Tuesday, 31 December 2019

The Health Benefits of Omega 3 Fatty Acids

By Kyle J. Norton

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the prevention of diseases, researchers examined the myriad health benefits of omega-3 PUFAs.

According to the search of epidemiological studies, omega-3 PUFAs exerted a strong activity against the risk and treatment of
* Cardiovascular diseases
Cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.

The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaques build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain, respectively.
* Diabetes
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

Most common types of diabetes are
**Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

** Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose due to either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

* Cancer
Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
* Alzheimer's disease
Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal. 

According to statistics, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.

* Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

* Depression
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness. Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself.

Furthermore, omega 3 fatty acids improved fetal health including slightly increase a baby’s weight at birth and the length of time the baby is in the womb, both of which may be beneficial. Breast milk contains DHA.

However, researchers explained, "there are also some controversies about their efficacy and certain benefits to human health".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the promotion of health benefits, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits by Shahidi F1, Ambigaipalan P. (PubMed)

Beta-Sitosterol, the Potential Anti-Skin Cancer Supplement

By Kyle J. Norton

Skin, a large organ that forms the out layers of our body has a serval layer of ectodermal tissue to protect the underlying muscles, bones, ligaments and internal organs against foreign pathogenic invasion.

Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and often detected at an early stage.

Most cases of primary skin cancer start in the cell on the surface of the inner ling of the skin. At the advanced stage, the cancerous cells can travel a distance away from the skin to infect other healthy tissue and organ through blood and fluid circulation.

There are 3 main types of cells in the top layer of the skin (called the epidermis):
Squamous cells, Basal cells, and Melanocytes.

Long-term cumulative sun exposure is one of the major causes of basal cell and squamous cell skin cancer. Exposure to ultraviolet (UV) radiation is the leading cause of melanoma.

Certain risk factors that make some people susceptible to the development of skin cancer than others, include the increase in age, weakened immune system, gender, skin tone, genetic preposition, and family history.

According to the statistics, skin cancer is the most common cancer in the US. one in five Americans will develop skin cancer in their lifetime.

Every day, approximately 9,500 people in the U.S. are diagnosed with skin cancer due to a misunderstanding of the health benefits and risk of sun and tanning exposure.

Most common symptoms at the early stage, are a large brownish spot with darker speckles, a mole that changes in color, size or feel or that bleeds, a small lesion with an irregular border and portions that appear red, pink, white, blue or blue-black.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of cancer, researchers compared the effects of Betulinic acid (1), betulinic acid-3-acetate (2), 3-acetyl betulin aldehyde (3), oleanolic acid-3-acetate (4), 3-β-hydroxy-28,19-β-olenolide (5), and β-sitosterol (6) were isolated from Platanus orientalis on skin cancer cells.

According to the chemical analysis, The (1 ) is the most abundant component (4.63%) compared to the least of the (5) (0.017%) the least.

All isolated compounds showed a significant cytotoxic effect against human keratinocyte, mouse melanoma, and human skin epithelial carcinoma cancer cells according to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

In other words, all compounds found in Platanus orientalis work synergistically against the skin cancer risk in vivo.

Taken altogether, beta-sitosterol may be considered supplements for the prevention of od skin cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A validated high-performance thin-layer chromatography method for the identification and simultaneous quantification of six markers from Platanus orientalis and their cytotoxic profiles against skin cancer cell lines by Khan I1, Sangwan PL, Dar AA, Rafiq RA, Farrukh MR, Dhar JK, Tasduq SA, Koul S. (PubMed)

Tocopherols Protect the Heart Against the Risk of Cardiovascular Diseases CVD

By Kyle J. Norton

Cardiovascular disease (CVD) is a group of conditions associated with the heart and blood vessels.

In other words, anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

The causes of cardiovascular diseases are associated with the accumulation of plaques in the arteries, impeding the blood flow which carries the nutrients and oxygen to the heart, which causes damage to the heart tissue and reduced function of the arteries.

In other words, high blood pressure, high blood cholesterol, smoking, diabetes, weight, depression and family history associated with the early onset of plaques accumulated and impeding function of the arteries are the prevalent risk factors of cardiovascular diseases.

According to the statistic cardiovascular disease is the leading cause of death in women in the US with 90% of women having one risk factor.

Believe it or not, women are 4 times more likely to die from heart disease than breast cancer and 2/3 of women are not aware of heart disease is such a risk for them, according to the Jean Hailes for Women Health in the article cardiovascular health.

According to statistics, heart disease is the second leading cause of death, claiming more than 48,000 lives every year.in Canada.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of tocotrienol on oxidative stress and inflammation in the manifestation of aging-related cardiovascular disease.

According to the analysis,  vitamin E supplement demonstrated significant activity in reducing the expression of oxidative stress induced by chronic inflammation.

