Friday, 22 March 2019

Bilberry Protects the Nerve System against Neurotoxicity

By Kyle J. Norton


Neurotoxicity refers to the destruction of nerve tissue caused by toxins that have entered central and/or peripheral nervous system.

In other words, neurotoxicity is a result of any substance including a biological, chemical, or physical agent that causes an adverse effect on the nerve system.

Central nerve system comprised the brain and spinal cord is the complex of nerve tissues that control the activities of the body through the message transmitted by the neurons.

Most common causes of neurotoxicity are exposure to natural or man-made toxic substances, including drug, and medication. Long-term exposure to those toxins has been found to alter the activity of the nervous system.

Most common symptoms of neurotoxicity are a headache, altered sensation, tingling and numbness in the limbs.

In severe cases, neurotoxicity can induce vission loss, loss of memory and cognitive function and change behavior, psychological problems and sexual dysfunction.

Therefore, if you are taking medication and experience some of the aforementioned symptoms, please check with your doctor to rule out the possibility of a medication overdose.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers with an aim to discover a natural compound which protects the neurons damage induced neurotransmitter dopamine (DA) by a neurotoxic metabolite, 6-hydroxy DA, through increased expression of ROS examined the effects the antioxidant activities of anthocyanin-rich preparations of Vaccinium species (Vaccinium myrtillus, Vaccinium corymbosum, and Vaccinium oxycoccus).

V. myrtillus preparation: 50% inhibition with 7 microM of total anthocyanins were the most potent inhibition of oxidation and 1.5-4 times higher than that for the other preparations or for the purified anthocyanin.

According to the components analysis, antioxidant activity in the assay correlated strongly with the Vaccinium content of anthocyanins and total cyanidins, but not quercetin or myricetin.

Based in the findings, researchers wrote in the final report, "The results provide evidence for the high potency of anthocyanins towards a potentially neurotoxic reaction, and provide a basis for in vivo testing of these flavonoids and their physiological metabolites in the context of neuro- and mitochondrial-protective effects".


In order to reveal more information about bilberry anti neurotoxic activity, researchers once against evaluated the Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) protection of retinal ganglion cells (RGCs) against neurotoxicity in the induction of retinal damage. 

The vitro study included RGC cultures (RGC-5, a rat ganglion cell-line transformed using E1A virus) and cell damage and radical activation induced by 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1, a peroxynitrite donor).

The vivo study included mice induced retinal damage by N-methyl-D-aspartic acid (NMDA)-

According to the assays, VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and radical activation in RGC-5 in vitro and in mouse forebrain homogenates.
VMA inhibited lipid peroxidation in concentration-dependent manner.

Furthermore, intravitreously injected VMA significantly inhibited the NMDA-induced morphological retinal damage and increased TUNEL-positive cells in the ganglion cell layer.

Where terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) is a method for detecting DNA fragmentation of DNA breaks generated during apoptosis.

The results suggested VMA and its bioactive comapound anthocyanidins process neuroprotective effects in vitro and in vivo models of retinal diseases.

Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a function remedy for the prevention and treatment against neurotoxicity, pending to the validation of larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity by Yao Y1, Vieira A. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. (PubMed)

Bioactive Plantbased Betanin Protects the Liver Against Injury Naturally

By Kyle J. Norton


Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.

Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of injury may be necessary.

Most cases of liver injury can lead to abdominal pain and tenderness caused by bleeding blood in the abdomen that irritates the abdominal tissue. 

The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.

According to the statistics, liver injury has been found constituting 5% of all traumas, making it the most common abdominal injury.

Liver injury can be classified by the liver injury scale, depending on the area of the damage
* Grade I <10% surface area < 1 cm in depth 
* Grade II 10–50% surface area 1–3 cm 
* Grade III >50% or >10 cm >3 cm 
* Grade IV 25–75% of a hepatic lobe \
* Grade V >75% of a hepatic lobe 
and grade VI Hepatic avulsion

In other words, based on the grade of liver injury, patients either treated with nonoperative management and observation for a full self-recovery or surgery.

Betanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a natural compound for the protection of liver against injury researchers examined protective effect of betanin against liver injury induced by carbon tetrachloride (CCl4) in common carp (Cyprinus carpio L.).

