Wednesday, 18 September 2019

Healthy Food Onion Processes Neuro-Protective Activity

By Kyle J. Norton

Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.

In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.

Neurodegenerative disease is the class of condition associated with the progressive loss of neuron occurred mostly in older adults, including dementia. The most common dementia in the US is Alzheimer`s disease (AD).

Alzheimer's disease is an irreversible, progressive brain disorder caused by the slowly lost of neuron in the brain that affects the memory and thinking skills and, eventually, the ability to carry out the simplest tasks as the disease progress into advanced stage.

According to the statistic, dementia affects over 47.5 million people worldwide, approximately 58 percent are living within low and middle-income countries.

Believe it or not, 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019 and two-thirds of people with Alzheimer's disease are women.

Conventionally, as of today, there is no cure for dementia. Treatment of dementia is focusing to improve dementia symptoms and slow down the progression of the disease.

Some researchers suggested that the increased incidence of the onset of Alzheimer's disease over the past few decades may be correlated to the promotion of a high-fat diet in the US.

Dr. Rollins CPE, the lead scientist wrote, "HFD-induced obesity during adolescence exacerbated brain volume alterations by adult life in the 3xTg mouse model in comparison to control-fed mice and mediated volumetric alterations of select brain regions, such as the hippocampus".

And, "Further, HFD-induced obesity aggravated memory in all mice, lowering certain memory measures of B6129s control mice to the level of 3xTg mice maintained on a CD. Moreover, a decline in the volumetric trajectories of hippocampal regions for all mice was associated with the degree of spatial memory impairments on the MWM.".

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of cognitive impairment, researchers examined the neuroprotective potential of Allium cepa (A. cepa, Onion) in aluminum chloride induced animal model neurotoxicity.

The study included mice induced neurotoxicity by aluminum chloride (50 mg/kg/day) orally were treated by supplemented with different doses of A. cepa hydroethanolic extract for a period of 60 days.

Before treatment of onion, aluminum chloride treated mice resulted in significant motor incoordination and memory deficits, observed by the increased oxidative stress and elevated levels of acetylcholinesterase (AChE) and aluminum levels in the brain.

Onion supplement injection in aluminum exposed animals not only significantly improved muscle coordination and memory deficits but also decreased the levels of oxidative stress, AChE and decreased abnormal aluminum deposition induced by the aluminum chloride.

Decreased vacuolated cytoplasm associated with the death of neurons and pyramidal cells in the hippocampal area of the mice brain caused by toxicity was also reversed by the injection of A. cepa supplementation.

The results strongly suggested that onion processes anti-neuro-toxicity induced cognitive impairment in an animal model.

Dr. Singh T, the lead scientist, after taking other factors into account wrote, "significant neuroprotective potential of A. cepa in aluminum-induced neurotoxicity".

Taken altogether, onion may be considered a neuroprotective remedy, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neuroprotective effect of Allium cepa L. in aluminium chloride induced neurotoxicity by Singh T1, Goel RK. (PubMed)
(2) Protective effects of onion-derived quercetin on glutamate-mediated hippocampal neuronal cell death by Yang EJ1, Kim GS, Kim JA, Song KS. (PubMed)
(3) Contributions of a high-fat diet to Alzheimer's disease-related decline: A longitudinal behavioural and structural neuroimaging study in mouse models by Rollins CPE1, Gallino D2, Kong V3, Ayranci G2, Devenyi GA4, Germann J2, Chakravarty MM. (PubMed)

Phytochemical Lycopene Detoxes the Liver Against Toxicity

By Kyle J. Norton

Human toxicity is a general term refers to any substance which causes harm to human health if inhaled, ingested or absorbed through the skin.

Liver toxicity is a process that causes liver damage by reducing the function of the liver. 

Liver oxidative stress caused by a toxic substance such as an overdose of the supplement has been found to constitute most cases of acute liver damage.


The liver is the largest internal organ which not only filters the blood from the digestive system before passing them to other parts of the body but also plays a critical role in the production cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver stress is a condition in which the function of the liver is partly reduced. Hepatic stress can be observed by the levels of liver stress-makers, including transaminases aspartate transaminase (AST) and alanine transaminase (ALT).

Abnormal high levels of transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are early indications of liver damage or injury.

Epidemiologically, drugs that induce liver injury are nonsteroidal anti-inflammatory drugs (NSAIDs), anti-infective drugs (anti-tubercular drugs), anti-cancer drugs, hormonal drugs, immunosuppressive agents, sedative and neuropsychiatric drugs.

Acetaminophen according to study is the most form of medication that implicates drug-induced liver injury

However,  antibiotics are the class of drugs  that cause liver toxicity most commonly

Conventionally, treatment of liver toxicity is totally depending on the types of inducers, including
* Management of drug-induced liver injury by discontinuing the suspected drug.

Acetaminophen poisoning is treated by antidote N-acetylcysteine.

* Glucocorticoids are used for the treatment of the immune-mediated drug-induced liver injury.
And,
* Intravenous N- acetylcysteine is used for the treatment of non-acetaminophen-related acute liver failure

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potential compound for the prevention of liver injury, researchers investigated the potential oxidative damage of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in hepatic microsomal fractions in an animal model.

The study included rat liver microsomes that were divided into four groups.
* Group I served as a control and is incubated with vehicle (toluene). 

* Groups II and IV incubated with 20 µM lycopene for 1 h before further incubating; and

* Groups III and IV with 15 nM of TCDD for further 1 h.

Based on the tested analysis, groups treated by TCDD showed a significant increase in liver oxidative stress observed by increasing levels of Hydrogen peroxide (H2O2) production, lipid peroxidation (LPO), 

Protein carbonyl content and activities of uridine 5'-diphospho-glucuronyltransferase (UDPGT) and P450 associated with liver damage also increased substantially in the TCDD treament groups.

