Sunday, 17 November 2019

Herbal Turmeric, the Natural Prevention and Treatment of Colitis

By Kyle J. Norton

Colitis is a condition associated with inflammation of the inner lining of the colon.

There is no exact cause of colitis. Certain risk factors such as colon infection, inflammatory bowel disease (Crohn's disease, ulcerative colitis), ischemic colitis, allergic reactions, and microscopic colitis have been found to increase the risk of the onset of the condition.

Most common symptoms of colitis are totally depending on the types, including abdominal pain, cramping, diarrhea, with or without blood in the stool.

Types of colitis according to the  Catholic University of the Sacred Heart, are including
microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis.

Epidemiologically, people with untreated colitis may experience complications of

* Congenital abnormalities
Women who are pregnant with Ulcerative colitis are associated with significantly increased risk of some selected congenital abnormalities (limb deficiencies, obstructive urinary, and multiple congenital abnormalities) according to the birth outcomes in women with ulcerative colitis examined in a nationwide.

* Nutritional deficiency
Malnutrition, particularly protein-energy malnutrition and vitamin and micronutrient deficiencies, as well as dysregulation of the intestinal microbiota, are common features of IBD.

Conventionally, besides treating colitis with antibiotics, certain medications also are prescribed to improve the symptoms and quality of life of the patients, inclduing anti-diarrheal medications.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of colitis, researchers examined the effects of novel gut health product (GHP), an encapsulation of asafoetida (ASF) and CUR complex used as a carrier agent to encapsulate bioactive components for the treatment of colitis.

According to the rat model of 5%, dextran sulfate sodium (DSS) induced UC, treatment of GHP significantly attenuated the disease activity index, colitis score, histopathological changes, and myeloperoxidase activity.

Furthermore, GHP also demonstrated significant protective effects against DSS induced colitis.

Additionally, also in an animal model of dextran sodium sulfate (DSS)-induced colitis, a specific, curcumin preparation containing essential turmeric oils (ETO-curcumin) compared to standard curcumin at three specific doses (0, 5, 25 or 50 mg/kg), both ETO and standard curcumin treatments provided protection against DSS-induced inflammation.

However, according to the tested assays, ETO-curcumin improved disease activity index (DAI) dose-dependently, compared the anti-inflammatory efficacy of standard curcumin remained constant.

In other words, ETO-curcumin was more superior in the expression of anti-inflammatory efficacy compared to standard curcumin.

Moreover, ETO-curcumin displayed anti colitis activity in the colon by exerting anti-inflammatory cytokines including IL-10 and IL-11 as well as FOXP3.

Collectively, Dr. Toden S., the lead scientist, wrote at the final report, " the combined treatment of curcumin and essential turmeric oils provides superior protection from DSS-induced colitis than curcumin alone, highlighting the anti-inflammatory potential of turmeric".



Taken altogether, turmeric plus essential turmeric oils may be considered supplements for the prevention of colitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber by Gopi S1, Amalraj A2, Jude S2, Varma K2, Sreeraj TR2, Haponiuk JT3, Thomas S. (PubMed)
(2) Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis by Toden S1, Theiss AL2, Wang X3, Goel A. (PubMed)
(3) Colitis - The Complications by Kyle J. Norton

Cranberry Improves the Ratio of Gut Microbiota

By Kyle J. Norton

Gut microbiota is a complex community with over trillion microorganisms that live in our digestive tracts.

According to the ESMN, the microbiota can weight up to 2 kg, including 1/3 of gut microbiota found in most people, comapred to 2/3 that are specific to individuals depending on geography, environment, and lifestyle.

In healthy individuals, the ratio of good and bad microorganisms is balanced. In other words, healthy gut microbiota levels maintain the structure and function of the gastrointestinal tract.

A balanced ratio of gut microbiota plays a critical role in the digestion of certain foods that the stomach and small intestine have not been able to digest, in the production vitamins, improvement of digestive functioning and modulation of the immune function.

Use of antibiotics has been found to damage the gut ecosystem, leading to certain chronic illnesses such as inflammatory bowel disease, obesity, cancer, and autism. 

Unhealthy gut microbiota has been found to 
* Decrease the interaction with the immune function against inflammatory immune disorders.

* Increase the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

* Reduce nutrient extraction from the diet, thus increasing the risk of obesity and obese complication.

* Increase the risk of control brain insulin signaling and metabolite levels that can lead to bad neurobehaviors.

Further, the unbalanced ratio of gut microbiota functions also alters immune homeostasis, leading to the onset of autoimmune disorders which in turn can affect the development of not only intestinal but also systemic autoimmune diseases.

Compared to probiotics, the prebiotics is compound in food that induces the growth or activity of beneficial microorganisms in the gut.

In other definition, it is a special form of dietary fiber that acts as a fertilizer that promotes the growth of good bacteria in your gut.

In the gastrointestinal tract, prebiotics can alter the composition of organisms in the gut microbiome.

In other words, prebiotics raises the levels of healthy bacteria against bad bacteria.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the promotion of digestive functioning, researchers examined the effect of cranberries' impact on gut microbiota.

The randomized, double-blind, cross-over, controlled design trial included a total of 11 healthy adults consumed for 5 days each a control diet (animal-based diet (meats, dairy products, and simple sugars) plus 30 g/day placebo powder) and a cranberry diet (animal-based diet plus 30 g/day freeze-dried whole cranberry powder).

According to the tested analysis of the stool, urine, and blood samples, compared to the pre-control diet, control diet modified 46 taxonomic clades in the gut, including an increase in the abundance of Firmicutes and decrease in Bacteroidetes and increased bacteria-derived deoxycholic acid and decreased acetate and butyrate in stool

In other words, the control diet induces a significant change of gut microbiotas by favoring the "bad" organisms.

