Wednesday, 26 June 2019

Herbal Bilberry, the Potent Treatment for Retinitis Pigmentosa

By Kyle J. Norton


Retinitis pigmentosa is a genetic condition characterized by the breakdown and gradual loss of cells in the retina.

The retina is the light-sensitive tissue lined the back of the eye. The function of the retina is to convert the light received into neural signals before sending them to the brain for visual recognition.

Most cases of retinitis pigmentosa are diagnosed during the teenage years and at birth. Some patients who carry the genetic preposition may develop the disease in the later years.

The later diagnosed case is usually mild with slow progression compared to those presented in the teen years and at birth.

Most common symptoms of patients with retinitis pigmentosa are difficulty seeing at night and a loss of side (peripheral) vision. However, at the disease progress into the later stage, most patients also experience tunnel vision.

Conventionally, the treatment of retinitis pigmentosa is totally depending on the condition. The aim of treatment is to slow the vision loss and improve the patient quality of life.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of retinitis pigmentosa with not side effects examined the effects of Bilberry (Vaccinium myrtillus L.) and lingonberry (Vacciniumvitis-idaea) containing high amounts of polyphenols (anthocyanins, resveratrol, and proanthocyanidins) against blue light a high-energy or short-wavelength visible light-induced retinal diseases such as age-related macular degeneration and retinitis pigmentosa. 

According to the results from the cultured murine photoreceptor (661 W) cells exposed to blue LED light following treatment with B-ext, L-ext, or their constituents (cyanidin, delphinidin, malvidin, trans-resveratrol, and procyanidin B2), B-ext, L-ext, NAC, and their active components improved the viability of 661 W cells against the blue light damage.

The efficacy was found to be attributed to the injection of tested compounds in inhibiting the generation of intracellular ROS induced by the blue LED light irradiation.

Furthermore, B-ext and L-d with also protected the cells integrity against the activation of proteins by stimuli associated with the production of production of proinflammatory cytokines.

Moreover, B-ext, L-ext, and NAC inhibited proteins involved cells death and autophagy against cell damaged by the blue light.

Dr. Ogawa K the lead scientist said, "These findings suggest that B-ext and L-ext containing high amounts of polyphenols exert protective effects against blue LED light-induced retinal photoreceptor cell damage mainly through inhibition of ROS production and activation of pro-apoptotic proteins".

In a murine model of photo-stressed retina, researchers examined the bilberry extract through a stomach tube in Balb/c mice (750 mg/kg body weight) light-induced visual function impairment.

According to the tested assays, bilberry extract suppressed photo-induced apoptosis in the photoreceptor cell layer and shortening of the outer segments of rod and cone photoreceptors.

Bilberry extracts also reduced the levels of photo-induced reactive oxygen species (ROS), oxidative and endoplasmic reticulum (ER) stress markers observed by the analysis.

In other words, bilberry inhibited the ER stress in the retina, and at least in part, in Müller glial cells. 

Based on the findings, researchers suggested, "bilberry extract attenuates photo-induced apoptosis and visual dysfunction most likely, and at least in part, through ROS reduction, and subsequent ER stress attenuation in the retina".

Taken altogether, bilberry processed abundantly bioactive compounds may be considered a function remedy for the prevention and treatment of age-related macular degeneration and retinitis pigmentosa, pending to the validation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro by Ogawa K, Kuse Y, Tsuruma K, Kobayashi S, Shimazawa M, Hara H1. (PubMed)
(2) Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina by Osada H1, Okamoto T1,2, Kawashima H1,2, Toda E1, Miyake S1,3, Nagai N1,2, Kobayashi S3, Tsubota K2, Ozawa Y. (PubMed)

Bromelain, the Anti Acute Inflammation Whole Food

By Kyle J. Norton

Acute inflammation is a natural response of the immune system to protect the human body against harmful stimuli and pathogens.

Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nerves system, the immune first line of defense stimulates the production of blood platelets to the cover the site of damage and pro-inflammatory to kill off pathogens which try to enter the body through the wound or damaged tissue.

Acute inflammation usually receded after a few days or weeks depending on the size and damage. However, if all pathogens were not eradicated after 3 to 8 weeks, the immune system will compromise, leading to chronic low-grade inflammation, a leading cause of chronic illness.

Most common symptoms of acute inflammation occurred with a short period of time such as hours is a pain, redness, immobility, swelling, and heat.

Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.


On finding a potential compound for the treatment of acute inflammation, researchers examined the effect of bromelain, a mixture of proteases derived from pineapple stem on inflammatory diseases, including murine inflammatory bowel disease.

According to the tested assays,
* In vitro, bromelain modulated the immune activity by removing a number of cell surface molecules that are vital to leukocyte trafficking.

* Bromelain inhibited neutrophil migration to IL-8 and decreased acute responses to inflammatory stimuli in the initiation of the production of pro-inflammatory cytokines.

* In vivo, bromelain treatment generated a 50-85% reduction in neutrophil migration in 3 different murine models of leukocyte migration into the inflamed peritoneal cavity through its anti-inflammatory properties.

In other words, through its anti-inflammatory activity, bromelain inhibited primary long-term effect on abrogation of firm adhesion of leukocytes to blood vessels at the site of inflammation in induction of inflammation.

Additionally, in an ovalbumin (OVA)-induced murine model of acute allergic airway disease (AAD) with female C57BL/6J mice sensitized with intraperitoneal (i.p.) OVA/alum and then challenged with OVA aerosols for 3 days, administration of 200 mg/kg bromelain twice daily for four consecutive days, exerted a significant anti-inflammatory activity against the overexpression of pro-inflammatory cytokines caused by the injection of ovalbumin (OVA).

Interestingly, bromelain also inhibited allergic inflammation by modulating the immune response against ovalbumin (OVA).