More precisely, the efficacy of vitamin E that decreases the oxidative stress-induced cardiovascular disease was attributed to the presence of chemical compounds tocotrienols and tocopherols

More precisely, tocopherols, a class of Vitamin E compounds showed a lesser antioxidative and anti-inflammatory activity compared to those of tocotrienols (the other class of Vitamin E compounds), in ameliorating aging-related cardiovascular diseases and its associated morbidities.

Based on the results, researchers said, "the potential of tocotrienols in improving inflammation, dyslipidemia and mitochondrial dysfunction in aging-related cardiovascular diseases...".

Taken altogether, tocopherols may be considered a supplement for reducing the risk of cardiovascular diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tocotrienol is a cardioprotective agent against aging-associated cardiovascular disease and its associated morbidities by Ramanathan N1,2, Tan E3, Loh LJ3, Soh BS3,4,5, Yap WN. (PubMed)

Monday, 30 December 2019

Phytochemical Beta-Sitosterol, the Anti-Bacterial Remedy

By Kyle J. Norton

Bacteria is a type of biological cell consisted of a single cell with a simple internal structure. The most common diseases caused by bacteria are strep throat, urinary tract infections, and tuberculosis.

Infection is an inflammatory condition caused by a microbial invasion on body tissues

Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, overuse of antibiotics has been found to make them resistant to antibiotics.

The most common symptoms of bacterial infection include redness and heat, swelling, fever, pain at the site of infection.

Out of trillions of strains of bacteria in the world, only a few cause diseases in humans. Believe it or not, our gut contains trillion microorganisms, most of them are bacteria.

Infection can be acute or chronic. In the acute phase of infection. The immune macrophages in the first line of defense stimulate the production of blood palette to cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens.

However, overproduction of pro-inflammatory cytokines in the acute phase of infection has also killed off or damage to the nearby healthy cells, leading to the formation of scars.

Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, and diarrhea, short term joint or muscle pain, fever, headache, skin rash and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body is fighting infection.

In most cases in a healthy individual, depending on the size of the wound, the immune system can easily eradicate all foreign invaders and the wound is recovered within days and weeks.

In chronic infection, the symptoms are most vague or no specific symptoms, including bronchitis and asthma, persistent low-grade chronic joint and muscle pain, or swelling and the alternations between diarrhea and constipation, bloating, or heartburn, In other words, the symptoms are totally depended on the location of the low-grade inflammation.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of infectious diseases, researchers examined the antibacterial activity of compounds from the powder of root bark of Malva parviflora (Malvaceae).

According to the chemical analysis of the extracts with petroleum ether (b.p. 60–80 °C), chloroform and ethanol, the chloroform extract showed antibacterial activity against Staphylococcus aureus and Escherichia coli compared to the effect of the ethanolic extract against only S. aureus.

The chloroform extract inhibited the bacterial strain properties were characterized as β-sitosterol by physical properties, chemical test, spectral analysis (FTIR, NMR, and MS) and compared the data obtained from the literature.

In other words,  phytochemical β-sitosterol prompted a strong anti-bacterial activity of root bark of Malva parviflora (Malvaceae)

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of bacterial infectious diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Structure elucidation of β-sitosterol with antibacterial activity from the root bark of Malvaparviflora by Mesfin Medihin Ododo,1 Manash Kumar Choudhury,2 and Ahmed Hussen Dekebo. (PMC)


Omega 3 Protects Against the Heart Abnormal Rate or Rhythm of the Heartbeat

By Kyle J. Norton

Cardiovascular disease is a medical condition affecting the cardiovascular system, including heart, blood vessels(arteries and veins).

Heart diseases are a class of diseases characterized by a wide range of conditions, such as coronary artery disease, heart rhythm problems (arrhythmias), and heart defects......

The term of heart disease is used interchangeably with cardiovascular diseases in expressed conditions that can lead to a heart attack, chest pain (angina) or stroke, involving narrowed or blocked blood vessels,

According to the statistics, heart disease is the leading cause of death in the US, approximately 610,000 people die of heart disease every year,  representing 1 in every 4 deaths. And coronary heart disease(CHD) is the most common type of heart disease, which kills over 300,000 people in 2015.

Coronary heart disease (CHD) kills over 370,000 people annually.

An arrhythmia is a condition associated with an abnormal rate or rhythm of the heartbeat.

The condition is caused by the electrical impulses that coordinate the  heartbeats don't work properly, causing your heart to beat too fast, too slow or irregularly

The most common symptoms of arrhythmia are, a fluttering in the chest, a racing heartbeat, a slow heartbeat, chest pain and shortness of breath.

Conventionally, treatments of arrhythmias include medications that stop or prevent arrhythmia or control the rate of arrhythmia and cardioversion, which uses electricity to shock the heart back into a normal rhythm.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of heart diseases, researchers examined the Omega 3 fatty acid effects of marine omega-3 polyunsaturated fatty acids (PUFAs) in relation to ventricular arrhythmia.

According to the tested analysis, marine omega-3 PUFAs not only showed a strong activity on atrial fibrillation but also in ventricular arrhythmias.