Comapred to the post control diet, the cranberry diet modified 9 taxonomic clades, including a decrease in the abundance of Firmicutes and an increase in Bacteroidetes in the flavor of the good organisms in the gut.

Furthermore, cranberry promoted the balancing ratio of gut microbiotas by attenuating control diet-induced increase in secondary bile acids and decrease the short-chain fatty acids (SCFA) and increase urinary anthocyanins and bacterially derived phenolic acids.

Based on the findings, researchers said, "an animal-based diet altered the microbiota composition to a less favorable profile, increased carcinogenic bile acids, and decreased beneficial SCFA. Cranberries attenuated the impact of the animal-based diet on microbiota composition, bile acids, and SCFA, evidencing their capacity to modulate the gut microbiota".


Taken altogether, cranberry may be considered a remedy for the promotion of gut health, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberries attenuate animal-based diet-induced changes in microbiotacomposition and functionality: a randomized crossover controlled feeding trial by Rodríguez-Morató J1, Matthan NR2, Liu J3, de la Torre R4, Chen CO. (PubMed)
(2) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MA4, Neto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)
(3) The influence of antibiotics and dietary components on gut microbiota by Ruth K. Dudek-Wicher, Adam Junka, and Marzenna Bartoszewicz. (PMC)

Saturday, 16 November 2019

Healthy Turmeric Blocks the Proliferation of Endometrial Cancer Cells

By Kyle J. Norton

Cancer is a group of the chronic disease characterized by cells growth disorderly and uncontrollably in the body tissue of the specific organ.

Over time, after growing in size through unlimited division, the tumor can spread to other tissues and organs in the body via lymph or blood.

Endometrium, the inner lining of women uterus is very susceptible to hormone change, particularly in the stages of the menstrual cycle.

Endometrial cancer is a late adulthood cancer that starts in the cells on the surface of the endometrial inner lining of the uterus caused by the alternation of cells DNA. Endometrial cancer is the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.

In the US, according to statistics, the average age of women diagnosed with endometrial cancer is 60. Endometrial is cancer is more common in white women, but black women diagnosed with endometrial cancer are more likely to die from it.

There are more than 600,000 women are endometrial cancer survivors in the US today. In 2019, approximately 61,880 new cases of cancer the uterus (uterine body or corpus) will be diagnosed and this cancer will cause the death of 12,160 women.

Accompanied by the general symptoms shared by other types of cancer, most common symptoms of endometrial cancer are 
* Abnormal vaginal bleeding
Vaginal bleeding between period within inappropriate amounts of blood flow should be checked with the doctor as soon as possible. The symptom may be caused by the expansion of overgrowth of pre-cancer uterine lining cells due to infection or breaking off the endometrial capillaries or blood vessels.

* Increase amount of vaginal discharge
An increase in the amount of vaginal discharge accompanied by abnormal odor or pain, itching, or burning sensation may be caused by infection or inflammation.

* Painful urination
Painful urination, most of the time is caused by infection of the urinary tract that affects the bladder in emptying, but sometimes it can be caused by infectious diseases.

* Pain during sex
Painful during most of the time is caused by vestibulitis and vaginismus sex, but in some cases, it can be caused by cancer or other reproductive diseases.

* Pain in the abdomen
There are many reproductive diseases can cause pain in the pelvis, such as appendicitis, salpingitis, uterine descensus,.. but it can be caused by the early stage of endometrial cancer.

* Swelling or lump in the pelvis
Swelling can be caused by inflammation of sexual transmitting virus or infection by bacteria. The lump may be caused by abnormal cells growth of the uterine lining or reproductive tissue.

*Anemia
Anemia may be caused by chronic loss of blood due to prolonged or heavy abnormal menstrual bleeding.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of endometrial cancer, researchers examined the anti-metastatic effect and molecular mechanism of curcumin in endometrial carcinoma (ECd ) of curcumin isolated from turmeric.

According to the assays carried out in EC cell lines,
*In vitro, curcumin inhibited EC cell migration and invasion.

* Curcumin treatment for 24 hours, decreased the expression levels of matrix metalloproteinase (MMP)-2 and -9 associated with cancer cell proliferation and survival.

* Futhermore curcumin for 24 hours treatment also inhibited the protease activities associated with metastatic potential in EC cell lines.

* Curcumin treatment exerted anti-metastatic effects by blocking the overexpression of pathways involved in cancer cell growth. 

* Moreover, combined with chemo drug ERK inhibitor U0126, curcumin works synergistically against enzymes associated with tumors proliferation, particularly, in the inhibition of the invasive capabilities of HEC-1B cells.

More precisely, curcumin inhibits tumor cell migration and invasion by reducing the expression and activity of MMP-2/9 associated with tumors proliferation via the suppression of the ERK signaling pathway in stimulating cancer cell growth.

Based on the finding and after taking other factors into account, Dr. QIAN CHEN, the lead scientist wrote in the final report, "curcumin is a potential therapeutic agent for EC".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of endometrial cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin suppresses migration and invasion of human endometrial carcinoma cells by QIAN CHEN,1,* QING GAO,1 KUNLUN CHEN,1 YIDONG WANG,1 LIJUAN CHEN,1 and XU LI. (PMC)
(2)
Cancer of Endometrium/Endometrial Cancer by Kyle J. Norton

Herbal Ashwagandha Exerts Cytostatic Effect Against Multiple Myeloma In Vitro

By Kyle J. Norton

Multiple myelomas (Myeloma) is a type of cancer originated from plasma cells in the bone marrow.

The disease is a condition of DNA alternation of white blood cell normally responsible for the production of antibodies to protect our body against infection with some characteristics.

According to the statistics provided by the American Cancer Society, multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%).