Based on the findings, researchers wrote, " these studies demonstrate that bromelain can effectively decrease neutrophil migration to sites of acute inflammation".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of acute inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain treatment decreases neutrophil migration to sites of inflammation by Fitzhugh DJ1, Shan S, Dewhirst MW, Hale LP. (PubMed)
(2) Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma by Secor ER1, Carson WF, Singh A, Pensa M, Guernsey LA, Schramm CM, Thrall RS. (PubMed)

Herbal Turmeric,The Traditional Treatment of the Oral Lichen Planus

By Kyle J. Norton

Oral lichen planus (OLP) is a condition characterized by chronic inflammation, affecting the mucous membrane of the oral cavity.

The disease is caused by the abnormal reaction of the immune system that attacks and triggers the death of the basal cells of the oral epithelium.

Oral lichen planus can have different shapes an colors, including white, lacy patches, red, swollen tissues, or open sores.

Most common areas of oral cavity affected by oral lichen planus (OLP)  are inside of the cheeks, the gums, tongue, palate and the inner tissues of the lips.

Besides the aforementioned symptoms, patients with OLP may also experience symptoms of pain, burning sensation or pain, bleeding, and irritation with tooth brushing, inflammation of the gums (gingivitis).

In serious cases, OLP  can also affect the patients speaking, chewing or swallowing.

Conventionally, most cases of OLP are managed by pinpoint the allergens that trigger the immune attack accompanied by topical ointments or gels. Corticosteroids are the first line treatment with an aim to reduce inflammation and pain in patients with oral lichen planus.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of oral lichen planus (OLP), researchers launched a review to identify studies from the database of medical literature up to December 18, 2018.

4 trials assessed the comparative efficacy of topical curcumin vs. topical corticosteroids and 3 trials assessed the efficacy of oral curcumin vs. placebo were selected.

According to the results, topical curcumin showed to reduce pain, burning, and clinical manifestations of OLP versus baseline, effects similar or inferior to those of topical corticosteroids.

Interestingly, oral curcumin trials exerted no significant benefits of curcumin therapy versus placebo but there were some potential benefits and reasonable safety in an observational extension study.

In order to reveal more information about the effect of curcumin on OLP, researchers at Zhejiang University once again reviewed the published literature by searching PubMed, EMBASE, EBSCO, and Cochrane Library.

The search identified 9 studies which met the inclusion criteria, including six randomized, double-blind clinical trials; two pilot clinical trials; and one case report.

Based on the results of a total of 259 OLP patients included in the systematic review, researchers found that
* 7 studies showed statistically significant differences in pain severity and clinical appearance of oral lesions after treatment with curcumin compared to baseline.

* 3 controlled clinical trials compared to corticosteroids; curcumin exerted a similar efficacy in pain severity and clinical appearance of oral lesions.

Dr. Lv KJ, the lead scientist wrote, "Curcumin is a safe treatment and can be used as an adjunct in combination with corticosteroids to reduce pain, burning sensations, and the clinical appearance of oral lesions in OLP patients".


Taken altogether,  turmeric process a main ingredient of curcumin may be considered a supplement for the treatment of oral lichen planus, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin, a turmeric extract, for oral lichen planus: A systematic review by White CM1,2, Chamberlin K1,3, Eisenberg E. (PubMed)
(2) Clinical safety and efficacy of curcumin use for oral lichen planus: a systematic review by Lv KJ1, Chen TC2, Wang GH1, Yao YN1, Yao H. (PubMed)

Whole Food Onion Protects the Endometrial Cells Integrity Against the Risk of Endometriosis

By Kyle J. Norton


Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else in the body instead of the inside of the uterus.

More precisely, during the maturation, the layer of endometriosis lining on the inside of the uterus is normally expelled, some of the endometriosis tissues grow somewhere else in the body.

Most common endometriosis tissues are diagnosed within the pelvic region, on the lining of peritoneum, in the ovaries, and on the surface of the uterus's an outside wall. However, endometriosis has also been found in the fallopian tubes, the cervix, the vagina, and even the vulva.

According to the statistics, 20% of reproductive age women with endometriosis present without symptoms, 55% of women who have developed the new onset of severe menstrual cramps.

Additonally, endometriosis also induce sub-fertility (less fertile than a normal couple) in 25% of women.

Conventionally, endometriosis is treated either by medications or surgery, including
* Medication for pain with an aim to ease painful menstrual cramps.

* Hormone therapy may be accompanied by the pain medication also with an aim to reduce menstrual pain such as hormonal contraceptives. Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists, Progestin therapy. and aromatase inhibitors.

In surgery perspective,
* In women who want to get pregnant, surgery removes the endometriosis implants while preserving the uterus and ovaries.

* Hysterectomy with removal of the ovaries may be performed if pregnancy is not a concern.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of endometriosis, researchers examined the effects of quercetin (3,3',4',5,7-pentahydroxyflavone), a major dietary flavonol found in the onion on the risk of endometriosis.

In human endometriosis cell lines (VK2/E6E7 and End1/E6E7 cells), 
* Quercetin inhibited the proliferation and induced the cell cycle arrest.

* Administration of quercetin not only induced cell apoptosis with DNA fragmentation, loss of mitochondrial membrane potential but also exhibited cytotoxicity of reactive oxygen species production in the tested cell lines.

* Quercetin also suppressed the expression of signaling pathways associated with endometrial cells survival and growth.

On endometriosis auto-implanted mouse models,
* Administration of quercetin also promoted the antiproliferative and anti-inflammatory effects.

* Quercetin injection also attenuated the proliferation with sub-G0/G1 cell cycle arrest and increased the apoptosis of VK2/E6E7 and End1/E6E7 cells by inhibiting the gene associated with the onset and progression of endometriosis. 

In other words, quercetin inhibited the risk and onset of endometriosis by the increased expression and decrease expression of Micro RNA (miRNA) involved in the initiation and progression of endometriosis in vitro and vivo.

Dr. Park S, the lead scientist said, "Hence, quercetin may potentially act as a natural therapy to reduce and treat human endometriosis".