Moreover, according to the results of studies chosen to the investigation
Rats fed diets enriched in fish oil, sunflower oil, or beef tallow for 6 weeks, with the hearts either subjected to ischemic preconditioning or not showed ischemic preconditioning reduced ventricular arrhythmias in all dietary groups.

* According to the results of heart rate and heart rate variability recorded at rest, during submaximal exercise, and during a 2-min coronary artery occlusion at rest in dogs with a healed myocardial infarction before and after 3 months supplementation with a fish oil or corn oil, fish oil, but not corn oil reduced heart rate and heart variability at rest, but not during exercise or during coronary occlusion

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of diseases abnormal heart rhythm, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 fatty acids and cardiac arrhythmias by Rix TA1, Christensen JH, Schmidt EB. (PubMed)
(2) Omega-3 Fatty Acids: Anti-Arrhythmic, Pro-Arrhythmic, or Both? by C. von Schacky. (PMC)

Tocopherols Inhibits the Onset of Colorectal Cancer in Men ONLY

By Kyle J. Norton

The colon-rectum formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces and into substances of which some of them to be reabsorbed and reused by the body.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.

Colorectal cancer is relatively very common and slowly growing and progressing cancer.

The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increased in age, family and personal history, genetic preposition are some of the prevalent risks of the disease.


Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cancers, researchers examined the associations of serum carotenoids, retinol, and tocopherols with colorectal cancer risk.

According to the case-control study nested within the Japan Collaborative Cohort Study, including micronutrients measured in prediagnostic serum samples from 116 men and women who developed colorectal cancer during an 8-yr follow-up period and from 298 matched controls,
* In men, the higher level of serum total carotenoids was associated with a decreased risk with the multivariate-adjusted odds ratio (OR) for the highest vs. the lowest tertile of 0.34.

* The increased serum retinol in all subjects and alpha-tocopherol also associated with a decreasing risk of cancer with the ORs for the highest tertiles were 0.29 and 0.29, respectively.

* In women, the higher levels of alpha- and total carotenoids were instead related to increased risk: with the corresponding ORs of 4.72 (95% CI = 1.29-17.3), 2.00 (0.70-5.73), and 2.47 (0.73-8.34), respectively.

Taken altogether, tocopherols may be considered a supplement for treatment of colorectal cancer in MEN only, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort: effect modification by sex for carotenoids by Wakai K1, Suzuki K, Ito Y, Kojima M, Tamakoshi K, Watanabe Y, Toyoshima H, Hayakawa N, Hashimoto S, Tokudome S, Suzuki S, Kawado M, Ozasa K, Tamakoshi A; Japan Collaborative Cohort Study Group. (PubMed)

Cranberry Inhibits the Onset of Insulin Resistance

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

Diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Insulin resistance is a condition in which cells that convert glucose to energy in the muscles, body fat, intestine, and liver ignore the signal o the hormone insulin signaling.

 In other words, signals sent out by the hormone insulin was ignored by the cell of the muscles, body fat, and liver that process the function to convert glucose into energy.

Epidemiologically, people with insulin resistance are associated with an increased risk of prediabetes, type 2 diabetes and chronic conditions such as heart attacks, strokes, and cancer.

According to statistics, over 100 million Americans are living with insulin resistance. Approximately 1 in 3, including half of those age 60 and older have a silent blood sugar problem known as insulin resistance.

There are no single causes of insulin resistance, Epidemiologically, aging, ethnicity, overweight or obese, too much belly fat, physical inactivity, smoking and certain medical conditions such as Cushing’s disease or polycystic ovary disease are some of the prevalent factors that induce the risk of the condition.

However, most people with some of the aforementioned risk factors have never developed insulin resistance.

Most cases of insulin resistance in the Western world are involved in the clogged up insulin receptors.
As the signals of hormone insulin are blocked, insulin resistance develops, leading to more production of insulin by the body.

Over time insulin resistance that leads to damage to the beta cell in the pancreas, an early condition of prediabetes and types 2 diabetes.

The most common symptoms of patients with insulin resistance are tiredness, hunger and difficulty concentrating.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of prediabetes, researchers investigated the potential of a polyphenol-rich extract from cranberry (CE) on metabolic disorders in DIO-mice

Mice selected to the study were pre-fed either a Chow or a High Fat-High Sucrose (HFHS) diet for 13 weeks to induce obesity and then treated either with CE (200 mg/kg, Chow + CE, HFHS + CE) or vehicle (Chow, HFHS) for 8 additional weeks.

According to the tested analysis, CE did not reverse weight gain or fat mass in Chow- or HFHS-fed mice.

However, HFHS + CE fully reversed hepatic steatosis by stimulating the genes involved in lipid catabolism (e.g., PPARα) and inhibiting the production of several pro-inflammatory genes in the liver.

These results were attributed to the efficacy of HFHS + CE in the improvement of the levels of glucose tolerance and normalization of insulin sensitivity in the tested mice.

Moreover, the ratio of gut microbiota was significant to improve in the HFHS + CE group compared to HFHS controls.

