of AFB positive pulmonary tuberculosis, with 100 patients randomly received catechin (500 microg) with antitubercular treatment (ATT) (cases) and the other 100 received starch (500 microg) with ATT (control), researchers at the Chhatrapati Shahuji Maharaj Medical University found that CTN treatment group exerts a significant activity in reduced levels of free radical expression through reduced oxidative stress in compared to control, observed by analysis of the blood samples.

Further analysis suggested that green tea CTN treatment group restores the balances antioxidant and free radicals ratio by stimulated production of levels of enzymatic antioxidant (catalase, superoxide dismutase, glutathione peroxidase) and non enzymatic antioxidant (total thiol, reduced glutathione) levels and significant decreased expression of free radicals (lipid peroxidation, nitric oxide).

These results re-constituted the efficacy of crude catechin extract as adjuvant therapy in management of oxidative stress seen in pulmonary tuberculosis patients.

Moreover, in monitor the extent of oxidative stress in mice infected with M tuberculosis and the role of crude green tea extract in repairing the oxidative damage by divided them into three groups of normal, infected-untreated and infected-treated with 9 members in each group, scientists indicated that infectous untreated group exerted a significant enhancement of antioxidants produced by the natural defense of the body such as erythrocytic catalase and glutathione peroxidase activities along with elevated levels of free radical defenders such as erythrocytic total thiols but decreased levels of antioxidant activity of superoxide dismutase and glutathione in erythrocytes and increased levels of free radicals plasma lipid peroxidation as compared to normal animals as expected.


These results suggested that non CTN tested mice exerted the protection against application of infectious agent selectively either through expression of natural antioxidant produced by the body or antioxidants produced by the body were inhibited by the injection substance.

Importantly, ingestion of green tea CTN upon 7 days in infectious mice group completely restored the normal values of antioxidants and ROS ratio observed by the oxidative stress parameters.

In other words, green tea treatment group showed an increased catalase, glutathione peroxidase, total thiol and decreased extent of lipid peroxidation with concomitant increase in the levels of SOD and glutathione in infected animals, thus reducing development of tuberculosis risk.


The above differentiation were supported by the Department of Experimental Medicine and Biotechnology, Chandigarh in the study to determine whether or not polyphenols derived from green tea could down-regulate tryptophan-aspartate containing coat protein (TACO) gene transcription in reduced uptake/survival of M. tuberculosis within macrophages.

TACO gene transcription allows mycobacterial entry/survival within a mobile white blood cell, especially at sites of infection.of the innate immune system,

According to the reverse-transcriptase polymerase chain reaction and reporter assay technology, application of major component of green tea polyphenols, epigallocatechin-3-gallate EGCG reduced expression of TACO gene transcription within white blood cells in the immune system through its ability in inhibited Sp1 transcription factor in initiation of infectious cellular processes.

Sp1 transcription factor plays an important role in cell differentiation, cell growth, apoptosis, immune responses.
Dr. Anand PK, the lead authors, said, "The down-regulation of TACO gene expression by epigallocatechin-3-gallate was accompanied by inhibition of mycobacterium survival within macrophages as assessed through flow cytometry and colony counts" and "epigallocatechin-3-gallate may be of importance in the prevention of tuberculosis infection".

Taken together, green tea and its bioactive polyphenols in attenuated risk and treatment of tuberculosis caused by Mycobacterium tuberculosis may contribute significantly to the prevention and treatment of tuberculosis in third world countries where the conventional medicine are scarce or un-affordable to general population.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Effect of green tea extract (catechins) in reducing oxidative stress seen in patients of pulmonary tuberculosis on DOTS Cat I regimen by Agarwal A1, Prasad R, Jain A.(PubMed)
(2) Protective effect of green tea extract against the erythrocytic oxidative stress injury during mycobacterium tuberculosis infection in mice by Guleria RS1, Jain A, Tiwari V, Misra MK.(PubMed)
(3) Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages by Anand PK1, Kaul D, Sharma M.(PubMed)

Tuesday, 18 September 2018

Herbal Anise Detoxes Your Kidney From Medicine and Chemicals Toxicity, Scientists Say

Kyle J. Norton 

Anise may have a potential and therapeutic effect in reduced risk of nephrotoxicity caused by intake of some medicine and chemicals, some scientists suggested.

Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.

The disease is caused by a poisonous effect of prolonged use of certain medication and accumulation of harmful chemicals.

According to the American physician association, long term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs and rifampicin are associated to increase damage to the kidney.

And people with age over 60 are at increased risk of nephrotoxicity, if the above medicne are prescribed for prolonged periods.

Continuously, the association wrote, "Drug-induced nephrotoxicity tends to be more common among certain patients and in specific clinical situations" and " Drugs cause approximately 20 percent of community-and hospital-acquired episodes of acute renal failure".

Dr. Koren G, in the classification of drug and chemicals that cause nephrotoxicity suggested, "Drugs and chemicals may affect renal function by pharmacologically decreasing glomerular filtration rate and/or renal blood flow" and " A variety of xenobiotics or their metabolites may be deposited in the renal tubule causing obstruction of urine flow and a secondary damage to tubular epithelium"(4).

If you experience symptoms of decreased urine output,.fluid retention that causes legs, ankles or feet. swelling,.... and shortness of breath, you may have acute kidney failure, please check with you doctor to rule out the possibility.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to to Egypt and the Mediterranean region,  used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....


Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the investigation of the effect of Pimpinella anisum (P. anisum) in alleviated gentamicin (GM) in induction of nephrotoxicity, in a group of 40 male wistar rats divided into four groups: control, sham administrated normal saline orally and intraperitoneally (i.p.), GM received 100 mg/kg bw/day and GM and ethanolic extract of P. anisum with an oral dose of 300 mg/kg bw/day for 8 days, researchers found that GM groups demonstrates a significant increase of plasma levels of creatinine which in an indication of improper function of kidneys,  levels of Blood urea nitrogen (BUN) which is an indication of how the kidneys in filtered out the wastes and levels of malondialdehyde (MDA), a maker of oxidative stress.

Mice injected with GM also displayed an absolutely increased excretion of sodium and potassium inducing fluid or electrolyte imbalances and impaired kidney function.

Oral GM adminstrated mice also showed a  decreased level of reducing ability of plasma (FRAP) level, a marker of antioxidant defense in compared to the sham group. 

Interestingly, application of herbal anise in GM group at dose of 300 mg/kg expressed an improvement of various aspects through significantly reduced the plasma concentrations of renal function markers and gentamicin-induced tubule damage.

Dr. Changizi-Ashtiyani S, the lead author said, " the potential therapeutic impact of P. anisum to attenuate GM-induced nephrotoxicity. Therefore, the simultaneous use of ethanolic extract of P. anisum during GM administration is recommended to reduce its nephrotoxicity effects".

Amazingly, in the study to evaluate the effect  Pimpinella anisum L. against lead intoxication in induction of nephrotoxicity in young rats intoxicated by lead acetate, researchers found that  oral adminstration of aqueous extract of P. anisum L. (500 and 750 mg/kg) for 15 days show an strong improvement in reduced expression of urea, creatinine, acid uric, and gamma-GT by  −71%, −1.23%, −1.80% and −5.88% of kidney damage bioamrkers caused by lead toxicity.

Importantly, injection of anise extracted also decreased the level of lipid hydroperoxide (LPO) of −13.56%, an indication of antioxidant activity induced by the application
 and increased the concentration of total proteins (+8.88%) in expression of kidney and liver protective effects without changing histological structures of the kidney between the studied groups.

Dr. Bekara Amina, the lead author, after taking into account of other con founders, said, "P. anisum L. may have a nephroprotective potential against harmful effect induced by lead toxicity on kidney".