Taken altogether, onion processed an abundantly high amount of quercetin may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Quercetin inhibits proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo by Park S1, Lim W2, Bazer FW3, Whang KY4, Song G. (PubMed)

Tuesday, 25 June 2019

Phytochemical 3,3'-Diindolylmethane, the Anti Nasopharyngeal Cancer Functional Supplement

By Kyle J. Norton


The nasopharynx is the upper part of the pharynx, connecting with the nasal cavity above the soft palate that allows a person to breathe through the nose.

Nasopharyngeal cancer is a medical condition characterized by cells growth irregularly and disorderly in the tissues of the nasopharynx.

Most cases of nasopharyngeal cancer start in the cells on the surface of the inner lining of the nasopharynx. The early stage of nasopharyngeal cancer is asymptomatic due to the very small size of the tumor.

However, at the advanced stage, the oversize may suppress the nearby nerves and blood vessels, leading to severe throat pain and symptoms of a lump in your neck blood in the saliva, bloody discharged from your nose, particularly, persistent nasal congestion or ringing in your ears, accompanied with the general symptoms shared with other cancers.

According to the statistics provided by the American cancer society, nasopharyngeal cancer (NPC) is quite rare in the United States). The risk of cancer is less than one case for every 100,000 people.
Epidemiologically, some patients at this stage may also experience symptoms of frequent ear infections, hearing loss and headaches.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

The exact causes of nasopharyngeal cancer are unknown. Gender, family history, ethnicity, where you live, poor diet, infected by the Epstein-Barr virus are some of the prevalent factors of nasopharyngeal cancer.

On finding potential and plant-based compound for the treatment of nasopharyngeal cancer, researchers examined the antitumor effects of DIM in a long-term low-dose manner in nasopharyngeal carcinoma (NPC).

The study included NPC cells induced by 20 µmol/l DIM for over a month.

During the experiment, the injection showed significantly reduced the cell metastasis in vivo.

Furthermore, according to assays, DIM significantly reduced the proliferation and migration of without inducing apoptosis.

Long-term dose administration also exerted antitumor activity by altering the signaling pathways which are mutated in human cancer and protein associated with the anti-apoptosis, proliferation and cell survivals.

Moreover, in order to reveal more information about DIM antitumor efficacy, researchers launched an investigation of the pro-apoptotic and anti-proliferative effects of 3,3'-diindolylmethane (DIM) in various tumor cell types.

DIM-induced apoptosis and inhibited proliferation in nasopharyngeal carcinoma cells by inhibiting the activity of telomerase which is crucial for the survival of cancer cells, in a dose‑dependent manner.

The mRNA and protein expression of hTERT which is a catalytic component of human telomerase and used as a biomarker of a tumor was inhibited following treatment with DIM without causing a change of telomerase RNA (hTR).

In other words, DIM-induced apoptosis and inhibited proliferation were attributed to its activity on telomerase by targeting the expression of hTERT.

The results indicated that DIM inhibited nasopharyngeal carcinoma cells by shortening the telomeres in a concentration‑dependent manner.

Taken altogether, 3,3'-Diindolylmethane may be considered a supplement for the prevention and treatment of nasopharyngeal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) ERK signaling mediates long-term low concentration 3,3'-diindolylmethaneinhibited nasopharyngeal carcinoma growth and metastasis: An in vitro and in vivo study by Li F1, Chen C1, Chen SM1, Xiao BK1, Tao ZZ. (PubMed)
(2) Pro-apoptotic and anti-proliferative effects of 3,3'-diindolylmethane in nasopharyngeal carcinoma cells via downregulation of telomerase activity by Li F1, Xu Y2, Chen C1, Chen SM2, Xiao BK1, Tao ZZ. (PubMed)

Cucumber, the Best Food to Promote Heart Health

By Kyle J. Norton

The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body tissues and organs.

Most cases of heart dysfunction are associated with the reduced function of the heart muscle, leading to reduce blood flow that facilitates heart failure and the backup of blood into the lungs or rest of the body.

According to the statistics provided by the US government, heart disease is a leading cause of death in the US. Over 600,000 died of heart disease, every year including 370,000 people died of coronary heart disease (CHD), accounting to 1 in 4 deaths.

Most common symptoms of heart disease are poor appetite, weight loss, shortness of breath,  sudden collapse, blood clots and stunted growth found in children.

If you have experienced some of the aforementioned symptoms, please check with your doctor to rule the risk of heart disease.

By following a healthy dietary intake, physical activity, weight management, smoking cessation, blood pressure control, and lipid management, most cases of heart disease are preventable.

Dr. Melanie Warziski Turk, in the evaluation of the risk of heart disease in women, wrote, "Because heart disease is frequently preventable, increasing awareness of personal risk and preventative measures is a key element of healthcare for women".

And, "Nurse clinicians can evaluate, educate, and counsel women regarding their risk for this pervasive disease and promote behavior changes that will decrease that risk. Research evidence supports that lifestyle behaviors are the cornerstone of heart disease prevention".

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound for the improvement of heart health, researchers investigated the therapeutic impact of cucurbitacin I on the heart.

According to the tested assay, phenylephrine (PE)-induced muscle cell enlargement and cardiac hypertrophy was inhibited by the pretreatment of the cardiomyocytes with cucurbitacin I.

Furthermore, cucurbitacin I protect the heart connective tissues against the onset of cardiac fibrosis.

More importantly, cucurbitacin I also significantly expressed the heart muscle protective effect by inhibiting the factors associated with the increase of blood pressure.

In order to reveal more information about cucumber anti-cardiac hypertrophy, a leading cause of heart failure, researchers evaluated cucurbitacin B anti-hypertrophy and anti-fibrosis potential both in vitro and in vivo.

Selected mice induced cardiac hypertrophy after 1 week of surgery, were given cucurbitacin B treatment for 4 weeks.

