Thursday 30 April 2020

Herbal Enchinanea Processes Anxiolytic Effects with No Side Effects

By Kyle J. Norton

An anxiolytic is a type of medication, or other intervention, that inhibits anxiety.

Anxiety is a mental disorder characterized by worry about future events and fear of current events.

Some researchers suggested that anxiety disorders are conditions associated with the combination of biological, psychological, and individual factors and the most commonly reported psychiatric conditions and frequently occur as comorbid disorders.

According to the statistic, anxiety disorders are the most common mental illness in the U.S., affecting 40 million adults in the age of 18 and older, or 18.1% of the population every year.

The exact causes of anxiety disorders are debatable. However, a family history of anxiety recent or prolonged exposure to stress, excessive consumption of stimulants such as caffeine or tobacco is associated with the onset of the disorders.

The symptoms of anxiety disorders can be psychological or physical, including difficulty concentrating and sleeping, irritability, persistent stomachaches or diarrhea, sweaty palms, shaking and rapid heartbeat.

People experience anxiety differently. Some people feel a sudden moment of anxiety just a bad feeling, it comes and goes, only lasting a short time. Depending on how people cope with the moments of anxiety, the events can be brief or last a few days.

However, in some persons, if anxiety does not go away, they may require treatment from the related field specialists.

If you are frequently experience symptoms of nervousness, restlessness, or being tense feelings of danger, panic, or dread rapid heart rate rapid breathing, or hyperventilation,..... you may have developed an anxiety disorder.

Echinacea also is known as purple coneflowers, is a flowering plant of the genus Echinacea, belongings to the family Asteraceae, native to eastern and central North America. The herb has been used in traditional and herbal medicine to treat or prevent colds, flu, infections by stimulating the immune function, etc.

On finding a potential phytochemical for the treatment of psychological diseases, researchers examined the anxiolytic effects of a standardized Echinacea extract.

According to the results of a double-blind, placebo-controlled trial with a standardized Echinacea Angustifolia root extract included volunteers who scores above 45 points on the state or on the trait subscale of the State-Trait Anxiety Inventory (STAI) treated with 40 mg Echinacea or with placebo tablets twice daily for 7 days followed by a 3 week-long washout period, 
* State anxiety scores were decreased by approximately 11 points by the end of the treatment period in the Echinacea group, compared to the decrease of around 3-points in the placebo group (p< 0.01).

* The effect maintained over the washout period and the difference from placebo was significant from the 7th day of treatment throughout.

* Furthermore, the changes were less robust with trait anxiety scores, but the preparation performed better than placebo in patients with high baseline anxiety.

* More importantly, neither BDI nor PSS scores were affected by the treatments. Adverse effects were rare and mild, and all were observed in the placebo group.

After talking about other factors into account, researchers said, "These findings suggest that particular Echinacea preparations have significant beneficial effects on anxiety in humans".

Taken altogether, Herbal Enchinanea may be considered adjunct therapies in the treatment of anxiety disorder, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Double-blind placebo controlled trial of the anxiolytic effects of a standardized Echinacea extract by Haller J1,2, Krecsak L3, Zámbori J. (PubMed)

Pinto Beans (Phaseolus) in the Promotion of Gut Microbiota Functioning

By Kyle J. Norton

Gut microbiota or gastrointestinal microbiota, the complex community of microorganisms in our digestive tracts plays a critical role in a variety of metabolic functions, including produced vitamins, synthesized all essential and nonessential amino acids, and carried out biotransformation of bile.

Gut microbiota protects the intestinal structures and functions by attaching to the gut wall against the entry of pathogenic, enteroinvasive bacteria into the epithelial cells.

The gut microbiota plays a vital role in human health, including the key processes of nutrition-enhancing the digestive functioning, lipid, and energy metabolism by inducing the production of short-chain fatty acids (SCFAs), phenolics, and other molecules, and pathogen resistance by promoting the immune function.

In a healthy individual, the levels of gut microbiota are balanced that allow the body to function in an optimal way.

Furthermore, gut microbiota also is found to stimulate the production of some vitamins (B and K), digest certain foods that the stomach and small intestine have not been able to digest, particularly in the combat against the aggression of other bad microorganisms.

In the immune perspective, gut microbiota protects the intestines by alerting the immune response against foreign invasion through specific receptors, induced immune system in the production of the proinflammatory cytokines.

However, the imbalance of digestive gut microbiota has been found to induce a number of diseases, syndromes, and functional aberrations, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and wider systemic manifestations of disease such as obesity, and type 2 diabetes.

Imbalanced gut microbiota is found in obese patients, compared to healthy weight individuals.

On finding a natural ingredient for the prevention and treatment of digestive diseases, scientists examined how legume type and processing method affected digestibility, and subsequent gut microbiota and short-chain fatty acid (SCFA) formation from the pinto bean in vitro digestion.

Pinto bean is also known as common bean, genus Phaseolus and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish beige background, thus appearing painted or spotted.

According to the tested analysis of the digestion residues that were fractionated into the soluble and insoluble fiber, and fermented by microbiota from pig feces,
* In vitro, the digestibility was affected significantly by processing method and legume type.