Moreover, in the study of a total of 40 male Wister albino rats divided randomly into four groups (1st group was control; 2nd group treated with star anise, 3 rd group received Etoposide, and 4th group treated with both star anise and Etoposide(chemotherapy medication used for the treatments of a number of types of cancer), application of the herbal products, displayed similar efficacy as those in ansie through significantly decreased elevation in creatinine, blood urea, sodium, potassium and chloride while calcium ions induced in the injection of Etoposide.

The study also addressed the inter uncorrelated between star anise water extract and the injection of Etoposide observed by assay supported the detrimental effect of Etoposide in the ameliorating effect of star anise water extract on renal toxicity.

Dr. Ali Salman Hassan according to the information findings said, "star anise has a promising role and it worth to be considered as a natural substance for ameliorating the renal toxicity and injury induced by Etoposide chemotherapy".

Taken together, Anise may be considered as an adjunct therapy in combined with standard medicine in reduced risk of nephrotoxicity, particularly in patient undergoing chemotherapy for cancer treatment.

Intake of herbal extract should be taken with extreme care  in prevented liver toxicity.

However, further data collection on large example size and multi centers studies performed with human consumption of the whole food during the acute phase of the disease will be necessary to complete the picture of herbal anise kidney protective possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pimpinella anisum L. ethanolic extract ameliorates the gentamicin- induced nephrotoxicity in rats by Changizi-Ashtiyani S1, Seddigh A2, Najafi H3, Hossaini N4, Avan A5, Akbary A6, Manian M7, Nedaeinia R8.(PubMed))
(2) Prevention of Etoposide induced kidney toxicity, electrolytes, injury and KI67 alternations in male rats tre ated with star anise Ali Salman Hassan Al-Ameri Environmental studies/Biology/Ministry of Education, Iraq(JBAAR)
(3) Nephroprotective effect of Pimpinella anisum L. aqueous extract against lead toxicity: In vivo study by Bekara Amina, Ait Hamadouche, Kahloulakhaled, Aoues Abdelkader(Research Gate)
(4) The nephrotoxic potential of drugs and chemicals. Pharmacological basis and clinical relevance by Koren G(PubMed)

Green Tea: The Drink Which Ameliorates Symptoms and Progression of Rheumatoid Arthritis(RA)

By Kyle J. Norton, Master of Nutrition

Green tea exhibited anti inflammatory effect in reduced symptoms and progression of
Rheumatoid Arthritis, some institutes suggested

Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.

According to statistic, In US, approximately, 90 million adults and children suffered directly from arthritis, inducing  social and economic consequences to over 240 million people who are having a family member affected by the disease.

The disease was also found to infect a third of those aged 18-64.

Although, the disease is caused by immune defense attacking its the body healthy tissue, researchers as of today are not sure what trigger the abnormal function. But they do know that certain risk factors are associated to increased risk of rheumatoid arthritis, including genetic alternation, as people with certain genes are more likely to develop RA,  geographic factor as RA is rare in less developed and rural parts of the world, hormone factor as RA is more common in women than in men,.... and family history.

Other risk factors including smoking, people with certain medical conditions such as auto immune disease,  unhealthy diet such as high in red meat and less in fruits and vegetables, physical inactivity also promote early onset of RA.

The Karolinska Institutet in the study of the risk factors of RA wrote, "nongenetic risk factors (smoking, alcohol intake, parity, silica exposure, body mass index, fatty fish consumption, and education), and genetic risk factors (shared epitope [SE] and 76 single-nucleotide polymorphisms [SNPs])" and "....many (familial) risk factors remain to be identified, in particular for seronegative RA"(4).

The results of chronic inflammation caused by immune attacking the joints, inducing over expression of pro inflammatory cytokines can lead to damage of cells in the inflammatory site and nearby healthy cells, including bone, cartilage, tendons,.... and ligaments,

Untreated chronic joint inflammation can also cause complications of  total destruction of joint tissue.

If you experience symptoms of joint pain, tenderness, swelling, redness, stiffness,.... restriction or loss of joint range of motion, you may have RA.