Taken altogether, cranberry combined with conventional medicines may be considered a remedy for the improvement of glucose tolerance and insulin sensitivity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss by Anhê FF1, Nachbar RT2, Varin TV3, Vilela V4, Dudonné S5, Pilon G6, Fournier M7, Lecours MA8, Desjardins Y9, Roy D10, Levy E11, Marette A. (PubMed)

Omega 3 Fatty Acids Improve the Immune Functioning in Vivo

By Kyle J. Norton

An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens, including bacteria, viruses, parasites, etc. and tumor cells, including irregular cells growth, cancer cells to keep us healthy.

In most cases, the immune system does a great job of keeping people healthy and preventing infections. But sometimes problems with the immune system can lead to illness and infection.

Although the immune system has done a great job in protecting us against foreign invasion, unfortunately, during the process od their functions, they may induce the production of free radicals and chain of free radicals that can be harmful to our body.

Immunomodulatory activity is an action that improves the underactive immune function susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

In other words, depending on the substances that affect the immunomodulatory process, some may improve the immune function by modulating the genes involved immune responses and protect the immune system against toxins or immunotoxic effects such as abnormal allergic reactions, other such as heavy metals can induce opposite effects.

In normal immunity, active immunity may also be artificially acquired active immunity caused by the injection of the vaccine, a substance that contains antigen and passive immunity is an auto-response of the immune system against infection through the production of antigen.


Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the improvement of the immune functioning, researchers examined the long-chain n-3 PUFAs (LCPUFAs) anti-atopic disease risk in infants.

The study included pregnant Sprague-Dawley rats randomly assigned to consume either SDA (3 g SDA/100 g fat) or a control (no SDA) diet, 5 d before parturition and through lactation (21 d).

Additionally, for oral tolerance (OT) treatment, 10-d-old pups were fed ovalbumin (Ova; 200 μL of 8 mg/mL) or placebo daily for 5 d. At 21 d,

According to the experimental results of pups (both sexes) that were weaned to their respective maternal diet until 6 wk of age and killed, the SDA-enriched maternal diet showed a higher levels of plasma phospholipid (PL) EPA (15 times higher), docosapentaenoic acid (DPA; 3 times higher), and DHA (1.3 times higher) content in 3-wk-old pups, accompanied by higher B-cell function [plasma ovalbumin-specific IgG1, compared with the control diet.

Furthermore, compared with pups fed a control diet, the splenocytes from pups fed with the SDA diet had more (23%) helper T (Th) cells (CD3+CD4+) and activated (12%) Th cells (CD4+CD28+) (P < 0.02) than controls.

Moreover, at 6 wk, the SDA group stimulated ex vivo with LPS, also had 30% more CD4+CD25+ splenocytes and produced less inflammatory IL-6 (50%) and TNF-α (30%) and more immunoregulatory IL-10 (45%) cytokines, compared to the control group.

However, the splenocytes and plasma PLs from the 6-wk-old SDA group had more EPA (2x) and DPA (3.5x) (P < 0.05), but not DHA, compared to the control group.

Additionally, the Ova-exposed group also had less (30%) plasma Ova-IgG1 than the placebo group.

Based on the findings, researchers said, "Feeding SDA during lactation and weaning altered immune responses in directions believed to be beneficial".
Taken altogether, Omega-3 fatty acids may be considered a functional food for the improvement of the immune response, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Feeding a Bioactive Oil Enriched in Stearidonic Acid during Early Life Influences Immune System Maturation in Neonatal Sprague-Dawley Rats by Patel D1, Goruk S1, Newell M1, Chen G1, Richard C1, Field CJ. (PubMed)

Cruciferous Vegetables Reduce the Risk of Atherosclerosis

By Kyle J. Norton

A cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels.

The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaques build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain.

Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.

Atherosclerosis is a slow, progressive disease that may begin as early as childhood, caused by damage to the inner lining of the artery. However, the actual causes of the condition are debatable.

Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.

Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.

According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis, including  13.8% among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.

Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease and physical inactivity, particularly smoking.

Some researchers suggested that since cholesterol makes up a big part in the plaque, an unhealthy diet with high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential remedy for the prevention of plaque accumulated on the arterial wall, researchers the effect of vegetable intake alone, and relationships to specific types of vegetables containing different phytochemical profiles on atherosclerosis.

According to the food-questionnaire returned by the participants, using the total vegetable intake calculated at baseline (1998),
* Women consuming ≥3 servings of vegetables each day had ≈4.6% to 5.0% lower mean common carotid artery IMT (CCA-IMT, P=0.014) and maximum CCA-IMT (P=0.004) compared with participants consuming <2 servings of vegetables.

* Furthermore, for each 10 g/d higher in cruciferous vegetable intake, there was an associated 0.006 mm (0.8%) lower mean CCA-IMT (P<0.01) and 0.007 mm (0.8%) lower maximum CCA-IMT (P<0.01).