* Autoclaving resulted in higher digestibility.

* The in-vitro digested bean residues caused a rapid pH decrease in the first 12 h during the fermentation with pig feces, and a significant increase in the formation of SCFAs.

More precisely, there is a positive modulation of the gut microbiota by the in-vitro digested bean residues.

Pinto bean exhibited the highest relative abundance in the treatments with germinated bean's soluble residues related to the gut microbiota.

Taken altogether, Pinto beans may improve the balance of the gut microbiota, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Gut microbiota and short chain fatty acid composition as affected by legume type and processing methods as assessed by simulated in vitro digestion assays by Chen Y1, Chang SKC2, Zhang Y3, Hsu CY4, Nannapaneni R. (PubMed)

Wednesday 29 April 2020

Tocopherols Inhibits the Onset of Age-Related Macular Degeneration in Elderly

By Kyle J. Norton

Age-related diseases are medical conditions associated with the increase of age.

Most recently age-related diseases in the elderly are cardiovascular diseases and macular degeneration.

Cardiovascular diseases are a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.

Age-related macular degeneration is a medical condition that causes irreversible blurring of the central vision in people over age 60.

In other words, AMD may cause significant visual disability.

Most cases of the early stage of AMD were diagnosed during routine eye health examinations.

The elderly at the early stage of age-related macular degeneration is asymptomatic. However, some patients may experience symptoms of slightly blurred central vision. Most cases of the early stage of AMD were diagnosed during routine eye health examinations.

Over time, age-related macular degeneration may affect the vision including the reading as the blurred area increased in size.

The advanced age-related macular degeneration has been found to induce irreversible blindness and visual impairment, according to the epidemiological studies.

According to statistics, approximately 11 million people in the US have some form of age-related macular degeneration. The risk of getting advanced age-related macular degeneration increases from 2% for those ages 50-59 to nearly 30% for those over the age of 75.

Besides aging, some researchers suggest that other factors such as smoking, family history, gender, race, sun exposure, diet, and obesity also increase the risk of AMD developing.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of degenerative diseases, researchers examined the effect of β-, γ-, and δ-tocopherols scavenging free radical and cation radicals of another form of vitamin A-retinal against the onset of age-related macular degeneration.


According to the analysis, β-, γ-, and δ-tocopherols showed a significant in scavenging of cation radicals of retinal, followed by retinoic acid, (0.03 to 5.6) × 109 M-1·s-1, and retinol, (0.08 to 1.6) × 108 M-1·s-1.

Trolox is substantially less efficient at scavenging retinoid cation radicals than α-tocopherol and urate, but it is more efficient at scavenging the cation radicals of retinoic acid and retinol than δ-tocopherol.

These scavenging activities suggest that tocopherols can effectively compete with amino acids and proteins for retinoid cation radicals, thereby protecting these important biomolecules from oxidation.

Based on the results, researchers said, "tocopherols can diminish the oxidative damage to the skin and retina and thereby protect from skin photosensitivity and the development and/or progression of changes in blinding retinal diseases such as Stargardt's disease and age-related macular degeneration (AMD)".

Taken altogether, tocopherols may be considered a supplement for reducing the risk of age-related macular degeneration, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Scavenging of Retinoid Cation Radicals by Urate, Trolox, and α-, β-, γ-, and δ-Tocopherols by Rozanowska M1,2, Edge R3, Land EJ4, Navaratnam S5, Sarna T6, Truscott TG. (PubMed)

Omega -3 Fatty Acids Inhibits the Risk of Breast Density induced Breast Cancer in Obese

By Kyle J. Norton


The women's breasts are made up of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a women's breast is totally determined by the amount of fat.

Breast density is a term that refers to relatively high amounts of glandular tissue and fibrous connective tissue and relatively low amounts of fatty tissue in the breast seen by a mammogram.

Besides genetic preposition, younger age women, women with a lower-body max index and taking hormone therapy in menopausal women have been found to have higher breast density.

Epidemiologically, women who have a high breast density are at an increased risk of breast cancer. Therefore, this group of women is recommended to have a regular mammogram testing beginning at age 40 and consider repeating the screening annually.


Breast cancer is a medical condition associated with abnormal cell growth in the breast tissue due to the alternation of cell DNA.

Most cases of breast cancer (malignant breast neoplasm) start in the cells on the surface of the inner lining of the tissues of the breast either from the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the early stage of breast cancer, most patients experience the forming of lumps or modules on the breast or nearby breast tissue.

However, at the later stage, patients may experience symptoms of swelling of all or part of a breast, breast or nipple pain, nipple retraction and large lumps on the breast.

Some invasive breast cancer in this stage can also induce secondary metastasis through the blood and fluids circulation.

According to the statistic, women diagnosed with breast cancer at stage 0 and 1 have the 5 years of the survival rate of 100%. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of breast cancer, researchers compared the effects of Lovaza (n-3FA) on breast density in obese and nonobese women.

According to the Isobaric tag for relative and absolute quantitation (iTRAQ) method used to analyze plasma from obese and lean women at each time point (baseline, 12 and 24-months, n = 10 per group), several differentially expressed proteins (hemopexin precursor, vitamin D binding protein isoform 1 precursor [VDBP], fibronectin isoform 10 precursor [FN], and α-2 macroglobulin precursor [A2M]) associated with inflammatory expression and breast cancer risk.

