Saturday, 25 January 2014

Herbal Cascara Sagrada (Rhamnus purshiana) and type 2 diabetes

Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.,
Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
The Ingredients
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.

The benefits
Emodin, a natural component of Cascara Sagrada, beside stimulates  AMP-activated kinase (AMPK) activity in skeletal muscle and liver cells, but is found to be effective in treating insulin sensitivity by regulating the glucose homeostasis, by AMPK activation of that the component may represent a novel therapeutic principle in the treatment of type 2 diabetic models. The Tsinghua University and Shanghai Institute of Materia Medica in the study of emodin also support the use of emodin in treating diabetes and metabolic syndrome

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(1) Emodin regulates glucose utilization by activating AMP-activated protein kinase by Song P, Kim JH, Ghim J, Yoon JH, Lee A, Kwon Y, Hyun H, Moon HY, Choi HS, Berggren PO, Suh PG, Ryu SH.(PubMed)
(2) Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARĪ³-agonist activity by Chen Z, Zhang L, Yi J, Yang Z, Zhang Z, Li Z.(PubMed)
(3) Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice by Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y.(PubMed)