Furthermore, the activity of antioxidant enzymes superoxide dismutase, glutathione peroxidase, catalase, glutathione-S-transferase, and glutathione reductase and the microsomal thiol content produced by the rat liver microsomes were significantly decreased in the TCDD treament groups.

Lycopene treatment group IV not only normalized the activities of the enzymes, thiol and carbonyl content but also significantly reduced LPO and H2O2 production.

These results suggested that TCDD  induced liver toxicity by increasing the levels of free radicals and decreasing the antioxidant activity in rat liver microsomes.

Based on the findings, researchers concluded, "TCDD induces significant oxidative stress in liver microsomes as manifested by increased LPO, H2O2 production, protein carbonyl content and activities of UDPGT and P450 and decreased antioxidant enzymes activities and thiol content".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of liver toxicity, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats by Abdel-Rahman HG1, Abdelrazek HMA2, Zeidan DW3, Mohamed RM4, Abdelazim AM. (PubMed)
(2) Ameliorative effect of lycopene against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced rat liver microsomal toxicity: an in vitro study by Aly HA1, El-Shitany NA2, El-Beshbishy HA3, Ashour OM. (PubMed)
(3) Liver Toxicity by Anam Bashir, and Dhruv Mehta. (NCBI)

Herbal Turmeric, a Natural and Potential Treatment of Uveitis with No Side Effects

By Kyle J. Norton

Uveitis is a type of eye inflammation, affecting the middle layer of tissue in the eyewall (uvea).

The condition has been found to onset suddenly and get worse quickly. Most common symptoms of uveitis are eye redness, pain, and blurred vision that can affect one or both eyes.

In some cases, patients with the condition also experience symptoms of light sensitivity, floaters and decreased vision.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

The exact cause of uveitis is unknown. However, some researchers suggested that people with a compromised immune system associated with inflammatory disease and infected diseases are at an increased risk of uveitis.

Other risk factors, epidemiologically such as eye injury, diseases that affect the eye such as diabetes are also found in the patients with uveitis.

Most cases of uveitis are treated by prescription eye drops in combination with anti-inflammatory medications. If all fail, surgery may be necessary.

Untreated uveitis has been found to induce complication of glaucoma, cataracts, optic nerve damage and retinal detachment.

Out of the prevalent factors of uveitis, some researchers suggested that aging associated with the weakened immune system may be the major factor that causes uveitis.

Dr, Marwan R. Abdulaal, the lead scientist said, "Uveitis is a vision-threatening inflammation of the eye that carries considerable morbidity. It is responsible for 10% of legal blindness in the United States and up to 25% in the developing world".

And. "The aging body has a changing response of the immune system, which might reflect a different pattern of uveitis in the elderly population".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of uveitis, researchers examined the effect on turmeric administered 4 h after induction of E. coli lipopolysaccharide-induced uveitis in rats.
Compared to the control group, turmeric showed significantly suppressed inflammation with a significantly lower mean clinical grade, histopathological grade, and aqueous humor (AH) protein level, second to the conventional medicine prednisolone.

The turmeric administered 4 h did not affect proinflammatory cytokines levels of TNF-alpha levels.

However, when the aqueous extract was administered starting from 3 days before induction of uveitis, treatment group not only showed a similar effect on the mean clinical and histopathological grade, as well as AH protein but also reduced TNF-alpha levels, comparable to treatment group.

Based on the findings, researchers said, "topically applied a standardized aqueous extract of C. longa suppresses endotoxin-induced uveitis in rats by reducing TNF-alpha activity".

In order to reveal more information about turmeric anti-uveitis property, researchers examined the anterior uveitis induced in rabbits by intravitreal injection of lipopolysaccharide from Escherichia coli after pretreatment with C. longa and B. aristata aqueous extracts.

According to the clinical and histopathologic grading, anterior segment inflammation in the control group was significantly higher compared to both the extract-treated groups.

More precisely, the inflammatory cell count in the control group was 30.75 cells/mL compared to 2.39 and 11.56 cells/mL in the C. longa- and B. aristata-treated groups, respectively.

Similarly, C. longa- and B. aristata-treated groups also exerted strong effects on the protein content and TNF-alpha level as of that on the aforementioned study.

Taken altogether, turmeric may be considered supplements for the prevention and treatment of uveitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Topically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats by Agarwal R1, Gupta SK, Agarwal P, Srivastava S. (PubMed)
(2) The anti-inflammatory effects of Curcuma longa and Berberis aristata in endotoxin-induced uveitis in rabbits by Gupta SK1, Agarwal R, Srivastava S, Agarwal P, Agrawal SS, Saxena R, Galpalli N. (PubMed)
(3) Uveitis in the Aging Eye: Incidence, Patterns, and Differential Diagnosis by Marwan R. Abdulaal, Bachir H. Abiad, and Rola N. Hamam. (PMC)

Herbal Coltsfoot(Tussilago farfara) Protects the Lung Against Tuberculosis (TB)

By Kyle J. Norton

The lung is a vital organ located near the backbone on either side of the heart with major functions to inhale oxygen from the air to the bloodstream that nourishes the body cells and exhale carbon dioxide from the bloodstream.

Other functions of the lung are to maintain the right levels of pH, filter out blood clots, protect the heart against shock, infection, and speech.

Tuberculosis (TB) is a contagious disease caused by bacteria called Mycobacterium tuberculosis.

The bacteria attacked the lung tissue, leading to the significantly reduced function of the lung in the inhaling and exhaling.

The disease is also found to cause major damage to other parts of the body.

According to statistic, 25% of the world's population is infected with TB. In 2016, 10.4 million people around the world became sick with the disease-inducing the death of  1.7 million people.

Most common signs and symptoms of TB are associated with reduced lung function, including coughing that lasts a long period of time, coughing up blood, chest pain, particularly in breathing or coughing, fatigue, fever, night sweats, and chills.