More precisely, according to the Western blot analysis, n-3FA administration alters the expression of parameters associated with inflammation and exerted a tumor protective activity in obese, including the aforementioned proteins.

Moreover, the posthoc analysis also revealed that n-3FA administration reduced BD selectively in obese postmenopausal women.

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of breast cancer by reducing the breast density, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 Fatty Acids Responsive Proteins and Reduction in Breast Density in Obese Postmenopausal Women by Sun YW, Xu H, Benitez G, Chen KM, Stanley A, Stanley B, Zhu J, Thompson H, Manni A1, El-Bayoumy K. (PubMed)
(2) Influence of Obesity on Breast Density Reduction by Omega-3 Fatty Acids: Evidence from a Randomized Clinical Trial by Sandhu N1, Schetter SE2, Liao J3, Hartman TJ4, Richie JP5, McGinley J6, Thompson HJ6, Prokopczyk B5, DuBrock C7, Signori C1, Hamilton C8, Calcagnotto A3, Trushin N5, Aliaga C9, Demers LM8, El-Bayoumy K9, Manni A. (PubMed)

Tuesday 28 April 2020

Ashwagandha Protects the Liver Against Injury

By Kyle J. Norton

The liver is the largest internal organ in the human body, played an essential role in filtering blood from the intestine before passing them to other parts of the body.

The organ also produced cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones and vitamins.

Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.

Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases, surgery to stop the bleeding and remove the part of injury may be necessary.

Most cases of liver injury can lead to abdominal pain and tenderness caused by bleeding blood in the abdomen that irritates the abdominal tissue.

The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.

According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.

The most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale or bluish skin.

In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain and swollen and tenderness.

Depending on the degree of injury, patients are either treated with nonoperative management and observation for a full self-recovery or surgery.


Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In the urgency to discover a natural ingredient for the prevention and treatment of liver diseases, researchers examined the effects of withanolides (WA) from Withania somnifera root extract on hepatic toxicity in an animal model

According to the tested analysis, the application of WA profoundly protects wild-type mice but not Nrf2-disrupted mice against APAP hepatotoxicity.

Where Nrf2 is a protein that regulates the expression of antioxidant proteins against oxidative damage.

In vivo and in vitro, WA is a potent inducer of Nrf2-dependent cytoprotective enzyme expression.

In other words, WA  protects the liver damage against oxidative stress by enhancing the function by the activation of antioxidant enzyme protein independently to a redox-regulated substrate adaptor protein Keap1 and dependently on pathway associated with limit proliferation in cells. 

Taken altogether, Ashwagandha processed a high amount of bioactive compound WA may be considered supplements for the prevention of liver toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms by Palliyaguru DL1, Chartoumpekis DV2, Wakabayashi N2, Skoko JJ2, Yagishita Y2, Singh SV2, Kensler TW. (PubMed)

Cabbage Kills fibrosarcoma Cells in Vitro

By Kyle J. Norton

Cancers are a class of chronic diseases caused by the alternation of DNA of healthy cells.

In other words, healthy cells become cancerous if they grow uncontrollably and disorderly out of range of a normal healthy cell population which can only divide between 40 and 60 times.

Fibrosarcoma is a medical condition characterized by irregular cell growth in the fibrous connective tissue. The tumor can be classified into low grade, intermediate malignancy, and high malignancy, depending on different degrees of differentiation:

Fibrosarcomas occur as a soft-tissue mass or as a primary or secondary bone tumor. The 2 main types of fibrosarcoma of bone are
*Primary fibrosarcoma is a fibroblastic malignancy that produces variable amounts of collagen.

* Secondary fibrosarcoma of bone arises from a preexisting lesion or after radiotherapy to an area of bone or soft tissue.


The most common symptoms of fibrosarcoma are painless or tender mass in an extremity or trunk, pain or soreness caused by suppressed nerves and muscles and limping or other difficulty using legs, feet, arms hands.

The most common prevalent factors associated with the risk of fibrosarcoma are radiation exposure. damaged lymph system or lymphedema, exposure to chemicals. and family history. 

According to the statistics provided by the Canadian Cancer Society, in 2016, approximately 1,025 Canadians were diagnosed with soft tissue sarcoma, 575 men were diagnosed with soft tissue sarcoma, causing 306 death. 445 women were diagnosed with soft tissue sarcoma, causing 349 death.


Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast.

The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find a natural food for the prevention of oxidative stress-induced cancers researchers examined the cytotoxic effects and the mode of interaction of biologically synthesized Ag and Au nanoparticles (NPs) using Brassica oleracea L. var. capitata f. rubra (BOL) on HT-1080 cancer cells, a fibrosarcoma cell line.

According to the tested differentiation, the Ag and Au NPs have easily entered and accumulated into the cytosol and nucleus to exert

* The free radical scavenging activity under in vitro conditions is found to be higher for the Ag NPs when compared to the Au NP.

*  A strong cytotoxic effect (both nanoparticles (NPs)) exerted )mediated through nuclear morphological changes and DNA damage.

