Scientists may have discovered a bioactive compound isolated from horseradish for the prevention and treatment of liver cancer, according to the studies.
Liver cancer is a medical condition caused by irregular cell growth in the liver. Most cases of primary liver cancer start in the cells on the surface of the inner lining of the liver. At the early stage of liver cancer, the patient may not experience any symptoms.
However, at the later stage, the overgrowth of tumor in the liver may suppress the nearby tissue and nerve cells, leading to localized symptoms and severe pain.
According to the world standard statistics, the onset of liver cancer rate is 10.1 per 100,000 people (15.3 in males and 5.3 in females).
The highest mortality rates occurred observed in the East Asian countries probably due to the high incidence of hepatitis virus.
The world standardized mortality rate for liver cancer is 9.5 per 100,000 people (14.3 in males and 5.1 in females).
Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
With an aim to find a natural compound for the prevention and treatment of liver cancer, researchers looked into Allyl isothiocyanate (AITC), a bioactive ingredient and N-acetylcysteine (NAC) conjugate anti-liver cancer effects through the SK-Hep1 cells line.
At 0.1-5 microM, AITC inhibited a significant MMP-2/-9 expression in SK-Hep1 cells compared with controls associated with the decrease of MMP-2/-9 messenger RNA levels.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Allyl isothiocyanate influences cell adhesion, migration and metalloproteinase gene expression in SK-Hep1 cells by Hwang ES1, Kim GH. (PubMed)
(2) Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells by Hwang ES1, Lee HJ. (PubMed)
(3) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)