Intake of coffee caffeine regularly are associated to a significantly attenuated risk of neurodegenerative conditions, particular in the onset of Parkinson's diseases, a recent study suggested.
Parkinson's disease is neuro degenerative disease caused by deficiency of the dopamine and.degeneration of the basal ganglia of the brain, affecting muscular normal function.
Dopamine acted as as a neurotransmitter and a precursor of other substances including epinephrine.
is a compound present in the body involved brain function in the roles of reward-motivated behavior.
Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
According to the Harvard School of Public Health, Boston, in compared population comprised 47,351 men and 88,565 women free of Parkinson's disease, stroke, or cancer at baseline, caffeine intake is associated to reduced risk and progression of PD, in compared the top and bottom one-fifth men participants. No effect is found for decaffeinate coffee intake regardless to numbers of cup consumed.
Caffeine, a chemical stimulant found abundantly in caffeinated products, including tea and coffee is a class of methylxanthine having a profound impact in central nervous system (CNS).
Interestingly, among women, numbers of caffeinated coffee intake daily have a strong implication in attenuated risk of PD linearly, in compared to lowest intake of moderated intake groups.
Further more, a case-control study conducted in western Washington State in 1992-2000. Incident PD cases (n = 210) and controls (n = 347) with frequency matched on gender and age identified from enrollees of the Group Health Cooperative health maintenance organization, returned questionnaires by participants indicated, consumption of 2 cups/day showed a strong expression in reduced risk of PD.
More importantly, in the review of twenty-six studies included: 7 cohort, 2 nested case-control, 16 case-control, and 1 cross-sectional study, the total relative odd ratio for the association between caffeine intake in low to moderate groups and PD was 0.75.
But, in cohort studies, reduced risk of PD significantly decreased if only women participants were considered.
Researchers, at above study revealed that PD risk is associated to a linear relation between levels of caffeine exposure of relative odd ratio of 0.76, per 300 mg caffeine intake.
Finally, some researchers addressed that, in the concerns of PD patients in expression a significant impairment of dopaminergic neuron transmission, caffeine acted as acts as a nonselective adenosine receptor antagonist may have a profound effect in treatment of PD through adenosine A2A receptors function in regulation of glutamate and dopamine release.
Taking together, there is no doubt that risk of PD has an extremely inverse association to caffeine intake, particular in moderated drinkers.
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(1) Can coffee consumption lower the risk of Alzheimer's disease and Parkinson's disease? A literature review by Wierzejska R1.(PubMed)
92) Prospective study of caffeine consumption and risk of Parkinson's disease in men and women by Ascherio A1, Zhang SM, Hernán MA, Kawachi I, Colditz GA, Speizer FE, Willett WC.(PubMed)
(3) Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake by Checkoway H1, Powers K, Smith-Weller T, Franklin GM, Longstreth WT Jr, Swanson PD.(PubMed)
(4) Association of coffee and caffeine intake with the risk of Parkinson disease by Ross GW1, Abbott RD, Petrovitch H, Morens DM, Grandinetti A, Tung KH, Tanner CM, Masaki KH, Blanchette PL, Curb JD, Popper JS, White LR.(PubMed)