Tuesday, 31 July 2018

* Aloe Vera, The Herb and Plant That Inhibits Polycystic Ovarian Syndrome (PCOs)

By Kyle J. Norton

Scientists from some respectable institutes suggested that aloe vera may have a potential and profound effect in reduced symptoms, risk and treatment of polycystic ovarian syndrome(PCOs).

Polycystic Ovarian Syndrome is a condition characterized by endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women[1].

According to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21)[1].

Women with PCOs may experience some of the symptoms of irregular, oligomenorrhea or absent menstrual periods, male pattern hair growth, acne, weight gain, obstructive sleep apnea, closure of the upper airway, causing stop breathing while sleeping, difficult to conceive, anxiety, emotional disturbance, poor quality of life, menstrual cycle disturbances, depression, autonomic dysfunction, problematic eating and general psychosocial dysfunction.

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan.

The herb is most commercial cultivated due to its health benefits.

Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes,...... and elevated of cholesterol, The herb also is one of many popular herb studied in scientific ways with some conflicted results.

According to the study by Desai BN, Maharjan RH, Nampoothiri LP.  70% PCOS women have abnormal serum lipid levels (dyslipidemia) and 50% of these women are obese.

Several classes of pharmacological agents have been used to manage dyslipidemia with serious   adverse effects.

The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

Application aloe vera in Charles Foster female rats induced PCOs by oral administration of non-steroidal aromatase inhibitor letrozole (0.5 mg/kg body weight, 21 days) exerts  a significant reductions of plasma triglyceride and LDL cholesterol levels, and increase of HDL cholesterol by restoring the ovarian steroid status.

 The Aloe vera gel treatment also caused reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities.

Other study also indicated that Aloe vera gel formulation exerts a protective effect in against the PCOS phenotype by altering key steroidogenic activity. These results are attributed to phyto-components in the gel.


Dr.Pérez YY and the research team in the study of Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice, said,  " the polyphenol-rich extract from Aloe vera. decrease significantly both body weight (p < 0.008) and blood glucose levels, calculated using the homeostasis model assessment for insulin resistance (HOMA-IR)".

Also in the confirmation of above result, the study of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models, vera leaf pulp extract suggested hypoglycaemic activity on IDDM and NIDDM rats, the effectiveness being enhanced for type II diabetes in comparison with glibenclamide.

Taken together, aloe vera can be used as secondary and therapeutic treatment in ameliorated all aspects of symptom, progression and treatment of  polycystic ovarian syndrome.

 However, further data collection performed with human consumption during the course of the investigation are necessary to complete the picture of Aloe Vera, protective effect against polycystic ovarian syndrome (PCOs) possibilities.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Sources
[1]. The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Symptoms(Revised edition with Citations) by Kyle J. Norton
[2] Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model by Desai BN, Maharjan RH, Nampoothiri LP.(PubMed)
[3] Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model by Maharjan R, Nagar PS, Nampoothiri L.(PubMed)
[4].  Drug-induced lupus: an update by Vasoo S.(PubMed)

Monday, 30 July 2018

* Contrary to Popular Belief, Coffee, The Beverage That Reduces Risk of Kidney Stones


By Kyle J. Norton


Food therapy is a model of diet, using foods as a form of medicine for healing purposes by centered on concepts of food that contains ingredients for treatment of diseases if eating in moderation.

However, the concept may be best  practice in diseases prevention. In treatment of ailments, food theory takes longer to ease symptoms, depending to stages of the treatment that directly address to the cause of disease.

Kidney stones is a composed of mineral salts formed in the kidneys.

The single cause of kidney stone is debatable. However, some researchers suggested that dehydration, food restriction, Rotavirus infection, over intake of calcium and supplements, ,,, and high fat intake are associated to increased risk of forming of kidney stone(4).

According to statistic, kidney stones effect over 10% of world population.

Men account for the 80% of those with kidney stones and are at risk of the forming between 30 and 40 years of age. 

About 75% of kidney stones are calcium stones.

Symptoms of kidney stone include excruciating intermittent pain, usually in the flank (the area between the ribs and hip), that spreads across the abdomen, often to the genital area and inner thigh. 

The pain tends to come in waves, gradually increasing to a peak intensity, then fading, over about 20 to 60 minutes. 

The pain may radiate down the abdomen toward the groin or testis or vulva(4).

If you experience the above symptoms, you may have kidney stones please see your doctor as soon as possible.

Epidemiological studies linking coffee and caffeine intake in risk of kidney stone formation are totally depended to daily amount of consumption.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the Warsaw Agricultural University, coffee and tea consumed daily and regularly expressed an increased risk of kidney stone by more than 80% in compared to risk of other factors, probably due to presence of oxalates if the amount of intake is over 240-ml (8-oz) daily.

In fact, in the analyzed nutritional habits of 22 stone formers with special regard to oxalate content as one of the main nutritional lithogenic factors associated with kidney stones, researchers found that risk of kidney stone increased substantially for men and women if dietary oxalate intake was over 354 mg and 406 mg, respectively.

In a total of 217,883 participants; over a median follow-up of >8 y, 4982 incident cases of kidney stone occurred studies, researchers files the following results.
1. The highest quintile of caffeine intake (95% CI: 12%, 38%) showed a significant reduced risk of developing stones by 26%, according to the Health Professionals Follow-Up Study (HPFS).
2. Caffeine inkate showed a 29 % lower risk in the NHS I cohort, and
3. and 31% lower risk in the NHS II cohort

Dr. the lead author said. "Among 6033 participants with 24-h urine data, the intake of caffeine was associated with higher urine volume, calcium, and potassium and with lower urine oxalate and supersaturation for calcium oxalate and uric acid".

Furthermore, a prospective study in investigated relation between intake of 21 different beverages and risk of symptomatic kidney stones in a cohort of 45,289 men, 40-75 years of age conducted by the Harvard School of Public Health, suggested that the risk of stone formation decreased by 10%. of the amount for each 240-ml (8-oz) serving consumed daily in caffeinated coffee.

Taking altogether, the findings demonstrated a significant effects of  caffeinated coffee intake of less than or equal to 240-ml (8-oz) in decreased risk of formation of kidney stones.

Due to small example size of above studies, further data collection on large sample size and multi centers clinical studies performed with human consumption during the course of the investigation will be necessary to complete the picture of caffeinated coffee intake of  less than 240-ml (8-oz) in reduced risk of kidney stone possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Tea and coffee as the main sources of oxalate in diets of patients with kidney oxalate stones by Gasińska A1, Gajewska D.(PubMed)
(2) Caffeine intake and the risk of kidney stones by Ferraro PM1, Taylor EN1, Gambaro G1, Curhan GC1.(PubMed)
(3) Prospective study of beverage use and the risk of kidney stones by Curhan GC1, Willett WC, Rimm EB, Spiegelman D, Stampfer MJ.(PubMed)
(4) Kidney stone by Kyle J. Norton

^^^^^Garlic, The Herb and Roots Spice That Gobbles Up Arterial Plaques Before They Can Cause Atherosclerosis


Kyle J. Norton, Master of Nutrition


Recent study suggested that patients with atherosclerosis may be benefits from adding aged garlic extract with supplement into their diet.

Atherosclerosis is a disease with plaque builds up inside the arteries, affecting the levels of oxygen in the blood as well as increasing risks of heart attacks, strokes, and peripheral vascular disease.

Atherosclerosis is a slow, progressive disease that may begin as early as childhood, caused by damage of the inner lining of the artery. However, the actual causes of the condition are  debatable.

Some researchers suggested that atherosclerosis may be caused by long term high blood pressure,
high cholesterol and triglycerides (a type of fat) in the blood. Particularly, in high levels of insulin in the blood from diabetes and in exposure to chemicals from smoking tobacco.

Patients with early stage of atherosclerosis may not experience any symptoms. However, as the disease progress, patients may have the symptoms of chest pain if the blockage occurs in an artery of the heart (coronary artery) and leg cramps during exercise or walking, if the blockage occurs in the legs.