* The activation (both nanoparticles (NPs)) of inflammatory and apoptosis pathways. More precisely, both nanoparticles (NPs) regulated the mRNA and protein expression of caspase-3 and caspase-7, TNF-α, and NF-κB for the induction of intrinsic and extrinsic apoptosis and inflammatory pathways in Ag NP- and Au NP-treated cells.

* The activity of speeding up would healing.

Based on the results, researchers wrote, "Nonetheless, both Ag NPs and Au NPs show potential ... biological synthesis... on cancer and wound healing".
Taken altogether, cabbage may be considered a remedy for the prevention and treatment of fibrosarcoma, pending to the confirmation of the larger sample size and multicenter human study.



Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Interaction of silver and gold nanoparticles in mammalian cancer: as real topical bullet for wound healing- A comparative study by Sivakumar AS1, Krishnaraj C2, Sheet S3, Rampa DR4, Kang DR1, Belal SA1, Kumar A5, Hwang IH6, Yun SI2, Lee YS3, Shim KS. (PubMed)

Monday 27 April 2020

Omega -3 Fatty Acids Inhibits the Prevalent Factors Involved in the Onset of colorectal cancer

By Kyle J. Norton


Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.

The colon-rectum formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA, including
*Rectal cancer is the slowest growing cancer. Therefore, most cases of rectal cancer are diagnosed at the advanced stage in the older population.

* Colon cancer is relatively very common and slowly growing and progressing in a predictable way.

Most cases of primary colon cancer start in the cell on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.

The common type of colorectal cancer are adenocarcinomas, originated in epithelium tissues and squamous cells that make up the bowel lining together with the gland cells, 

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Colorectal cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increased in age, family and personal history, genetic preposition are some of the prevalent risks of the disease.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of clonic diseases, researchers examined omega-3 PUFAs influences on DNA methylation level in colorectal cancer (CRC) rat model.

According to the tested analysis of N-methyl phosphite nitrourea and omega-3, PUFAs fed to the rats during tumor induction, tumor incidence in omega-3 treated rats was much lower than in CRC model rats.
In other words, omega-3 PUFAs process anti colorectal cancer property.

More precisely, 6 PUFA members categorized to omega-3 and omega-6 families showed similar activity in lowering the ratio of omega-6/omega-3 PUFAs in the omega-3 PUFAs treatment group than in the CRC model group.

Interestingly, the normal cytosine nucleotide DNA (5 mC) content, in omega-3 PUFAs treated rats was higher than in CRC model rats. These results suggested that omega-3 PUFAs promoted 5 mC synthesis.

Where 5mC oxidation reaction is mutated in human tumors.

Based on the findings, researchers said, "omega-3 PUFAs probably inhibited tumor growth via regulating DNA methylation process, which provided a novel anticancer mechanism of omega-3 PUFAs from epigenetic view".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 Polyunsaturated Fatty Acids Inhibited Tumor Growth via Preventing the Decrease of Genomic DNA Methylation in Colorectal Cancer Rats by Huang Q1, Wen J1, Chen G1, Ge M1, Gao Y1, Ye X1, Liu C1, Cai C. (PubMed)
(2) Effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in patients with colorectal cancer: a study protocol for a double blind randomized controlled trial by Haidari F1, Abiri B2, Iravani M3, Razavi SM4, Sarbakhsh P5, Ahmadi-Angali K6, Vafa M. (PubMed)

Herbal Angelica Sinensis Promotes the KidneyFunction Against Diabetic Renal Damage

By Kyle J. Norton

Diabetes is a condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.

The actual causes of diabetes are debatable. As researchers do not know why some people without genetic mutations are susceptible to disease development, while others do not.
Diabetic nephropathy (Dn) is a chronic kidney disease in diabetics, a leading cause of end-stage renal failure.

Epidemiologically, diabetic nephropathy is also associated with cardiovascular disease and increases the mortality of diabetic patients.

Metabolic and hemodynamic alterations, oxidative stress, and activation of the renin-angiotensin system are some of the risk factors that have been found in patients with Dn.

The most common causes of diabetic renal damage are associated with hyperglycemia, abnormally uncontrolled or fail to manage high blood sugar in the blood.

Long-term unmanaged hyperglycemia can damage the part of the kidneys thus reducing the kidney function in filter waste from the blood filters, leading to 'leaky' syndrome that allows protein into your urine.

Diabetic renal inflammation is a condition associated with inflammation in the development of diabetic nephropathy.

Inflammation is a natural defense of the immune system that protects the body against the insult from the foreign invasion.

Acute inflammation occurs quickly or within the hours and lasts a few days or weeks and the damaged tissues are healed itself after all pathogens are killed off.

However, if the immune system can not completely destroy all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.

On finding a natural ingredient for the prevention and treatment of renal diseases, scientists examined the effects and mechanisms of an arabinoglucan (AG) isolated from Angelica sinensis on DN, which was induced in rats by streptozotocin.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the results of intraperitoneally AG for 8 weeks in tested rats,* Diabetic rats exhibited renal dysfunction evidenced by reduced creatinine clearance, increased blood urea nitrogen and proteinuria, along with marked enhanced mesangial expansion. All of these abnormalities were reversed by the AG.

