Thursday, 23 January 2014

Phytochemicals Phytic acid and Prostate cancers

Phytic acid (Inositol hexaphosphate) are phytichemicasl of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
The health benefits
In prostate cancer, inositol hexaphosphate (IP6) expressed its anti cancer effect in inhibiting the cells proliferation and induced apoptosis through targeting the PI3K, a family of enzymes involved in cellular functions and  in multiple cellular processes pathway. Other in the study of the same found that Inositol hexaphosphate (IP6) inhibited both growth and proliferation and decreased cell viability of human prostate carcinoma PC-3 cells through certain pathways, including aberrant EGF receptor (EGFR) or IGF-1 receptor (IGF-1R) pathway in downregulation of growth promoting and survival signaling cascades in advanced and androgen-independent human PCa PC-3 cells.
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(1) Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target by Gu M, Roy S, Raina K, Agarwal C, Agarwal R.(PubMed)
(2) Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells. by Gu M, Raina K, Agarwal C, Agarwal R.(PubMed)