Every year, approximately, 32,110 new cases are diagnosed, including 18,130 in men and 13,980 in women. The disease also causes the death of 12,960 Americans including 6,990 in men and 5,970 in women.

The Grades of multiple myeloma are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

The exact causes of MS are unknown. Epidemiologically, the increase of age (If you are between 50 and 70 years old you are at higher risk to develop Multiple Myeloma), gender (men are more likely to develop multiple myeloma than women), race (Cancer tends to affects blacks more often than whites), previous multiple myeloma, exposed to certain chemicals, family history, and radiation
Most common symptoms of MS are
* Bone pain
Abnormal growth of plasma cells can cause a collapse of the bone.

* Infection
Overcrowding of abnormal plasma cells reduces the functions of white blood cells produced by the bone marrow, leading to a weakened immune system. Most common infections found to be pneumonia and pyelonephritis.

* Anemia
As a result of malignant plasma cells has to interfere with the normal production of red blood cells.

* Bleeding
Due to the lower production of the platelet.

* Renal failure
Abnormal plasma cells can also affect the function of the kidney in getting rid of waste, causing urea and creatinine accumulated in the bloodstream.

* Neurological symptoms
Due to hypercalcemia, as a result of the breakdown of the bone cause of the release of calcium into the bloodstream.

However, most people with some of the above symptoms never developed MS.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of tumor of the bone marrow, researchers examined the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera on drug-resistant subpopulation known as cancer stem cells (CSCs).

According to tested assays, WND exhibited similar cytostatic effects by inhibiting cancer cell growth and division. on drug-resistant and drug-sensitive cell lines in the nM range.

In cancer cell lines MM-CSCs and RPMI 8226, the administration of WND also induced cancer cell death and apoptosis.

However, , WND did not increase the accumulation of the fluorescent P-gp substrate rhodamine 123 in MM-CSCs associated with cancer cells drug resistance. More precisely, the result suggested that WND at the tested doses may not inhibit P-gp accumulation involving in the development of resistance of cancer cells to chemotherapeutic drugs.

Based on the findings, researchers said, " the WND-induced cytostatic effect may be independent of P-gp efflux".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of myeloma, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells by Issa ME1, Wijeratne EMK2, Gunatilaka AAL2, Cuendet M. (PubMed)

Friday, 15 November 2019

Betacyanins, Protects the Proteins, Lipid and Cells Against Oxidative Stress

By Kyle J. Norton

Inflammation is a natural response of the immune system that tries to protect the body against invasive pathogens.

In the acute phase of infection, after receiving the information transmitted by the central nervous system, the white blood cells of the first line of defense stimulate the production of blood platelets to cover the site of damage and pro-inflammatory cytokines, killing off the foreign invaders.

During the acute phase of infection, overproduction of proinflammatory cytokines may cause damage to nearby healthy cells, leading to the formation of scars.

Most cases of infection are stopped at the acute phase of infection. The wound is slowly healed within a few days or weeks.

However, if the immune system can not destroy all pathogens within a period in the range of 3 to 8 weeks, it will adapt to the new change, leading to chronic inflammation.

In other words, chronic inflammation happens when the immune response lingers, causing low-grade inflammation. Chronic inflammation over time may damage the body tissues and organs.

In some cases, the infection may be latent in which the pathogen remains within the body for a long time without producing any symptoms, such as the hepatitis virus.

Diseases associated with chronic inflammation include cancer, heart disease, rheumatoid arthritis, type 2 diabetes, and obesity.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

On finding a natural pigment for the prevention and treatment of disease associated with chronic inflammation, researchers examined the effects of Beetroot (Beta vulgaris L.) juice (BRJ, betacyanins, and betaxanthin) anti-inflammatory activity in vitro and in vivo.

The study included rats induced myocardial injury by isoproterenol (ISP) at 24 h intervals, followed by oral administration of BRJ for 28 days at doses of 150 and 300 mg/kg.

According to the tested assays, pretreatment with BRJ (150 and 300 mg/kg) not only reduced oxidative/nitrosative stress but also restored the cardiac endogenous antioxidants in myocardial injury rats.

ISP induced cardiac inflammatory cytokines such as NF-α, IL-6, and IL-10 and biomarkers of inflammatory promotion such as NF-κB also were inhibited by the pretreatment of BRJ.

Oxidative stress-induced hyperlipidemia level was significantly reduced by the BRJ pretreatment.

The results strongly suggested that BRJ pretreatment mitigates cardiac dysfunction and structural damages by decreasing oxidative stress, inflammation in cardiac tissues.

Dr. Raish M, the lead scientist said, "These results further support the use of BRJ in traditional medicine against cardiovascular diseases".

Furthermore, in rat induced renal damage by Paraquat injected intraperitoneally randomly divided into four groups: a control group, a paraquat group, and two paraquat groups that were treated with betanin at 25 and 100 mg/kg/d three days before and two days after paraquat administration.

According to the differentiation of the proteins associated with pro-inflammatory cytokines and pathways that promote inflammatory stimulation, betanin administration found in the family of betacyanins alleviated the paraquat-incurred acute kidney injury by decreasing oxidative stress associated with the inflammatory expression.

Taken altogether, betacyanins processed abundantly bioactive ingredient betanin in BRJ may be considered a remedy for the prevention and treatment of disease associated with inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Beetroot juice alleviates isoproterenol-induced myocardial damage by reducing oxidative stress, inflammation, and apoptosis in rats by Raish M1, Ahmad A2, Ansari MA3, Alkharfy KM2, Ahad A1, Khan A3, Ali N4, Ganaie MA5, Hamidaddin MAA. (PubMed)
(2) Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)

Cranberry, the Best in Hyperglycemia Management Against Diabetics Complications

By Kyle J. Norton

Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate glucose.