Some patients may also experience symptoms of unintended weight loss.

Conventionally, the length of treatment of TB depending on the severity of the disease takes longer compared to other infections with at least six months of antibiotics intake, including Isoniazid, Rifampin (Rifadin, Rimactane) and Ethambutol (Myambutol).

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belongings to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound which processes antitubercular activity, researchers examined the effect of Arctium lappa and Tussilago farfara extracts for activity against Mycobacterium tuberculosis.

In Mycobacterium tuberculosis H37Rv, according to the tested analysis, the ethyl acetate extract of Tussilago farfara displayed antitubercular activity with a MIC of 62.5 μg/mL.

The anti-tuberculosis property of Tussilago farfara against the Mycobacterium tuberculosis H37Rv was attributed to the compounds including mixture of β sitosterol/stigmasterol (4), trans-caffeic acid (7), kaempferol (8), quercetin (9), kaempferol-3-O-glucoside (10), loliolide (11), a (4:1) mixture of p-coumaric acid/4-hydroxybenzoic acid (12), p-coumaric acid (13). in the extract.

In compound comparison, the best anti-tuberculosis activity was observed in the p-coumaric acid (13) (MIC 31.3 μg/mL or 190.9 μM) alone and in mixture with 4-hydroxybenzoic acid (12) (MIC 62.5 μg/mL).

Based on the findings, researchers aid, "The above results provide for the first time some scientific evidence to support, to some extent, the ethnomedicinal use of Arctium lappa and Tussilago farfara as traditional antitubercular remedies.".

Taken altogether, coltsfoot may be considered a remedy for the treatment of tuberculosis, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents by Zhao J1, Evangelopoulos D2, Bhakta S2, Gray AI1, Seidel V. (PubMed)

Tuesday, 17 September 2019

Herbal Coltsfoot Protects Intestinal Mucosal Barrier Against the Risk of Colitis

By Kyle J. Norton

Colitis is a condition characterized by the inflammation of the inner lining of the colon.

The disease can be caused by infection, such as inflammatory bowel disease (Crohn's disease (CD), ulcerative colitis(CD)), ischemic colitis, allergic reactions, and microscopic colitis.

Most cases of colitis are involved in the damage of the intestinal mucosal barrier, particularly to those of ulcerative colitis.

Epidemiologically, damage and a reduction of gut bacteria by dietary chemicals, such as antibiotics of the protective mucus layer and the underlying tissue by the poorly inactivated digestive proteases induced both UC and CD.

The intestinal mucosal barrier is the outermost inner layer of the lining of the intestines which plays an essential role to ensure the adequate containment of undesirable luminal contents within the intestine and preserves the ability to absorb nutrients.

Additionally, the intestinal mucosal barrier also processes various immunological mediators, including cytokines and chemokines stimulated by gut microbiota and host immune responses, thus maintaining a well-balanced relationship between gut microbes and the host immune system.

In other words, the intestinal mucosal barrier protects the colonic integrity by interacting with the gut microbiota and the immune response to prevent the inflammation of the colon that causes the onset of colitis.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of inflammatory bowel disease (IBD), researchers examined the anti-colitis effect of Tussilagone (TSL), a major component of Tussilago farfara.

On mice subjected to acute colitis induced by dextran sulfate sodium (DSS), tussilagone showed a significant protective effect by ameliorating weight loss, and colonic inflammatory damage.

Proteins associated with pro-inflammatory cytokines such as the expression of tumor necrosis factor-α and interleukin-6 and the activity of myeloperoxidase in colonic tissues were inhibited by tussilagone-treated mice. 

Furthermore, tussilagone treatment reduced the numbers of nuclear factor-kappa B (NF-κB) in the induction of cytokines and increased the numbers of nuclear factor erythroid 2-related factor 2 (Nrf2) involved the production of antioxidant enzymes in nuclei of colonic tissues.

Based on the findings, researchers said, " tussilagone treatment attenuated DSS-induced colitis in mice through inhibiting the activation of NF-κB and inducing Nrf2 pathways, indicating that tussilagone is a potent therapeutic candidate for the treatment of intestinal ".

Taken altogether, coltsfoot may be considered a remedy for the treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tussilagone, a major active component in Tussilago farfara, ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis by Cheon HJ1, Nam SH1, Kim JK. (PubMed)

Cucurbitacin B Inhibits Non Small Lung Cancer Cells in Vitro and Vivo

By Kyle J. Norton

Lung cancer is a medical condition caused abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers is derived from epithelial cells.

Non-small lung cancer is the most common type of lung cancer that accounts for 80% to 85% of all cases of lung cancers, usually grows and spreads methodically and predictably.

Most common types of lung cancers include
*  Squamous-cell carcinoma often found in an outer area of the lung

* Large-cell carcinoma found in the center of the lung by an air tube

* Adenocarcinoma found in any part of the lung.

According to the statistics provided by the American cancer society, lung cancer is a leading cause of death among both men and women. Most people diagnosed with lung cancer are 65 or older, compared to a very small number of people diagnosed are younger than 45.

Most common prevalent factors of non-small cell lung cancer include
1. Smoking
Smoking is a major cause of lung cancer by enhancing oxidation stress by combining the inhaling air  with cancer-causing chemical substances (carcinogens) in the cigarette.
 Normally, our body can withstand and repair this damage, but prolonged exposure your lung to these danger carcinogens can result in lung cancer development.

2. Second-hand smoke
Prolonged exposure to second-hand smoke can also increase the risk of lung cancer.

3. Exposure to certain chemicals
There is an increased risk of lung cancer for people who inhale or exposing certain industrial chemical such as radon gas, arsenic, chromium, nickel, etc. in the workplace.