In the advance stage, if atherosclerosis develops in the arteries or the brain, it may cause a heart attack and stroke, respectively. 

Truly, change and diet and life style not only has strong impact in prevent early onset of atherosclerosis but also inhibits progression of the condition. 

Dr.Torres N the lead scientist in the joint study of conducted by the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, said, " In many cases, diet is a major driving force, which is much easier to change and follow than other factors. It is important to establish that the first strategy to treat atherosclerosis is to modify lifestyle habits, focusing on the beneficial properties of specific nutrients" and " epidemiological, clinical and experimental studies have demonstrated that diet plays a central role in the prevention of atherosclerosis. In particular, we include information about fiber, plant sterols and stanols, niacin, taurine, olive oil, omega 3 fatty acids, antioxidants, minerals, methyl nutrients and soy"(5).

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia, used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.

According to the UCLA-School of Medicine, Los Angeles, the effectiveness of garlic in reduced homocysteine and progression of Atherosclerosis is the result of the changing white (wEAT) and brown (bEAT) epicardial adipose tissue(form of visceral fat deposited around the heart) in plaque stabilization.


In a placebo-controlled, double-blind, randomized trial (conducted 2005-2007), with 65 intermediate risk patients (age 60+/-9 years) treated with a capsule containing aged garlic extract (250 mg) plus Vitamin B12 (100 microg), folic acid (300 microg), Vitamin B6 (12.5 mg) and l-arginine (100 mg) daily for a 1 year, researchers found that the application exerts a favorable improvement in oxidative biomarkers, vascular function, and reduced progression of atherosclerosis.

(AGE) retard the progression of coronary calcification in patients with coronary artery disease in vitro and vivo,


Dr. Morihara N, the lead author at the joint study said, " Antiatherosclerotic activity of AGE is at least partly due to the suppression of inflammation and lipid deposition in the vessels during the early stage of atherosclerotic development".

 The experiment of a total of 157 healthy postmenopausal women (age 65 ± 6) randomized study, 500 mg isoflavonoid-rich herbal preparation, including garlic powder, reduced risk of cardiovascular disease and atherosclerosis progression through lowering high blood cholesterol.

Although garlic prevents the development of cholesterol-induced experimental atherosclerosis and possesses the direct anti-atherogenic activity, intake of garlic supplement should be taken with care to patients with ulcer.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis by Ahmadi N1, Nabavi V, Hajsadeghi F, Zeb I, Flores F, Ebrahimi R, Budoff M.(PubMed)
(2) Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial by Budoff MJ1, Ahmadi N, Gul KM, Liu ST, Flores FR, Tiano J, Takasu J, Miller E, Tsimikas S.(PubMed)
(3) Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E-Knockout Mice by Morihara N1, Hino A2, Yamaguchi T3, Suzuki J3.(PubMed)
(4) Anti-atherosclerotic effects of garlic preparation in freeze injury model of atherosclerosis in cholesterol-fed rabbits by Sobenin IA1, Andrianova IV2, Lakunin KY3, Karagodin VP4, Bobryshev YV5, Orekhov AN6.(PubMed)
(5) Nutrition and Atherosclerosis by Torres N1, Guevara-Cruz M1, Velázquez-Villegas LA1, Tovar AR(PubMed)

* How to Restore Your Normal Levels of Testosterone, Suggested By Scientists


Kyle J. Norton, Master of Nutrition

Recent studies conducted by some academic institutes suggested that garlic may have a potential in modified the levels of serum testosterone in the blood, depending over or under expressions.

Sex hormone testosterone plays an essential role on the male reproductive physiology, including the testes, a primary productive organ in production of spermatozoa and reproductive hormones.

Furthermore, the male steroid hormone also processes a specific function in building bone and muscle mass as well as stimulating sexual desire in both sexes.

In women, testosterone is produced by the ovaries in women in small amount. The hormone also produced small quantities by the adrenal glands in both sexes.

Truly,  over expression of testosterone may cause reduced production of antioxidants, such as glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) by natural antioxidant enzymes and increased presence of free radical in the body, that can lead to cytotoxicy and weaken function of immune system.

In other words, abnormal high levels of testosterone in the blood, can alter the balance the ratio of antioxidants and free radicals in the body, leading to free radicals in induction of oxidative stress, a primarily causes of chronic ailments.

Some researchers suggested that over production of testosterone may associate to increase risk of prostate cancer, caused by oxiadtive stress effects in the prostate gland.

On the other hand, under expression of testosterone may induce symptoms of erectile dysfunction, reduced sperm count and sperm quality, decreased libido or sexual activity, infertility, reduced muscle mass...... and increased body fat.

According to the Catholic University of The Sacred Heart, hypogonadism in men also reduced production of natural antioxands that also lead to oxidative stress, in turn related with augmented cardiovascular risk(8).
In immune response, low levels of testosterone may increase immune production of white blood cells that protects the body against infection. However, prolonged period of low levels of testosterone can also lead to long term over production of white blood cells, a leading cause of auto immune diseases.

Garlic may be the next generation of natural testosterone reducer or inducer. Garlic increases production of the hormone when it is low and inhibits excessive testosterone when it is high.

Garlic (Allium sativum) is a species in the onion genus, belongings to family Amaryllidaceae, native to central Asia.

The herb  or food has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure, cholesterol, natural antibiotic, etc.

Dr. Prasad S lead research at the Industrial Toxicology Research Centre, diallyl sulfide (DAS), a constituent of garlic, exerted antioxidant activities against testosterone-induced oxidative stress in male Swiss albino mice, by significantly restored the testosterone-induced antioxidant enzymes and decreased lipid peroxidation.

The effects of garlic supplementation on protein metabolism also suggested that dietary supplementation with 0.8 g/100 g garlic alters hormones associated with protein anabolism by increasing testicular testosterone and decreasing plasma corticosterone in rats fed a high protein diet.

In the concerns of conventional medicine driamycin (ADR), a potent cytotoxic drug that cause many adverse effects on different body organs, researchers at the Faculty of Medicine, Zagazig University conducted an experience to evaluate the effect of aged garlic extract (AGE) when it is used combination with driamycin (ADR).

At the end of the study, researcher found that aged garlic extract (AGE), a garlic preparation, AGE can be used as an adjuvant therapy to resume male infertility and weak spermatogenesis induced by cytotoxic drugs or other environmental toxins through its cytoprotective and antioxidant properties.

In fact, like all natural phytochemiecals, garlic is both testosterone booster and testosterone reducer, depending to the levels of testosterone in the body and amount of garlic intake.

However, use of garlic extracts and supplements should be taken with care, as overdoses may induce liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Protective role of garlic oil against oxidative damage induced by furan exposure from weaning through adulthood in adult rat testis by El-Akabawy G1, El-Sherif NM2.(PubMed)
(2) Chronic crude garlic-feeding modified adult male rat testicular markers: mechanisms of action by Hammami I1, Amara S, Benahmed M, El May MV, Mauduit C.(PubMed)
(3) The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding by Hammami I1, Nahdi A, Mauduit C, Benahmed M, Amri M, Ben Amar A, Zekri S, El May A, El May MV.(PubMed)
(4) Modulatory effects of diallyl sulfide against testosterone- induced oxidative stress in Swiss albino mice by Prasad S1, Kalra N, Shukla Y.(PubMed)
(5) Testosterone and oxidative stress: the oxidation handicap hypothesis by Carlos Alonso-Alvarez,1,* Sophie Bertrand,1 Bruno Faivre,2 Olivier Chastel,3and Gabriele Sorci1,2(The Royal Society Publicizing)
(6) https://www.stronghealthtips.com/garlic
(7) Effects of testosterone on antioxidant systems in male secondary hypogonadism by Mancini A1, Leone E, Festa R, Grande G, Silvestrini A, de Marinis L, Pontecorvi A, Maira G, Littarru GP, Meucci E(PubMed)
(8) The impact of aged garlic extract on adriamycin-induced testicular changes in adult male Wistar rats by Nasr AY(PubMed)

Sunday, 29 July 2018

*****Infectious Diseases: The Anti Fungal Infection Whole Food

Kyle J. Norton, Master of Nutrition


 The finding of whole food medication by renowned scientists all over world to replace the single ingredient of Western medicine with little or no side effect has been difficult due to no commercial benefits and patent right to producers.