The disease is either caused by cells in the pancreas died off or receptor sites clogged up by fat and cholesterol, such as type 2 diabetes.

Most cases of type 1 diabetes are associated with a gene mutation that causes the immune to attack the insulin-producing beta cells in the pancreas.

Acquired diabetes in most cases is caused by unhealthy lifestyle choices, including high-fat diet and physical inactivity.

According to the statistics provided by the CDC, approximately 23.1 million people in the United States are living with diagnosed diabetes, costing the healthcare system more than $245 billion per year.

Sadly, there is an estimation that another 7.2 million people have diabetes but remain undiagnosed, accompanied by another 84.1 million adults 18 years and older with prediabetes.

Hyperglycemia, a hallmark of diabetes is a condition of abnormally high blood glucose in the blood.

Most cases of hyperglycemia are a result of poor management of blood glucose including uncontrol diet, physical inactivity, miss-medication and improper use of insulin injection.

Uncontrolled diabetes or hyperglycemia over the long-term can lead to diabetic complications, including coronary heart disease, stroke, hypertension, depression, pain, polypharmacy, and functional disability.

Long-term elevated glucose values above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L) has been found to induce symptoms of frequent urination, increased thirst, blurred vision, fatigue, and headache.

In severe cases, some patients may also experience life-threatening complications such as fruity-smelling breath, shortness of breath, weakness, confusion, and coma.

Dr in the study of hyperglycemia in the aging population wrote, "Higher levels of Sirt1 and PGC-1α and increased expression of gluconeogenesis pathway genes are found in the hyperglycemic NOD mice. Increased Sirt6 abundance is found in the hyperglycemic NOD mice, which might increase DNA damage repair".

And, "With aging, lower Sirt1 abundance and activity, increased acetylated histone modifications and Sirt7 levels, and NOR methylation is found. Thus, whereas in normal aging cell metabolism is reduced, in the diabetic mice a compensatory mechanism may elevate Sirt1 and Sirt6 levels, increasing gluconeogenesis and DNA repair from the oxidative damage caused by hyperglycemia".

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diabetes complications, researchers examined the effect of aqueous solutions of two different cranberry powders (CP and CP-SAB) on hyperglycemia.

In vitro, in vitro CP and CP-SAB administration showed a significant inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) associated with the management of hyperglycemia linked to type 2 diabetes.

Low levels of α-amylase have been found in patients with diabetes.
α-glucosidase is associated with the digestion of carbohydrates is elevated in patients with disbetes

According to the chemical analysis, the efficacy of CP and CP-SAB that inhibits hyperglycemia was probably attributed to the chemical constituents p-Coumaric acid and quercetin derivatives, the main phenolic compounds identified in the cranberry powders. 

Furthermore, increased with increased dose (1-5 mg/mL) of CP-SAB exerted the increased α-glucosidase inhibitory activity from 60% to 100%.

At 5 mg/mL, CP-SAB exerted a maximum of 40% inhibition against α-amylase.

Levels of ACE were also significantly inhibited by CP-SAB at the concentration of 100 and 200 mg/mL sample concentrations.

Based on the results, researchers wrote, "These in vitro results indicate the potential of cranberry powders as a dietary supplement and food-based strategies for potential hyperglycemia management".

Taken altogether, cranberry may be considered a remedy for the management of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potential of cranberry powder for management of hyperglycemia using in vitro models by Pinto Mda S1, Ghaedian R, Shinde R, Shetty K. (PubMed)
(2) Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes by Flávia Gerelli Ghiraldini,1 Ana Carolina Vitolo Crispim, and Maria Luiza Silveira Mello. (PMC)

Thursday, 14 November 2019

Herbal Turmeric Inhibits the Ischemia/Reperfusion (I/R) Injury In the Liver

By Kyle J. Norton

Liver formed part of the detoxed organs in the human body is the largest internal organ that filters the blood from the digestive tract, before passing them to the rest of the body.

The liver also plays an essential role to produce cholesterol to build a strong cell wall, produce steroid hormones and vitamin D and aid the digestive function in food absorption and detoxify toxic chemicals and metabolizes drugs.

Liver disease is a process of reduced function of the liver acutely or gradually.

Liver cancer is a chronic liver disease associated with irregular cell growth that starts in the cells on the surface of the liver's inner lining tissue, before penetrating into deeper layers to form tumors through cell proliferation.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

According to the Canadian Liver Foundation, approximately one in ten Canadians, or more than 3 million people in Canada has some form of liver disease.

Believe it or not, 95% of deaths from liver disease are due to chronic hepatitis B and C, alcoholic liver disease, non-alcoholic fatty liver disease, and liver cancer, including 25% of obese patients.

Most common signs and symptoms of liver disease are jaundice, abdominal pain, and swelling in the legs and ankles, itchy skin, dark urine color, pale stool color, or bloody or tar-colored stool and tendency to bruise easily.


If you have experienced some of the aforementioned symptoms that do not heal in a short period of time, please check with your doctor to rule out the possibility.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound that processes the liver-protective effects, researchers examined the efficacy of curcumin on liver ischemia/reperfusion (I/R) injury.

According to the analysis, curcumin protects the liver by reducing the liver oxidative stress and inflammation that can lead to ischemia-reperfusion injury in hepatic surgery and transplantation

Furthermore, mitochondria dysfunction associated with abnormal cell metabolism e in the liver, and liver Kupffer cells (KCs) activation associated with liver inflammation that causes IR were also inhibited by the injection of curcumin.

Vascular cell adhesion molecule overexpression and polymorphonuclear neutrophil injury-induced inflammation and immune-inflammatory response induced liver injury were also decreased by the curcumin administration.

Moreover, the efficacy of curcumin in the protection of the liver through the aforementioned activity was also found to be associated with the suppression of pathways in the reduction of liver ischemia-reperfusion injury.

