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Tuesday, 14 January 2014

Food Therapy - Strawberries and Colon cancer

Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with suitable climate for commercial profits and for health benefits.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Colon Cancer is defined as a condition of the abnormal proliferation of cells in the colon.



Nutrients and Chemicals constituents

1. Carbohydrate
2. Dietary fiber
3. Omega 3 fatty acid
4. Calcium
5. Iron
6. Magnesium
7. Phosphorus
8. Potassium
9. Sodium
10. Zinc
11. Copper
12. Manganese
13. Selenium
14. Vitamin C
15. Thiamin
16. Niacin
17. Pantothenic acid
18. Vitamin B-6
19. Folate
20. Vitamin B-12
21. Vitamin A
22. Vitamin E
23. Vitamin K
24. Etc. 

The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

The benefits
Ellagitannins (ETs), a class of hydrolyzable tannins found in strawberry, may have beneficial effects against colon cancer as the component releases ellagic acid (EA) and are converted by gut microbiota to urolithin A (UA; 3,8-dihydroxy-6H-dibenzopyran-6-one) type metabolites, which may persist in the colon through enterohepatic circulation. Other study also found that Polyphenol-rich strawberry extracts to potential antiproliferative effectiveness using human cervical cancer (HeLa) and Colon cancer (CaCo-2) cells. In study of multiple phenolic compounds, researchers showed the Crude extracts (250 microg/mL) and pure compounds (100 microg/mL) inhibited the growth of human oral (CAL-27, KB), colon (HT29, HCT-116), and prostate (LNCaP, DU145) cancer cells with different sensitivities observed between cell lines.

The Side effects
1. Some people may beexperience anaphylactoid reaction to the consumption of strawberries

2. Oxalation
Oxalates in high concentration can cause problem for people with kidney diseases.
3. Etc.  

References
(1) Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling by Sharma M, Li L, Celver J, Killian C, Kovoor A, Seeram NP.(PubMed)
(2) Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro by McDougall GJ, Ross HA, Ikeji M, Stewart D.(PubMed)
(3) Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties by Zhang Y, Seeram NP, Lee R, Feng L, Heber D.(PubMed)