The study included fish treated with 1, 2, and 4 % betanin in fodder throughout the experiment for 20 days followed by intraperitoneally injected with 20 % (v/v in peanut oil) carbon tetrachloride (CCl4) at a volume of 0.5 mL/kg body weight.

Where carbon tetrachloride (CCl4)  is a highly toxic liquid chemical.

Injection of CCL4, after 3 days showed liver histological damages accompanied by the induced liver CYP2E1 activity associated with some degrees of steatosis and increased serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT), the indication of oxidative stress.

Furthermore, CCL4 also induced liver damage expressed by the depletion of glycogen storage.

Compared with the CCl4 control group, the betanin-treated groups reduced CYP2E1 expression, decreased malondialdehyde level, increased liver antioxidative capacity observed by the increased glutathione level and superoxide dismutase and catalase activities.

Moreover, the betanin-treated groups also increased liver glycogen storage, and reduced serum AST/ALT activities, with significant differences in the 2 and 4 % treatment groups.

These results suggested betanin processes liver protective effects against liver injury by restoring some levels of liver function through its antioxidant activity.

Dr. Han J, the lead scientist wrote in the final report, " betanin attenuates CCl4-induced liver damage in common carp. Moreover, the inhibition of CYP2E1 activity and oxidative stress may have significant roles in the protective effect of betanin".

Taken altogether, betanin may be considered supplements for the treatment of liver injury, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin attenuates carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio L.) by Han J1, Gao C, Yang S, Wang J, Tan D. (PubMed)
(2) Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying/antioxidant enzymes in human liver cell lines by Krajka-Kuźniak V1, Paluszczak J, Szaefer H, Baer-Dubowska W. (PubMed)

Phytochemical 3,3'-Diindolylmethane Prevents the Onset of Hypoxia

By Kyle J. Norton


Hypoxia is a condition of deficiency in the amount of oxygen reaching the tissues, leading to permanent damage to the brain, liver, and other organs.

Most common symptoms of hypoxia include fast heart rate, rapid breathing, shortness of breath, slow heart rate and sweating.

Hypoxemia is a condition of the abnormally low level of oxygen in the blood.

There are many risk factors associated with the onset of hypoxemia, including reduced oxygen levels on the high altitude, damage of the lung that affects the breathing and exhaling function.

People with lung and heart disease such as asthma, poor blood circulation, and anemia are at a higher risk of hypoxemia.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

In the searching a potential compoundagainstt the onset of hypoxia, researchers examined the neuroprotective potential of 3,3'-diindolylmethane (DIM) in cellular and animal models of Parkinson's disease and lipopolysaccharide-induced inflammation.

In hypoxia-induced damage in mouse hippocampal cells in primary cultures, the 18 h of hypoxia-induced apoptotic processes in terms of the mitochondrial membrane potential, associated with the process of energy storage during oxidative phosphorylation. activation of a protein associated with cell death induced by fragmentation of cell nuclei.

Injection the DIM significantly demonstrated strong neuroprotective and anti-apoptotic actions in hippocampal cells exposed to hypoxia through decreasing the expression genes (Ahr and Arnt) involved the regulation of inflammatory signaling pathways and increasing the gene (Erβ) expression involved suppressing the inflammatory responses.

Futhermore, DIM decreased the expression of AhR-regulated CYP1A1 in stimulating the inflammatory response.

The results strongly suggested impairment of protein expression of AhR and ARNT, but not ERβ plays a key role in the neuroprotective action of DIM against hypoxia-induced cell damage.

Where aryl hydrocarbon receptor nuclear translocator (ARNT) is a component of the DNA binding form of the Ah receptor required for receptor function.

And aryl hydrocarbon receptor (AhR) is protein associated with the regulation of genes expression.

In other words, the mutation of genes aryl hydrocarbon receptor (AhR) or aryl hydrocarbon receptor nuclear translocator (ARNT) are the culprits in the induction of neuro oxygen deficiency.

Based on the findings, researchers wrote in the final report, "This study may have implication for identifying new agents that could protect neurons against hypoxia by targeting AhR/ARNT signaling".