Fungal infection is a common diseases  caused by over growth of fungus.
In other words, the immune system that protect the body against micro organisms has been overwhelming by the over growth of fungus.

People with weakened immune system such as cancer treatment, frequent use of antibiotics are associated to increase risk of fungal infection.

Patients with diabetes are also more prone to fungal infections. Fungal infection associated to diabetes include jock itch, athlete's foot,..... and ringworm.

Depending to the locations of infection, patients may experience symptoms of common peeling, cracking, scaling redness, blisters Itching,...... and burning sensation.

In women, signs of yeast infection may include itching and swelling around the vagina. burning sensations or pain during urination or intercourse,........ and unusual vaginal discharge.

In men, signs of yeast infection may include burnding and itching around the head of the penis,
redness and swelling, pain during urination or sex,..... an small, rash-like bumps.  

If you experience some of the signs and symptoms indicated above, you may be infected by yeast. Please check with your doctor as soon as possible.

If you are given topical creams, oral medicine or anti fungal injection, please make sure you understand the common and serious of side effects before applying.

Garbanzo bean(Chickpea) and its bioactive phytochemicals may be considered as anti fungal function food in prevention and treatment of over growth of fungal species, some scientists suggested.

Garbanzo bean also known as chickpea is an edible legume of genus Cicer and the family Fabaceae.

It is one of the earliest cultivated vegetables in mankind, native to Middle East.

The joint study lead by the ICAR-Indian Agricultural Research Institute suggested, chickpea with abundant bioactive compounds may be used along with the relevant antioxidant capacities as anti fungal whole food, through expression of defense related enzymes like l-phenylalanine ammonia lyase, peroxidase and polyphenol oxidase(1).
Phenylalanine ammonia lyase is an enzyme that converts ammonia and trans-cinnamic acid involved properly function of neuro function(7) .

Peroxidase and polyphenol oxidase are antioxidants  that inhibit over expression of free radicals.

According to the study by the All India Institute of Medical Sciences, in the emergence of epidemic fungal pathogenic resistance to current antifungal drugs, C-25 found in Garbanzo beans(Chickpea) not only processes an effective antimycoticity but also antiproliferative agent against human oral cancer cells(2).

In support to the above, chickpea is found to exhibit inhibitory activity against Aspergillus flavus in a study conducted by the South China Normal University(3).

Cicerfuran, 2-(2-methoxy-4,5-methylenedioxyphenyl)-6-hydroxybenzofuran, phytoalexin and cicerfuran showed antimicrobial activity with MICs as low as 25microg/ml against Bacillus subtilis and Pseudomonas syringae, and four species of filamentous fungi, Aspergillus niger, Botrytis cinerea, Cladosporium herbarum and Monilinia aucupariae(4).

Other antioxidant such as Cicerarin(5), Cicerin(6) and arietin(6) may also be considered as
novel chickpea peptides with differently anti fungal potencies.

Taken altogether garbanzo bean(chickpea) may be consideres as functional food for prevention and treatment of fungal infection. People with  high risk of fungal infection may want to add a portion garbanzo bean(chickpea) which processes abundant biobactive compounds  into daily diet for preventive measure.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Development of Mesorhizobium ciceri-Based Biofilms and Analyses of Their Antifungal and Plant Growth Promoting Activity in Chickpea Challenged by Fusarium Wilt. by Das K1, Rajawat MVS1, Saxena AK1,2, Prasanna R1.(PubMed)
(2) Antifungal and antiproliferative protein from Cicer arietinum: a bioactive compound against emerging pathogens by Kumar S1, Kapoor V2, Gill K1, Singh K1, Xess I3, Das SN2, Dey S1(PubMed)
(3) Some 2S albumin from peanut seeds exhibits inhibitory activity against Aspergillus flavus by Duan XH1, Jiang R, Wen YJ, Bin JH.(PubMed)
(4) Antibacterial and antifungal activity of cicerfuran and related 2-arylbenzofurans and stilbenes by Aslam SN1, Stevenson PC, Kokubun T, Hall DR.(PubMed)
(5) Cicerarin, a novel antifungal peptide from the green chickpea byChu KT1, Liu KH, Ng TB.(PubMed)
(6) Cicerin and arietin, novel chickpea peptides with different antifungal potencies by Ye XY1, Ng TB, Rao PF.(PubMed)
(7) Effects of cinnamic acid on memory deficits and brain oxidative stress in streptozotocin-induced diabetic mice by Hemmati AA1, Alboghobeish S2, Ahangarpour A(PubMed).

The Anti-inflammatory Diseases Natural Whole Food and Plant

Kyle J. Norton, Master of Nutrition


The efficacy of botany in the use of plants for treatment and cure diseases with little or no side effects have drawn interest in today conscientious scientists, since the discovery of aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)...

However, the development of synthetic single medicine for treating diseases is not beneficial to patients but profits to the big pharmaceutical companies symptoms.

The use of conventional medicine for the treatment of one disease is found to induce serious side effects in the short term and serious complications in the long-term.

Examples
* Intake of aspirin may facilitate symptoms of black, bloody, or tarry stools; coughing up blood, severe nausea, vomiting,........ and stomach pain. Long-term use of the medicine can cause stroke as a result of  burst blood vessels,.... and gastrointestinal bleeding.

* Administration of quinine can induce serious symptoms of fever, chills, confusion, weakness, sweating; severe vomiting, stomach pain,.... and diarrhea chest pain. And long term intake can induce trouble breathing, severe dizziness, fainting, fast or pounding heartbeats,.... and problems with vision or hearing.

Inflammation is a natural process of immune reaction that protest our body against infection and injure. Over expression of inflammatory substances produced by the immune system may cause the localized physical condition of reddened, swollen, hot, and often painful. However, in some cases, over the presence of pro inflammatory cytokines can induce cytotoxicity that damages  healthy cells and tissue.

According to the free dictionary by Farlex(4), there is a 3 major components that make up the state of acute inflammation, including
* Changes in the caliber of blood vessels and the rate of blood flow through them (hemodynamic changes)
* Increased capillary permeability, and 
* Leukocytic exudation.

And chronic inflammation may be a slow onset but it is characterized by persistent inflammation and lack of clear resolution as the infectious tissues and cells are no longer able to overcome the effects cause by the injuring agents.

Chronic inflammation can eventually cause several diseases and conditions, including some cancers, auto immune diseases,....... and rheumatoid arthritis.

Alfalfa, a botany plant may be used to modulate immune response for treatment of acute inflammation and diseases associated to chronic inflammation, some scientists suggested.

Alfalfa is a flowering plant in the genus Medicago, belongings to the family Fabaceae, cultivated all over the world as hay for cattle feeding.

The herbal plant has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhanced digestive system, bleeding disorder, kidney and urinary tract infection, etc.

North American aboriginals have used Alfalfa seed as food in making bread and mush.

According to studies, alfalfa expressed significant anti-inflammatory effect through the inhibiting production of pro-inflammatory cytokins during injure, foreign invasion and free radical domino's action, etc....

The University of Maryland study of novel pectic polysaccharide from alfalfa(Medicago sativa L.) stem, suggested that the phytochemicals isolated from alfalfa exert significant anti-inflammatory effect against mRNA expressions of the pro-inflammatory cytokine genes, especially for IL-1β antibody(1).

IL-1β is a pro inflammatory cytokines that used the major source of macrophages in response to the early stage of inflammation. 

Chronic inflammatory expression of human IL-1β is associated to gastric inflammation and tumorigenesis in stomachs of studies mice.

 The chloroform extract of alfalfa aerial part also  inhibited the function of lipopolysaccharide (LPS) of Gram-negative bacteria in stimulated immune responses in induced inflammation and suppressed LPS-mediated activation of the extracellular signal-regulated the proinflammatory and prothrombotic responses of nuclear factor kappa-B pathway(2).

