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Wednesday, 15 January 2014

Herbal Cat's claw and Cancers

Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae. It has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

Ingredients
The chemical constustuents of Cat's claw include, ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

The benefits
Cat's claw (Uncaria tomentosa), the popular herb has emerged in scientific community in searching of organic chemical constistuents in treating cancers. Study of ethanol extract from the bark of the herb in different concentrations is found to be effective  in inhibiting proliferation of cervical carcinoma, breast carcinoma and lung carcinoma (A-549) with little of adverse effects. In the isolation of pentacyclic oxindole alkaloid mitraphylline from the dried inner bark of Cat's claw, concentrations of mitraphylline (5 microM to 40 microM) inhibited the proliferation of human Ewing's sarcoma MHH-ES-1 and breast cancer MT-3 cell lines in a dose-dependent manner. With that result in mind, the herb may be a potential agent in treating certain types of human cancers in the future.



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Side effects
1. It may cause allergic reaction, including itching, rash and allergic inflammation of the kidneys, etc. to certain people, according to the article of `Uncaria Tomentosa`by Wikipedia(a)
2. If you are taking blood pressure medicines, blood-thinning medications, hormones, or insulin do not take cat's claw
3. Do not take Cat's claw if you are pregnant or breast feeding with out approval of your related field specialist
4. Do not take cat’s claw if you have low blood pressure or an autoimmune disease (such as lupus or multiple sclerosis) or have had an organ or bone marrow transplant.
5. Etc.

References
(1) Topical plant data base (Rain tree)
(2) Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition by Pilarski R, Filip B, Wietrzyk J, Kuraś M, Gulewicz K.(PubMed)
(3) Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines, by García Giménez D, García Prado E, Sáenz Rodríguez T, Fernández Arche A, De la Puerta R.(PubMed)