Based on the findings researchers said, "This paper gives an overview of the protective effects of curcumin against I/R injury in the liver and discusses the studies that have linked biological functions of curcumin with liver I/R injury improvement".


Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention against ischemia-reperfusion injury, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effects of curcumin against ischemia-reperfusion injury in the liver by Bavarsad K1, Riahi MM2, Saadat S1, Barreto G3, Atkin SL4, Sahebkar A. (PubMed)

Lycopene Processes Anti Ulcerative Colitis Activity, Scientists Say

By Kyle J. Norton

Ulcerative colitis (UC) is a type of inflammatory bowel disease induced chronic inflammation and ulcers (sores) in the digestive tract.

The other type of IBD is Crohn's disease, caused by inflammation of the lining of the digestive tract, other than the colon and rectum.

IBS affects the colon and the rectum, leading to bloody diarrhea accompanied by symptoms of belly pain, not feeling hungry, fatigue, weight loss, dehydration.

Some patients may also experience symptoms of joint pain or soreness and sudden urges to empty the colon right away.

Inflammation is a process of the immune system that responds to harmful pathogens.

Inflammation can be acute or chronic. In the acute phase of infection, the immune system after receiving information from the neurons, macrophages, the largest white blood cells in the first line of defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.

The UC is caused by the immune system mistakenly attacks the cell of the colon, leading to low-grade inflammation.

According to the statistic, in the US, approximately, 1.6 million Americans are living with inflammatory bowel disease, including 907,000 people with ulcerative colitis.

More precisely, the risk of people diagnosed with ulcerative colitis per 100,000 person-years is between 2 and 14.

Conventionally, the treatment of UC is focused on reduced symptoms and prevent the fare up. In some cases, surgery may be necessary if the medication fails.

The exact causes of UC are not identified. Many prevalent factors are associated with UC, including aging, ethnicity, and family. However, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong implication in inducing the rise of ulcerative colitis.

Dr. Patricia Sarlos, the lead scientist in the study of the genetic preposition in the risk of UC, wrote, " Ulcerative colitis (UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals".

And, "Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play a central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease.".

The results strongly link the risk of IBD in people who process the mutated gene inherited from the parent
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of colitis researchers examined the protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in an animal model.

The study included conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) that were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as the reference drug, following by 4% AA to induce rats UC.


Based on the tested analysis, the levels of stress marker such as malondialdehyde (MDA), pro-inflammatory cytokines such as interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased in the both targeted groups compared to the AA group.

Levels of nuclear factor-erythroid 2-related factor 2 (Nrf-2) associated with the increased antioxidant enzymes produced by the host was also increased comapred to control.

Furthermore, Tumor necrosis factor, a cell-signaling protein (cytokine) involved in systemic inflammation was significantly decreased and catalase activity (CAT) associated with levels of antioxidants increased in the TLC group, compared to the AA group 

The results strongly suggested conventional and colon-targeted lycopene showed a significant effect in the reduced risk of UC.

Based on the findings, researchers said, "sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC,".

Taken altogether, lycopene found in tomato combined with conventional medicine may be considered a remedy for the prevention and treatment of UC, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You.  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats by Tekeli İO1, Ateşşahin A2, Sakin F3, Aslan A4, Çeribaşı S5, Yipel M. (PubMed)
(2) Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature by Patricia Sarlos, Erzsebet Kovesdi, Lili Magyari, Zsolt Banfai, Andras Szabo, Andras Javorhazy, and Bela Melegh. (PMC)

Wednesday, 13 November 2019

Turmeric, the Anti Hypercholesterolemic Herbal Remedy, Scientists Find

By Kyle J. Norton

Cholesterol, a waxy substance produced by the liver or the dietary plays a critical role to aid digestive function in absorbing nutrients and fluids, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to hypercholesterolemia, a leading cause of heart disease, and stroke.

Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.

The condition is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).


 People with hypercholesterolemia at the early stage are asymptomatic. However, patients with familial hypercholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.

According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US.

In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol. and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.

Sadly, only 50% of people hypercholesterolemia are getting treatment.

Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong impact on the increased incidence of hypercholesterolemia in the US.

Dr. ROBERT B. KELLY, the lead scientist wrote, "The most beneficial changes result from reducing intake of saturated and trans fats; increasing intake of polyunsaturated and monounsaturated fats; fortifying foods with plant stanols or sterols; isocalorically adding tree nuts to the diet; consuming one or two alcoholic drinks per day; and adopting a Portfolio, Mediterranean, low-carbohydrate, or low-fat diet".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.


The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of hyperlipidemia, researchers examined the efficacy of curcumin on hypercholesterolemia, one of the most important risk factors for atherosclerosis and subsequent cardiovascular diseases.

The experimental study included selected 24 male Sprague-Dawley rats that were divided into six groups, namely normal group diet, high-cholesterol diet (HCD) 2%, HCD + 100 mg/kg b.w. curcuminoid fraction, HCD + 300 mg/kg b.w. curcuminoid fraction, HCD + cider 1% v/v, and HCD + curcuminoid cider 2% v/v for 4 weeks.

According to the tested analysis of total cholesterol levels measured at day 1, 14, and 28, curcuminoid cider at 2% v/v significantly lowered total cholesterol levels compared to the positive control.

Furthermore, curcuminoid fractions at 100 and 300 mg/kg) and curcuminoid cider (1 and 2% v/v) inhibited the gene expression of CD44 associated with membrane cholesterol and intercellular adhesion molecule (ICAM)-1involved in the measurement of lipid metabolic impairment.

Moreover, curcuminoid fractions at 100 and 300 mg/kg) and curcuminoid cider (1 and 2% v/v) also lower the levels of iNOS, which has been found to mediate HCD-induced liver fibrosis.

