Sunday, 12 January 2014

Bastard Teak and Non alcoholic Liver disease (NAFLD)

Bastard Teak (Premna tomentosa) is Indian ayurvedic medicine used widely in the treatment of liver disorder.
Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.  

The prevalence of non alcoholic of liver disease is worrisome to Western world as it not only effects the organs donors, but also increase the medical cost in the future. AS well known, the liver is the first live of defense in detoxifying toxin accumulated in the body, and healthy liver is associated with  a balanced diet that includes nutrients and herbs that support a healthy liver. In the study of the extracts from the ayurvedic plant, Premna tomentosa (PT), pretreatment of (750 mg/kg, orally) for 15 days and then induced with hepatotoxicity by AA (640 mg/kg, intraperitoneally) in animals, was found to significantly inhibit induced alterations in the levels of cholesterol, triglycerides, free fatty acids, phospholipids, serum lipoproteins, and lipid-metabolizing enzymes, as well as to exert a beneficial effect against liver injury-induced membrane damage. Of that result, the extract may be considered for human trial for it efficacy in treating liver disorder, including Non alcoholic fatty disease.

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(1) Assessment of the protective potential of Premna tomentosa (L. Verbenaceae) extract on lipid profile and lipid-metabolizing enzymes in acetaminophen-intoxicated rats by Devi KP, Sreepriya M, Balakrishna K, Veluchamy G, Devaki T.(PubMed)
(2) Protective effect of Premna tomentosa (L. Verbenaceae) extract on membrane-bound phosphatases and inorganic cations transport in acetaminophen-induced hepatotoxicity rats, by Devi KP, Sreepriya M, Balakrishna K, Devaki T.(PubMed)

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