4. Family history
Risk of lung cancer increased if one of the members of your direct family has lung cancer.

5. Lung disease
Risk of ling can caner increase if you have or previously had certain types of lung disease

6. Excessive drinking
According to the study by Freudenheim et al., R. Curtis Ellison MD suggested that alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer. This study, like others, suggests a weak, positive association between consuming larger amounts of alcohol (>2 drinks a day) and lung cancer risk.

Out of many risk factors, some researchers aging may be one of the major condition as most patients with lung cancer was diagnosed with the age of 65 and over.

Dr. Federico Venuta, the lead researcher wrote, "The respiratory system undergoes a number of structural, physiological and immunological changes with age. For this reason, at this stage of our life, it is not always easy to differentiate disease from a normal state".

And, "From the epidemiological point of view, early-stage lung cancer is observed more frequently in elderly patients; in fact, stage I disease increases from 79% in patients younger than 65 years to 87% in those above 75 years (). Also, resectability obviously increases with age (,): from 15.3% in those younger than 54 years to 25% above 75 years".



The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural and potential compound for the treatment of non-small lung cancer (NSCLC) with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables anti-NSCLC in vitro.

Four NSCLC cells (H1299, A549, HCC-827, and H661) in vitro and the highly aggressive H1299 xenograft in vivo were included in the study.

According to the tested assays, CuB significantly induced G2/M cell-cycle arrest and mitochondrial apoptosis.

Injection by the thiol antioxidant N-acetylcysteine (NAC) in the experiment showed to attenuate all cellular effects of CuB completely.

Interestingly, pretreatment with glutathione synthesis inhibitor butithione-sulfoxime (BSO), significantly exacerbated CuB's cytotoxic effects against the tested cancer cells in both vitro and vivo.

Further analysis of the anti-NSCLC efficacy of CuB, researchers found that CuB induces cell death via rapidly and significantly decrease the levels of protein thiols and GSH/GSSG ratio by disrupting cellular redox balance induced cytotoxicity.


Dr. Kausar H, the lead scientist said, "CuB interacts with and modulates cellular thiols to mediate its anti-cancer effects. Collectively, our data shed new light on the working mechanisms of CuB and demonstrate its therapeutic potential against NSCLC".

Furthermore, CuB also exerted anti-NSCLC in vitro and vivo CuB by exhibiting a strong anti-migratory and anti-invasive ability against metastatic NSCLC at nanomolar concentrations.

In other words, CuB showed significant tumor angiogenesis-inhibitory effects by the inhibition of migratory, invasive and tube-forming capacities of human umbilical vein endothelial cells.

Moreover, in experimental EMT model CuB also suppressed the overexpression of protein associated with the production of proinflammatory cytokines in the initiation of cellular change and Wnt/β-catenin signaling axis in stimulating the production of formation of new blood vessels to facilitate cancer proliferation.

Taken altogether, cucumber processed a high amount of CuB may be considered supplements for the prevention and treatment of non-small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Lung cancer in elderly patients by Federico Venuta, Daniele Diso, Ilaria Onorati, Marco Anile, Sara Mantovani, and Erino A. Rendina. (PMC)

Tomato Inhibits the Onset and progression of Non-Alcoholic Fatty Liver Disease (NAFLD)

By Kyle J. Norton

Nonalcoholic fatty liver disease (NAFLD) is a chronic condition caused by fat accumulated in the liver over time, in the absence of excessive alcohol use. 

The disease can be classified into the types of non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH).

Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of cirrhosis and liver cancer.

According to world statistics, nonalcoholic fatty liver disease (NAFLD) is normally known as a disease of the Western world. However, due to the economic prosperity of Southeast Asian, the disease also was found in a large number of population in the cities, causing concerns of many scientists in the region.

According to the statistics, in the US, over 100 million people have non-alcoholic fatty liver disease and the condition is more double over the past 20 years. The disease also is the most prevalent liver disease in children.

Among the more affluent regions of China, the prevalence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 15%. The number may decrease substantially if the poor rural populations where obesity is non-existence are also taking into account.

The exact causes of NAFLD aren't well understood. Some researchers suggested that certain risk factors such as long-term use of certain medications, genetic preposition, insulin resistance, high cholesterol and triglycerides in the blood, polycystic ovary syndrome, metabolic syndrome, obesity, and type 2 diabetes are associated with the onset of the disease.

Recent studies also found that people with obstructive sleep apnea, underactive thyroid (hypothyroidism(10) and underactive pituitary gland (hypopituitarism) also at an increased risk of the NALFD.

Some researchers suggested that unhealthy diet such as high-fat diet may also have a strong implication on NAFLD(12)(13).

Dr. Jensen VS, the lead scientist in the study high-fat diet-induced non-alcoholic fatty liver disease, wrote, "In humans and animal models, excessive intake of dietary fat, fructose, and cholesterol have been linked to the development of non-alcoholic fatty liver disease (NAFLD)"(13).

And, " Only HFr-fed rats developed dyslipidemia as characterized by higher levels of plasma triglycerides compared to all other groups (p < 0.0001). Hepatic dysfunction and inflammation was confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control"

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for the treatment of non-alcoholic fatty liver disease (NAFLD), researchers examined the effect of tomato juice consumption on high-fat diet-induced alterations in certain intestinal bacterial groups.

The study included a rat model with NAFLD induced by a high-fat diet that was randomly assigned to involving four experimental groups, including NA (standard diet and water), NL (standard diet and tomato juice), HA (high-fat diet and water) and HL (high-fat diet and tomato juice).

Rats with NAFLD were found to have an impaired gut microbiota profile observed by reducing the abundance of Bifidobacterium and Lactobacillus and increasing Enterobacteriaceae.

Futhermore, according to the tested analysis, NAFLD rat also showed reduced concentrations of propionate, butyrate and phenolic catabolites and an increased acetate to propionate (Ac : Pr) ratio. 

In other words, levels of antioxidant enzymes in the gut also decreased by the in NAFLD induced by high-fat diet rats compared to NA and HA.