* Furthermore, overproliferation of glomerular mesangial cells (GMCs) was halted by AG treatment, and inflammation mediators were attenuated.

* the AG significantly inhibited the expression of nuclear factor-κB (NF-κB) and receptor for advanced glycation end products (RAGE) associated with oxidative stress, both in diabetic kidneys and in high glucose-induced GMCs.

* Moreover, AG can also directly interact with RAGE and disrupt RAGE binding to advanced glycation end products using microscale thermophoresis.

Based on the results, researchers suggest, "AG, acting as a RAGE antagonist, is a promising agent for the prevention and treatment of DN".


Taken altogether, Angelica sinensis may be considered a remedy for the protection of diabetic renal damage, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A branched arabinoglucan from Angelica sinensis ameliorates diabetic renal damage in rats by Sui Y1, Liu W1,2, Tian W3, Li XQ3,4, Cao W. (PubMed)

Sunday 26 April 2020

Herbal Ashwagandha Inhibits the Onset of Progression of HIV Infection

By Kyle J. Norton


Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated of acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...

Human immunodeficiency virus HIV-1 is the most widespread type worldwide that can lead to acquired immunodeficiency syndrome (AIDS).

Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).

According to the statistic, AIDS is the fifth leading cause of death in the US.

People between ages 25 and 44 in the United States are at substantially higher risk compared to other age groups.

Approximately 36.7 million people worldwide living with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.

According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.

However, the virus can also transmit through infected blood transfusion, infected mother to children.

Most people infected by the HIV virus may experience symptoms of fever, muscle aches and joint pain similar to those of influenza in the early stage of the viral attacks.

According to epidemiological studies, people who have serval sexual partners are the most at risk of HIV infection.

However, the virus can also transmit through infected blood transfusion, infected mother to children.

If untreated, the virus will slowly multiply and destroy the cells of the immune system, leading to chronic signs and symptoms of fever, fatigue, swollen lymph nodes,...

If an infected individual has the numbers of T-cell count below 200, the person is considered to have AIDs.


Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and he Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In the urgency to discover a natural ingredient for the prevention of infectious diseases, researchers examined the clinical efficacy and safety of a new polyherbal preparation, Immu-25, in HIV-infected patients.

The open-label pilot study. included 36 patients (10 female, 26 male) with a mean age of 35 +/-10 years, with confirmed HIV infection with a CD4 count <500 cells/microL, received two capsules of the test drug twice daily for 18 months.

According to the results of the study, the polyherbal preparation produced good symptomatic improvement within 6 months with an increase in mean (95% CI) weight from 58 (53-64)kg to 63 (56-69)kg, 64 (58-72)kg and 68 (62-74)kg after 6, 12 and 18 months of treatment, respectively.

The application decreased the incidence and severity of symptoms such as diarrhea, fatigue, anorexia, cough, and fever in the participants.

Furthermore, there was a decrease in the mean (95% CI) viral load from 326 438 (428 600-186 420) copies/mL to 180 495 (258 300-124 000) copies/mL and 22 069 (42 100-16 000) copies/mL after 6 and 12 months of treatment, respectively.

Most importantly, the decrease in viral load was associated with an increase in mean (95% CI) CD4 count from a baseline of 243 (203-388) cells/microL to 336 (263-486) cells/microL after 6 months of therapy, and this continued to rise to 527 (285-767) cells/microL (p < 0.001) and 618 (362-1012) cells/microL (p < 0.001) after 12 and 18 months of treatment, respectively.

However, mild gastrointestinal adverse effects had been reported by some of the participants.

Based on the evidence, researchers said, "herbal drug may have a good immunomodulatory effect and has potential as a co-therapeutic agent in the management of HIV infection. Further studies are warranted to confirm its therapeutic potential".

Taken altogether, Ashwagandha may be considered supplements for the prevention and treatment of HIV infection, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of the antiretroviral activity of a new polyherbal drug (Immu-25) in patients with HIV infection by Usha PR1, Naidu MU, Raju YS. (PubMed)

Herbal Dandelion(Taraxacum officinale) Prevents the Risk of Impaired Immune Function, According to Study

By Kyle J. Norton

An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens, including bacteria, viruses, parasites, etc. and tumor cells, including irregular cells growth, cancer cells to keep us healthy.

In most cases, the immune system does a great job of keeping people healthy and preventing infections. But sometimes problems with the immune system can lead to illness and infection.

It is one of the body's defense system against diseases.

Although the immune system has done a great job in protecting us against foreign invasion, unfortunately, during the process of their functions, they may induce the production of free radicals and chain of free radicals that can be harmful to our body.

Immune dysfunction is a chronic condition, depending on the parts of the immune system affected.

There are 2 types of immune dysfunction
* The underactive immune system is also known as the weakened immune system. People with the underactive immune system are susceptible to infection, recurrent infections.

The most common symptoms of the underactive immune system are infection including frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections and Inflammation and infection of internal organs.

However, blood disorders, such as low platelet counts or anemia and digestive dysfunction are also some of the common symptoms found in patients with the underactive immune system.