* Some vegetable types showed no associated with CCA-IMT (P>0.05).

* Interesting, there were no associations observed between vegetables and plaque severity (P>0.05).

Based on the results, researchers said, "Increasing vegetables in the diet with a focus on consuming cruciferous vegetables may have benefits for the prevention of subclinical atherosclerosis in older adult women".
Taken altogether, cruciferous vegetables may be considered functional remedies for the prevention of atherosclerosis, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous and Total Vegetable Intakes Are Inversely Associated With Subclinical Atherosclerosis in Older Adult Women by Blekkenhorst LC1,2,3, Bondonno CP4,2, Lewis JR4,3,5,6, Woodman RJ7, Devine A4, Bondonno NP2, Lim WH8, Zhu K9, Beilin LJ2, Thompson PL10, Prince RL3,9, Hodgson JM. (PubMed)

Sunday, 29 December 2019

Angelica Sinensis In the Treatment of Mammary Gland Hyperplasia in Vivo

By Kyle J. Norton


Mammary gland hyperplasia or hyperplasia of the breast is the benign overgrowth of mammary ductal epithelial cells and interstitial fibers.

Believe it or not, patients with mammary gland hyperplasia are found in 99.3% of the total patients with breast-related diseases, in which 5–10% have the potential to develop breast cancer.

Hyperplasia is the enlargement organ or tissue caused by an increase in the reproduction rate of its cells.

Hyperplasia of the breast is considered an early stage of breast cancer.

According to the statistics, atypical ductal hyperplasia (ADH) is the common form of hyperplasia of the breast found in about 5% to 20% of the diseases.

Although atypical ductal hyperplasia (ADH) is benign, the progression of the condition has been found to induce ductal carcinoma in situ (DCIS) and invasive carcinoma.

Mammary gland hyperplasia doesn't cause symptoms, However, some patients may experience a lump or pain.

Conventionally, most cases of mammary gland hyperplasia are treated by surgery that removes the abnormal cell growth.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a natural compound for the treatment of diseases associated with the breast, researchers examined the effect of acupuncture combined with medication (Rule Granule) on mammary gland hyperplasia in an animal model.

A total of 55 female SD rats were randomized into blank control group (n=10), model group (n=10), acupuncture group (n=11), medication group (n=10), and acupuncture plus medication group (n=9), as follow

* The MGH model was established by muscular injection of E2 benzoate(0.5 mg/kg, once daily for 20 days), followed by injection of P (5 mg/kg) into the lateral muscle of the hind-limb, once daily for 5 days, and the rats of the control group were treated by muscular injection of normal saline at the same site and in the same procedures.

* Acupoint group A composed of bilateral Tianzhong (SI 11), Ganshu (BL 18) and Zusanli (ST 36), and group B composed of Tanzhong (CV 17), and bilateral Wuyi (ST 15) and Hegu (LI 4) were alternatively punctured with filiform needles and stimulated swiftly by twirling the needle in each acupoint for 20-30 sec, once daily for 30 days.

* Rats of the medication group and acupuncture +medication group were treated by gavage of Rule Granule fluid containing Baishao (Paeonia Iactiflora Pall), Danggui (Angelica Sinensis), etc. (1.5 mL/100 g for each rat) and those of the other groups treated by gavage of distilled water (1.5 mL/100 g). The treatment was given once daily for a continuous 30 d. At the end of the experiments,

According to the results of the analysis, the hyperplasia of the mammary gland was found to improve significantly. The serum PRL and E2 contents and the expression of prolactin receptor (PRLR), estrogen receptor (ER) and progesterone receptor (PR) was significantly decreased, and the content of P was notably increased in the acupuncture, medication, and acupuncture plus medication groups relevant to the model group.

Furthermore, acupuncture plus medication were significantly superior to those of both simple medication and simple acupuncture in down-regulating serum PRL and E2 contents and PRLR, ER and PR immunoactivity, as well as in up-regulating serum P content.

Additionally, no significant differences were found between the medication and acupuncture groups. 

Based on the findings, researchers said, "The therapeutic effects of acupuncture plus Rule Granule are better than those of simple acupuncture and simple Rule Granule".

Taken altogether, Herbal Angelica used a combination with other herbal medicine and acupuncture
for the treatment of mammary gland hyperplasia, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Effect of Acupuncture Combined with Gavage of Rule Granule on Serum Prolactin, Estradiol and Progestone Contents and Their Receptor Expression in Breast in Mammary Gland Hyperplasia Rats].[Article in Chinese] by Zhao X1, Qiao D2, Hou M. (PubMed)

Cleaver(Galium aparine) Protects the Cells of Thymus Against Alternation of DNA in Vivo

By Kyle J. Norton

The thymus is a small, irregular-shaped gland in the top part of the chest, just under the breastbone and between the lungs.

The thymus formed part of both the lymphatic system and the endocrine system plays a critical role in the development of T-lymphocytes or T cells, in the immune system through the production of hormones

Unlike most organs, the thymus at its largest in children. Once the children reach puberty, the thymus starts to slowly shrink and replaced by fat.