Green tea, a precious drink processed numbers of health benefit anf known to almost everyone in Asia and Western world.

According to the joint study lead by Washington State University College of Pharmacy, green tea showed to ameliorate the expression of pro-inflammatory mediators including (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs), through the effects of its phytochemical compounds of EGCG and EGC antioxidant activities.

IL-6 and IL-8 are pro inflammatory cytokines activated by systematic immune response in prevented damage of tissue in the acute phase of infection. Prolonged over expression of IL6 and IL8 can cause damage to cells in the infectious region as well as surrounding healthy cells.

Cox-2 are prostaglandins with function in mediated pathogenic infection, including the inflammatory response.

Dr. Fechtner S, the lead researcher said," EGCG is the most effective catechin at inhibiting downstream inflammatory signaling, its effectiveness could be hindered by the presence of (epicatechin) EC".

In the investigation of the anti-inflammatory activity of green versus black tea aqueous extract in a rat model with orally/daily distilled water as placebo, indomethacin (1.0 mg/kg body weight; a non-steroidal/anti-inflammatory drug), or tea aqueous extracts (for 28 or 14 consecutive days administrated from day 0 or 14 of arthritis induction, respectively), researchers found that group treats with high dose of GTE (from day 0) significantly alleviated (P < 0.05-0.001) the progression and all complications induced by rheumatoid arthritis in compared to placebo.

More importantly, researchers also found that the expression of anti-arthritic activity of the high dose of GTE (from day 0) mediated by significantly decreasing the systemic production of pro-inflammatory cytokines and the expression of chemokine receptor-5, a protein in activated immune activities in the in synovial tissues,was comparable (P > 0.05) with that of indomethacin (12.9-53.8 vs. 9.5-48.4%, respectively).

Furthermore, the anti-arthritic potency of tea aqueous extracts was doses dependent in the order of high dose of GTE > low dose of GTE ≥ high dose of BTE > low dose of BTE.

Other study suggested that green tea extract in reduced symptoms and risk of complications probably are the result in regulating chemokine(a family of cytokines secreted by cells) production in immune reaction and chemokine receptor expression in interaction with proimflammatory cytokines of human RA synovial fibroblasts in rat adjuvant-induced arthritis (AIA).

Taking together, green tea nay be served as a functional food to reduce symptoms and risk of complications for patients with rheumatoid arthritis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts by Fechtner S1, Singh A1, Chourasia M2, Ahmed S3.(PubMed)
(2) Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis by Ramadan G1, El-Beih NM1, Talaat RM2, Abd El-Ghffar EA1.(PubMed)
(3) Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis by Marotte H1, Ruth JH, Campbell PL, Koch AE, Ahmed S.(PubMed)
(4) To what extent is the familial risk of rheumatoid arthritis explained by established rheumatoid arthritis risk factors? by Jiang X1, Frisell T, Askling J, Karlson EW, Klareskog L, Alfredsson L, Källberg H(PubMed)

Monday, 17 September 2018

Yoga In Reduced Physical and Psychological Symptoms of Parkinson's Disease


People who participated in yoga class have a profound and positive impact in reduced symptoms of  Parkinson's disease, a renowned study suggested.

Yoga, the accident technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been well known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

Parkinson's disease is a condition affected motor and non motor functions and cause severe debility and poor quality of life, a recent study suggested.

According to statistic, approximately one million are living with Parkinson's disease (PD) in the U.S.
Every year, over 60,000 Americans are diagnosed with PD.

And, if you are men, you are 1.5 time more likely to have Parkinson's disease in compared to women.

In the discussion with 28 experienced yoga experts, who fulfilled the inclusion criteria, selected validating the content of the an integrated yoga module(IYM) for PD, researchers found that 21 out of 28 exhibited significant content validity by applying Lawshe's formula for the content validity ratio (CVR) of 0.42.

