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Sunday, 12 January 2014

Antioxidants and Non alcoholic fatty liver disease (NAFLD)

A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with other cell, which in turn, causes oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospho-lipids, DNA and RNA, etc., leading to aging of the organisms, as a result of widespread damage due to set of a chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls.
Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.  

Antioxidants have been found to assist the body in selfrepairment of the cell damage caused by oxidative stress in balancing of the electrons. Oxidative stress is found to cause hepatic damage in patients with acute and chronic hepatitis B virus (HBV) infection and these imbalances in some researches were found to be associated in patients with Non alcoholic fatty liver disease (NAFLD). In a prospective study of 29 patients with NAFLD, 25 diseased controls with chronic viral hepatitis, and 23 healthy controls, lipid peroxidation are significantly increased among patients with NAFLD compared to healthy subjects, but there were no significant correlation between histological grading or staging and levels of pro and antioxidants. This study demonstrate that oxidative may be considered as a potential cause in managing patients with Non alcoholic fatty disease.

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References
(1) Oxidant stress and antioxidant status among patients with nonalcoholic fatty liver disease (NAFLD).

Madan K, Bhardwaj P, Thareja S, Gupta SD, Saraya A.(PubMed)
(2) [Investigation of oxidative stress and antioxidant defense in patients with hepatitis B virus infection and the effect of interferon-alpha plus lamivudine combination therapy on oxidative stress].[Article in Turkish. by Acar A, Görenek L, Aydin A, Eyigün CP, Eken A, Sayal A, Pahsa A.(PubMed)