Sunday, 19 January 2014

Phytochemical Anacardic acids and Prostate cancer

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

The health Benefits
Anacardic acid (6-pentadecylsalicylic acid), a natural chemical constituent from ancient plant Amphipterygium adstringens, also known as a non-specific histone acetyltransferase inhibitor of p300, beside exhibuts its anti-inflammatory, anticancer, antioxidative, and antimicrobial effects, but also revealed that Src protein expression, tumor cell proliferation, and microvessel density could be remarkably suppressed by anacardic acid and may be considered as a potent agent to treat prostate cancer. Other study of Anacardic acid (6-pentadecylsalicylic acid), also showed to inhibit of prostate cancer by  down-regulates androgen receptor (AR) through suppressing p300.

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Back to Phytochemical Therapy

(1) Anacardic acid (6-pentadecylsalicylic acid) inhibits tumor angiogenesis by targeting Src/FAK/Rho GTPases signaling pathway by Wu Y, He L, Zhang L, Chen J, Yi Z, Zhang J, Liu M, Pang X.(PubMed)
(2) Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling by Tan J, Chen B, He L, Tang Y, Jiang Z, Yin G, Wang J, Jiang X.(PubMed)