At the end of the experiment, cucurbitacin B demonstrated a strong anti- hypertrophy and anti-fibrosis ability evidenced by decreased heart weight, myocardial cell cross-sectional area, and interstitial fibrosis.


Additionally, the levels of heart systolic and diastolic abnormalities induced by the surgery was also moralized by the application of cucurbitacin B.

Furthermore, gene expressions induced hypertrophic and fibrotic markers, reserved microvascular density in pressure overload-induced hypertrophic mice were also normalized by the injection cucurbitacin B.

Taken altogether, cucumber and its bioactive compound cucurbitacin I and B (CuB) may be used for the improvement of heart health, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings by Moon Hee Jeong,# 1 Shang-Jin Kim,# 2 Hara Kang, 3 Kye Won Park, 4 Woo Jin Park, 1Seung Yul Yang, 5 and Dong Kwon Yang. (PMC)
(2) Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy by Yang Xiao, Zheng Yang, Qing-Qing Wu and Xiao-Han Jiang. (Research Gate)
(3) Cardiac Health: Primary Prevention of Heart Disease in Women by Melanie Warziski Turk, PhD, MSN, RN,a Patricia K. Tuite, MSN, RN,b and Lora E. Burke, PhD, MPH, FAHA, FAAN. (PMC)

Healthy Food Turmeric Protects the Skin Damage Against Aging

By Kyle J. Norton

Skin aging is a natural process that can not be stopped. However, there are some people have a younger looking skin compared to their biological age.

The evidence of skin aging can be visible by increasing wrinkles and sagging skin.

Skin is the largest organ in the human body. The skin not only shields us against the invasion of foreigner pathogens but also serves as the third detoxed organ besides the liver and kidney.

Additionally, the skin also protects the skeletons and internal organs against the mechanical impacts and pressure, variations in temperature, micro-organisms, radiation, and chemicals.

However, when skin ages, it also reduces the function of the aforementioned protection as seen in the elderly.

Besides biological causes of skin aging, long-term exposure to sunlight, particularly UVB is one of the major culprit associated with damages of elastin, leading to wrinkles, sagging skin that loses stability to rebound from the stretch.

According to the free radical theory of aging, free radical bombardment overtime can cause oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospholipids, DNA and RNA, leading widespread cell damage including the skin cells after attacking the lipid bilayers of the cell walls.

In other words, according to the theory, free radical cause internal and external cell damage, that lead to aging cells.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural and effective compound for the protection against skin aging, researchers examined the effects of curcumin in acute and chronic injury: burns and photo-damaged skin.

In photo-damaged skin, injection of curcumin inhibited the phosphorylase kinase (PhK) which plays an important role in promoting photocarcinogenesis and skin damage through activation of NF-kB-dependent signaling pathways.

In other words, curcumin inhibited phosphorylase kinase (PhK) in the induction of the apoptosis of photo-damaged cells, thus promoting the survival of precancerous cells and allowing for subsequent tumor transformation.

In the treatment of skin injury, application of a curcumin gel showed rapid healing of burns, with little or no residual scarring.

Furthermore, the curcumin gel was also beneficial in the repair of photo-damaged skin, including pigmentary changes, solar elastosis, thinning of the skin with telangiectasia (actinic poikiloderma), and premalignant lesions such as actinic keratoses, dysplastic nevi, and advanced solar lentigines, but the repair process takes many months.

In order to know more information about turmeric anti-photoaging activity, researchers looked into anti-skin aging due to intrinsic (chronologic) and extrinsic aging (photo-aging) of plants from 35 families.

Curcumin found in turmeric not only showed potency in the inhibition of tyrosinase, hyaluronidase, elastase, and collagenase associated with skin aging induced by UV radiation but also scavenges free radicals from skin cells, prevents trans-epidermal water loss and contributes to protecting skin from wrinkles.

In summary, curcumin protects the skin against aging intrinsically (chronologic) and extrinsically. 

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of skin aging, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Signaling pathways targeted by curcumin in acute and chronic injury: burns and photo-damaged skin by Heng MC. (PubMed)
(2) Potential role of natural compounds against skin aging by Tundis R, Loizzo MR, Bonesi M, Menichini F. (PubMed)

Healthy Legume Navy Bean Induces Colon Cancer Cell Apoptosis in Vivo

By Kyle J. Norton

The colon is the 2nd part of the digestive system found in the large bowel which consists of the colon and rectum, with a function that absorbs water from the small bowel contents and breaks down certain materials in the feces into substances in which some of them are reabsorbed and reused by the body. 

Colon cancer is a chronic condition characterized by irregular cell growth in the tissues of the colon tissues due to the alternation of the cell DNA.

Most cases of colon cancer begin in the cell on the surface of the inner lining of the colon tissue, before penetrating into deeper layers to form a tumor.

Colon cancer is relatively very common, slowly growing and progressing in a predictable way.

Together with rectal cancer, colorectal cancer is the third most commonly diagnosed cancer in Western countries, including the US and Canada.

According to the statistics, the lifetime risk of developing colon cancer is about one in 23. Colon cancer accounts for  71% of all cases of colorectal cancer. The overall 5 years survival rate of localized colon cancer is 90%.

Conventionally, the treatment of colon cancer is totally depending on the stage and grade of cancer, including surgery, radiotherapy, and chemotherapy.
* If the cancer is only limited to the mucosa such as a single layer of epithelial cells, a layer of connective tissue, and a thin muscle layer than it can be cured in most cases.

*  If cancer has spread through the muscular layer of the bowel or the lymph note, the curable rate is lower.

 * If cancer has spread to other organs, the curable rate is even lower. Grade of the cancer is calculated dependently to how aggressive cancer.

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.

On finding a natural compound for the treatment of colon cancer, scientists examined the protective effects of cooked navy bean consumption in the risk of cancer.

The experiment included 160 male obese ob/ob mice randomly assigned to cooked navy beans (whole beans), the insoluble fraction (bean residue) or soluble fraction of the 60% (vol:vol) ethanol extract of cooked navy beans (bean extract), or a modified AIN-93G diet (16.6% fat including 12.9% lard) as control diet after 2 azoxymethane injections.