Additionally, the applications also inhibited LOX-1 associated with high circulating cholesterol levels.

In other words, curcuminoid fractions at 100 and 300 mg/kg) and curcuminoid cider (1 and 2% v/v) displayed their hypocholesterolemic effects via attenuating genes related to oxidative stress in vivo.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of hypercholesterolemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Roles of Spicy Foods and Their Bioactive Compounds in Management of Hypercholesterolemia by Zhao Y1, Chen ZY. (PubMed)
(2) Efficacy of Oral Curcuminoid Fraction from Curcuma xanthorrhiza and Curcuminoid Cider in High-cholesterol Fed Rats by Mauren FM1, Yanti2, Lay BW. (PubMed)
(3) Diet and Exercise in the Management of Hyperlipidemia by ROBERT B. KELLY, MD, MS. (The American Family Physician)

Herbal Ashwagandha Protects the Beta Cells of Pancreas Against the Onset of Diabetes in Vivo

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream. Insulin resistance and hyperglycemia are hallmarks of diabetes.

In other words, insulin produced by the pancreas is either blocked by the clogging-up of the insulin receptors by fat and cholesterol or the death of beta cells in the pancreas. In some cases, diabetes can also be associated with autoimmune disease, attacking the beta cells.

There are some major types of diabetes, including the best known, type 1 and 2.
* Type 1 diabetes is associated with a genetic proposition that leads to the immune system to attack insulin-producing cells of the pancreas.

* Type 2 diabetes (acquired diabetes), is a condition caused by either the pancreas doesn't produce enough insulin, or the insulin does not work properly due to dysfunction of the insulin receptors.

In pregnancy, gestational diabetes is a type of diabetes occurred during the second or third trimester of pregnancy. Gestation diabetes goes away after giving birth.

However, omen with gestation diabetes is associated with a substantial risk of diabetic developing sometimes in the future.

Epidemiologically, obesity, an unhealthy lifestyle with physical inactivity are some of the most common risk factor associated with the slow onset of diabetes.

Interestingly, some researchers suggested, night shifts workers accompanied by unhealthy lifestyles are linking to a high risk of type 2 diabetes.

" risk of type 2 diabetes is actually higher than simply adding the individual risks associated with unhealthy lifestyle and shift work together, indicating that combining an unhealthy lifestyle with irregular night-time working adds a further risk".

"It is well-established that unhealthy lifestyle behaviors such as smoking, a poor diet, and little exercise, and being overweight or obese increase the risk of type 2 diabetes. Shift work, especially night shift work, has also been associated with a greater risk of type 2 diabetes".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

With an aim to find a potent compound for the treatment of diabetes, researchers examined the effects of Withania somnifera (WS) on lipid peroxidation (LPO) and pancreas in type 2 diabetic rats.

The study included type 2 diabetes induced by a single intraperitoneal injection of STZ (100 mg/kg) to 2 days old rat pups pretreated by WS.

According to the tested analysis, untreated rats group showed significant levels of lipid peroxidation (LPO) observed by reducing levels of antioxidant enzymes produced by the host including glutathione (GSH) contents and by enzymatic activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT).

However, injection of WS not only caused a significant decrease in blood glucose and tissue LPO levels casued by the application of STZ but also a significant increase in GSH contents, compared to type 2 diabetic control rats.

Furthermore, antioxidant enzymes reduced in the untreated rat such as GPx, GR, GST, SOD, and CAT were also increased compared to type 2 diabetic control rats.

Most importantly, the significant reduction in the number and size of pancreatic beta-cells in STZ rats was normalized upon the administration of WS, evident from the histopathological examination.

In other words, WS protects the cells in the pancreas against oxidation and maintains the integrity of beta cells in insulin production in type 2 diabetes rats.

Based on the findings, researchers said, "WS has shown strong free radical scavenging activity and helped in improving the non-enzymatic and enzymatic antioxidants in type 2 diabetic rats".


Taken altogether, Ashwagandha WS may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of type 2 diabetes, pending to the results of large example size and multicenter study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats by Anwer T1, Sharma M, Pillai KK, Khan G. (PubMed)
(2) Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats by Kyathanahalli CN1, Manjunath MJ, Muralidhara. (PubMed)
(3) Night shifts and an unhealthy lifestyle linked to high risk of type 2 diabetes by BMJ

Tuesday, 12 November 2019

Korean Cabbage Inhibits the Initiation of Atherosclerosis

By Kyle J. Norton

The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to supply oxygen and nutrients and removal of metabolic wastes.

Heart disease is a group of medical conditions casued by the narrowed or blocked blood vessels that can lead to a heart attack, coronary heart disease or stroke.

According to the statistic from the CDC, approximately over 600,000 Americans die of heart disease every year. The condition is a leading cause of death in both men and women.

Atherosclerosis is a medical condition associated with plaque building up in the arteries, leading to the narrowing of the arterial function in the transportation of oxygenated blood to the heart and other blood of the body.

Plaques are substances made up of the accumulated fat, cholesterol, calcium, and other substances found in the blood, including cadmium.

Long-term accumulation of plaque can also cause hardening and stiffing arterial walls can lead to the blockage of the arteries and risk of heart disease depending on the location of the blockage.

Most people in the early stage of atherosclerosis do not experience any symptoms. However, as the condition progresses and the location affected, patients may develop chest pain, shortness of breath, sweating, and anxiety.

Most common causes of atherosclerosis are the imbalance of the ratio of bad cholesterol and good cholesterol in the blood, long-term smoking, obesity, an increase in age, obesity and some medical conditions, such as diabetes and high blood pressure.

Cabbage is a species of Brassica oleracea belong to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find a natural food for the prevention and treatment of heart disease, researchers examined the effect of effects of 3-(4'-hydroxyl-3',5'-methoxyphenyl)propionic acid (HDMPPA) originating from Korean cabbage on the prevention of atherosclerosis.