Oral administration of tomato juice partially ameliorated high-fat diet-induced disturbances, particularly by increasing Lactobacillus abundance and diminishing the Ac : Pr ratio. 

More precisely, tomato juice protected the gut microbiome composition against the alternation induced NAFLD.

Researchers after taking into account of co and confounders wrote, "(Tomato juice may be) a potential improvement of the metabolic pattern of NAFLD'.

Taken altogether, tomato may be considered a dietary supplements for the prevention and treatment of NAFLD, pending to large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A study of the prebiotic-like effects of tomato juice consumption in rats with diet-induced non-alcoholic fatty liver disease (NAFLD) by García-Alonso FJ1, González-Barrio R, Martín-Pozuelo G, Hidalgo N, Navarro-González I, Masuero D, Soini E, Vrhovsek U, Periago MJ. (PubMed)
(2) Non-Alcoholic Fatty Liver Disease (NAFLD) Treatment In Healthy Food Perspective by Kyle J. Norton

Herbal Turmeric Improves the Inflammatory Response Against Renal Toxicity

By Kyle J. Norton

The immunomodulatory effect is a process in which the immune function is modulated to the needs of the body.

The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.

The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system.

* The overactive immune system is also known as autoimmune diseases.

In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.

Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.

Most common symptoms of acute inflammation occurred with a short period of time such as hours is a pain, redness, immobility, swelling, and heat.

Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.

However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.

Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the modulation of the immune response, researchers examined the metformin and curcumin alone or in combination on nephrotoxicity induced by GM.

According to the tested differentiation,
* Both metformin and curcumin, when used alone, were effectively decreasing GM-induced nephrotoxicity.

* Both drug combination exerted a synergistic effect in ameliorating a GM-induced kidney injury, by expressively improved renal dysfunction.

* Moreover, in a GM treated animal model, metformin and curcumin showed strong protection against oxidative stress by decreasing the activities and expression of various oxidative enzymes.

* The combination also exerted a strong anti-inflammatory response by inhibiting the expression of pro-inflammatory cytokines in GM intoxicated group of animals.

Based on the findings, researchers said, " combinational treatment of metformin and curcumin might have a synergizing effect and substantial potential against nephrotoxicity".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for controlling the body's immune response, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Combinational effect of curcumin and metformin against gentamicin-induced nephrotoxicity: Involvement of antioxidative, anti-inflammatory and antiapoptotic pathway by Cao L1, Zhi D1, Han J1, Kumar Sah S2, Xie Y. (PubMed)

Monday, 16 September 2019

Cranberry Protects the Bladder Against Radiation Cystitis in Prostate Cancer Patients

By Kyle J. Norton

Cystitis is a medical condition associated with inflammation of the bladder, leading to the symptoms of bladder irritation and swelling. Women are prone to the condition compared to men.

Most common cause of the bladder cystitis is a bacterial infection involved in a urinary tract infection (UTI). However, radiotherapy, long-term use of certain medicines and hygiene products have also been found to induce bladder inflammation.

Most common symptoms of cystitis are frequent urge to urinate, urge to urinate after you’ve emptied your bladder, cloudy or strong-smelling urine, pain during sexual intercourse and sensations of pressure or bladder fullness.

In serious cases, patients may also experience symptoms of fever, blood in your urine and cramping in your abdomen or back.

The prostate warped around the around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder that makes some of the semen to carry sperm.

Prostate cancer is a medical condition caused by abnormal cell growth in the tissue of the prostate. The low-growing prostate cancer may be detected during the physical (rectum) exams.

Conventionally, antibiotics are effective for the treatment of cystitis if the bacteria that cause the infection has been identified.

Most cases of acute cystitis are treated by nitrofurantoin monohydrate/macrocrystals, trimethoprim-sulfamethoxazole (TMP-SMX) accompanied by nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil) or acetaminophen (Tylenol) to reduce pain and inflammation.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of prostate diseases, researchers examined the effect of highly standardized cranberry capsules (containing 72 mg proanthocyanidins [PACS]) compared with that of placebo capsules on the incidence and severity of radiation cystitis.

The double-blinded randomized placebo-controlled study included 41 men with prostate cancer who took one capsule a day at breakfast during treatment for 2 weeks.

According to the tested analysis,
* Cranberry capsules (65%) group showed the reduced incidence of cystitis compared with those that took placebo capsules.

* The severe cystitis was reduced to 30% of men in the cranberry group compared to 45% in the placebo.

* Furthermore, cranberry capsules group also significantly reduced symptoms of pain/burning.

* Additionally, the cranberry capsules group also showed a stronger urine stream and a decrease of the used significantly fewer pads/liners, compared to placebo.

Based on the results, researchers said, "Men receiving radiation therapy for prostate cancer may benefit from using cranberry capsules, particularly those on low hydration regimens or with baseline urinary symptoms".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of cystitis.in prostate cancer patients, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Standardized cranberry capsules for radiation cystitis in prostate cancer patients in New Zealand: a randomized double-blinded, placebo-controlled pilot study by Hamilton K1, Bennett NC, Purdie G, Herst PM. (PubMed)
(2) Cranberry intervention in patients with prostate cancer prior to radical prostatectomy. Clinical, pathological and laboratory findings by Student V1, Vidlar A1, Bouchal J2,3, Vrbkova J3, Kolar Z2,3, Kral M1, Kosina P4, Vostalova J. (PubMed)

Bromelain Ameliorates Endometrial Pain

By Kyle J. Norton

Endometriosis is a medical condition caused by the tissue of the endometrium that grows outside the uterus, leading to severe abnormal pain.

Most cases of endometriosis are found to involve the ovaries, fallopian tubes and the tissue lining the pelvis.

