By Kyle J. Norton
In seeking a natural therapy with no side effects, scientists may have a herbal remedy for normalizing blood pressure, according to studies.
Hypertension is a chronic condition caused by abnormally high blood pressure.
High blood pressure is a condition of a cluster of metabolic syndrome associated with the increased risk of heart disease and stroke.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
In high blood pressure individuals, due to the elevated blood pressure in your arteries, the heart has to work harder than normal to pump blood through the blood vessels.
In low blood pressure individuals, the reduced blood pressure in the arteries drops can cause the heart to pump blood at a slower rate than normal.
According to the standard guidelines, the levels of blood pressure are normal if it is more than 120 over 80 and less than 140 over 90 (120/80-140/90).
People with blood pressure lower than 120/80 are considered normal without being accompanied by symptoms of light-head or dizziness.
According to the statistics provided by the CDC, in the U.S. 29% or 100 million adults have hypertension during 2015–2016 and hypertension prevalence increased with age and was 33.2% among those aged 40–59 and 63.1% among those aged 60 and over.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.
Researchers in the course of finding a natural ingredient for the treatment of high blood pressure investigated the safety and effect of intrapulmonary administration (by inhalation) of 60 % honey solution, 10% dextrose, or distilled water in normal or diabetic subjects.
Twenty-four healthy subjects, 16 patients with type 1 diabetes mellitus, and six patients with hypertension were selected to participate in the study.
Twelve healthy subjects were subjected to distilling water inhalation for 10 min, and after one week they received inhalation of honey solution (60% wt/v) for 10 min. Another 12 healthy subjects received inhalation of 10% dextrose for 10 min.
Honey treatment showed a mild reduction of blood pressure compared to no change in another group.
From a time perspective, systolic and diastolic blood pressure was reduced by honey inhalation in hypertensive patients at 60 and 120 min.
After taking into account co and confounders, researchers said, "honey inhalation was safe and effective in reducing...elevated blood pressure in hypertensive patients".
Moreover, in order to obtain more information on honey antihypertensive activity, researchers investigated the aqueous extract obtained from the mixture of the fresh leaf of Persea Americana, stems, and a fresh leaf of Cymbopogon citrus, fruits of Citrus medica, and honey on ethanol and sucrose-induced hypertension in rats.
Rats included in the study were divided into eight groups of 6 rats each and daily treated for 5 weeks. The control group received distilled water (1 mL/kg) while rats of groups 2, 3, and 4 received ethanol 40 degrees (3 g/kg/day), 10% sucrose as drinking water, and the two substances respectively.
The remaining groups received additional sucrose and ethanol, the aqueous extract (50, 100, and 150 mg/kg) or nifedipine (10 mg/kg) respectively.
Group treated with ethanol and sucrose showed a significantly (p < 0.001) increased blood pressure and heart rate compared to distilled water-treated rats.
Chronic treatment of ethanol and sucrose also exerted significantly decreased the activities of antioxidant enzymes produced by the host, observed by the levels of superoxide dismutase (SOD) and catalase (CAT) and elevated levels of oxidative stress observed by the stress marker malondialdehyde (MDA) levels.
However, administration of the aqueous extract or nifedipine prevented all changes caused by chronic ethanol and sucrose, including the hemodynamic, biochemical, oxidative, and histological impairments.
The finding clearly suggested that aqueous extract including honey possesses antihypertensive activity by the improvement of biochemical and oxidative status, through its antioxidant property.
Taken altogether, honey used alone or combined with other herbs may be considered anti-hypertension functional remedies with no side effects, pending the confirmation of a large sample size and multicenter human study.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Intrapulmonary administration of natural honey solution, hyperosmolar dextrose or hypoosmolar distill water to normal individuals and to patients with type-2 diabetes mellitus or hypertension: their effects on blood glucose level, plasma insulin and C-peptide, blood pressure and peaked expiratory flow rate by Al-Waili N1. (PubMed)
(2) Antihypertensive potential of the aqueous extract which combine leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model by Dzeufiet PD1, Mogueo A, Bilanda DC, Aboubakar BF, Tédong L, Dimo T, Kamtchouing P. (PubMed)
Friday 26 August 2022
Sunday 21 August 2022
Phytochemical Beta-Sitosterol in the Prevention of Melanoma Brain Metastases
By Kyle J. Norton
Melanoma is skin cancer caused by the alternation of melanocyte DNA in the skin pigment, leading to the formation of moles that change in the color, size, or shape of the skin.
Most cases of melanoma start in the melanocytes or pigment-producing cells in the outer layer of the skin.
Melanoma-induced metastasis cancer in the brain is secondary cancer as a result of the spreading of melanoma cancer cells.
Melanoma spread to the brain shares the characteristics of melanoma.
Metastasis is a process in which cancer cells travel a distance away from the originated site to induce secondary malignant growths.
