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Sunday, 12 January 2014

Weight Loss and Non alcoholic liver disease

Healthy Weight loss is defined as a reduction of the total body mass for the purpose in improving heath due to related illness, including heart diseases, stroke, over expression of cholesterol, fatty liver, etc.
Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.  

Non alcoholic fatty liver diseases is widespread in Western world with no affirmative treatment. Most physicians suggested healthy diet with less in saturated  and trans fat and reduction of  patients' weight would be beneficial in management of the disease. As n-3 polyunsaturated fatty acids (PUFA)has been found to be effective in treating  patients with nonalcoholic fatty liver disease (NAFLD) associated with hyperlipidemia with no adverse effects. In the study of the effect of weight reduction diet as an exclusive treatment for NAFLD, in 44 patients with NAFLD whom  received a diet including a 500 to 1000 kcal per day intake reduction as30% fat, 15% protein, and 55% carbohydrate for six months, reduction of body weight, waist circumference and decrease diastolic blood pressure are significant. Total cholesterol, LDL, triglyceride, ALT, AST, GGT and CK18-M30 levels were significantly decreased as well. Of these result, weight reduction diet should be considered as a therapy in managing non alcoholic liver disease.

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References
(1) How Much Weight Loss is Effective on Nonalcoholic Fatty Liver Disease? by Ghaemi A, Taleban FA, Hekmatdoost A, Rafiei A, Hosseini V, Amiri Z, Homayounfar R, Fakheri H.(PubMed)
(2) Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia by Zhu FS, Liu S, Chen XM, Huang ZG, Zhang DW.(PubMed)