Some researchers suggested the cause of endometriosis is a result of a layer of endometriosis lining on the inside of the uterus is expelled, instead, some of the endometriosis tissues grow somewhere in the body in the last stage menstrual cycle (menstruation).

Endometriosis also reacts to hormone signals of the monthly menstrual cycle, by building up tissue, breaking it and eliminating, according to the stage of the menstrual period. Since they grow in somewhere other than in the uterus when they break, the period blood has no way to exit, causing blood attaching to the organs or lining of the abdomen, resulting in scars or adhesion as well as weakening the normal function of organs.

According to statistics, endometriosis affects
a) About 20% of reproductive age women with endometriosis present but without symptoms.

b) About 55% of women who have developed the new onset of severe menstrual cramps.

c) About 25% of women with sub-fertility (less fertile than a normal couple)

Endometriosis can vary in appearance. It may be clear or white, reddish, brown or blue-black, and cysts. The condition can be classified according to the stage of severity:
* Minimal stage:
The top surface, few in number. Commonly they are found in the inside wall of uterus, ligaments, and ovary.

* Mild stage:
Deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage.

* Moderate stage:
Many implants, endometrial cysts present, affecting ovary function, causing scar tissues and adhesion is also present.

* Severe stage:
Intensive peritoneal implants, large endometromas present and dense adhesion.
Each woman experiences differently to endometriosis. Some women may have extensive endometrial tissues in their body but feel little or no pain, while other women may only be in the early stage of endometriosis but have excessive pain.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential ingredient for the treatment of endometriosis-associated pelvic pain, researchers evaluated the antioxidant activity of a preparation containing N-acetyl cysteine, alpha lipoic acid, and bromelain.

The multicenter, open-label, non-comparative clinical trial included a sample of 398 patients with a mean age of 34.6 ± 7.2 years with endometriosis-associated pelvic pain.

According to the results of a combination of N-acetyl cysteine, alpha lipoic acid and bromelain treatment after 6 months, in comparison of 92.7% of the patients with pain intensity > 4 on the visual analogue scale (VAS) at the baseline, the percentage was decreased to 87.2% (p = 0.074) at 3 months of treatment.

Also compared to the baseline, the percentage decreased even more at 82.7% (p < 0.05) at the 6 months treatment.

More importantly, the use of medicine for pain relief also was also reduced upon on the application of the combination, according to the results of the experiment.

Dr. Lete I, the lead scientist said at the final report, "Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics".


Taken altogether, bromelain used alone or combined with other remedies may be considered supplements for the prevention and treatment of endometrial pain, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(2) Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study by Lete I1, Mendoza N2, de la Viuda E3, Carmona F. (PubMed)

Green Peas (Pisum Sativum) Improves the Digestive Functioning in Flavor of Good Bacteria

By Kyle J. Norton

The digestive system included the gastrointestinal tract, the liver, pancreas, and gallbladder plays a critical role to maintain the body normal function by providing nutrients and fluids to the body and remove waste through the secretary system.


Digestion is a process of the digestive system by breaking out down food after food intake through mechanical and enzymatic action.

Indigestion, on the other hand, is symptoms of another digestive disease, including GERD. Most cases of indigestion not caused by underlying diseases can be resolved quickly.

People with indigestion experience symptoms differently. Some may feel the symptoms of occasionally while others may feel often and daily.

There are a number of risk factor associated with digestive disorders including bacterial and/or viral infection, inflammation, lactase deficiency, anti-inflammatory drugs and certain conditions such as ruptured or perforated organs, muscle dysfunction, gallstones.

However, some researchers suggested that there is a strong correlation between the risk of digestive disorders in obese patients.

Dr. Su Youn Nam, in the investigation of obesity-related digestive diseases, wrote, "Obesity-related digestive diseases include gastroesophageal reflux disease, Barrett’s esophagus, esophageal cancer, colon polyp and cancer, nonalcoholic fatty liver disease, hepatitis C-related disease, hepatocellular carcinoma, gallstone, cholangiocarcinoma, and pancreatic cancer".

And, "Although obesity-related esophageal diseases are associated with altered mechanical and humoral factors, other obesity-related digestive diseases seem to be associated with obesity-induced altered circulating levels of adipocytokines and insulin resistance".

The findings strongly indicated the risk of digestive disorder in obese is substantially higher compared to healthy weight individuals.

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the treatment of digestive diseases, researchers investigated the effects of soybean meal (SBM) substitution by a mixture of rapeseed meal (RSM), white lupine seeds (WLS) and pea seeds (PS) on gastrointestinal function in Hyplus rabbits.

Selected Hyplus rabbits were fed by either control diet (SBM15) containing 15% SBM, or diet SBM7.5 containing 7.5% SBM, 5% RSM, 4% WLS and 3% PS. In diet SBM0 or diet SBM0, SBM completely was replaced by RSM, WLS and PS (10%, 8%, and 6%, respectively).

Based on the tested analysis, the experimental diets did not cause significant differences in performance parameters evaluated in vivo and post-mortem, and in the nutrient and energy digestibility of nitrogen retention.

However, the change of enzymatic activity of large gut microbiota in flavors of the good bacteria was found to have a similar effect in the comparison of diet SBM and the mixture of RSM, WLS, and PS.

In other words,  pea seeds (PS) used a combination with rapeseed meal (RSM) and lupine seeds (WLS)  processes a significant effect in balancing the levels of microbiota in the promotion of digestive functioning.

Taken altogether, green peas used alone or combined with other healthy food may be considered a  remedy for the promotion of gastrointestinal health,  pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effects of rapeseed meal and legume seeds as substitutes for soybean meal on productivity and gastrointestinal function in rabbits by Gugołek A1, Juśkiewicz J2, Strychalski J1, Zwoliński C1, Żary-Sikorska E3, Konstantynowicz M. (PubMed)
(2) Obesity-Related Digestive Diseases and Their Pathophysiology by Su Youn Nam. (PMC)

Health Food Onion Processes Anti-Atherogenic Property

By Kyle J. Norton


Atherosclerosis is a condition characterized by the accumulated plaque on the arterial wall. Over time the condition can cause stiffening and hardening of the arteries, leading to cardiovascular disease.