Furthermore, in hypoxia induces oxidative damage in retinal pigment epithelial cells (RPE cells) by cobalt chloride (CoCl2, 200 µM) and/or DIM (10 and 20 µM). DIM significantly attenuated the CoCl2-induced expression of a protein (VEGF) associated with the formation of blood vessels in the ARPE-19 cells compared to the lower levels under normal condition.

Similar to those of the aforementioned characteristics, DIM deactivated the genes which play an integral role in the body's response to low oxygen concentrations (HIF-1α) and pro-apoptosis (NF-κB, p38 MAPK) induced by CoCl2.

DIM also inhibited the induction of hypoxia by CoCl2 through the inhibition of oxidative stress detected by fluorescence microplate assay.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention of hypoxia, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Selective Aryl Hydrocarbon Receptor Modulator 3,3'-Diindolylmethane Impairs AhR and ARNT Signaling and Protects Mouse Neuronal Cells Against Hypoxia by Rzemieniec J1, Litwa E1, Wnuk A1, Lason W1, Krzeptowski W2, Kajta M. (PubMed)
(2) 3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1α and NF-κB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions by Park H1, Lee DS2, Yim MJ2, Choi YH3, Park S4, Seo SK4, Choi JS5, Jang WH6, Yea SS6, Park WS7, Lee CM8, Jung WK9, Choi IW. (PubMed)

Herbal Turmeric Protects Your Vision Against Eye Diseases

By Kyle J. Norton


Eye diseases are the condition characterized by the change of vision, including a gradual loss of cells in the retina and neurons associated with the loss of vision.

Most eye diseases at the early stage are asymptomatic and painless with no change in the vision until the disease has become quite advanced.

People have an eye problem at one time and another. Most eye conditions are minor and go away sometimes without even noticing.

Most common causes of eye diseases are inflammation as a result of microbial infection, including bacterial, viral, parasitic or fungal infection, eye structure damage due to physical impact, genetic preposition due to mutation of certain associated with the vision, medical conditions such as diabetes and allergens.

In elderly, eye diseases are caused by optic nerve damage and visual field loss, hormone change, aging induce loss of flexible of eye small blood vessels and eye muscles due to aging,.... including age-related macular degeneration, glaucoma, cataract.

According to statistics, approximately one person in three has some form of vision-reducing eye disease by the age of 65 in the US. Age-related macular degeneration (AMD), glaucoma, cataract are the most prevalent eye disease found in the elderly.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural whole food or supplement for the treatment of eye disease, researchers examined curcumin, the major curcuminoid of the turmeric, used in many countries since ancient time for preventing and/or treating major anterior segment eye diseases.

In vitro and in vivo, curcumin showed beneficial effects on major anterior segment eye diseases, including the anti-angiogenesis effect in corneal diseases; anti-inflammation or anti-allergy effects in dry eye disease, conjunctivitis.

Injection of curcumin protected the eye against the attacks of free radicals and degradation in cataracts and neuroprotective effects in glaucoma.

In vitro, a novel nanocarrier formulation comprising Pluronic-F127 stabilized D-α-Tocopherol polyethylene glycol 1000 succinate nanoparticles, used to solubilize high concentrations (4.3 mg/mL) of curcumin exerted a significantly protect against cobalt chloride induced hypoxia and glutamate-induced toxicity on the retinal cell line (R28).

In vivo, the novel nanocarrier formulation protects the eye against models of ocular hypertension (OHT) and partial optic nerve transection (pONT).

The findings strongly support the notion of curcumin and curcumin combined with other supplements extensively used in many countries since ancient time for preventing and/or treating a multitude of diseases including eye disease.


Also, the topical application of CN twice-daily for three weeks significantly reduced retinal ganglion cell loss compared to controls.

Dr, the lead scientist said, "Our novel topical CN formulation has potential as an effective neuroprotective therapy in glaucoma and other eye diseases with neuronal pathology".

