Berberine and Polycystic Ovarian Syndrome (PCOs)

Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen), resulting in male pattern hair development, acne,irregular period or absence of period, weight gain and effecting fertility. It effects over 5% of women population or 1 in 20 women.
Berberine, is a phytochemical found in the group of protoberberine group of isoquinoline alkaloids,  in many herbal plants including Oregon grape, barberry,  turmeric, goldenseal, etc.

The effects
Polycystic ovary syndrome (PCOS) is characterized of metabolic disorder associated with insulin resistance (IR). Herbal medicine has been studied throughout research community to find a little or no effect treatment with some successes. Berberine, a chemical constituent found in many herbs, has exerted its health benefits by improving improved some of the metabolic and hormonal derangements in a group of Eighty-nine subjects with PCOS and IR treated Chinese women with PCOS. When compare to metformin (MET), the phytochemical Berberine  showed decrease in waist circumference and waist-to-hip ratio, fasting plasma glucose, fasting insulin, homeostasis model assessment for IR, area under the curve of insulin, cholesterol and triglycerides as well as increase in high-density lipoprotein cholesterol and sex hormone-binding. Other in the study of the same but in combination with Letrozole, showed the effectiveness of berberine in lowering  blood sugar levels in db/db mice and exerting anti-dyslipidemia in human. These results indicated that berberine may be considered a potential source in treating Polycystic Ovarian Syndrome (PCOs).

The side effects
1. Bernerine may cause toxicity and reduced fetus weight
2. Do use berberine if you are pregnant or breastfeeding women and newborns.



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References
(1) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W, Zhao H, Wang A by Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y.(PubMed)
(2) Effect of Berberine on Hormonal and Metabolic Features in Obese Women With Polycystic Ovary Syndrome (PCOS)14:32 EST 15th January 2014 | BioPortfolio
(3) Developmental toxicity evaluation of berberine in rats and mice by Jahnke GD, Price CJ, Marr MC, Myers CB, George JD.(PubMed)