Additionally, in a randomized controlled pilot study investigated the effectiveness of yoga intervention on physiological and health-related QOL measures in people with PD with 13 people with stage 1-2 PD randomized to either a yoga (n = 8) or a control group (n = 5) and the yoga group participated in twice-weekly yoga sessions for 12 weeks, searchers found that yoga participants demonstrate a significant improvement in Unified Parkinson's Disease Rating Scale (UPDRS)scores, improved diastolic blood pressure (P = 0.036) and average forced vital capacity (P = 0.03) over time, in compared to control.

Furthermore, researchers also indicated that yoga group expressed positive trends of improvement in depression scores (P = 0.056), body weight (P = 0.056) and forced expiratory volume (P = 0.059).

More profoundly, Yoga participants reported more positive symptom changes including immediate tremor reduction in compared to control group. Collectively, yoga significantly improve aspects of QOL and physiological functions in stages 1-2 PD patients.

Importantly, in support of the above differentiation, the California State University, in the measuring the effect of an eight-week adaptive yoga program on the physical and psychological status of individuals with Parkinson's disease pilot study suggested, after assessing the result of 10 participants with a Hoehn and Yahr stage of 2 or 3 prior to and after an 8-week control phase and again after they underwent an 8-week adaptive yoga program scientists suggested that yoga participants not only reduced expression of depression, anxiety in both gender, but also enhanced sit-and-reach flexibility in male participants in compared to female counterparts.

In younger participants, yoga showed a enormous improvement of Single-Leg Balance test(SLB) time after intervention.

Indeed, in the compare the effects of power training (PWT) and a high-speed yoga program on physical performances in older patients with Parkinson's disease (PD), researchers indicated that both yoga program and PWT programs can significantly improve physical performance in older persons with PD.

In other words, Dr. Ni M, the led author said, "both training groups showed significant improvements (P<.05) in all physical measurements except functional reach on the more affected side, SLS, and postural sway compared with the pretests, and significantly better scores for UPDRSMS, BBS, Mini-BESTest, Timed Up and Go, functional reach on the less affected side".

Taking altogether, yoga no doubt has a fabulous effect in improve both physical and psychological symptoms in early stage of Parkinson's disease. Some researchers even suggested that yoga may be used as integrated form of exercise conventionally with conventional therapy.


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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Development and validation of a yoga module for Parkinson disease by Kakde N1, Metri KG1, Varambally S1, Nagaratna R1, Nagendra HR1.(PubMed)
(2) Comparative Effect of Power Training and High-Speed Yoga on Motor Function in Older Patients With Parkinson Disease by Ni M1, Signorile JF2, Mooney K3, Balachandran A1, Potiaumpai M1, Luca C4, Moore JG5, Kuenze CM1, Eltoukhy M1, Perry AC1.(PubMed)
(3) A randomized controlled pilot study of the therapeutic effects of yoga in people with Parkinson's disease by Sharma NK1, Robbins K1, Wagner K1, Colgrove YM1.(PubMed)
(3) Measuring the effect of an eight-week adaptive yoga program on the physical and psychological status of individuals with Parkinson's disease. A pilot study by Boulgarides LK1, Barakatt E, Coleman-Salgado B.(PubMed)
(4) Controlled pilot study of the effects of power yoga in Parkinson's disease by Ni M1, Mooney K2, Signorile JF3.(PubMed)

Aloe Vera, The Functional Herb Which Normalizes High Blood Pressure Quickly With No Adverse Effects

By Kyle J. Norton

Good news to people with hypertension, Aloe Vera may be a potential and therapeutic agent for lowering high blood pressure a renowned University study suggested.

Hypertension is a condition of abnormal high blood pressure, leading to symptoms of headaches, shortness of breath or nosebleeds......

Hypertension is a measurement with home systolic/ diastolic BP > or = 135/85 mmHg.

According to statistic, he prevalence of hypertension affects over 39.4% for men and 29.3% for women in the Western World.

Prolong untreated hypertension is found to induce complications of strokes, heart attacks, heart failure, or kidney disease.

