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Saturday, 11 January 2014

Herbal Burdock and Breast cancer

Burdock is plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. It has been used over thousand of years in Chins and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

The ingredients
It contains carbonated water, sugar,, manloid colourings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate,11-tridecadien-3,5,7,9-tetraynde-hydrocostus lactone,dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.

The benefits
Arctigenin, a dietary phytoestrogen and natural lignan product of Arctium lappa L inhibited human breast cancer MDA-MB-231 cell growth by inducing apoptosis in vitro and in vivo. Other lignan constituen, Arctiin ofof Arctium lappa, induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer.

The Side effects
1. Overdose can be poisoning and may lead to symptoms of
acute poisoning include phenothiazines, tricyclic antidepressants, and antihistamines.
2. It may cause dermatitis and allergic/inflammatory responses to certain people with contact as a result of lactones which the plant produces.
3. Do not use burdock if you are pregnant or breast feeding.
4. Etc.
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References
(1) Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation by Hsieh CJ, Kuo PL, Hsu YC, Huang YF, Tsai EM, Hsu YL.(PubMed)
(2) Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression by Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D, Sakai T.(PubMed)