Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that
supply the ducts with milk. there is also rare cases that breast cancer
starts in other areas of the breast. In 2010, over 250,000 new cases of
breast cancer were expected to be diagnosed in women in the U.S. alone
and the risk of getting invasive breast cancer during life time of a
women is 1/8.
The health benefits
Dietary foods with Anacardic acid (AnAc;
2-hydroxy-6-alkylbenzoic acid) may be potential to reduce the risk of
breast cancer as its AnAc 24:1(omega5) purified from geranium inhibits
breast cancer cell proliferation, cell cycle progression, and apoptosis
in an ER-dependent manner. Other in the study of Synthesis of benzamides
related to anacardic acid, showed a
exhibited activities similar to that of AA, In U937 cells, it induced
cell-cycle arrest in the G1 phase, caused apoptosis in about 20 % of the
cells and increased the acetylation levels of H3.
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References
(1) Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer
cell proliferation by Schultz DJ, Wickramasinghe NS, Ivanova MM, Isaacs
SM, Dougherty SM, Imbert-Fernandez Y, Cunningham AR, Chen C, Klinge
CM.(PubMed)
(2) New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators.
Souto JA, Benedetti R, Otto K, Miceli M, Alvarez R, Altucci L, de Lera AR.(PubMed)
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