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Saturday, 11 January 2014

Curcumin and Non alcoholic Fatty liver disease (NAFLD)

Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.. Curcumin is one of the natural phenols in the plant.

Turmeric has long been used in herbal medicine in treating diseases and today its curcuminoid, curcumin has attracted many interests from researchers in many parts of the world. Curcumin, as an antihyperlipidemic agents, has been found to lower the "bad cholesterol" low density lipoprotein (LDL),  and increase high density lipoprotein (HDL) of which reduce the risk of fat accumulated in the tissues in the liver. Ecessive fat deposited in hepatocytes may cause metabolic imbalances, causing Non- alcoholic fatty liver diseases. In the support of the above, the water-soluble curcumin derivative was tested for its efficacy against steatohepatitis which is an inflammation of the liver with concurrent fat accumulation in liver, the derivative not only significantly alleviated fibrosis but also decreased the grade of liver steatosis.

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References
(1) Curcumin and liver disease.Vera-Ramirez L, PĂ©rez-Lopez P, Varela-Lopez A, Ramirez-Tortosa M, Battino M, Quiles JL.(PubMed)
(2) [The effects of curcumin derivative on experimental steatohepatitis].[Article in Chinese] by Zeng CH, Zeng P, Deng YH, Shen N, Peng ML, Liu Q, Ren H.(PubMed)