The most common diseases associated with thymus are myasthenia gravis (MG), pure red cell aplasia (PRCA) and hypogammaglobulinemia.

In other words, the myasthenia gravis is a condition caused by abnormally large thymus that produces antibodies that block or destroy the muscles' receptor sites.

The most common symptoms of thymus gland dysfunction are shortness of breath, cough, chest pain, trouble swallowing, loss of appetite and weight loss, headaches, swelling of head face or neck, a bluish color to the skin and dizziness, according to the American Cancer Society.

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, cancerous cells can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Thymoma and thymic cancer are medical conditions associated with malignant cells form on the outside surface of the thymus due to the alternative of cell DNA.

According to statistics, thymoma is uncommon and occurs in less than 1 person per 1.5 million people develops thymoma. In other words, about 400 Americans suffer from the development of thymoma each year.


Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.

On finding a potential compound for the treatment of cancer, researchers investigated hot component Diosmetin (DGVL) extracted from the traditional Chinese herb Galium verum L. on the thymus of U14-bearing mice.

According to the tested analysis,
* DGVL inhibited tumor growth and significantly increased the thymus weight compared to control.

* DGVL elevated serum levels of IL-2 and significantly reduced levels of TNF-α, TGF-β1, and IL-10 in dose-dependent manner. 

In other words, DGVL protected the thymus tissues by increasing the anti-inflammatory and decreasing the pro-inflammatory expressions.

* DGVL protected thymus tissue against the proliferation of the tumor growth by inhibiting thymus lymphocyte apoptosis.

* Furthermore, the ratio of CD4(+)/CD8(+) T lymphocytes was significantly increased from 0.69 to 2.29 by treatment with DGVL, observed by the strong immune function.

* The expression of healthy cell death (Fas and FasL) on the thymus was lower in the DGVL treatment group compared to control.



Based on the findings, researchers said, " DGVL can inhibit tumor growth and protect tumor-induced apoptosis of the thymus, and the mechanism is closely associated with reduced cell death in the thymus and a Fas-FasL-dependent pathway".

Taken altogether, herbal cleaver used combination with other herbal medicines may be considered an anti thymus tumor remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effects of diosmetin extracted from Galium verum L. on the thymus of U14-bearing mice by Zhao R1, Chen Z, Jia G, Li J, Cai Y, Shao X. (PubMed)

#Healthy Food Common Fig or Fig (Ficus carica) Processes Antiviral Activities in Vitro

By Kyle J. Norton

Unlike bacteria, a virus replicates only inside the living cells of an organism. Viruses can infect all types of life forms, including humans and microorganisms, such as bacteria and archaea.

In other words, viruses are made up of a piece of genetic material, such as DNA or RNA enclosed in a coat of protein. Virtual infection is a result of a viral invasion that uses components of invaded cells to multiply, leading to the damages or alternation of the DNA or RNA of the host cells.

Anti-viral effects are the use of certain substances to cause the destruction of a virus.

In the acute phase of viral infection, depending on the types of viruses, the viruses after entering the body start to attack the specific host cells. The cold and flu virus will attack the cells in the respiratory system and the human immunodeficiency virus (HIV), which causes AIDS, will attack the white blood cells of the immune system,

The viral infection has been known to carry over some different stages. After successfully attaching to the host cell, the virus releases its mRNA into the host cell, leading to the recruit of the host cell's enzymes to accelerate the viral multiplying, then breaking free from the host cell to start the cycle all over again.

The white blood cells in the systematic immune response in the acute phase of infection stimulate the production of the proinflammatory cytokines to the site of infection with an aim to protect our body by killing off the invaders.


The battle between the immune white blood cell and viral invaders in most cases is in the flavor of the immune system, leading of the death of invaders and healing of the infection.


However, if the immune system can not kill off the invaders with 3 - 8 weeks, it then will adapt to the change, leading to chronic inflammatory and infectious diseases.

According to the statistics provided by the CDC, infectious diseases cause over 15 million visits to physician offices and 3.7 million visits to the emergency department in the US every year.

Fig is a species of F. Carica, belongings to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches.

On finding natural compounds for the treatment of infectious diseases, researchers examined the latex of fig fruit (Ficus carica) on skin infections with the possible viral origin.

According to the tested differentiation of 5 extracts (methanolic, hexanoic, ethyl acetate, hexane-ethyl acetate (v/v) and chloroformic) for their antiviral potential activity against herpes simplex type 1 (HSV-1), echovirus type 11 (ECV-11) and adenovirus (ADV) in vitro, the hexanoic and hexane-ethyl acetate (v/v) extracts inhibited multiplication of viruses at concentrations of 78 µg mL(-1).

Furthermore, these two extracts were possible candidates as herbal medicines for herpes virus, echovirus, and adenovirus infectious diseases.

Most importantly, all extracts had no cytotoxic effect on Vero cells at all tested concentrations.

