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Thursday, 30 January 2014

Cruciferous vegetables and Cancer prevention

Cruciferous vegetables are the group of  vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

Nutrients and chemical constituents
1. Carbohydrates
2. Sugars
3. Dietary fiber
4. Omega 3 fatty acid
5. Protein
6. Beta-carotene
7. Lutein and
8. Zeaxanthin
9. Thiamine (Vitamin B1)
10. Riboflavin (Vitamin B2)
11. Niacin (Vitamin B3)
12. Pantothenic acid (B5)
13. Vitamin B6
14. Folate (Vit. B9)
15. Vitamin C
16. Calcium
17. Tryptophan
18. Iron
19. Magnesium
20. Phosphorus
21.Potassium
22. Zinc
23. Etc.
Its chemical constutuents include  glucosinolates, dithiolthiones, indoles , glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc..

The benefits
Consumption of Cruciferous vegetables is known for its interaction with with detoxification enzymes in reducing the risk of cancer. sulforaphane (SF) derived from isothiocyanates, a major phytochemical found in broccoli  is associated to the tissue uptake level of SF in the body organ with increased levels of glutathione S-transferases (GSTs)  and NQO1(member of the NAD(P)H dehydrogenase (quinone) family) genes varied by 3- to 6-fold among the organs of SF-treated rats. The chemopreventive properties of  sulforaphane and its effect on cancer stem cells (CSCs) may be another source for initiating and maintaining cancer, as  sulforaphane may target CSCs in different types of cancer through modulation of some pathways.


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The Side effects1. People who has over production of IgM immunoglobulins which makes blood thicken should talk to their doctor before taking high amount of broccoli.
2. Allergic reaction??
3. Etc.

References
(1) Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention by Veeranki OL, Bhattacharya A, Marshall JR, Zhang Y.(PubMed)
(2) Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts by Li Y, Zhang T.(PubMed)