Navy bean treated group showed a significant reduction of numbers of mice with dysplasia, adenomas, or adenocarcinomas (whole beans 54%, bean residue 81%, and bean extract 91%) compared to control.

Furthermore, focal hyperplasia was found in fewer mice on each of the 3 bean diets percent reduction from control (whole bean 56%, bean residue 67%, and bean extract 87%).

Based on the results, Dr. Bobe G, the lead scientist, after taking other factors into account wrote, "both the soluble and the insoluble fraction of the extract contribute to the cancer-protective effect of cooked navy beans".

Moreover, in colon carcinogenesis in carcinogen-induced genetically obese mice randomly placed on one of four diets (control, whole navy bean, bean residue fraction, or bean extract fraction) for 26 to 28 wk, researchers found that bean fed mice showed a significant effect in the protection against the numbers of genetic alternation and pro-inflammatory cytokines induced the early onset of colon changes.

Dr. Mentor-Marcel RA, the lead researcher said, "Changes in a subset of inflammation-associated serum proteins and colon gene expression may serve as response indicators of dietary attenuation of colon carcinogenesis".

Taken altogether, navy bean used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice by Mentor-Marcel RA1, Bobe G, Barrett KG, Young MR, Albert PS, Bennink MR, Lanza E, Colburn NH. (PubMed)
(2) Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice by Bobe G1, Barrett KG, Mentor-Marcel RA, Saffiotti U, Young MR, Colburn NH, Albert PS, Bennink MR, Lanza E. (PubMed)
(3) Bowel (Colorectal ) Cancer by Kyle J. Norton


Monday, 24 June 2019

Healthy Food Turmeric, the Potential Adjunctive Chemotherapy for Lung Cancer

By Kyle J. Norton


The lung located near the backbone on either side of the heart is a vital organ that inhales oxygen from the air then transporting them to the bloodstream to nourish the body cells need and exhales carbon dioxide from the bloodstream.

Lung cancer is a chronic condition caused by the alternation of cells DNA that starts in the cells on the surface of the inner lining of the lung tissue. Most common form of primary lung cancers is derived from epithelial cells.

According to the statistics, lung cancer is the leading cause of cancer deaths in the US. 1 in 16 people in the US will be diagnosed with lung cancer in their lifetime. Every year approximately over 220,000 people in the US are diagnosed with lung cancer this year. 

Believe it or not, 60% to 65% of all new lung cancer diagnosed are among people who have never smoked or are former smokers.

Depending on the types and aggressiveness of cancer cells originated, lung cancer can be classified into
* Non-small cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer that usually grows and spreads methodically and predictably, including
* Squamous-cell carcinoma is often found in an outer area of the lung,

* Large-cell carcinoma is found in the center of the lung by an air tube.

* Adenocarcinoma found in any part of the lung.

* Small cell lung cancer
Small cell lung cancer is a fast-growing type of lung cancer, that spread quickly to distant parts of the body in a relatively early stage, including
* Small cell carcinoma in which the cells are small, round and resemble oats.

* Mixed small cell/large cell carcinoma in which malignant tumor found in combining of components of small cell lung carcinoma with large cell lung carcinoma.

* Combined small cell carcinoma, a malignant tumor is found in combining a component of small cell lung carcinoma with components of non-small cell lung carcinoma.

Most common symptoms of lung cancer are shortness of breath, cough-up blood, pain, fluid in the chest, wheezing and hoarseness accompanied by general symptoms shared by other types of cancer.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of lung cancer, researchers examined curcumin (diferuloylmethane) anticancer properties.

According to the tested assays,
* Curcumin can be an effective adjunct in treating solid organ tumors by activation of tumors suppressive genes such as p53, DNA protective gene, and gene-associated with cell growth and apoptosis

* Curcumin protects the lung cell integrity against the pathway associated with the pro0duction of proinflammatory cytokines.

* Curcumin stimulates the transcription factors associated with the growth inhibition and apoptosis in tumor cells.

These results strongly suggested that curcumin can be adjunctive chemotherapy to augment currently available treatment protocols, that decreased side effects and toxicity without compromising therapeutic efficacy.


Dr. the lead scientists, after taking into account of co and confounder wrote, " Curcumin is one such potential candidate, and this review presents an overview of the current in vitro and in vivo studies of curcumin in lung cancer"

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin and lung cancer--a review by Mehta HJ1, Patel V, Sadikot RT. (PubMed)
(2) Curcumin and Lung Cancer: the Role of microRNAs by Lelli D1, Pedone C1, Majeed M2, Sahebkar A. (PubMed)
(3) Lung Cancer by Kyle J. Norton

Phytochemical Betacyanins Inhibit Proliferation of Chronic Myeloid Leukemia Cell in Vitro

By Kyle J. Norton

Leukemia is a medical condition caused by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myeloid or lymphoblastic leukemia.

Bone marrow is soft tissue inside the hollow center of the major bone, including spine, pelvis, underarm, leg...

Chronic leukemia is a disease characterized by a slow but still excessive build up of relatively immature abnormal white blood cells. 

Chronic leukemia has a tendency to spread slowly to other parts of the body through the bloodstream and/or lymphatic system.

Chronic Myeloid Leukemia (CML) is a condition of slow growth and spreading of abnormal granulocytes. In CML, granulocytes have become abnormal and growth uncontrollably in the bone marrow and/or lymphatic system and appeared less immature in the bloodstream.

According to the statistics provided by the American Cancer Society, in the US approximately 8,990 new cases will be diagnosed with CML, including 5,250 in men and 3,740 in women and 1,140 people will die of CML, including 660 men and 480 women in 2019.

Besides the constitutional symptoms, such as
* Fatigue
Fatigue is a result of not enough red blood cell to transport oxygen to the body cells.

