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Thursday, 23 January 2014

Phytochemical Anacardic acid and Lung cancer

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.

The health benefits
Anacardic acid (AA), a chemical conpound found in some foods and herb has exerted its cytotoxicity  property to causes cell on A549 lung adenocarcinoma cells through the activation of mitochondrial-mediated involved in initiating a caspase-independent pathway and an contact activation pathway executioner such as cytochrome c. The phytochemical on the other hand also expresses its anticancer, anti-inflammatory, and radiosensitization through suppresion of a protein complex that controls transcription of DNA, the NF-kappaB signalling pathway. These results may demonstrate a novel role for anacardic acid in potentially preventing or treating cancer through modulation of certain pathways.


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References
(1) Anacardic acid induces mitochondrial-mediated apoptosis in the A549 human lung adenocarcinoma cells by Seong YA, Shin PG, Kim GD.(PubMed)
(2) Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis by Sung B, Pandey MK, Ahn KS, Yi T, Chaturvedi MM, Liu M, Aggarwal BB.(PubMed)