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Saturday, 25 January 2014

Phytyochemical Anacardic acid and anti microbal activity

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.

The health effects
An anacardic acids mixture isolated from Amphipterygium adstringens has performed its anti bacterial effect as an alternate to antibiotics by inhibition of the regulator of virulence and biofilm formation in the pathogenic bacteria Pseudomonas aeruginosa. Anacardic acid mixture (AAM) showed 94% of inhibition of the violecin production at 166 μg/mL and 86% of inhibition of pyocyanin production  at 200 μg/mL). Otehr in the study of a new anacardic acid, indicated that its deviratives, 16'Z-nonadecenyl]-salicylic acid and masticadienonic acid also inhibited bacterial activity against Streptococcus mutans and Porphyromonas gingivalis with minimum inhibitory concentrations.



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References
(1) Amphypterygium adstringens anacardic acid mixture inhibits quorum sensing-controlled virulence factors of Chromobacterium violaceum and Pseudomonas aeruginosa by Castillo-Juárez I, García-Contreras R, Velázquez-Guadarrama N, Soto-Hernández M, Martínez-Vázquez M. (PubMed)
(2) Isolation of the new anacardic acid 6-[16'Z-nonadecenyl]-salicylic acid and evaluation of its antimicrobial activity against Streptococcus mutans and Porphyromonas gingivalis by Rivero-Cruz BE, Esturau N, Sánchez-Nieto S, Romero I, Castillo-Juárez I, Rivero-Cruz JF.(PubMed)