Taken altogether, common fig or fig (Ficus carica)  may be considered a remedy for the prevention and treatment of viral infection, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In vitro cytotoxic and antiviral activities of Ficus carica latex extracts by Lazreg Aref H1, Gaaliche B, Fekih A, Mars M, Aouni M, Pierre Chaumon J, Said K. (PubMed)

Saturday, 28 December 2019

Phytochemical Tocopherols Kill Acute Myeloid Leukemia Cells in Vitro

By Kyle J. Norton

Leukemia is a condition characterized by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Bone marrow is soft tissue inside the hollow center of the major bone. including spine, pelvis, underarm, leg. etc.

Acute leukemia is a condition caused by a rapid increase in the numbers of extreme immature white blood cells that appear in the bloodstream in the other parts of the body, including tissue and organs.

 Acute leukemia can also be classified into
* Acute lymphoblastic leukemia (ALL)
Acute lymphocytic leukemia (ALL) is a type of cancer with the abnormal growth of extreme immature lymphocytes overproduced by the bone marrow and/or lymphatic system. The condition has a tendency to multiply quickly, leading to the death of normal white blood cells in the bone marrow and/or lymphatic system.

In ALL, lymphocytes appear immature in the bloodstream. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia with about 80% of all cases.

* Acute myeloid leukemia (AML)
Acute myelogenous leukemia (AML) is a cancer of myelogenous lining caused by the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal blood cells. In AML, granulocytes appear immature in the bloodstream.

According to the statistics, in 2019, approximately 21,450 people of all ages including 11,650 men and boys and 9,800 women and girls) in the United States will be diagnosed with AML.

AML is the second most common type of leukemia diagnosed in adults and children, but most cases occur in adults. AML makes up 32% of all adult leukemia cases.

The 5-year survival rate for people 20 and older with AML is approximately 24%. For people younger than 20, the survival rate is 67%.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.


On finding a potential phytochemical for the treatment of leukemia, researchers examined the effect of δ-tocopherol in acute myeloid leukemia.

Compared to other leukemia cell lines, δ-T as low as 20 µM showed a strong activity on AML cell line KG-1.

The δ-T inhibition of AML cell line KG-1 was observed in a set of primary cells collected from patients newly diagnosed with AML.

Furthermore, δ-T also induced apoptosis and cell cycle arrest against KG-1 cells.

The results of δ-T anti-AML activity were attributed to the inhibition of protein cyclin-d1 associated with the G1 phase of the cell cycle arrest and a set of homeobox proteins associated with cancer cell growth and apoptosis.

Taken altogether, tocopherols may be considered a supplement for the prevention and treatment of acute myeloid leukemia pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Reduction in Cell Viability and in Homeobox Protein Levels Following in Vitro Exposure to δ-tocopherol in Acute Myeloid Leukemia by Collins J1, Safah H2, Lobelle-Rich P2, Whaley S3, Campbell S3, Saba NS. (PubMed)

Cruciferous Vegetables Inhibit the Risk and Progression of Prostate Cancer

By Kyle J. Norton

Cancer is a class of diseases characterized by abnormal cell growth of cells caused by the alternation of prostate cell DNA.

Prostate gland wrapped around the around a tube (the urethra), is a gland of the male reproductive system found in front of the rectum and just below the bladder with a function that produces some of the semen that carries sperm.

Prostate cancer is cancer originating from the inner lining of the prostate gland caused by irregular prostate cell growth. Prostate cancer is slow-growing cancer. However, they can be deadly in the advanced stage by traveling a distance away to infect other healthy tissue and organs.

Most prostate cancers are found in the yearly annual physical exam, designed for the male at a higher risk of prostate cancer.

The exact causes of prostate cancer are unknown. However, the most common risk factor associated with the onset of the disease is genetic mutation inherited from the parents. mutation of BRCA1 and BRCA2 reserves the function of tumor suppressor genes which normally repair mistakes in a cell's DNA to allow DNA mutation of the prostate cells.

According to the statistic provided by the American Cancer Society, 1 in 9 men will be diagnosed with prostate cancer during his lifetime. Approximately, 6 cases in 10 are diagnosed in men aged 65 or older.

The most common symptoms of prostate cancer include frequent urination, weak or interrupted urine flow or the need to strain to empty the bladder. and the urge to urine frequently at night due to the large size of the tumor that suppresses the bladder and the flow of urine.

Some patients may also experience symptoms of blood in the urine, blood in the seminal fluid and pain or burning during urination caused by the tumor that breaks the nearby small veins and nerve cells.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding potential and natural foods that process anti-cancer property, researchers investigated the protective effect of sulforaphane (SFN), an isothiocyanate (ITC) derived from cruciferous vegetables against the prostate cancers.

According to the tested analysis,
* SF exerted a strong antioxidative and chemopreventive activity by delaying or blocking carcinogenesis, in vivo.

