The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Methicillin-resistant Staphylococcus aureus (MRSA) is a substantial contributor to morbidity and mortality. Emodin (EM), the major component found in Cascara Sagrada and many other plants combined with ampicillin (AM) or oxacillin (OX) have a showed a positive effects against all strains of bacterias, resulted in a fractional inhibitory concentrations index (FICI) ranging from 0.37-0.5 and from 0.37-0.75, respectively. Other in the study of the effect of glycoside on the antibacterial activity of aloin, showed Aloe-emodin (inhibition diameter < 5.0 mm), changed the morphology of E. coli and damaged the outer cell structure.
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(1) Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus.by Lee YS, Kang OH, Choi JG, Oh YC, Keum JH, Kim SB, Jeong GS, Kim YC, Shin DW, Kwon DY.(PubMed)
(2) [Relationship between antibacterial activity of aloe and its anthaquinone compounds].