* The overactive immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system that attacks the body tissues.

An impaired immune system is a condition in which the immune system does not work properly and can't effectively protect a person against infection. 

Medical conditions with the use of immune suppression can weaken or impair the immune system.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the improvement of the immune system, scientists examined the 6 kinds of Chinese traditional herbs on the restoration of the suppressed immune functions in scald mice.

Polygonum cuspidatum, Taraxacum officinale, and Oidenlandia diffusa (wild) roxb showed immunomodulating effects as measured with 3 immunological parameters.

Furthermore, all tested herbal medicine demonstrated a strong effect on cell-mediated, humoral and non-specific immunity, compared to the depressed immune system in the control non-treated scald mice in various degrees.

More importantly, the immunomodulatory effects are varied according to the dosage of drugs.

Taken altogether, Dandelion may be considered an antioxidant remedy for the improvement of the immune functioning, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [The use of Chinese traditional medicines to improve impaired immune functions in scald mice].[Article in Chinese] by Luo ZH. (PubMed)

Saturday 25 April 2020

Cranberry, the Prebiotic and Anti-Bacterial Functional Food

By Kyle J. Norton

Compared to probiotics, prebiotics are compound in food that induces the growth or activity of beneficial microorganisms in the gut.

In other definition, they are special forms of dietary fiber that act as fertilizers to promote the growth of good bacteria in your gut.

In the gastrointestinal tract, prebiotics can alter the composition of organisms in the gut microbiome.

In other words, prebiotics raises the levels of healthy bacteria against bad bacteria.

Gut microbiota is a complex community with over trillion microorganisms that live in our digestive tracts.

In healthy individuals, the ratio of good and bad microorganisms is balanced. In other words, healthy gut microbiota levels maintain the structure and function of the gastrointestinal tract.

In fact, a balanced ratio of gut microbiota plays a critical role in the digestion of certain foods that the stomach and small intestine have not been able to digest, in the production vitamins, improvement of digestive functioning and modulation of the immune function.

The use of antibiotics has been found to damage the gut ecosystem, leading to certain chronic illnesses such as inflammatory bowel disease, obesity, cancer, and autism.

Further, the unbalanced ratio of gut microbiota functions also alters immune homeostasis, leading to the onset of autoimmune disorders which in turn can induce intestinal and systemic autoimmune diseases.

On finding a potential compound for the treatment of digestive diseases researchers investigated the cranberry prebiotic or antimicrobial effect on gut microbiota.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

According to the results of the analysis, cranberry extracts and whole cranberry powder showed a strong activity that broadly modulates the gut microbiota by reducing the abundance of Enterobacteriaceae and increasing the abundance of Bacteroidaceae.

In other words, cranberry extracts and whole cranberry powder improved the ratio of gut microbiota by increasing the population of good bacteria and reducing the numbers of bad bacteria.

In a gut simulator, more precisely, salicylate found in cranberry showed a major contribution to reduce levels of Enterobacteriaceae and elevated Bacteroidaceae in a dose-dependent manner.

Taken altogether, cranberry combined with other herbal medicine may be considered a prebiotic and antimicrobial remedy for the treatment of digestive diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model by O'Connor K1, Morrissette M1, Strandwitz P1, Ghiglieri M1, Caboni M1, Liu H2, Khoo C2, D'Onofrio A1, Lewis K. (PubMed)

Green Peas (Pisum Sativum) Improves Insulin Sensitivity in Vivo

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.


Insulin sensitivity is a term to measure how sensitive the body's cells are in response to insulin. 

In other words, in insulin resistance subject, signals sent out by the hormone insulin was ignored by the cell of the muscles, body fat, and liver that process the function to convert glucose into energy.

Epidemiologically, people with insulin resistance are associated with an increased risk of prediabetes, type 2 diabetes and chronic conditions such as heart attacks, strokes, and cancer.


Insulin resistance is considered a hallmark of type II diabetes and a condition in the cluster of metabolic syndrome.

There is no single cause of insulin resistance. Medical conditions, being extreme overweight, ethnicity, genetic proposition, and physical inactivity are some of the prevalent risks of insulin resistance.

Most cases of insulin resistance in the Western world are involved in the clogged up insulin receptors.
As the signals of hormone insulin are blocked, insulin resistance develops, leading to more production of insulin by the pancreas.

Over time insulin resistance that leads to damage to the beta cell in the pancreas, an early condition of prediabetes and types 2 diabetes.

According to the US statistics, approximately, 60 to 70 million individuals are affected by insulin resistance with 40% of individuals older than 50 years may be at risk for insulin resistance.

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the treatment of diabetes, researchers investigated the total RNA extracted from livers of rats fed a high-fat diet (HFD) or HFD + pea hulls (PH) diet.

According to the tested analysis,
* PH group showed a significant increase in the intermediaries of β-oxidation: C16-OH and C16:1 acylcarnitines (>50%, p < 0.05) and 3-hydroxybutyrate (100%, p < 0.05), a catabolic process that fatty acid molecules are broken down, compared with the HFD group.

Where increased 3-hydroxybutyrate levels are associated with insulin sensitivity and reduced demand for insulin.