Anti-atherogenic activity is the process to prevent or inhibit atherogenesis associated with the reduced formation of fatty plaques in the arteries.

 In other words, anything, including the use of substances such as herbal remedy that prevents the blockage or narrowing of the arteries is considered atheroprotective effects.

Plaque in the arteries is formed by substances including fat, cholesterol, calcium, and other substances found in the blood in the bloodstream. However,  most cases of atherosclerosis are also involved in the amount of cholesterol which normally returned to the liver in healthy individuals remaining in the blood due to low levels of good cholesterol (HDL) or overexpression of bad cholesterol (LDL).

In other words, an unhealthy ratio of low and high-density lipoprotein is also one of the major risk factors of atherosclerosis.

The healthy ratio of blood cholesterol is any number that is less than 4 (LDL)/ 1 (HDL).


Some researchers suggested by increasing the levels of good cholesterol in the blood, the risk of atherosclerosis can be reduced.

Dr. Feig JE and colleagues wrote, "Pharmacologic agents, such as fibrates and niacin that increase HDL cholesterol levels have been associated with decreased cardiovascular events and beneficial effects on the coronary and carotid arteries".

And, "...potential mechanisms by which HDL may exert these anti-atherogenic effects, namely through its role in reverse cholesterol transport, its effects on endothelial cells, and its anti-inflammatory/antioxidant activities".

The results strongly suggested a healthy diet including nuts, coffee, cocoa, grapes, and berries with high levels of HLD may have a profound effect on the prevention of atherosclerosis.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potent ingredient which processes cardioprotection researchers examined the quercetin and polyuronide contents of rapidly dried onion (Allium cepa L. cv. Momiji No. 3) powder (OP) prepared from the outer layers (from second to the fourth scale leaves from the surface) of onion bulbs anti-atherogenic effect.

The study included rats fed a high-fat diet treated by quercetin 4'-glucoside (50%), free quercetin (30%) and quercetin 3,4'-glucoside (20%) as quercetin derivatives in boiling-water extraction.

According to the tested differentiation, in high-fat diet Wistar rats, additional OP did not show a significant difference in total cholesterol, HDL-cholesterol and triglyceride concentrations compared to rats fed a high-fat diet without OP.

However, the atherogenic index (AI) associated with cardiovascular disease risk of Wistar rats fed an OP-added high-fat diet was lower compared to those fed with a diet without OP.

Moreover, the incremental elastic modulus (IEM), a measurement of the stiffness of the larger arteries from rats fed the OP-added diet was also significantly lower compared to rats fed by diet without OP.

Additionally, both rat groups were found to exert similar AI and IEM values if the rats fed the diet without OP were allowed spontaneous exercise.

In other words, OP protected the cardio-tissue by exerting an anti-atherogenic effect through other unknown mechanisms associated with regular exercise, without affecting the parameters of cholesterol.

Based on the results, researchers wrote, "These results suggest that OP intake is effective for decreasing the risk of arteriosclerosis".

Taken altogether, onion processed a higher mount of onionin A (ONA) may be considered a remedy for the prevention and treatment of arteriosclerosis, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Physicochemical characteristics of rapidly dried onion powder and its anti-atherogenic effect on rats fed high-fat diet by Hamauzu Y1, Nosaka T2, Ito F3, Suzuki T4, Torisu S3, Hashida M5, Fukuzawa A6, Ohguchi M3, Yamanaka. (PubMed).
(2) Atheroprotective effects of HDL: beyond reverse cholesterol transport by Feig JE1, Shamir R, Fisher EA. (PubMed)

Sunday, 15 September 2019

Turmeric Bioactive compound Curcumin, the Potential Treatment for Reducing Radiation Dermatitis Severity in Cancer Patients

By Kyle J. Norton

Radiation dermatitis is skin damage caused by exposure to radiation. The condition is often found in patients with radiotherapy for the treatment of cancer.

According to statistics, approximately 85% of patients with radiotherapy are affected by the symptoms of moderate-to-severe skin reactions, particularly in the first 2 weeks of the treatment.

Depending on the period of exposure and levels of skin damage, some patients with radiation of dermatitis may experience symptoms of mild skin redness, itchiness, peeling, moistness,... and blistering

In severe cases, patients may also induce painful broken skin, that prone to infection. 

If you are treated with radiotherapy, you make sure that you know all the side effect for preventive measure.

Believe it or not, patients with certain medical conditions, inclduing skin disease, obesity
 malnutrition, infectious diseases, and diabetes are more prone to radiation dermatitis, compared to those who do not.

Most cases of radiation dermatitis are treated successfully by topical steroid cream often prescribed by radiologist. However, if the topical cream failed, antibiotics, silver leaf nylon dressing may be prescribed to reduce symptoms and prevent infection.

Dr. Benoîte Méry, the lead scientist in the examined the risk of skin damage in breast cancer patients who were treated by radiation wrote, "54 patients were enrolled in 2013. Eight patients (14.8%) had grade ≥2 toxicity. The average weight and chest sizes were 65.5 kg and 93.6 cm, respectively. Bra cup size is significantly associated with a risk of grade 2 dermatitis [odds ratio (OR) 3.46, 95% confidence interval (CI) (1.29–11.92), p = 0.02]. Anthropometric breast fat mass measurements, such as thickness of left [OR 2.72, 95% CI (1.08–8.26), p = 0.04] and right [OR 2.45, 95% CI (0.99–7.27), p = 0.05] axillary fat, is correlated with an increased risk".

And, "Breast size and its different anthropometric measurements (thickness of left and right axillary fat, nipple-to-pectoral muscle distance) are correlated with the risk of skin toxicity".