* SF induced biochemical and epigenetic changes, preventing, delaying, or reversing preneoplastic or advanced prostate lesions, associated with the risk of cancer developing through increasing the expression of antioxidant protein NRF2.

* SF activity networks involved in cell death programming through ceratin intrinsic methods of apoptosis by causing cell cycle arrest, mitosis interruption, activation of caspases and mitochondria depolarization.

Based on the evidence, researchers said, "These outcomes encourage the consumption of Brassica specimens, which could be easily achieved by the incorporation of food and vegetables rich in cruciferous isothiocyanates in the diet".


Taken altogether, dietary cruciferous vegetables may be considered functional remedies for the protection of the prostate against cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1)

Cruciferous Vegetables as Antioxidative, Chemopreventive and Antineoplasic Functional Foods: Preclinical and Clinical Evidences of Sulforaphane Against Prostate Cancers by Ferreira PMP1, Rodrigues LARL2, de Alencar Carnib LP2, de Lima Sousa PV2, Nolasco Lugo LM2, Nunes NMF1, do Nascimento Silva J1, da Silva Araûjo L3, de Macêdo Gonçalves Frota K2. (PubMed)

Turmeric, the Best Antioxidant Functional Remedy

By Kyle J. Norton

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.

Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

Antioxidants keep our bodies functioning properly by reducing the risk of diseases associated with oxidative stress.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.

Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.

Oxidative stress is a result of an imbalance of the ratio of free radicals and antioxidants in the body.

The expression of oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the prevention and treatment of diseases associated with oxidative stress, researchers examined the effects of curcumin supplementation on oxidative stress and antioxidant defense enzymes in human subjects.

The meta-analysis reviewing the randomized controlled trials published in English in any year in Pubmed, Embase, Cochrane Central, Scopus, and Google Scholar, compared the treatment of curcumin to either placebo or standard of care or no intervention.

According to the examing of 127 titles and abstracts identified in 17 articles, including participants, ranged from 22 to 160 across the included studies, curcumin significantly reduced oxidative stress markers MDA, and increased superoxide dismutase, catalase,, and glutathione peroxidase, compared to control.

Furthermore, in subgroup analyses, curcumin could significantly reduce MDA levels with or without use of piperine, compared to only increase the SOD level in presence of piperine.

Based on the results, researchers said, "The administration of piperine with curcumin may enhance the efficacy of curcumin on antioxidant defense system".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements to enhance the levels of antioxidants in the host, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions: a comprehensive meta-analysis of randomized controlled trials by Alizadeh M1, Kheirouri S. (PubMed)

Thursday, 26 December 2019

Herbal Angelica Inhibits Osteoclastogenesis and Bone Resorption Against the Risk of Osteoporosis

By Kyle J. Norton

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

The condition is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries and considered as a major health problem in both elderly men and women.

Scientists as of today do not know the exact causes of osteoporosis. However, they do know that certain factors are associated with the onset and progression of the disease.

Osteoporosis is the common disease among the elderly, probably due to the aging effect that induces nutrition deficiency, vitamin D, reduced hormone production and production of bone mass, and increased bone reabsorption.

Osteoclastogenesis is a procedure processed in many stages. Interferes with the specific stage of the process, can induce the imbalanced osteoclasts and osteoblast.

The osteoclast is a type of cell differentiated from another type of cell called a macrophage that breaks down the bone that leads to bone resorption.

In patients with osteoporosis, this balance shifts in favor of osteoclasts compared to those of osteoblasts.

In other words, in osteoporotic patients, bone resorption is far more exceedingly to bone formation.

Furthermore, the imbalance of osteoclasts and osteoblast also is found in patients with Paget's disease, rheumatoid arthritis, osteopetrosis, periodontal disease, and bone cancer metastases.


Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the protection of bone density, researchers examined the effect of Angelica Sinensis (AS) extract on RANKL-induced osteoclast differentiation.

The study is to examine the osteoclast precursor cell line bone marrow macrophages (BMMs) cultured and stimulated with RANKL followed by treatment with AS at several doses by regulating the complex networks involved in osteoclastogenesis and bone resorption.

According to the results of the experiment, AS extract protected the bone density by inhibiting RANKL-mediated osteoclast differentiation in bone marrow macrophages (BMMs) in a dose-dependent manner without any evidence of cytotoxicity. 

AS extract also inhibited the mRNA expression of transcription factors that are activated in immune cells and other cell types following stimulation by a variety of factors in RANKL-treated BMMs.

In other words, AS protected bone density integrity against osteoclastogenesis and inhibited bone resorption, the expression of cytokines, growth factors, and hormones induced by the treatment of RANKL.

Taken altogether, herbal Angelica may be considered an anti osteoclastogenesis and bone resorption remedy to protect the bone mineral density against the onset of osteoporosis, pending to larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica sinensis extract inhibits RANKL-mediated osteoclastogenesis by down-regulated the expression of NFATc1 in mouse bone marrow cells by Kong L, Zhao Q, Wang X, Zhu J, Hao D1, Yang C. (PubMed)