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Thursday, 30 January 2014
Herbal Cascara Sagrada (Rhamnus purshiana) and Prostate cancer
Cascara sagrada is a species of
buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to
western North America, it's bark has been used in traditional medicine
for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
Prostate cancer is defined as a
condition in which the cells of prostate has become cancerous, causing
abnormal cell growth which spread to the distant parts of the body.
Most prostate cancers are slow growing and enlarged prostate and
prostate cancer may be detected during the Physical (rectum) exams
The chemical constituents of Cascara Sagrada
include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A,
B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones
palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Aloe-emodin, a chemical constituent in
Cascara Sagrada is found to inhibit both proliferation and
anchorage-independent growth of PC3 cells by targeting mTORC2. Other
major compound of emodin, Cascara Sagrada in the study of its effective
on prostate and lung cancers, showed to inhibit proliferation, induce
apoptosis, suppress angiogenesis, impede metastasis, and enhance
chemotherapy as a novel blocker of CXCR4 expression.
(1) Aloe-emodin suppresses prostate
cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW,
Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(2) Emodin inhibits invasion and migration of prostate
and lung cancer cells by downregulating the expression of chemokine
receptor CXCR4 by Ok S, Kim SM, Kim C, Nam D, Shim BS, Kim SH, Ahn KS,
Choi SH, Ahn KS.(PubMed)