Taken altogether, turmeric may be considered a supplement for the prevention and combined with primary medicine for the treatment of eye disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin, A Potential Therapeutic Candidate for Anterior Segment EyeDiseases: A Review by Liu XF1, Hao JL1, Xie T2, Mukhtar NJ1, Zhang W3, Malik TH4, Lu CW1, Zhou DD. (PubMed)
(2) Topical Curcumin Nanocarriers are Neuroprotective in Eye Disease by Davis BM1, Pahlitzsch M1, Guo L1, Balendra S1, Shah P1, Ravindran N1, Malaguarnera G1, Sisa C1, Shamsher E1, Hamze H1, Noor A1, Sornsute A2, Somavarapu S2, Cordeiro MF. (PubMed)

Thursday, 21 March 2019

Curcumin, the Bioactive Compound of Turmeric Protects the Blood Vessels Against Cardiovascular Disease

By Kyle J. Norton


Cardiovascular disease (CVD) refers to any conditions caused by the underlying damage of blood vessels and the heart.

In other words, depending on the location of the blockage or disruption, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack) or stroke.

According to the statistics provided by the American Heart Association, approximately 84 million people in this US suffer from some form of cardiovascular disease, leading to the death of about 2,200 people a day.

The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight and smoking.

Epidemiological studies suggested that most people with CVD are also associated with atherosclerosis, a condition caused by long-term plaque buildup on artery walls, which can narrow the arteries and reduce blood flow through your arteries to the heart.

Some researchers suggested the promotion of the Western diet over the past few decades may have a strong implication on the rise of CVD.

Dr. Mirmiran P, the lead scientist, in the examination of the diet pattern and the risk of CVD in Iran, said, "During a mean 4.7 ± 1.4 years of follow-up, 57 participants experienced CVD-related events. In the fully adjusted model, we observed an increased risk of CVD-related events in the highest compared to the lowest tertile category of Western dietary pattern score (HR = 2.07, 95% CI = 1.03-4.18, P for trend = 0.01)".

And "the Western dietary pattern, characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks, is a dietary risk factor for CVD in the Iranian population".

The results strongly indicated the increased risk of CVD in people who follow the Western diet pattern.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a potential compound for the treatment of cardiovascular disease (CVD) associated with the largest mortality worldwide, scientists examined the cardiovascular protective properties of curcumin in CVDs.

According to the review, curcumin showed significant activity against the onset of CVDs, including cardiac hypertrophy, heart failure, drug-induced cardiotoxicity, myocardial infarction, atherosclerosis, abdominal aortic aneurysm, stroke, and diabetic cardiovascular complications.

In dyslipidemia, an important and common cardiovascular risk factor in the general population, researchers assessed the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD), through searching the database of medical literature.

The comprehensive literature search conducted on PubMed, Embase, Ovid, Medline and Cochrane Library databases were to identify randomized controlled trials (published as of November 2016).

Based on the results of 7 eligible studies (649 patients) satisfied the guideline and criteria, researchers found that
* Turmeric and curcumin significantly reduced serum low-density lipoprotein cholesterol (LDL-C) levels as compared to those in the control group.

* Turmeric and curcumin also were effective in lowering serum total cholesterol (TC), levels in patients with metabolic syndrome.

* Turmeric extract have a greater effect on reducing serum TC levels compared to curcumin.

* Both turmeric and curcumin did not improve the serum high-density lipoprotein cholesterol (HDL-C).

* More importantly, turmeric and curcumin are safe, and no serious adverse events were reported in any of the included studies.

Dr. Qin S, the lead researcher wrote, "Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs".

Taken altogether, turmeric and its bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiovascular disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of curcumin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin, the golden spice in treating cardiovascular diseases by Li H1, Sureda A2, Devkota HP3, Pittalà V4, Barreca D5, Silva AS6, Tewari D7, Xu S8, Nabavi SM. (PubMed)
(2) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials by Qin S1, Huang L1, Gong J1,2, Shen S1,2, Huang J1,2, Ren H2, Hu H. (PubMed)
(3) Western dietary pattern increases risk of cardiovascular disease in Iranian adults: a prospective population-based study by Mirmiran P1, Bahadoran Z2, Vakili AZ3, Azizi F. (PubMed)

Herbal Artichoke, the Best Hepatoprotecitve Functional Remedy, According to Studies

By Kyle J. Norton


The hepatoprotective or liver protective effect is an action that maintains the liver healthy functioning against any harmful toxins.

The liver is the largest internal organ in the human body and the only organ which can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood come from the digestive tract, before passing it to the rest of the body.