Dr. Toby Lawrence, in the evaluation of "The Nuclear Factor NF-κB Pathway in Inflammation" siad, "The nuclear factor NF-κB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-κB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules" and " NF-κB has long been considered the “holy grail” as a target for new anti-inflammatory drugs"(6).

The cinnamic acid derivatives and fatty acids active constituents of the extract were also effective in ameliorated inflammation and immune response through inhibition of nitric oxide (NO), tumor necrosis factor (TNF-α), and prostaglandin E2 (PGE2), involved in the development of inflammatory diseases(3).

Nitric oxide (NO), plays a duo role in the pathogenesis of inflammation as anti-inflammatory mytokine under normal physiological conditions. However, the molecule also acts as a pro-inflammatory mediator in abnormal situations.

Tumor necrosis factor (TNF-α), a key regulator of the inflammatory response, plays an important role inregulated cellular responses, which include cell death, survival, differentiation, proliferation and migration by stimulating a change of vascular endothelial cells in expression of pro-inflammation.

Prostaglandin E2 (PGE2) may function in both the promotion and resolution of inflammation.

However, under the abnormal condition such as persistent tissue damage, the hormone may contribute to the up-regulation of the pro-inflammatory cytokines.

Taking together, alfalfa no doubt has processed an anti inflammatory effects through inhibited free radicals, proinflammatory cytokins and hormone that involve the development of inflammatory and auto immune diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Structural, thermal, and anti-inflammatory properties of a novel pectic polysaccharide from alfalfa(Medicago sativa L.) stem by Chen L, Liu J, Zhang Y, Dai B, An Y, Yu LL1. (PubMed)
(2) Chloroform extract of alfalfa (Medicago sativa) inhibits lipopolysaccharide-induced inflammation by downregulating ERK/NF-κB signaling and cytokine production by Choi KC1, Hwang JM, Bang SJ, Kim BT, Kim DH, Chae M, Lee SA, Choi GJ, Kim DH, Lee JC. (PubMed)
(3) Anti-Inflammatory Activities of Cinnamomum cassiaConstituents In Vitro and In Viv by Jung-Chun Liao,1 Jeng-Shyan Deng,2 Chuan-Sung Chiu,3,4. (HindaWi)
(4) Acute inflammation, the free dictionary by Farlex
(5) IL-1β by Science Direct
(6) The Nuclear Factor NF-κB Pathway in Inflammation by Toby Lawrence. (PMC)



Saturday, 28 July 2018

* 8 Veggies That Normalize Prostate Grand in Enlarged Prostate (Benign Prostatic Hyperplasia(BPH)) Patients

By Kyle J. Norton

Benign prostatic hyperplasia(BPH) is a condition, characterized by increased in the number of cells of prostate gland, causing partial, or sometimes virtually complete obstruction of the urinary tract.

According to statistic, BPH commonly starts at age of 30 and symptoms usually can not be realized until age of 50.

More than half of men between age of 60-70 are experience symptoms of BPH and only 10% are required treatment.

Suggestion of BPH is associated to nutritional status and eating habits,.

According to the study, 30 male patients with clinically confirmed and treated disease of the prostatic gland, including 15 men (aged 51-75 years) with BPH and 15 men (aged 51-73 years) with PC, improper nutritional status lead to incorrect nutritional habits which fail to improve health status may be the cause of the development of some diet-dependent diseases, such as BPH and prostate cancer(a).

Most symptoms of enlarged prostate are related to bladder function in urinary excretion, if you experience of some of symptoms of a weak stream of urine, difficulty starting urination, dribbling of urine, especially after urinating,..... and a sense of not fully emptying the bladder, you may develop enlarge prostate.

In severe case, patients may also develop symptoms of night time frequent urination and a strong and sudden desire to urinate,....  and blood in the urine.

 As the size of prostate increase, the sex organ may press on the urethra that not only cause urinary problems but also can cause urinary pain (dysuria or pain with urination).

Most common causes of enlarged prostate are prostate cancer and prostate infection (prostatitis). However, in compared to diet of men in Far East, risk of enlarged prostate of men who follow Western diet is substantial higher. These results suggested that aging, unhealthy diet and life style are associated to increased risk of enlarged prostate.

Some researchers suggested that a proper diet with vegetable, fruit containing zinc may reduce the risk of the disease from starting(b)(c).

Epidemiological studies, indicated that intake of vegetables and fruits accompanied with healthy life style may be associated in prevented risk and treatment of enlarged prostate(d)(e)(f).

The efficacy may be due to enhancement of antioxidants effect on over production of prostate cells(g)(h).

Types of vegetables that curd Enlarged Prostate (Benign Prostatic Hyperplasia(BPH))
1. Tomato
Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purposes and often in green house.

According to the study by Institute of Biological Chemistry and Nutrition, lycopene found in tomato inhibited the progression and reduced symptoms of BPH.(1)

But, intake of lycopene in the study at Universität Bonn, showed no protection from the development of PCA(5), but consumption of tomato products, lycopene ingestion might also be effective in PCA therapy(2).

Profluss®), composition of Serenoa repens, selenium and lycopene, displayed a siginificant antiinflammatry activities in reduced risk of BPH by reducing extension and grading of flogosis(3) and relieved the BHP symptoms(4).


2. Onion
The onion is a plants in the genus Allium, belongings to the family Alliaceae, a close relation of garlic.

The veggy is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations of the root also spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

Rich sources of flavonoids in onion may be effective in treating benign prostatic hyperplasia (BPH)(6).

According to the Istituto di Ricerche Farmacologiche Mario Negri, intake of onion showed an inverse association to BPH(7).

3. Whole grain
Wholegrain is cereal grains containing cereal germ, endosperm, and bran.

The study by Beijing Medical University, conducted in 1993-1995 in Beijing of BPH in 413 rural and 419 urban male over 40 years of age, showed an increased BPH incidence with daily intake of total calories, fat and animal protein, and the decreased daily intake of vegetables and whole grain, the sources of phytoestrogens(8).

The study of the University of Illinois in Chicago, indicated an inverse associations with dietary intake of plant foods, including whole grain cereals(9).

Other researchers suggested that BPH is associated with elevations in plasma estradiol/testosterone ratio, insulin, and insulin-like growth factor-I and daily aerobic exercise can reduce all of these plasma factors, particularly when combined with a low-fat, high-fiber diet consisting of whole grains, fruits, and vegetables(10).

4. Organic soybean
Soybean is genus Glycine, in the family Fabaceae,  native to Southeast Asia

One of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop..

Now, it is grown worldwide with suitable climate for commercial profit and a healthy foods for people in Asian.

In a rat model of benign prostatic hyperplasia (BPH), Application of Anthocyanin, a major chemical constituent in the pigment and potent antioxidant of black soy bean, inhibit the volume and suppress the proliferation of the prostate(11) and

The study Central South University, also indicated that soybean isoflavone inhibits prostate hyperplasia through increased expressions of nitric oxide and nitric oxide synthase in rats(12).

Moreover, the soybean Isoflavone also reduced the risk of prostate hyperplasia through increased acid phosphatase and PAP in a dose-dependent manner in rats, according to the Central South University, in Shanghai(13).

5. Cruciferous vegetables
Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Sulforaphane (SFN) an isothiocyanate derived from cruciferous vegetables in the study of its effect in normal (PrEC), benign hyperplasia (BPH1) and cancerous (LnCap and PC3) prostate epithelial cells induced cell cycle arrest and apoptosis in BPH1, through its activities in effects on cell proliferation, HDAC activity and downstream targets in normal and cancer cells(14).

Ethyl isothiocyanate (PEITC), found in cruciferous vegetables, in the testing on androgen-influenced growth of the prostatesuch as benign hyperplasia, regulated the hormone-dependent growth of the prostate, through negated the testosterone-mediated enhancement of the androgen receptor (AR), via down-regulating transcription factor Sp1 expression and Sp1 binding complex formation(15).