* Infections
As white blood no longer function normally in fighting against foreign invasions such as virus and bacteria.

* Unintentional weight loss
Weight loss unintentionally of over 10% has been found in patients of CML.

* Loss of appetite
It is one of the general symptoms accompanied by cancers.

* Bone and joint pain
It is a result of increased bone marrow pressure due to an excess build-up of white blood cells.

*  Fever
It is a result of infection

* Abnormal blood bleeding and bruising
They are the results of abnormal blood's platelets.

8. Excessive sweating, night sweats
Night sweats are an early symptom of some cancers, especially in CML.

CML also induces specific symptoms such as
* Enlarged lymph nodes, spleen
In CML lymph nodes can swell more than 1cm in children and 2 cm in adult.

* Becoming too full easily is one of the specific symptoms of ALL due to enlarged lymph nodes or spleen pressing onto the abdomen.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belongings to the group of Betalains, found abundantly in beets, chard, etc.

In the urgency to find a potential compound for the treatment of leukemia, researchers examined the antiproliferative effects of betanin, a principle betacyanin pigment, isolated from the fruits of Opuntia ficus-indica on chronic myeloid leukemia.

On human chronic myeloid leukemia cell line (K562), application of betanin decreased the proliferation of K562 cells at a dose and time-dependent with an IC(50) of 40 microM.

According to the tested analysis, the anti-proliferative activity of betanin was associated with chromatin condensation, cell shrinkage and membrane blebbing.

In other words, cells treated with betanin showed a fragmentation pattern typical for apoptotic cells.
Particularly, at 40 microM betanin, the phytochemical compound induced 28.4% cells cycle arrest in sub G0/G1 phase.

Moreover, treatment with betanin not only activated the proteins such as PARP cleavage associated with pro-apoptosis but also inhibited the proteins such as Bcl-2 involved in anti-apoptosis.

Based on the findings, Dr. Sreekanth D, the lead scientist wrote, "betanin induces apoptosis in K562 cells through the intrinsic pathway and is mediated by the release of cytochrome c from mitochondria into the cytosol, and PARP cleavage".

Taken altogether, betacyanins processed abundantly bioactive compound betanin may be considered a remedy for the prevention and treatment of chronic myeloid leukemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562 by Sreekanth D1, Arunasree MK, Roy KR, Chandramohan Reddy T, Reddy GV, Reddanna P. (PubMed)
(2) Myelogenous leukemia - Chronic myelogenous leukemia (CML) by Kyle J. Norton

Whole Food Tomato Modulates Immune Function to the Body Needs

By Kyle J. Norton

The immune system plays a critical role in the body's defense against infectious organisms and other pathogens.

The immune function can be classified into subsystems, including the innate and adaptive responses.
* The innate responses are the general response of the immune system that can act quickly to destroy invaders, regardless of types of organism.

* The adaptive responses develop slowly on first exposure to a new pathogen slowly. In some cases, it may take a week or so before the responses are effective.

However, due to the quick division of bacteria, (a single bacterium with a doubling time of one hour can produce almost 20 million progeny), therefore, our body is totally depending to the innate immune system to destroy the invader in the first critical hours and days of exposure.

Believe it or not, if the innate immune subsystem cannot destroy the foreign invader in a set of period of time from 3 -8 weeks, it will compromise, leading to low-grade inflammation in facilitating the onset of various diseases, including cardiovascular disease, diabetes, and arthritis.

Immune modulation is the process to increase and decrease the immune functioning depending on the needs of the body. In people with a weakened immune system, modulation of the immune system are found to enhance immune functioning against the infectious agents.

However, in people with overactive immunity, modulation of the immune function will reduce the risk of the immune system attacking the body tissues.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a potential compound with immune modulatory activity, researchers examined the influence of tomato aqueous extract (TAE) on the in vitro inflammatory response.


According to the results observed by the Murine macrophages (RAW264.7 cells), PBLs and HUVECs incubated with TAE, TAE exerted a significant effect in the inhibition of pro-inflammatory cytokines such as L-1β, IL-6, IL-10, IL-12 and chemokines such as CCL2/MCP-1, CCL3/MIP-1α.

In the endothelial cell, TAE reduced ED-associated expression of adhesion molecules (ICAM-1, VCAM-1) associated with the production of inflammation.

In macrophages, the production of pro-inflammatory proteins associated with low-grade inflammation also inhibited the injection of TAE.

Based on the findings, researchers said, "during acute inflammation, TAE enhances cellular alertness and therefore the sensing of disturbed immune homeostasis in the vascular-endothelial compartment. Conversely, it blunts inflammatory mediators in macrophages during chronic inflammation".

In other words, TAE protects the integrity and viability of immune cells by modulating the immune activity depending on the needs of the body.

Furthermore, in a blinded, randomized, cross-over study, male subjects on a low-carotenoid diet consumed 330 ml/day of either tomato juice (37.0 mg/day lycopene) or carrot juice (27.1 mg/day beta-carotene and 13.1 mg/day alpha-carotene) for 2 weeks with a 2-week depletion period after juice intervention, researchers compared the effects of a low-carotenoid diet supplemented with either tomato (providing high amounts of lycopene) or carrot juice (providing high amounts of alpha- and beta-carotene) on immune functions in healthy man.

According to the results from the tested assays, juice consumption showed relatively fast responses in plasma carotenoid concentrations (p < 0.0002) without accompanied by concomitant changes in immune functions. 

However, increased plasma carotenoid concentrations after vegetable juice consumption were accompanied by a time-delayed modulation of immune functions in healthy men consuming a low-carotenoid diet.

Precisely, tomato juice modulated the immune function in a delay and concentration-dependent manner.