The results suggested that other parameters, such as the area treated with radiation must also be taken into account of radiation dermatitis.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a skincare product with no side effects, researchers reviewed the chemistry of turmeric on radiation dermatitis occurred in 95% of patients with radiation therapy (RT) for cancer.

The multisite, randomized, double-blinded, placebo-controlled trial included 686 breast cancer patients received four 500-mg capsules of placebo or curcumin three times daily throughout their prescribed course of RT until 1-week post-RT.

According to the severity (RDS) at the end of RT, using the RDS scale, compared to placebo, oral curcumin did not reduce radiation dermatitis severity at the end of RT.

However, curcumin group showed an improvement in fewer patients with RDS > 3.0.

In other words, oral curcumin exerted a prominent effect in inducing a trend toward reduced severity compared to the non-curcumin treated group.

According to the reports from participants, curcumin also showed a change in pain, symptoms, and quality of life, although they were not statistically significant between arms.

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for reducing radiation dermatitis severity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Turmeric: A condiment, cosmetic and cure by Gopinath H1, Karthikeyan K. (PubMed)
(2) Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients by Ryan Wolf J1,2,3, Heckler CE4,5, Guido JJ4,5, Peoples AR4, Gewandter JS6, Ling M7, Vinciguerra VP8, Anderson T9, Evans L10, Wade J11, Pentland AP12, Morrow GR. (PubMed)
(3) Correlation between anthropometric parameters and acute skin toxicity in breast cancer radiotherapy patients: a pilot assessment study by Benoîte Méry, MD,1 Alexis Vallard, MD,2 Jane-Chloé Trone, MD,2 Cécile Pacaut, MD,1Jean-Baptiste Guy, MD,2 Sophie Espenel, MD,2 Julien Langrand-Escure, MD,2 Edouard Ollier, MD,3 Guoping Wang, MD,1 Peng Diao, MD,2 Lise Bigot,2 Sylvie Mengue Ndong, MD,2Claire Bosacki, MD,1 Majed Ben Mrad, MD,2 and Nicolas Magné, MD, PhD. (PMC)

Green Beans Induces Weight Loss and Reduces Risk of CVD in Obese

By Kyle J. Norton

Obesity is a medical and chronic condition caused by long-term excessive body fat accumulated. Overweight is a condition of excess body weight relative to height.

According to the Body Mass Index(BMI), people who have a BMI between 25 to 29.9 is considered overweight and a BMI of over 30 is an indication of obesity.

According to the statistic, 68% of the American population is either overweight or obese. However,
in 2016, more than 1.9 billion adults, 18 years and older, were overweight, and over 650 million were obese worldwide.

Most common causes of obesity are associated with an increased intake of energy-dense foods that are high in saturated and trans fat, processed foods and red meat and physical inactivity.

The WHO in the explanation of the causes of obesity wrote, "Changes in dietary and physical activity patterns are often the result of environmental and societal changes associated with development and lack of supportive policies in sectors such as health, agriculture, transport, urban planning, environment, food processing, distribution, marketing, and education".

Certain medical conditions such as hypothyroidism, polycystic ovary syndrome, Cushing's syndrome,..., genetic preposition and use of certain medications that can cause weight gain or water retention, such as corticosteroids, antidepressants or some seizure medications, also increases the risk of overweight and obesity.

Cardiovascular diseases (CVD) are a class of conditions associated with the dysfunction of the arteries and heart, affecting the heart functioning.

According to the statistics provided by the CDC, heart disease is the leading cause of death for both men and women. Men are associated with 1/2 of the deaths due to heart disease in 2015, comapred to women.

Believe it or not, more than 63),000 Americans die from heart disease each year or 1 in every 4 deaths are caused by heart disease.

On another hand, stroke is a medical condition caused by poor blood flow to the brain, leading to brain cell death in the affected region.

Dr. Luma Akil, the lead scientist in the investigation the risk of CVD in obese wrote, "Obesity is among the leading causes of elevated cardiovascular disease (CVD) mortality and morbidity. In the present study, the associations between the increase in body mass index (BMI) and the increasing rates of CVD and high blood pressure (HBP)".

And, " Data from Behavioral Risk Factor Surveillance System were obtained and analyzed for obesity rates, percent of myocardial infarction, stroke, and HBP from 2005–2009".

In other words, if you are obese, your risk CVD are substantially higher comapred to non-obese individuals

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belong to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a potent whole food which process anti-anti-obesity activity,  researchers examined the effect of edible dry bean consumption (Phaseolus vulgaris L. including green beans) modulates diet-induced obesity in rats and mice.

Sprague-Dawley rats and a diet-induced obesity model in C57Bl/6 mice included in the vivo suggested, cooked dry bean showed a positive modulation of plasma lipids and hepatic proteins that involves in lipid biosynthesis.

In both animal species, short-term feeding of a bean-containing diet demonstrated a reduced plasma total cholesterol and LDL-cholesterol without affecting HDL-cholesterol or total TAG associated with the target of cholesterol catabolism and excretion.

More importantly, bean-fed obese mice displayed a significant weight loss within a 12 d time frame.

In other words, dry beans injection in a short-term of 7-14 day ) not only had a strong effect on weight regulatory effects but also exerted a cardioprotective against CVD obese mice.

Taken altogether, green beans or other dried beans may be used as an adjunct therapy for the prevention of cardiovascular disease, pending to the confirmation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Edible dry bean consumption (Phaseolus vulgaris L.) modulates cardiovascular risk factors and diet-induced obesity in rats and mice by Zhu Z1, Jiang W, Thompson HJ. (PubMed)
(2) Relationships between Obesity and Cardiovascular Diseases in Four Southern States and Colorado by Luma Akil, PhD-C, Candidate and H. Anwar Ahmad, Ph.D., MBA, MCIS. (PMC)