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Sunday, 26 January 2014

Phytochemical Phytic acid and Diabetes

Phytic acid (Inositol hexaphosphate) are phytichemicasl of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The benefits
In streptozotocin-induced diabetic rats, fed with or without phytic acid supplementation for thirty days, showed a positive effects in lowering spike in random blood glucose, in the same group, serum triglycerides and increased total cholesterol and HDL was also reduced. On the levels of blood glucose and some enzymes of carbohydrate and lipid metabolism with rats fed formulated diets supplemented with zinc or without zinc, formulated diets supplemented with zinc plus phytic acid extracted from sweet potato (Ipomea batatas) or commercial phytic acid respectively, showed a lowered blood glucose levels in Phytic acid extract consumption from sweet potato and commercial phytic acid plus zinc supplement. These results may indicted that the use of sweet potato diet in diabetic management.



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References
(1) The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats by Omoruyi FO1, Budiaman A1, Eng Y1, Olumese FE2, Hoesel JL3, Ejilemele A3, Okorodudu AO (PubMed)
(2) The effect of phytic acid on the levels of blood glucose and some enzymes of carbohydrate and lipid metabolism by Dilworth LL, Omoruyi FO, Simon OR, Morrison EY, Asemota HN(PubMed)