* mRNA of Hadha, a gene involved in β-oxidation, was significantly reduced by 53% (p < 0.005) in the PH group compared with the HFD group,

* Levels of peroxisome-proliferator-activated receptor alpha (PPAR-α) associated with lipid metabolism in the liver were no different in both groups.

Based on the results, scientists said, " feeding PH alters lipid metabolism in the liver, which may contribute to improved glucose tolerance in insulin-resistant rats".

Taken altogether, green peas may be considered a functional food for the treatment of insulin resistance,  pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Improved glucose tolerance in insulin-resistant rats after pea hull feeding is associated with changes in lipid metabolism-targeted transcriptome by Chan CB1, Gupta J, Kozicky L, Hashemi Z, Yang K. (PubMed)

Friday 24 April 2020

Healthy Food Cabbage Protects the Cells Integrity Against Oxidative Stress

By Kyle J. Norton

Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body.

In other words, oxidative stress is either caused by overexpression of free radical or depletion of antioxidant enzymes in the body.

Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.

Long-term oxidative stress presented in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.

More precisely, exogenous factors, such as cigarette smoke, and endogenous factors, such as the oxidative burst from activated macrophages are some of the factors involved in the risk of oxidative stress.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.

Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.

Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

On findings a natural wholefood for the prevention and treatment of diseases associated with oxidative stress, researchers investigated the effects of red cabbage anthocyanin (RCA)-enriched extract on H₂O₂ expression on HepG2 cells.

According to chemical analysis, all derivatives of cyanidin (268 ± 2 μg/mg) found in RCA, mainly with 19% nonacylated, 51% monoacylated, and 31% diacylated structures with ferulic, sinapic, p-coumaric, and caffeic acids exerted antioxidant activity against the oxidative stress induced by the injection of H₂O₂.

Furthermore, the application of RCA extracts markedly ameliorated cell apoptosis and improved viability.

Moreover, in another study, cabbage extract protected against H2O2-induced cell death and did not elicit any cytotoxic effects by suppressing ROS production and increasing the expression of antioxidant proteins (SOD-1, catalase, and GPx) produced by the host.

In oxidative stress-exposed H9c2 cells, the protective effects of cabbage extract also inhibited apoptotic responses and activation of MAPK proteins (ERK1/2, JNK, and p-38) involved in the resistance of apoptosis by preserving mitochondrial functions.

Based on the results, researchers wrote, "cabbage extract protects against oxidative stress and suggests that it can be used as an alternative therapeutic strategy to prevent the oxidative stress in the heart".

Taken altogether, cabbage may be used as a functional food for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Characterization of Purified Red Cabbage Anthocyanins: Improvement in HPLC Separation and Protective Effect against H₂O₂-Induced Oxidative Stress in HepG2 Cells by Fang S1, Lin F2, Qu D3, Liang X4, Wang L. (PubMed)
(2) Cabbage (Brassica oleracea var. capitata) Protects against H2O2-Induced Oxidative Stress by Preventing Mitochondrial Dysfunction in H9c2 Cardiomyoblasts by Yang DK. (PubMed)

Elecampane (Inula helenium) Destroys Lung Cancer Cells in Vitro

By Kyle J. Norton

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' need and exhaling carbon dioxide from the bloodstream.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. The most common forms of primary lung cancers are derived from epithelial cells.


The most common form of primary lung cancers is derived from epithelial cells.

The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease and excessive drinking are some prevalent factors associated with lung cancer developing.

According to the statistics provided by the American cancer society, Lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 in women in the same year.

Lung cancer can be classified into 2 major types
* Non-small cell lung cancer is the most common type of lung cancer that usually grows and spreads methodically and predictably.

* Small cell lung cancer is a fast-growing type of lung cancer, that can spread to distant parts of the body in a relatively early stage.


On finding a natural ingredient for the prevention and treatment of lung diseases, scientists examined the anti-lung cancer effects of Alantolactone (ALT), a sesquiterpene lactone compound isolated from Inula helenium.

Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia. 

The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

According to tested analysis,
* ALT inhibited cell growth and induced S‑phase arrest and cell apoptosis in A549 and NCI‑H520 cells.

* ALT increased the level of ROS, inhibited the Akt/glycogen synthase kinase (GSK)3β pathway and induced endoplasmic reticulum (ER) stress to prevent proliferation and cause apoptosis of A549 and NCI‑H520 cells.

* Most importantly, ALT treatment sensitized lung cancer cells to Gemcitabine (GEM) by enhancing the chemo drug efficacy.

Based on the results, researchers suggest, "combined treatment with ALT and GEM may have potential as a clinical strategy for lung cancer treatment".

Taken altogether, Dandelion may be considered a remedy for the treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alantolactone enhances gemcitabine sensitivity of lung cancer cells through the reactive oxygen species-mediated endoplasmic reticulum stress and Akt/GSK3β pathway by Wang J1, Zhang Y1, Liu X2, Wang J2, Li B3, Liu Y3, Wang J. (PubMed)

Thursday 23 April 2020

Fermented Soy Improves Brain Blood Flow in Post-Stroke Hyperglycemia in Vivo

By Kyle J. Norton

Stroke is a medical condition in which the brain function is interrupted rapidly due to the loss of blood supply caused by the blockage of blood such as thrombosis and arterial embolism, or leakage of blood that lead to the death of brain cells.