Anti-metastasis is an action in which substances or substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor.
Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered to process antimetastatic activity.
Furthermore, β-sitosterol also increased the expression of oxidative stress to induce cancer cell apoptosis.
These results strongly indicated a significant role of mitochondrial complex I on human melanoma brain metastases compared to brain metastases from other cancers.
Melanoma is skin cancer caused by the alternation of melanocyte DNA in the skin pigment, leading to the formation of moles that change in the color, size, or shape of the skin.
Most cases of melanoma start in the melanocytes or pigment-producing cells in the outer layer of the skin.
Melanoma-induced metastasis cancer in the brain is secondary cancer as a result of the spreading of melanoma cancer cells.
Melanoma spread to the brain shares the characteristics of melanoma.
Metastasis is a process in which cancer cells travel a distance away from the originated site to induce secondary malignant growths.
Anti-metastasis is an action in which substances or substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor.
Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered to process antimetastatic activity.
Unlike melanoma-induced metastasis in the brain, brain cancer is a medical and chronic condition characterized by cell growth disorderly in the brain tissue with a small number that may be caused by gene defects from exposure to radiation or toxic chemicals. More than 190.000 people in the US are diagnosed with a brain tumor each year alone.
More than 190.000 people in the US are diagnosed with a brain tumor each year alone.
Most brain types of brain cancer in older adults aged 50 to 60 are Chordomas. The cancer is rare and slow-growing, but it can invade adjacent bone and put pressure on the nearby neural tissue.
Meningiomas are the most common type of benign brain tumor in the age group 40-50s. However, a small percentage of these tumors can be malignant.
According to the statistic provided by the Canadian cancer society, Every day about 25 Canadians is diagnosed with a brain tumor.
The 5-year survival rate of brain cancer is only 25%, compared to over 60% for cancers overall. Most adults with a diagnosis of aggressive glioblastoma survive only 1–2 years after their diagnosis.
Most brain types of brain cancer in older adults aged 50 to 60 are Chordomas. The cancer is rare and slow-growing, but it can invade adjacent bone and put pressure on the nearby neural tissue.
Meningiomas are the most common type of benign brain tumor in the age group 40-50s. However, a small percentage of these tumors can be malignant.
According to the statistic provided by the Canadian cancer society, Every day about 25 Canadians is diagnosed with a brain tumor.
The 5-year survival rate of brain cancer is only 25%, compared to over 60% for cancers overall. Most adults with a diagnosis of aggressive glioblastoma survive only 1–2 years after their diagnosis.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.
On finding a potential phytochemical that processed neuroprotective activity, researchers examined the effect of β-sitosterol on melanoma cell growth in vitro and inhibition of brain metastasis formation.
On finding a potential phytochemical that processed neuroprotective activity, researchers examined the effect of β-sitosterol on melanoma cell growth in vitro and inhibition of brain metastasis formation.
β-sitosterol exerted mitochondrial interference, against the test cancer cells by reducing the mitochondrial respiratory capacity, mediated by an inhibition of mitochondrial complex I in converting the energy from food for cell needs.
These results strongly indicated a significant role of mitochondrial complex I on human melanoma brain metastases compared to brain metastases from other cancers.
Moreover, the combination of vemurafenib with either β-sitosterol or a functional knockdown of mitochondrial complex I showed a completely abrogated BRAF inhibitor resistance in the tested cells.
Based on the findings, researchers said, " β-sitosterol represents a promising adjuvant to BRAF inhibitor therapy in patients with or at risk for, melanoma brain metastases".
Based on the findings, researchers said, " β-sitosterol represents a promising adjuvant to BRAF inhibitor therapy in patients with or at risk for, melanoma brain metastases".
Taken altogether, beta-Sitosterol may be considered a functional food for the prevention of melanoma brain metastases, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1)Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brainmetastasis by Sundstrøm T1,2,3, Prestegarden L1,2,4, Azuaje F5,6, Aasen SN1,7, Røsland GV8, Varughese JK1, Bahador M1, Bernatz S9, Braun Y9, Harter PN9, Skaftnesmo KO10, Ingham ES11, Mahakian LM11, Tam S11, Tepper CG12, Petersen K13, Ferrara KW11, Tronstad KJ8, Lund-Johansen M2,3, Beschorner R14, Bjerkvig R1,5, Thorsen F. (PubMed)
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1)Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brainmetastasis by Sundstrøm T1,2,3, Prestegarden L1,2,4, Azuaje F5,6, Aasen SN1,7, Røsland GV8, Varughese JK1, Bahador M1, Bernatz S9, Braun Y9, Harter PN9, Skaftnesmo KO10, Ingham ES11, Mahakian LM11, Tam S11, Tepper CG12, Petersen K13, Ferrara KW11, Tronstad KJ8, Lund-Johansen M2,3, Beschorner R14, Bjerkvig R1,5, Thorsen F. (PubMed)
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