Furthermore, the liver also processes a function of detoxifying chemicals and metabolizes drugs.

Symptoms of liver diseases include jaundice, abdominal pain, and swelling,  swelling in the legs and ankles,  itchy skin,  dark urine, and pale stool color, and tendency to bruise easily.

If you experience some of the above symptoms, please make sure that you check with your doctor to rule out the possibility of liver diseases.

Most cases of liver disease are associated with hepatitis viral infection and autoimmune diseases. However, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.

Dr. Suthat Liangpunsakul, the lead scientist, in the comparison of alcoholic disease in different regions wrote, "Alcoholic liver diseases (ALD) comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis".

And, " Inter-individual differences in susceptibility to the toxic effects of alcohol have been extensively studied—they include a pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. ALD is becoming more common in many parts of Asia but is decreasing in Western Europe".

The results clearly and strongly suggested that reducing intake alcohol and following a healthy diet pattern is the best way to decrease the risk of liver diseases, including the ALD.



Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detox agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.


Scientists on finding a natural ingredient which processes liver protective effect evaluated the preventive effects of ethanolic extract from artichoke against acute alcohol-induced liver injury in mice.

Selected male mice were treated with an ethanolic extract of artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily before administrated up to 40% alcohol (12 mL/kg body weight) orally 1 h after artichoke treatment for 10 consecutive days.

Injection of artichoke extract not only significantly prevented elevated levels of aspartate aminotransferase, alanine aminotransferase, the liver oxidative stress markers but also reduced the levels of triglyceride, total cholesterol.

Artichoke treatment mice also restored the levels of antioxidant enzymes which were reduced by the injection of alcohol.

According to the immunohistochemical analysis, artichoke also suppressed the levels of toll-like receptor (TLR) 4 which plays a critical role in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines and protein, nuclear factor-kappa B (NF-κB) associated with liver cells apoptosis in liver tissues.

The results indicated a liver protective activity in artichoke was attributed to the inhibition of the proinflammatory proteins in acute alcohol-induced liver injury mice.

In order to reveal more information about the liver protective effect of artichoke, researchers examined the herbal medicine against liver fibrosis, the main pathology of schistosomiasis and its complications are the major cause of death in infected cases.

Mice selected to the study infected with Schistosoma mansoni (S. mansoni) were divided into 5 groups. The first three groups were given artichoke leaf extract (ALE), ALE + praziquantel (PZQ) and PZQ respectively. The 4th was a positive control and the 5th was the negative control group.and were compared to PZQ.

Injection of ALE and ALE + praziquantel (PZQ) caused significant reduction of granuloma diameter, improvement of liver functions and liver fibrosis.

Furthermore, ALE induced statistically significant changes in hepatic stellate cells (HSCs) distribution.

Moreover, ALE also reduced granuloma size by increasing HSCs recruitment inside granuloma and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue.

Unfortunately, although, the herbal extract exerted a strong liver protective activity, it but failed to treat S. mansoni infection.

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver disease, pending to the confirmation of large sample size and multicenter human study.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Liver protective effects
(1) Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice by Tang X1, Wei R2, Deng A3, Lei T. (PubMed)
(2) Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment by Sharaf El-Deen SA1, Brakat RM2, Mohamed ASED. (PubMed)
(3) [Artichoke--untapped potential of herbal medicine in the treatment of atherosclerosis and liver diseases].[Article in Polish] by Horoszkiewicz M1, Kulza M, Malinowska K, Woźniak A, Seńczuk-Przybyłowska M, Wachowiak A, Florek E.(PubMed)
(4) Alcoholic Liver Disease in Asia, Europe, and North America by Suthat Liangpunsakul, Paul Haber, and Geoff McCaughan. (PMC)

Honey Protects the Bone Mass with No Side Effect, According to Studies

By Kyle J. Norton


Bone is a hard whitish tissue making up the skeleton in humans which provides a framework for the attachment of muscles and other tissues.

Bone density is the amount of bone mineral in bone tissue. Loss of bone density is found to induce osteoporosis.

Bone density is measured by the young adult bone density mean within 1 standard deviation (+1 or −1). The negative T-score is an indication of loss or lower bone density and the T-score of −2.5 or lower is an indication of osteoporosis.