Stroke is a condition associated with the plagues build-up in the arteries and high blood pressure. 

In other words, if plagues building up in the arteries is blocking the circulation of blood in any part of the brain, causing oxygen not to be delivered to the brain, resulting in some cells in the brain to die off and are unable reproduce,

Besides cancer and heart diseases, stroke is the third leading cause of death. Approximately 1/4 of all stroke victims die as a direct result of the stroke or its complications.

According to the statistics of the Heart and Stroke Foundation, strokes kill 45% more women than men in Canada.

There are 2 types of stroke
* Ischemic stroke is the most common type of stroke accounting for almost 80% of all strokes.

* Hemorrhagic stroke occurs when a blood vessel bursts inside the brain, causing an increase of the fluid pressure on the brain and harms the brain by pressing it against the skull.

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

The post-stroke hyperglycemia management is the interventions associated with the management of physiological variables such as blood glucose, blood pressure, hypoxia, hydration, and temperature


Fermented soy products are diverse varieties of soy food that are made from fermented soybeans, including miso, natto, tempeh, and soy sauce.


On finding a potential plant for the neuroprotection after stroke, researchers examined the effect of chungkookjang made with Sunchang Research Center for Fermentation Microbes 100730 and 100731 strains of Bacillus amyloliquefaciens(SRCM100730; CKJ730) and SRCM100731(CKJ731) on post-stroke hyperglycemia in Mongolian gerbils.

Where the Gerbil which either was fed 4.5% cooked soybeans (CSB), CKJ730, CKJ731, or cellulose (negative-control) in 40 energy% fat diets for 3 weeks, and then had artery occlusion for 8 min and continued taking the assigned diet for 5 weeks.

According to the results of the analysis,
* CKJ730 and CKJ731 had thrombolytic activity and prevented neuronal cell death.

* CKJ730 protected against post-stroke glucose dysregulation by restoring β-cell mass in the gerbils with transient artery occlusion.

* Serum tumor necrosis factor-α and interleukin-1β levels were lower in CKJ730 and CKJ731 than the negative control.

* CSB also improved glucose metabolism and suppressed inflammatory cytokines, but less than CKJ730 and CKJ731.

* Clostridia increased, and Bacteriodia slightly decreased in the negative-control group, compared to the normal control.

Collectively, researchers said, "the daily intake of chungkookjang fermented with B. amyloliquefaciens improved the gut microbiome, increased blood flow to the brain, suppressed systemic inflammation".

Taken altogether, potato may be considered a functional food for the prevention and treatment of post-stroke hyperglycemia-induced complications,, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chungkookjang, a soy food, fermented with Bacillus amyloliquefaciens protects gerbils against ishcmeic stroke injury, and post-stroke hyperglycemia by Jeong DY1, Jeong SY1, Zhang T2, Wu X2, Qiu JY2, Park S. (PubMed)

Omega 3 Fatty Acid Inhibits the Onset of Acute Dyslipidemia

By Kyle J. Norton

Fat including cholesterol and triglycerides consists of hydrocarbon molecules.

Dyslipidemia is a condition of abnormal levels of lipids in their blood.

Hyperlipidemia is a medical condition characterized by abnormally high levels of cholesterol in the bloodstream.

Overexpression of cholesterol levels in the bloodstream has been linked to plaques accumulation on the arterial walls, a major cause of some forms of heart disease and stroke.

Cholesterol is the type of fat produced by the liver or from fat intake playing a critical role in the building of strong cell walls, production of vitamin D and steroid hormones and bile acid to aid digestion in the small intestine.

Cholesterol produced by the liver in a healthy individual is returned to the liver by high-density lipoprotein (HDL).

The healthy ratio of HDL/LDL cholesterol is any numbers that are less than 1/4.

On the other hand, triglyceride is fat in the blood that comes from the outside source used by the body to convert to energy.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

Triglyceride is stored in the fat cells used to produced energy between meals and in the case when food is scarce.

Compared to cholesterol, triglycerides in high levels also associated with the risk of heart disease, particularly in people with high levels of LDL and low levels of HDL.

On finding a potential phytochemical for the treatment of diseases associated with high blood cholesterol, researchers examined the Omega 3 fatty acid activity in the management of hypertriglyceridemia.

According to the results of the study,
* Omega 3 fatty acids lowered LDL cholesterol and reduce CV risk.

* Omega 3 fatty acid also lowered triglyceride (TG) levels and elevated the high-density lipoprotein (HDL) cholesterol levels.

* Omega3 fatty acid inhibited the elevated TG levels that increased risk of CV events and very high TG levels are associated with acute pancreatitis.

Collectively, researchers said, " This review focuses on the clinical practice guidelines for the management of hypertriglyceridemia and the role of prescription omega-3 fatty acids in preventing pancreatitis and CV disease in individuals with high and very high TG levels".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of dyslipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(2) A Review of Clinical Practice Guidelines for the Management of Hypertriglyceridemia: A Focus on High Dose Omega-3 Fatty Acids by Karalis DG. (PubMed)