The experiments included 21 3-month-old rabbits fed an atherogenic diet containing 0.5% (w/w) cholesterol and 10% (w/w) coconut oil, whereas another two groups were given an atherogenic diet with intravenous injection of either HDMPPA or simvastatin (0.33 mg/kg/day) for 4 weeks.

According to the tested analysis, HDMPPA injected group not only showed a significant effect on the inhibition the oxidative modification of low-density lipoprotein (IC 50 = 1.4 microg/mL) but also increased 2,2'-diphenyl-1-picrylhydrazyl radical scavenging activity (IC 50 = 0.78 microg/mL) in a dose-dependent manner.

In hypercholesterolemic rabbits, the thickness of the innermost tunica (layer) of an artery or vein in the HDMPPA group was significantly reduced (control versus HDMPPA, 42%; simvastatin, 38%) without affecting the levels of cholesterol.

Furthermore, the plasma of the HDMPPA group exerted a significantly decreased activity against oxidation compared to that of the control group.

More precisely, HDMPPA also inhibited the generation of vascular reactive oxygen species by inhibiting the levels of cyclooxygenase-2 in the initiation of inflammation.

Based on the findings, researchers said, "HDMPPA prevents the development of aortic atherosclerosis in high-cholesterol-fed rabbits. The antiatherosclerotic effect of HDMPPA may be due to an antioxidative effect at a low dose without cholesterol-lowering effects".


Taken altogether, Korean cabbage may be considered supplements for the prevention and treatment of atherosclerosis, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid, an active principle of kimchi, inhibits development of atherosclerosis in rabbits by Kim HJ1, Lee JS, Chung HY, Song SH, Suh H, Noh JS, Song YO. (PubMed)
(2) Beneficial effects of polyphenol-rich Olive Oil in patients with early atherosclerosis by RJ Widmer,*,1 MA Freund,*,1 AJ Flammer,1 J Sexton,1 R Lennon,1 A Romani,2 N Mulinacci,2FF Vinceri,2 LO Lerman,1 and A Lerman. (PMC)

Lycopene Processes Anti OverGrowth of Candida Albicans

By Kyle J. Norton

Fungal infectious disease occur mostly in patients with a weakened immune system characterized by the disease caused by overexpression of specific fungal.

Most common mild fungal skin diseases can induce symptoms of a rash that may go away if the fungal infection is cured.
Candida is a class of yeasts that cause fungal infections worldwide. Under normal conditions, candida does not cause any health issue if they live outside of the body including on the surface of the skin. However, Candida can cause a significant health problem if they grow out of control in the deeper parts of the body, leading to candidiasis.

Candida albicans is a member of a large group of an organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract.

Oral candidiasis is an oral condition infected by the fungal C. albicans found mostly in people with a weakened immune system including patients who are taking the immune-suppressive medicine.

Biofilms are microbial communities in which cells stick to each other and often also to a surface.

Symptoms of oral Candida overgrowth include worse in the damp day, persistence drowsiness, lack of coordination, headaches, mood swing, loss of balance, rashes, bad breath, dry mouth, and postnasal drip.

If you experience some of the aforementioned symptoms, please make sure you check with your doctor for early treatment.

There are many risk factors associated with Candida overgrowth including medical conditions that cause weakened immune system, inhalant medicine, low level of stomach acids, and pregnancy.

Some researchers suggested aging due to a weaken the immune system may be one of the major risk factors that cause Candida overgrowth

Dr. Aikaterini Flevari, the lead scientists said, "Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections".

And, "The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species".

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of fungal infection, researchers examined the role of lycopene on C. albicans.

In fungal infection, lycopene exerted potent antifungal effects on pathogenic fungi, including C. albicans in an energy-independent manner.

In Candida albicans induced by fetal bovine serum (FBS) inhibited C, albicans by causing significant membrane damage and blocking the normal budding process.

In other words, the injection of lycopene induced C. albicans apoptosis by the destruction of membrane integrity.

Based on the findings, researchers said, "indicates that lycopene has considerable antifungal activity, deserving further investigation for clinical applications".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of C. albicans infection, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You.  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Damage to the cytoplasmic membrane and cell death caused by lycopene in Candida albicans by Sung WS1, Lee IS, Lee DG. (PubMed)
(2)

Treatment of invasive candidiasis in the elderly: a review by Aikaterini Flevari,1 Maria Theodorakopoulou,1 Aristea Velegraki,2 Apostolos Armaganidis,1 and George Dimopoulos. (PMC)

Monday, 11 November 2019

Brussels Sprouts Inhibits Renal Damage in Patients with Hypertension

By Kyle J. Norton

Hypertension is a condition of abnormally high blood pressure in the bloodstream. Hypertension a member of the cluster conditions of metabolic syndrome associated with an increased risk of cardiovascular disease and diabetes.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

According to the statistics provided by the American Heart Association, approximately, 103 million U.S. adults have high blood pressure, or 1 in 2 adults in the US have the syndrome.

The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine.

The kidneys formed a second detoxed organ in the body after the liver not only plays an essential role in regulating electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin,... but also filters blood that passes into the tubules. In the Urinary system, kidneys reabsorbed some necessary substances back into the blood, while waste, such as urea and ammonium are deposited into pelvis then into the ureter to the bladder for secretion.

Kidney disease is a condition that reduces the function of the kidney acutely or gradually.

Kidney damage is a condition that causes the reduced function of the kidney. Over time untreated kidney damage can induce the formation of scars. Over-expression of kidney scars can lead to kidney disease and kidney failure in severe cases.

