Aloe vera gel (AVG) and Polycystic Ovarian Syndrome (PCOs)

Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen), resulting in male pattern hair development, acne,irregular period or absence of period, weight gain and effecting fertility. It effects over 5% of women population or 1 in 20 women.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herb studied in scientific ways with some conflicted results.

The effects
In the view if certain side effects of several classes of pharmacological agents have been used to manage dyslipidemia in women with Polycystic Ovarian Syndrome (PCOs), some researchers have been studied through the altyernative nmedicine with an aim to find a better treatment with less or no side effects. Aloe vera gel (AVG), has found to be effective in reduction in plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol, reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities. Others in the study of the same but in comparison with Letrozole, showed  Aloe vera restored the estrus cyclicity, glucose sensitivity, and steroidogenic activity. Treatment combined with Letrozole  prevented the development of the PCO phenotype. These results showed a positive anti-hyperlipidemic effects and may be used in managing PCOS associated metabolic complication and restoring the ovarian steroid status.

The Side effects 1. High amount of vitamin K may reduce the effectiveness of anticogulation medicine
2. Causing additive effects for women who are under estrogen replacement therapy or taking the oral contraceptive pill.
3. It may cause stomach upset and diarrhea
4. The herb may induce lupus erythematosu due to its chemical constituent L-canavanine.



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References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model by Desai BN, Maharjan RH, Nampoothiri LP.(PubMed)
(2) Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model by Maharjan R, Nagar PS, Nampoothiri L.(PubMed)
(3) Drug-induced lupus: an update by Vasoo S.(PubMed)