Risk factors of losing bone density include gender, (women are more likely to develop osteoporosis compared to men) the increase in age, race, (African Americans have both lower rates of bone density loss and osteoporosis), family history.

People with low bone mass accompanied by progressive bone density loss over time are associated with an increased risk of developing osteoporosis.

Low bone mass is a risk factor of osteoporosis, The condition may also increase the incidence of bone fracture if it is accompanied by other risk factors.

Some researchers suggested that people who follow a healthy diet pattern are less likely to develop osteoporosis.

Dr. Małgorzata Kostecka in the examination of the role of a healthy diet in the prevention of osteoporosis in perimenopausal period, wrote, "Diet of a large part of society is not properly balanced which can cause abnormalities in achieving proper bone mineralization. Long-term deficiencies in calcium and vitamin D in daily diet are the cause of taking dietary supplements".

And, "Changes in the nutritional regimen are required already during childhood because nutritional mistakes are the main cause of diet-related diseases in adulthood".

The results indicated a link to an unhealthy diet in the risk of osteoporosis.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a natural remedy for the protection of bone structure investigated the honey effects on the cessation of exercise on bone properties in young female rats.

The experiment included a total of eighty four 12-week-old Sprague-Dawley female rats randomly divided into 7 groups: 16S, 16J, 16H, 16JH, 8J8S, 8H8S, and 8JH8S (8 = 8 weeks, 16 = 16 weeks, S = sedentary without honey supplementation, H = honey supplementation, and J = jumping exercise). 

Jumping exercise consisted of 40 jumps/day for 5 days/week and honey was given to the rats at a dosage of 1 g/kg body weight/rat/day via force feeding for 7 days/week.

After 8 weeks of cessation of exercise, honey supplementation groups (8JH) showed higher tibial energy, proximal total bone density, a midshaft cortical moment of inertia, and cortical area, compared to 16S. 

Continuous sixteen weeks of combined jumping and honey group (16JH) exerted a significant greater tibial maximum force, energy, proximal total bone density, proximal trabecular bone density, midshaft cortical bone density, cortical area, and midshaft cortical moment of inertia, compared to 16S.

Dr. Tavafzadeh SS, the lead scientist said, "the beneficial effects of 8 weeks of combined exercise and honey supplementation still can be observed after 8 weeks of the cessation and exercise and supplementation".

In other words, these comparative results suggested that long term combined exercise and honey supplementation may have a long term effect on the bone structure, even after the cessation of exercise and honey supplementation.

In order to reveal more information about honey effects on bone structure, researchers examined the jumping exercise intensities combined with honey on bone and gonadotrophins in an animal model.

The experimental groups selected to the study were required to exercise 20 or 80 jumps per day combined with or without honey supplementation (HJ20, HJ80, J20, and J80), Oher groups selected to the study also included honey supplementation (H), sedentary without supplementation control (C), and baseline control (C0) groups.

HJ80 showed the greatest beneficial effects on tibial and femoral mass, serum total calcium and alkaline phosphatase concentrations, compared to the lower levels of serum follicle stimulating hormone concentrations in H, J20, J80, particularly in the C group.

Furthermore, the serum luteinizing hormone concentrations were significantly (p < 0.05) greater in HJ20, HJ80 and J20 compared to J80.

The surprising result indicated moderate jumping exercise combined with honey supplementation may have a better effect compared to high-intensity exercise + honey supplement on bone mass and density.

Moreover, honey may have protection against the adverse effects induced by jumping exercise on gonadotropins in female rats.

Taken altogether, honey may be considered a functional remedy for the protection of bone mass regardless of the types of exercise, pending to the confirmation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bone Mechanical Properties and Mineral Density in Response to Cessation of Jumping Exercise and Honey Supplementation in Young Female Rats by Tavafzadeh SS1, Ooi FK1, Chen CK1, Sulaiman SA2, Hung LK. (PubMed)
(2) Effects of honey supplementation combined with different jumping exercise intensities on bone mass, serum bone metabolism markers and gonadotropins in female rats by Mosavat M, Ooi FK1, Mohamed M. (PubMed)
(3) The role of healthy diet in the prevention of osteoporosis in perimenopausal period by Małgorzata Kostecka. (PMC)