Taken altogether, tomatoes may be considered supplements for the modulation of immune function based on the body needs, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tomato Aqueous Extract Modulates the Inflammatory Profile of Immune Cells and Endothelial Cells by Schwager J1, Richard N2, Mussler B3, Raederstorff D. (PubMed)
(2) Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men by Watzl B1, Bub A, Briviba K, Rechkemmer G. (PubMed)

Antioxidant Alliin Suppresses Hyperglycemia in Vivo, Scientists Found

By Kyle J. Norton


Hyperglycemia is a medical condition characterized by abnormally high levels of glucose in the bloodstream

Although hyperglycemia is a hallmark in patients with diabetes, the condition can also occur to people without diabetes due to a certain medical condition such as pneumonia in the elderly.

Dr. Yuan, Lin, the lead scientists in the examination of hyperglycemia in patients with an
acute pancreatitis (AP) wrote, "Hyperlipidemia, fatty liver, hypertension, endoscopic retrograde cholangiopancreatography treatment, acute hyperglycemia, elevated lactate dehydrogenase, and creatine kinase, decreased calcium, and AB blood type were risk factors for hyperglycemia development after AP".

Most common causes of hyperglycemia are associated with uncontrolled diet, improper use of insulin and skip diabetic medication.

Most common symptoms of hyperglycemia are increased thirst frequent urination, fatigue (weak, and unintended weight loss. In severe cases, some patients may also experience symptoms of headaches, trouble concentrating and blurred vision.

If you have experienced some of the aforementioned symptoms, you may have abnormally elevated high blood sugar. 

Untreated hyperglycemia can lead to serious complications requiring emergency care, such as a diabetic coma. Over the long-term, persistently mild hyperglycemia can lead to complications eyes, kidneys, and nerves damage and heart disease and stroke.

By following the guidelines and recommendation in the management of blood glucose accompanied by a healthy and moderate exercise, diabetics may do just fine against hyperglycemia.


Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a potential compound for the treatment of hyperglycemia, researchers examined the effect of alliin against metabolic risk factors in diet-induced obese (DIO) mice.

Selected C57BL/6J DIO diet-induced obese mice are treated with drinking water with or without alliin (0.1 mg/ml) for 8 weeks.

Oral administration of alliin enhanced glucose homeostasis, increased insulin sensitivity and improved the lipid profile in the DIO mic without affecting the body weight, adiposity or energy balance.

In other words, alliin inhibited hyperglycemia selectively without normalizing the adiposity tissues inappropriate responses of energy intake and energy expenditure.

Based on the tested results, researchers found that the efficacy of alliin in the inhibition of hyperglycemia is partly associated with the modulation of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae.

In order to reveal more information about alliin antihyperglycemic activity, researchers examined the production and therapeutic efficiency of alliin extracted from garlic leaves of plants grown under ex-situ and in situ conditions.

According to the results of alliin aqueous leaf extracts (from ex-situ and in situ grown plants) were given to normal and alloxan-induced diabetic rats for five weeks, under in situ conditions, alliin extract lowered the serum glucose, triglycerides, total lipids, total cholesterol, low-density lipoprotein (LDL)-, and very low-density lipoprotein (VLDL)-cholesterol in diabetic rats by ~54%, 15%, 14%, 20%, 24%, and 15% compared to 35%, 14%, 10%, 12%, 17% and 11% from the ex situ grown plants.

Furthermore, compared to glibenclamide, the leaf extract of plants lowered serum enzyme levels (alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase) associated with liver oxidative stress toward the normal.

Moreover, The histopathological alteration in pancreas caused by alloxan was also inhibited markedly by leaf extract.

Based on the findings, Dr. Nasim SA, the lead scientist wrote, "These findings demonstrate leaf extract obtained from plants grown under in situ conditions possess higher therapeutic efficiency in comparison with leaf extract obtained from plants grown under ex situ condition".

In other words, geographic growth may influence the therapeutic potential of phytochemicals in plants.

Taken altogether, alliin may be considered supplements for the prevention and treatment of hyperglycemia, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice by Zhai B1, Zhang C1, Sheng Y1, Zhao C2, He X1,3, Xu W1,3, Huang K1,3, Luo Y. (PubMed)
(2) Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats by Nasim SA1, Dhir B, Kapoor R, Fatima S, Mahmooduzzafar, Mujib A. (PubMed)
(3) Risk Factors of Hyperglycemia in Patients After a First Episode of Acute Pancreatitis: A Retrospective Cohort by Yuan L1, Tang M, Huang L, Gao Y, Li X. (PubMed)

Sunday, 23 June 2019

Healthy Legume Pinto Bean, the Best to Control Hyperglycemia

By Kyle J. Norton

Hyperglycemia is a condition of abnormally high blood sugar in the bloodstream. Hyperglycemia is a condition characterized by the body which isn't properly using or doesn't make the hormone insulin.

 Hyperglycemia is a hallmark of type 2 diabetes associated with diabetic complications caused by uncontrol levels of blood glucose.  Another hallmark is insulin resistance.

In other words, poor management of blood glucose is the major cause of hyperglycemia in diabetic patients, including a poor diet, physical inactivity choices, symptoms of medicines intake.

Some patients with diabetes also experience symptoms of hyperglycemia as a result of skipping or not taking enough glucose-lowering medication.

Most common symptoms of hyperglycemia are frequent urination, increased thirst, blurred vision, persistent fatigue, and headache.

Believe it or not, untreated or long term persistently hyperglycemia in patients with diabetes has been found to induce serious symptoms such as shortness of breath, confusion, and coma.

Some researchers suggested that by the change of diet with a meal plan help, you can avoid hyperglycemia, such as eating often, watching the intake of sugar and carbohydrates, limiting the use of alcohol, and eating a diet rich in vegetables, fruit, and whole grains.

Dr. Donna B, the lead scientist wrote, "Management of diabetes and hyperglycemia has become an important quality care indicator in the hospital setting. Multiple health care organizations offer guidelines for glycemic control, including recommendations for medical nutrition therapy (MNT) and consistent-carbohydrate meal plans".

And, "... the rationale for consistent-carbohydrate meal plans and liberalizing the “diabetic diet;” and describes successful mealtime practices to improve coordination of meal delivery with blood glucose monitoring and insulin administration".