6. Squash
Squash is the genus Cucurbita, belongings to family Cucurbitaceae and native to Mexico and Central America.

In North America, squash is divided into summer squash or winter squash, depending on the maturity of squash when harvested, immature fruit called summer squash and mature fruit called winter squash.

ProstateEZE Max, a herbal formula containing Cucurbita pepo, Epilobium parviflorum, lycopene, Pygeum africanum and Serenoa repens in the study of benign prostate hypertrophy (BPH) demonstrated a positive effect in improvement of physical symptoms of BPH after 3 months of intake(16).

However, the Minneapolis VA Center for Chronic Diseases Outcomes Research in the reviews of 6 phytotherapeutic agents (Serenoa repens, Hypoxis rooperi, Secale cereale, Pygeum africanum, Urtica dioica, Curcubita pepo)from 44 studies, showed no convincing evidence supporting the use of Curcubita pepo alone for treatment of BPH(17).

7. Spinach
Spinach is an edible flowering plant in the genus Spinacia, belongings to the family of Amaranthaceae and native to central and southwestern Asia.

The green leaves vegetable is considered as a healthy plant containing vary vitamins and minerals.

The study of the effect of 3 anti-oxidants [a water-soluble natural anti-oxidant. NAO (200 mg/kg). found in spinach leaves; epigallocatechin-3 gallate, EGCG (200 mg/kg), a major green tea polyphenol; and N-acetylcysteine, NAC (125 mg/kg)] in TRAMP in wild-type male mice suggested the formula improved NAO in reduced hyperplasia at weeks 9 and 13(18).


In a case-control study of prostatic cancer which consisted of 100 patients matched for hospital, age (+/- 3 yr) and hospital admission date (+/- 3 months) to patients with benign prostatic hyperplasia(BPH) and hospital controls, conducted by the Kyoto University, researcher found that frequent intake of spinach (RR = 1.96: 1.01-7.73), a typical green and yellow vegetable, was associated to reduced risk BPH and prostate cancer(19).

8. Mushrooms
Mushroom, a standard name of white button mushroom is the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, belonogongs to the genus A. Muscaria in the family Amanitaceae.

In the examination of methanol extracts of 19 edible and medicinal mushrooms on 5alpha-reductase activity, scientists indicated that all 19 mushroom exert inhibited effects of the testosterone-induced growth of the ventral prostate in castrated rats(20).

But the study conducted by Gunma University Graduate School of Medicine, Maebashi suggested oral administration of extract of mushroom Phellinus linteus induced prostate enlargement(21).

Therefore using mushroom in treating BPH should be taken with care only with the approval of specialist.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(a) Nutritional status and nutritional habits of men with benign prostatic hyperplasia or prostate cancer - preliminary investigation by Goluch-Koniuszy Z, Rygielska M, Nowacka I.(PubMed)
(b) Diet and benign prostatic hyperplasia: a study in Greece by Lagiou P1, Wuu J, Trichopoulou A, Hsieh CC, Adami HO, Trichopoulos D.(PubMed)
(c) Associations of obesity, physical activity and diet with benign prostatic hyperplasia and lower urinary tract symptoms by Raheem OA1, Parsons JK.(PubMed)
(d) Nutrition and benign prostatic hyperplasia by Espinosa G.(PubMed)
(e) Dietary patterns and prostatic diseases by Sebastiano C1, Vincenzo F, Tommaso C, Giuseppe S, Marco R, Ivana C, Giorgio R, Massimo M, Giuseppe M.(PubMed)
(f) Fruit and vegetable consumption, intake of micronutrients, and benign prostatic hyperplasia in US men by Rohrmann S1, Giovannucci E, Willett WC, Platz EA.(PubMed)
(g) Evaluation of oxidative stress and DNA damage in benign prostatic hyperplasia patients and comparison with controls by Ahmad M1, Suhail N, Mansoor T, Banu N, Ahmad S(PubMed).
(h) Oxidative stress and antioxidant status in non-metastatic prostate cancer and benign prostatic hyperplasia by Aydin A1, Arsova-Sarafinovska Z, Sayal A, Eken A, Erdem O, Erten K, Ozgök Y, Dimovski A.(PubMed)
(1) Lycopene inhibits disease progression in patients with benign prostate hyperplasia by Schwarz S1, Obermüller-Jevic UC, Hellmis E, Koch W, Jacobi G, Biesalski HK(PubMed).
(2) [Tomatoes and lycopene in prevention and therapy--is there an evidence for prostate diseases?].
[Article in German] by Ellinger S1, Ellinger J, Müller SC, Stehle P.(PubMed)(3) Effects of Serenoa repens, selenium and lycopene (Profluss®) on chronic inflammation associated with benign prostatic hyperplasia: results of "FLOG" (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study by Morgia G1, Cimino S, Favilla V, Russo GI, Squadrito F, Mucciardi G, Masieri L, Minutoli L, Grosso G, Castelli T.(PubMed)
(4) Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus selenium and lycopene (Profluss) versus S. repens alone: an Italian randomized multicenter-controlled study by Morgia G1, Mucciardi G, Galì A, Madonia M, Marchese F, Di Benedetto A, Romano G, Bonvissuto G, Castelli T, Macchione L, Magno C.(PubMed)
(5) Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review by Ilic D1, Misso M(PubMed).
(8) Changes in the prevalence of benign prostatic hyperplasia in China by Gu F.(PubMed)
(9) Correlations of dietary patterns with prostate health by Stacewicz-Sapuntzakis M1, Borthakur G, Burns JL, Bowen PE.(PubMed)
(10) Benign prostatic hyperplasia: does lifestyle play a role by Barnard RJ1, Aronson WJ.(PubMed)
(11) Anthocyanin extracted from black soybean reduces prostate weight and promotes apoptosis in the prostatic hyperplasia-induced rat model by Jang H1, Ha US, Kim SJ, Yoon BI, Han DS, Yuk SM, Kim SW.(PubMed)
(12) [Effects of soy bean isoflavone on inhibition of benign prostatic hyperplasia and the expressions of NO and NOS of rats].[Article in Chinese] by Yang A1, Ren G, Tang L, Jiang W.(PubMed)
(13) [Inhibitive effect of soybean isoflavone on prostate hyperplasia in rats].[Article in Chinese] by Ren GF1, Huang YM.(PubMed)
(14) Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells by Clarke JD1, Hsu A, Yu Z, Dashwood RH, Ho E.(PubMed)
(15) Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation by Beklemisheva AA1, Feng J, Yeh YA, Wang LG, Chiao JW.(PubMed)
(16) A phase II randomised double-blind placebo-controlled clinical trial investigating the efficacy and safety of ProstateEZE Max: a herbal medicine preparation for the management of symptoms of benign prostatichypertrophy by Coulson S1, Rao A, Beck SL, Steels E, Gramotnev H, Vitetta L.(PubMed)
(17) Phytotherapy for benign prostatic hyperplasia by Wilt TJ1, Ishani A, Rutks I, MacDonald R.(PubMed)
(18) Slowing tumorigenic progression in TRAMP mice and prostaticcarcinoma cell lines using natural anti-oxidant from spinach, NAO--a comparative study of three anti-oxidants by Nyska A1, Suttie A, Bakshi S, Lomnitski L, Grossman S, Bergman M, Ben-Shaul V, Crocket P, Haseman JK, Moser G, Goldsworthy TL, Maronpot RR.(PubMed)
(19) A case-control study of prostatic cancer with reference to dietary habits by Oishi K1, Okada K, Yoshida O, Yamabe H, Ohno Y, Hayes RB, Schroeder FH.(PubMed)
(20) Anti-androgenic activities of Ganoderma lucidum by Fujita R1, Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S, Ueda C, Tajiri H, Kaneko S, Suimi Y, Kondo R.(PubMed)
(21) Administration of extract of mushroom Phellinus linteus induces prostate enlargement with increase in stromal component in experimentally developed rat model of benign prostatic hyperplasia by Shibata Y1, Kashiwagi B, Arai S, Fukabori Y, Suzuki K.(PubMed)
(22) Effect of a standardized extract of red orange juice on proliferation of human prostate cells in vitro by Vitali F1, Pennisi C, Tomaino A, Bonina F, De Pasquale A, Saija A, Tita B.(PubMed)
(23) Lycopene for the prevention and treatment of prostate disease by Ilic D.(PubMed)
(24) Effects of Serenoa repens, selenium and lycopene (Profluss®) on chronic inflammation associated with benign prostatic hyperplasia: results of "FLOG" (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study by Morgia G1, Cimino S, Favilla V, Russo GI, Squadrito F, Mucciardi G, Masieri L, Minutoli L, Grosso G, Castelli T.(PubMed)
(25) [The association of Serenoa repens, lycopene and selenium is superior to Serenoa repens alone in reducing benign prostatic hyperplasia].[Article in Italian] by Squadrito F1, Morgia G.(PubMed)
(26) The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms by Vidlar A1, Vostalova J, Ulrichova J, Student V, Stejskal D, Reichenbach R, Vrbkova J, Ruzicka F, Simanek V.(PubMed)
(27) Risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in a community based population of healthy aging men: the Krimpen Study by Kok ET1, Schouten BW, Bohnen AM, Groeneveld FP, Thomas S, Bosch JL.(PubMed)
(28) Enteric-coated, highly standardized cranberry extract reduces risk of UTIs and urinary symptoms during radiotherapy for prostate carcinoma by Bonetta A1, Di Pierro F.(PubMed)
(29) The medicinal action of androgens and green tea epigallocatechin gallate by Liao S.(PubMed)
(30) Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols by Hiipakka RA1, Zhang HZ, Dai W, Dai Q, Liao S.(PubMed)
(31) Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFκB pathway in the Noble rat model by Hsu A1, Bruno RS, Löhr CV, Taylor AW, Dashwood RH, Bray TM, Ho E.(PubMed)
(32) The medicinal action of androgens and green tea epigallocatechin gallate by Liao S.(PubMed)
(33) Risk factors for surgery for prostatic hypertrophy by Morrison AS.(PubMed)
(34) Food groups and risk of benign prostatic hyperplasia. by Bravi F1, Bosetti C, Dal Maso L, Talamini R, Montella M, Negri E, Ramazzotti V, Franceschi S, La Vecchia C.(PubMed)
(35) Benign prostatic hyperplasia: the opposite effects of alcohol and coffee intake by Gass R.(PubMed)
(36) Chronic caffeine intake increases androgenic stimuli, epithelial cell proliferation and hyperplasia in rat ventral prostate by Sarobo C1, Lacorte LM, Martins M, Rinaldi JC, Moroz A, Scarano WR, Delella FK, Felisbino SL.(PubMed)
(37) Inhibition of the experimental induction of benign prostatic hyperplasia: a possible role for fluted pumpkin (Telfairia occidentalis Hook f.) seeds by Ejike CE1, Ezeanyika LU.(PubMed)
(38) Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia by Hong H1, Kim CS, Maeng S.(PubMed)
(39) Inhibition of testosterone-induced hyperplasia of the prostate of sprague-dawley rats by pumpkin seed oil by Gossell-Williams M1, Davis A, O'Connor N.(PubMed)
(40) Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation. Nevin KG. Rajamohan T. Clinical Biochemistry. 37(9):830-5, 2004 Sep. [Comparative Study. Journal Article] UI: 15329324 Authors Full Name Nevin, K G. Rajamohan, T.
(41) Effects of coconut oil on testosterone-induced prostatic hyperplasia in Sprague-Dawley rats. by de Lourdes Arruzazabala M1, Molina V, Más R, Carbajal D, Marrero D, González V, Rodríguez E.(PubMed)
(42) 5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids by Pham H1, Ziboh VA.(PubMed)
(43) Comparison of fatty acid profiles in the serum of patients with prostate cancer and benign prostatic hyperplasia by Yang YJ1, Lee SH, Hong SJ, Chung BC.(PubMed)
(44) Prostate tissue and leukocyte levels of n-3 polyunsaturated fatty acids in men with benign prostate hyperplasia or prostate cancer by Christensen JH1, Fabrin K, Borup K, Barber N, Poulsen J.(PubMed)