Some researchers suggested that patients who are actively in modulated daily high blood pressure may be benefits in reduced risk of stroke by 35%, heart attack by 20%, and heart failure by 50%.

According to the WHO-based Healthy Diet Indicator (HDI), the American Heart Association 2006 Diet and Lifestyle Recommendations(4),
* The prevalence of untreated hypertension and treated hypertension was 22.4% and 8.5%.

* Patients with untreated hypertension had significantly lower HDI and AI-84 scores compared with non-hypertension.


* After adjusting for age, energy intake, smoking habit, alcohol drinking, physical activity and salt intake, a low adherence to HDI and a lowest quartile of AI-84 score were associated with a significantly higher prevalence of untreated hypertension, with an OR of 3.33 (95% CI 1.39 to 7.94, p=0.007) and 2.23 (1.09 to 4.53, p=0.027), respectively.

These results are agreed to general and popular belief that unhealthy diet plays an important role in induction of high blood pressure. Furthermore, a lower dietary quality was associated with increased prevalence of untreated hypertension.

People who eat more fruits and vegetables in compared to average daily intake are associated to a significantly lower risk of hypertension.

Dr. Utsugi MT in the comparison of fruits and vegetable intake daily said, "the highest-tertile consumptions of fruits, vegetables, potassium, and vitamin C were associated with a significantly lower risk of hypertension (45%, 38%, 46%, and 43% lower risk of home hypertension, respectively(5)".

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to enormous health benefits. Aloe vera has also been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, 

According to the Hamdard University ,aloeemodin, aloin A, a chemical compound found in Aloe Vera showed to express hypotensive effects by lower mean arterial blood pressure by 26 %, 52 %, and 79 % in the corresponding doses of 0.5, 1, and 3 mg/kg in animal study.


Dr. Saleem R, the lead author of the study suggested that Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigation.

In a total of In a double-blind, placebo-controlled, crossover study, healthy, Aloe-emodin, another major chemical compound\ inhibited vascular smooth muscle stiffness, a condition in the development of hypertensio, involved cell in support structural and biochemical and interior surface of blood vessels.

In hypertension, increased large-artery stiffness is partly due to intrinsic mechanical properties of vascular smooth muscle cells.

More importantly, a smooth muscle cells derived from hypertensive and control rats study, treatment of Aloe-emodin also significantly reduced hypertension by improving elastic value of vascular smooth muscle cell , through it effects on vascular smooth muscle cell cytoskeletal proteins in regulated function of cell division.

Other researchers suggested that the anti hypertensive properties of Aloe-emodin may be a result of inhibition of tonic tension and regulated apoptosis, pro- and anti-apoptotic activities on vascular smooth muscle cells.

With all the information collected, Aloe Vera may have an anti hypertensive effect in regulated protein in cell production on vascular smooth muscle which is a main cause of high blood pressure,but more precised understanding may be necessary to reassess this pharmaceutical value.

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Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Hypotensive effect of chemical constituents from Aloe barbadensis by Saleem R1, Faizi S, Siddiqui BS, Ahmed M, Hussain SA, Qazi A, Dar A, Ahmad SI, Qazi MH, Akhtar S, Hasnain SN.(PubMed)
(2) Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension by Sehgel NL1, Zhu Y, Sun Z, Trzeciakowski JP, Hong Z, Hunter WC, Vatner DE, Meininger GA, Vatner SF.(PubMed)
(3) Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta by Lim KM1, Kwon JH, Kim K, Noh JY, Kang S, Park JM, Lee MY, Bae ON, Chung JH.(PubMed)
(4) Diet quality and adherence to a healthy diet in Japanese male workers with untreated hypertension by Kanauchi M1, Kanauchi K(PubMed)
(5) Fruit and vegetable consumption and the risk of hypertension determined by self measurement of blood pressure at home: the Ohasama study by Utsugi MT1, Ohkubo T, Kikuya M, Kurimoto A, Sato RI, Suzuki K, Metoki H, Hara A, Tsubono Y, Imai(PubMed)