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Sunday, 12 January 2014

Phytochemicals Berberine and resveratrol and non-alcoholic fatty liver disease (NAFLD)

Bernerine is a phytochemical found abundantly in root, bark, stem in plants of  Berberis, including Oregon grape, barberry, tree turmeric, etc.
Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape wine, nuts, peanuts, etc.
Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.

Sadly to say, Non alcoholic liver diseases has become most prevalence incidence to cause liver diseases because of uncontrolled diet with high in saturated fat. Conventional medication such as ameliorate, a cholesterol absorption inhibitor, is found to be effective in decreasing cholesterol absorption in the small intestine and ameliorated non-alcoholic fatty liver disease (NAFLD) pathology but with many side effects.
In herbal medicine, certain herbs have found to be effective not only in reducing the symptoms of non alcoholic, but also prevent the abnormal alanine aminotransferase functions and fat accumulation in liver.
Berberine and resveratrol, the phytochemical found abundantly in many vegetables and fruits as well herbs and herbal formulae such as Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (, YCHD), Qushi Huayu Decoction (, QSHYD), and Danning Tablet, were found not only to improve biochemical and histological change in nonalcoholic fatty liver disease, but also associated with inhibiting lipid accumulation through adenosine monophosphate-activated protein kinase activation or up regulating low-density lipoprotein receptor (LDLR) expression, alleviating lipid peroxidation, and reducing the production of inflammatory cytokines. In such instance, Berberine and resveratrol, may be considered as a potential treatment for nonalcoholic fatty liver disease in the future.

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References
(1) Non-alcoholic fatty liver disease and liver transplantation: Outcomes and advances by Said A.(PubMed)
(2) The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial by Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato KI, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S.(PubMed)