Friday, 27 July 2018

^^^^^Garlic,The Spice That Gobbles Up Arterial Plaques Before They Can Cause Atherosclerosis

By Kyle J. Norton, Master of Nutrition


Herbal medicine, the study of botany that use plant for medical treatment and cure, linking health benefits in prevention, management and treatment of diseases has been present in human history over thousands of year.
Today, the whole herb treatment have drawn much interests in some conscientious scientists.

However, the journey of finding the specific whole food medicine for treatment of diseases has been encountered many obstacles, because of lacking financial support from commercial institutes and opposed by the big pharmaceutical companies.

Not only the discoveries can not be patent, they can also cause substantial drop of their profits.

Many researchers has raised question of quality of the herbs used in experimen as geographic differences, time of grown and harvest, may effect the potency.

Truly, although herbal plants have formed a fundamental source for conventional medicine, the big drug companies only interest in discovery of single ingredient medication, such as aspirin is synthesized from willow bark, quinine, synthesized from cinchona bark), and morphine,......and  synthesized from the opium poppy......

Lung Cancer is a chronic condition characterized by irregular and uncontrollable cells growth in the lung tissue, originally. At the advanced stage, the cancerous cells can travel a distance away from the lung to infect other healthy organs tissue.


In Canada, Lung cancer not only is the most commonly diagnosed cancer after melanoma skin cancers. it also is a leading cause of death in both men and women.
According to Canadian Cancer Society(6), In 2017, an estimated:
* 28,600 Canadians were diagnosed with lung cancer. This represents 14% of all new cancer cases in 2017.

* 21,100 Canadians died from lung cancer. This represents 26% of all cancer deaths in 2017.14,400 men were diagnosed with lung cancer and 11,100 died from it.


* 14,200 women were diagnosed with lung cancer and 10,000 died from it.


* On average, 78 Canadians were diagnosed with lung cancer every day.


* On average, 58 Canadians died from lung cancer every day
.

Long term cigarette smoking, second hand smoke and exposure to chemical smoke are the major causes of the disease.


And the symptoms of lung cancer include persistent cough that does not go away,
coughing up blood or rust-colored sputum (spit or phlegm), chronic chest pain that is often worse with deep breathing, coughing, or laughing, shortness of breath,.....and weight loss and loss of appetite.

In the advanced stage lung cancer patients may also experience symptoms of coughing up blood or rust-colored sputum (spit or phlegm).

According to the joint study lead by the Sun Yat-sen University Cancer Center, " The suicide mortality rates have significantly decreased (before 1993: 0.21%, 1994-2003: 0.16%, after 2004: 0.09%, P < .001). Male (OR 6.22, 95% CI: 4.96-7.98, P < .001), white (OR 3.89, 95% CI: 2.66-5.97, P < .001), being unmarried (OR 1.43, 95% CI: 1.22-1.67, P < .001), the elderly (60-74 vs <60: OR 1.24, 95% CI: 1.03-1.50, P = .024, >75 vs <60: OR 1.31, 95% CI: 1.05-1.63, P = .018) were independently associated with higher risk of suicide mortality" and "Surgery (OR: 1.44, 95% CI: 1.19-1.73, P < .001) was also relative with higher risk of suicide"(7).

Recent study suggested that garlic may be used as chemo prevention and treatment of lung cancer.


Garlic (Allium sativum) is a species in the onion genus, belongings to family Amaryllidaceae, native to central Asia. the herb has been used popularly in traditional and Chinese medicine for treatment of common cold and flu to the Plague, blood pressure cholesterol levels,...... and as natural antibiotic.
According to the study by Medical Research Center, College of Medicine, allyl sulfur compounds and garlic extract found in garlic exhibited anti non small cell lung cancer cell lines effects through interference on tumor cell division and tumor cell proliferation.

In benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells, application of oil-soluble organosulfur compounds in garlic induced suppression of cell proliferation, cell cycle regulation, attenuation of ROS formation, inhibition of DNA damage.


The examine of association between raw garlic consumption and lung cancer, a case-control study conducted between 2005 and 2007 in Taiyuan, China, showed that in compared with no intake, raw garlic intake is associated with lower risk of development of lung cancer with a dose-response pattern.

In fact, the Epidemiologic data collected by face-to-face interviews using a standard questionnaire among 1,424 lung cancer cases and 4,543 healthy controls also supported the negation of garlic intake and lung disease and suggested that garlic may potentially serve as a chemopreventive agent for lung cancer.

Dr. Yang GQ, the lead researchers at the 107th Hospital of the People's Liberation Army said, "black garlic extract (BGE) could have significant inhibitory action on the growth of lung cancer Lewis cells. The combination of BGE and radiotherapy (by 60Co gamma) significantly induced Lewis cells' apoptosis in G2/M stage".

Therefore, adding a portion of garlic in your diet  may be beneficial for increased protection against lung cancer development. However, further data collection on large sample size and multi centers clinical studies performed with human consumption during the course of the investigation will be necessary to complete the picture of harlicand its bioactive compounds protective effect against lung cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines by Hong YS1, Ham YA, Choi JH, Kim J.(PubMed)
(2) Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells by Wang K1, Wang Y1, Qi Q1, Zhang F1, Zhang Y2, Zhu X1, Liu G1, Luan Y1, Zhao Z3, Cai J4, Cao J4, Li S4.(PubMed)
(3) Raw Garlic Consumption and Lung Cancer in a Chinese Population by Myneni AA1, Chang SC2, Niu R3, Liu L4, Swanson MK1, Li J5, Su J5, Giovino GA6, Yu S5, Zhang ZF2, Mu L7.(PubMed)
(4) Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population by Jin ZY1, Wu M, Han RQ, Zhang XF, Wang XS, Liu AM, Zhou JY, Lu QY, Zhang ZF, Zhao JK.(PubMed)
(5) [Radiosensitization effect of black garlic extract on lung cancer cell line Lewis cells].[Article in Chinese] byYang GQ1, Wang D, Wang YS, Wang YY, Yang K.(PubMed)
(6) Lung cancer statistics of Canadian Cancer Society
(7) Trends in incidence and associated risk factors of suicide mortality in patients with non-small cell lung cancer by Zhou H1,2,3,4, Xian W4, Zhang Y1,2,3, Chen G1,2,3, Zhao S1,2,3, Chen X1,2,3, Zhang Z1,2,3, Shen J4, Hong S1,2,3, Huang Y1,2,3, Zhang L(PubMed)

Thursday, 26 July 2018

* Fennel, The Herb or Food Better Than Ibuprofen in Stopped Primary Painful Period


Kyle J. Norton

Adding a portion of fennel in daily diet may have a potential and positive effect in reduced pain caused by sensory neurons stimulus in women with primary dysmenorrhea, some scientists suggested.

The results of the investigation were carried out by numbers of respectable institutes, including the Babol University of Medical Sciences and Health Services and details of the experiment were published on online medical library.

Antinociceptive activity is an action or process of blocking the painful injurious stimulus by sensory neurons.

Dysmenorrhea, is also known as painful period, a menstrual cramp in the regions of pelvis or lower abdomen that last a few days during menstruation, caused by over production of certain hormones in the family of prostaglandins.

Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen. In some cases, the pain can also spread over to the whole abdomen and lumbosacral region.

There are 2 Types of dysmenorrhea
* Primary dysmenorrhea
Primary dysmenorrhea effects about 90% in the girls in the first 2 years of menstruation. Some researchers suggested that it may be caused by immature of the reproductive organs. 

* Secondary dysmenorrhea
Secondary dysmenorrhea is caused by gynecological diseases. including hormone imbalance, endometriosis, fibromas, pelvic immflammatory disease, etc. 

Accompanied to the painful period, women may also experience to psychological symptoms such as anxiety, depression, irritability, digestive symptoms such as nausea, vomiting and physical symptoms such as headaches, dizziness and painful breasts. 

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In order to compare the effect of combination of fennel extract/vitamin E with ibuprofen on the intensity of pain in primary dysmenorrhea among the students of Tabriz city in 2007-2009, researchers od the joint study lead by the Kosar Department of Shahid Motahhary Hospital carried out an investigation of 68 students from Medical and Tabriz universities, who were living in the dormitory, suffering from primary dysmenorrhea.

All participants were randomly divided into two groups of 34 students each (the two groups used combination of fennel extract/vitamin E and ibuprofen cross-over form in the 2 months).

Application of the combination displayed a mean of peak pain intensity in the first, second, third, sixth, and forty-eighth hours that is significant lower than the  ibuprofen group.


Also, combination of fennel extract/vitamin E was more effective than ibuprofen in the first hour (P < 0.03) and second hour (P < 0.04), according to the Visual Analogue Scale (VAS) tool for ranking the intensity of the pain.

These result suggested that fennel and vitamin E combination was more efficacy in blocking the neuron in transmitting pain caused by over expression prostaglandins hormone in induction of abdominal muscle constriction in compared to conventional medicine ibuprofen.

Dr. Nasehi M, the lead author, after taking into account of other co and con founders said, "Combination of fennel extract/vitamin E is effective on decreasing the intensity of pain of primary dysmenorrhea, and it is advised to those who cannot use chemical drugs".

In a separate study to investigate the effect of fennel used alone on primary dysmenorrhea symptoms and menorrheal duration, 80 female students satisfied the criteria and guideline were randomly divided in to two groups of intervention (n = 40) and control (n = 40).

The intervention group was given one soft capsule Fennel (30 mg) every 4 hours, 3 days before menstruation till the 5th day and continued for 3 months. The control group received no medication.

According to the result of the experiments, fennel treated group exerted significant decrease of the mean of nausea intensity and weakness from 1.93, and 2.88 after 3 months, in compared to control group from 2.37, 6.65 in control group.

Furthermore, in compared to control group, fennel group reduced the duration of menstrual period after two and three months of use.

Moreover, Fennel treated group demonstrated a strong improvement of quality and feelings of well-being after 1 and 3 months.

Taken together, fennel may be considered as functional food for treatment of Primary Dysmenorrhea without inducing adverse effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrition

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effect of fennel on pain quality, symptoms, and menstrual duration in primary dysmenorrhea by Ghodsi Z1, Asltoghiri M2.(PubMed)
(2) Comparison of the effectiveness of combination of fennel extract/vitamin E with ibuprofen on the pain intensity in students with primary dysmenorrhea by Nasehi M1, Sehhatie F2, Zamanzadeh V3, Delazar A4, Javadzadeh Y5, Chongheralu BM6.(PubMed)

* The Root Veggie That Inhibits Immune-Mediated, Cardiovascular, Infectious,....and Systemic Inflammatory Diseases Caused By Thrombosis

Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk and complications of thrombosis some scientists suggested.

The results of the analysis were reported in the online literature conducted by numbers of universities including Kobe Gakuin University.

You can view the abstract from the studies by clicking any link at the resources data.

Thrombosis is a medical condition characterized by formation of a blood clot inside a blood vessel, obstructing the flow of blood in circulatory system.

Thrombosis is considered  as a common cause of atherosclerosis.

The 2 major types of thrombosis are
* If the blood clot blocks a vein, it is classified as venous thrombosis.
 Veins are blood vessels that carry blood from the body back into the heart.
* If the blood clot blocks an artery, it is arterial thrombosis.
Arteries are the blood vessels that carry oxygen-rich blood away from the heart to the body.

The actual causes of thrombosis are debatable. However, some researchers suggested that diseases or conditions of the leg veins, immobility due to physical incapability,  bone fracture, obesity,... and genetic mutation of certain genes are associated to the causes and risks of thrombosis.

Importantly, certain medicine such as Apixaban, Dabigatran, Edoxaban, Heparin. Rivaroxaban ..... and Warfarin and birth control pills containing the hormones desogestrel, gestodene, drospirenone and cyproterone are also considered as risk factors of thrombosis.