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.

With an aim to find a potential ingredient for the prevention and treatment of hyperglycemia, researchers investigated the glycemic response of bean and rice traditional meals compared to rice alone in adults with type 2 diabetes.

The randomized 4 × 4 crossover trial, included 17 men and women aged 35-70 years with type 2 diabetes randomly assigned to control that received metformin (n = 14) or diet/exercise (n = 3).

The white long grain rice control, pinto beans/rice, black beans/rice, red kidney beans/rice test meals, matched for 50 grams of available carbohydrate, were consumed at breakfast after a 12 hour fast.

According to the blood sample taken, the postprandial net glucose values were significantly lower for the three bean/rice (pinto beans/rice, black beans/rice, red kidney beans/rice test meals) treatments in contrast to the rice control at 90, 120 and 150 minutes.

Furthermore, the incremental area associated with the levels of blood glucose under the curve values was significantly lower for the pinto and black bean/rice meals compared to rice alone, but not for kidney beans.

In other words, not all legumes exhibited the same anti hyperglycemia effects. However, all beans with rice attenuated the glycemic response compared to rice alone. 

The results strongly suggested by adding beans such as pinto beans into your traditional diet, hyperglycemia may be preventable.

Based on the findings, researchers wrote, "Promotion of traditional foods may provide non-pharmaceutical management of type 2 diabetes and improve dietary adherence with cultural groups".

Taken altogether, Pinto bean used a combination with rice may be considered a remedy for the prevention and treatment of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV. (PubMed)
(2) Bean and rice meals reduce postprandial glycemic response in adults with type 2 diabetes: a cross-over study by Thompson SV1, Winham DM, Hutchins AM. (PubMed)
(3) The Mealtime Challenge: Nutrition and Glycemic Control in the Hospital by Donna B. Ryan, MPH, RN, RD, CDE and  Carrie S. Swift, MS, RD, BC-ADM, CDE. (The American Diabetes Association)

Antioxidant Alliin, The Natural Cardio-Protective Compound

By Kyle J. Norton

The cardioprotective effect is an action including the use of substances such as herbal medicine for the prevention of heart damage.

In other words, substances that processed the activity to protect the heart functioning are considered heart protective agents.

Cardiovascular disease is the diseases associated with blood vessels and the heart. Plaque accumulated on the wall of the artery that causes blockage and reduced blood flow to the heart has been found to induce CVD in many instances, depending on the affected location.

For example, reduced blood flow to the brain can lead to stroke involved in the death of neurons and reduced oxygen-rich blood flow can lead to heart disease involved in heart muscles damage.

In the Western world, due to the promotion of high fat diet-induced over 68% of overweight and obese population in the US, maybe the culprit that causes the rise of cardiovascular disease in the recent year.

Dr. Frank M. Sacks, the lead scientist wrote, " Cardiovascular disease (CVD) is the leading global cause of death, accounting for 17.3 million deaths per year. Preventive treatment that reduces CVD by even a small percentage can substantially reduce, nationally and globally, the number of people who develop CVD and the costs of caring for them".

And, "This American Heart Association presidential advisory on dietary fats and CVD reviews and discusses the scientific evidence, including the most recent studies, on the effects of dietary saturated fat intake and its replacement by other types of fats and carbohydrates on CVD".

The findings strongly suggested following the healthy diet with a higher amount of fruits and vegetable that replace the harmful fats and carbohydrates with moderate exercise, cardiovascular disease is preventable.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a natural ingredient which processes cardioprotective property, researchers examined the synthetic form of S-ally-mercapto captopril (CPSSA), a new stable synthetic compound produced by a chemical reaction between allicin and the angiotensin-converting enzyme inhibitor captopril.

On fructose-induced metabolic syndrome rat model, alliin at 8 mg/kg-day exerted a significant cardioprotective effect by reducing insulin, triglycerides, and homocysteine concentrations.

However, the injection of the same dose had only a slight effect on SBP compared to Captopril (50mg/(kg day)) with only an improvement of blood pressure and homocysteine.

Compared to the treatment with a low dose of CPSSA (5mg/(kg day)) that lowered SBP but did not improve any other measured parameter, a higher dose (50mg/(kg day)) showed a significantly decreased blood pressure, triglycerides, and homocysteine concentrations.

In other words, alliin protected the cardiovascular system in a dose-dependent manner.

Based on the results, researchers said, "the combined molecule CPSSA integrates the anti-hypertensive, lipid-lowering, and homocysteine-reducing effects of both allicin and captopril, making it a potential cardiovascular protective agent".

In order to know more information about alliin cardioprotective activity, researchers looked into eval the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) in cardiovascular damage in hypercholesterolemic rabbits.

The study included New Zealand rabbits divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.

According to the tested assays, WGLL treatment demonstrated a cardioprotective activity by mediating the increases in fractional shortening, right ventricular function, peak systolic velocity, tricuspidal annular systolic velocity in live animals.

The levels of a protein associated with the generation of antioxidants (heme oxygenase-1 (HO-1)) were increased in HO-1 protein accompanied by a decrease in superoxide dismutase 1(SOD1).

Furthermore, levels of plaques associated with atherosclerosis, plasma ApoB involved in levels of cholesterol and the activity of LDH and CK (creatine kinase) were decreased in the treated rat's group.

Collectively, researchers said, "WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders".

Taken altogether, alliin may be considered supplements for cardioprotection, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effects of S-allylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome by Oron-Herman M1, Rosenthal T, Mirelman D, Miron T, Rabinkov A, Wilchek M, Sela BA. (PubMed)
(2) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(3) Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association by Frank M. Sacks, Alice H. Lichtenstein, Jason H.Y. Wu, Lawrence J. Appel, Mark A. Creager, Penny M. Kris-Etherton, Michael Miller, Eric B. Rimm, Lawrence L. Rudel, Jennifer G. Robinson. (Circulation)