Colon Cancer is defined as a condition of the abnormal proliferation of cells in the colon.
The Nutrients and Chemical constituents
2. Dietary fiber
5. Vitamin A ( Beta carotene, lutein and zeaxanthin)
6. B vitamins
7. Vitamin C
13. Zinc Beside it main component of Polyphenolic compound , it also saponin pisatin, L-pipecolic acid, glycoside-Pisatoside, tocopherols, cerebroside, etc.
Evidences in studies showed positive effect of chemical compounds (polyphenolics, and saponins) in dried peas against the progression of cancers. The organic molecule combinations of TI1B (rTI1B), representing a major The Bowman-Birk inhibitor (BBI) peas-derived serine protease inhibitor not only influenced the negatively the growth of human colorectal adenocarcinoma HT29 cells but not inactive mutant in a dose-dependent manner, but also inhibited the growth of non-malignant colonic fibroblast CCD-18Co cells. The result may suggested that serine proteases such as trypsin and chymotrypsin, should be considered as important targets in investigating the potential chemopreventive role of BBI during the early stages of colorectal carcinogenesis.
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The Side effects
Excessive intake of purine can cause health problems for people with untreated kidney and gallbladder diseases due to accumulation of uric acid.
(1) Review of the health benefits of peas (Pisum sativum L. by Dahl WJ, Foster LM, Tyler RT.(PubMed)
(2) The anti-proliferative effect of TI1B, a major Bowman-Birk isoinhibitor from pea (Pisum sativum L.), on HT29 colon cancer cells is mediated through protease inhibition by Clemente A, Carmen Marín-Manzano M, Jiménez E, Carmen Arques M, Domoney C.(PubMed)