According to the statistics, approximately 14 percent of the US population suffer some forms of chronic kidney disease (CKD), including 661,000 cases of kidney failure.

Believe it or not, almost half of the individuals with CKD also have diabetes and/or self-reported cardiovascular disease (CVD).


Blood in urine, protein in the urine, kidney stones, kidney infection, kidney pain, hepatitis C and other forms of kidney diseases are signs of kidney disease that can lead CKD.

With an aim to find a natural food for the prevention of stroke, researchers examined the effect of Brussels sprouts on high-sodium/low-potassium-fed stroke-prone spontaneously hypertensive animal model.

Stroke-prone spontaneously hypertensive rat (SHRSP) received the Japanese diet for 4 weeks included in the study was divided into
* Nontreatment group.

* SHRSP group received a Japanese diet and B. oleracea.

* A third group received a Japanese diet, B. oleracea, and PPARα inhibitor (GW6471).

* A group of SHRSP fed with regular diet served as control.

According to the tested analysis, compared to a regular diet, group treated with Japanese diet (high-sodium/low-potassium) showed to induce the increases of oxidative stress, inflammation, and proteinuria, along with glomerular and tubular damage.

The (AMPK/UCP2) pathway associated with the inhibition of ROS production and inhibits palmitate-induced apoptosis in endothelial cells was significantly suppressed by the Japanese diet.

However, Japanese diet-induced overexpression of oxidative stress accumulation, inflammation, renal damage, and proteinuria was totally prevented by the administration of Brussels sprouts.

Additionally, injection of Brussels sprouts also promoted the expression of antioxidant enzymes produced by the host observed by the increased level of a gene associated with drug toxicity without affecting the systolic blood pressure (SBP).
 

Taken altogether, Brussels sprouts may be considered supplements for the prevention of renal damage progression in hypertension, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis by Rubattu S1, Di Castro S, Cotugno M, Bianchi F, Mattioli R, Baima S, Stanzione R, Madonna M, Bozzao C, Marchitti S, Gelosa P, Sironi L, Pignieri A, Maldini M, Giusti AM, Nardini M, Morelli G, Costantino P, Volpe M. (PubMed)

Herbal Ashwagandha Kills Osteosarcoma Cells in Vitro

By Kyle J. Norton

Osteosarcoma is a type of bone cancer found mostly in teenagers and people over age 60.

Most cases of osteosarcoma are associated with genetic syndromes. In other words, Osteosarcoma is associated with a genetic preposition inherited from the parent.

According to the statistic from the American Cancer Society, each year, approximately 800 to 900 new cases of osteosarcoma are diagnosed in the United States with half of these are in children and teens.

The exact causes of osteosarcoma are unidentified. However, epidemiologically, besides gene expression, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity and exposure to bone radiation are also some prevalent factors found in patients with the disease.

Dr. Jeff W. Martin, the lead scientist at the Hospital for Sick Children and Queen's University wrote, "The etiology of this often aggressive cancer is currently unknown because complicated structural and numeric genomic rearrangements in cancer cells preclude the understanding of tumor development.",

And, " few consistent genetic changes that may indicate effective molecular therapeutic targets have been reported. However, high-resolution techniques continue to improve knowledge of distinct areas of the genome that are more commonly associated with osteosarcomas".

The overall 5-year survival rate for children and teens with osteosarcoma is 70%. If cancer has spread to the lung, the 5-year survival rate is only 40% comapred to localized cancer between 60% to 80%.

Conventionally, most cases of osteosarcoma are o treated with a combination of surgery, chemotherapy and radiation therapy.

In patients with high-grade tumors, before surgery, neo-adjuvant therapy may be necessary to shrink the tumor.
Ashwagandha (WA)also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of cancers, researchers examined evaluated the safety and pharmacokinetics of WA.

In Vitro, Withaferin-A (WF-A), a major bioactive compound found in WA exhibited strong antiproliferative activity against several osteosarcoma cell lines, with IC50 ranging from 0.32 to 7.6 μM. The lowest IC50 (0.32 μM).

At the lowest IC50 (0.32 μM), WF-A showed a significant effect on the inhibition of U2OS cell line, comapred to other cell lines.

Most importantly, WF-A induced ROS cytotoxicity against the tested cell lines in a dose-dependent manner and activation of cell death protein in osteosarcoma cells.

In the safety analysis if the phase I dose-escalation study, using the classical 3 + 3 design (C33D) is comprised of 72, 108, 144 and 216 mg of WA administered in two to four divided doses per day in selected patients, including 3 patients enrolled in each cohort with the last patient who was observed for at least 30 days for any dose-limiting toxicity before progressing to a higher cohort, researchers found that the formulation was generally well tolerated with no grade 3 or grade 4 adverse events were observed, however, the formulation at the tested doses caused 11 adverse events of grade 1 or grade 2 severity.

Mose common symptoms are fatigue, fever, edema, and diarrhea. No levels of WA circulation. were found in the blood plasma. The low oral bioavailability of WA was also observed during the experimental period.

Based on the findings, researchers wrote, "The formulation was well tolerated. However, WA appears to have low oral bioavailability. Further studies with improved formulations are warranted".


Taken altogether, Ashwagandha is safe and may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of osteosarcomas, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Safety and Pharmacokinetics of Withaferin-A in advanced stage high grade Osteosarcoma: A phase I trial by Pires N1, Gota V1, Gulia A2, Hingorani L3, Agarwal M2, Puri A. (PubMed)
(2) Withaferin-A Induces Apoptosis in Osteosarcoma U2OS Cell Line via Generation of ROS and Disruption of Mitochondrial Membrane Potential by Zhang HL1,2, Zhang H. (PubMed)
(3) The Genetics of Osteosarcoma by Jeff W. Martin,1 Jeremy A. Squire,2 and Maria Zielenska. (Hindawi)