Risks of deep vein thrombosis (DVT) and pulmonary embolism (PE), are increased substantially in pregnant women, especially in women who have an inherited clotting disorder.

Diseases associated to include immune-mediated disease, systemic inflammatory, cardiac,.......and infectious diseases.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the investigation to find a daily diet with proven antithrombotic effects in reduced risk of acute thrombotic events, reserachers at the Kobe Gakuin University launched an study to examine vegetables and fruits for antithrombotic activity.

The vegetables included 15 different varieties of carrot using ashear-induced in vitro platelet reactivity/thrombolysis method, Global Thrombosis Test, formerly Gorog Thrombosis Test.

According to the differentiation of the antiplatelet and thrombolytic activities, researchers showed that
* Different carrot varieties demonstrate a variable effect on thrombosis in vitro and in vivo.

* In laser-induced thrombosis model in mice, heat treatment of carrot variety
exerts an antithrombotic effect independent from heat treatment of the filtrate at 100 degrees C for 10 min.

* In oral intake, the particular heat resistant variety (SAKATA-0421) shows antithrombotic effect in vivo possibly due to antiplatelet reactivity and/or spontaneous thrombolytic activity.

Interestingly, the expression of antithrombotic activity showed no significant correlation between antithrombotic activity and the levels of polyphenolics and any other biochemical parameter, including antioxidant activity, alpha-carotene and beta-carotene, alpha-tocopherol and ascorbic acid

These results suggested that carrot demonstrated strong impacts in reduced blood clot accumulation regardless to the effect of individual ingredients. 

Dr. Yamamoto J, the lead author said, "An inappropriate diet is known to enhance the risk for acute thrombotic events and a regular diet with proven antithrombotic effects( including carrots) might be a beneficial way to prevent disease" and "the present study added a new variety to the list of antithrombotic fruits and vegetables".

Further analysis of the tissue linked to development of cardiovascular disease due to endothelial activation in induction of thrombosis of blood vessels, researchers at the Comanche County Memorial Hospital launched an investigation to evaluate the effect of diet-derived antioxidants in suppressed and/or delayed progression of cardiovascular disease.

The suggestions of water-dispersible forms of various carotenoids (beta-carotene, lutein and lycopene) from natural sources in microemulsion were recommended to study the effects of carotenoids on tissue factor activity in human endothelial cells.

According to the differentiation, all carotenoids suppressed tissue factor activity (P<.01) and gene expression in human endothelial cells which may have a strong effect in contribution of the development of blood clot in the vessels.

Endothelial cells in the endothelium have a essential effect in regulate vascular tone, cellular adhesion, smooth muscle cell proliferation, and vessel wall inflammation. 

Moreover, application of carotenoids also enhanced phosphorylation of Akt activity in human endothelial cells on tissue factor activity in regulation of thrombosis of blood vessels.

After taking into account of other co and con founders, Dr. Lee DK, the lead scientist said, "diet-derived antioxidants might suppress and/or delay progression of cardiovascular disease (through regulating endothelial activation in expression of thrombosis of blood vessels)".

The findings suggested that carrot and its bioactive carotenoids may be considered as functional food in reduced formation of blood clot in the vessels in induction of cardiovascular diseases.

However, intake of supplementation should be taken with extreme care as acute liver toxicity was reported in numbers of case in medical literature.

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) The antithrombotic effects of carrot filtrates in rats and mice by Yamamoto J1, Naemura A, Ijiri Y, Ogawa K, Suzuki T, Shimada Y, Giddings JC(PubMed)
(2) Carotenoids enhance phosphorylation of Akt and suppress tissue factor activity in human endothelial cells by Lee DK1, Grantham RN, Mannion JD, Trachte AL(PubMed)

The Herbal Extract That Kills Gastric/Stomach Cancer Cells, Scientists Find

By Kyle J. Norton


Scientists may have found a chemical constituent isolated from Andrographis paniculata, with potential in reducing risk and treatment of gastric cancer, a respectable institute study suggested.

Gastric/Stomach cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach.

Adenocarcinoma is the most common type of gastric cancer.

The causes of gastric cancer are debatable, but some researchers suggested that people with chronic
gastrointestinal reflux disease (GERD), a condition caused by the frequent backflow of stomach acid into the esophagus, is the most likely to develop the disease(4).

Other diseases associated with the early onset of gastric cancer are obesity and smoking(4).

According to the Universidad de Salamanca, bacteria and virus, including Helicobacter pylori are strongly associated with chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development(5).

If you experience some of the symptoms such as feeling bloated after eating, feeling full after only eating small amounts of food,  persistent heartburn, and severe indigestion, stomach pain,.... and persistent vomiting, please check with your doctor right the way for the arrangement of a diagnosis(4).

The picture captured during the exam may sometimes be misdiagnosis as an ulcer, a mushroom-shaped or linitis plastica.

If the suspicious area is found, endoscopic ultrasound may be necessary to rule out the cancer onset possibility.

Most importantly, in compared to antioxidant effects in a patient with H. pylori gastritis and gastric cancer, researchers found that concentration of serum superoxide dismutase and serum malondialdehyde that exhibiting oxidative stress caused by overexpression of free radicals are significantly higher and plasma ascorbic acid, the antioxidants are significantly lower in gastric cancer patients.

These results suggested gastric cancer is also associated to the imbalance of ratio of antioxidants produced by the host enzymes and free radical accumulation, leading to elevated ROS that causes oxidative stress in alternated DNA of gastric cells through cytotoxicity.

According to the Canadian cancer society, in 2017(6), an estimated:
* 3,500 Canadians were diagnosed with stomach cancer.

* 2,100 Canadians died from stomach cancer.

* 2,200 men were diagnosed with stomach cancer and 1,250 died from it.

* 1,300 women were diagnosed with stomach cancer and 790 died from it.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The herb has been used in traditional Siddha and Ayurvedic for treatment of common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...

According to the joint study lead by the Chosun University, Andrographolide, a natural compound isolated from Andrographis paniculata, exerted a potentiated apoptosis and reduction of the ability of a cell to form clones triggered by recombinant human tumor necrosis factor of signaling systemic inflammation involved immune stimulation.

The study also found that Andrographolide enhances TRAIL(a protein functioning as a ligand in regulated the process of cell death)-induced apoptosis through interfering cell division via a protein functioning involved the process of cell death and ROS generation in gastric cancer.

Dr. Lim SC, the lead author said, "Exposure of GC cells to andrographolide altered the expression level of several growth-inhibiting and apoptosis-regulating proteins, including death receptors".

In three gastric cancer cell lines (SGC7901, MGC803, BGC823), with Application of Andrographis significantly decreased gastric cancer cells adherence to stimulated endothelial cells by inhibited the E-selectin expression that activated cytokines of the immune system.

Taking all together, Andrographis paniculata with high levels of Andrographolide may be used as a therapeutically promising product in reducing risk and treatment of gastric cancer.

However, further data collection on large sample size and multi-center clinical studies performed with human consumption during the course of the investigation will be necessary to complete the picture of  Andrographis and its bioactive compounds protective effect against gastric cancer possibilities.

Intake of  Andrographis paniculata supplement should be taken with exceptional care as overdoses may cause acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Advances in study on the anti-tumor mechanism of andrographolide].[Article in Chinese] by Qi CL1, Wang LJ, Zhou XL. (PubMed)
(2) Andrographolide induces apoptotic and non-apoptotic death and enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in gastric cancer cells by Lim SC1, Jeon HJ1, Kee KH1, Lee MJ1, Hong R1, Han SI2(PubMed)
(3) Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression by Jiang CG1, Li JB, Liu FR, Wu T, Yu M, Xu HM. (PubMed)
(4) Stomach cancer by Mayo Clinic
(5) [Microorganisms and cancer: scientific evidence and new hypotheses].[Article in Spanish] by Velázquez E1, Peix A, Gómez-Alonso A(PubMed)
(6) Stomach cancer statistics (Canadian cancer society)