Thursday, 4 October 2018

#The Cruciferous Vegetables' Phytochemical Indole-3-Carbinol Which Kills Cancer Cells in Vitro, Scientists Suggest

By Kyle J. Norton, Master of Nutrition

Intake of cruciferous vegetables may reduce the onset of cancers, some scientists suggested.

Cancers are a group of chronic and medical diseases characterized by irregular cells growth in the body tissue caused by the change of DNA transcription of healthy cells.

Normal cells have the division of a limited cell cycle compared to a cancerous cell which can grow unlimitedly.

If an invasive tumor is growing too large, it can suppress the nerves and muscles surrounding them, leading persistent pain and other symptoms, depending on the locations.

The exact causes of cancer are unknown. Researchers do not know why people with the same health condition, some are susceptible to the onset of the diseases, while others do not.

However, an unhealthy diet, such as eating processed foods and fast foods that are high in fat and sugar and lifestyles such as smoking, overweight, physical inactivity, and excessive alcohol drinking are some of the major causes of cancer.

Truly, according to the article written by the Telegraph, an unhealthy lifestyle is responsible for half of the onset of the cancers. And being overweight or obese is a cause of 12 types of cancer.

Other prevalent risk factors of cancer development are genetic mutation inherited from the parents, environment toxic chemicals, radiation, virus, hormone imbalance,... and chronic inflammatory diseases.

Besides the general symptoms such as lumps, loss of appetite, fatigue, tiredness, unintended weight loss, patients with cancers also experience some symptoms totally depended to the location, types, and grade infected tissues and organs,

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

According to the recent study, indole-3-carbinol (I3C), a substance presented in cruciferous vegetables suppressed the proliferation of different tumor cells, including those isolated from breast, prostate, endometrium, and colon cancers, in vitro.

Dr. Popolo A, the lead author suggested, the effect of the chemical compound in the treatment of various cancers may be attributed to the interference of cancer cell cycle division and expression of a diverse set of genes involved cell differentiation.

Dr. Aggarwal BB and Dr. Ichikawa H. in the additional examination of the function of indole-3-carbinol (I3C) also found that application of the phytochemical also inhibited DNA-carcinogen abducted and new  blood vessels involved cancer cell survival formation, suppressed free-radical production, and stimulated 2-hydroxylation of estradiol in the reduction of cell proliferative and estrogenic activity and

Furthermore, indole-3-carbinol and its derivatives were found not only expressed the anti-cancer effects through restoring original gene formation but also inhibited free radicals production, ... but also interfered with cancer cell cycle division phase to induce apoptosis.

Other chemical compounds found in the cruciferous vegetables, showed to possess potent antitumor and chemopreventive activity including sulforaphane (SFN), an isothiocyanate and Allyl nitrile (3-butenenitrile).

Taking together, there is no doubt, cruciferous vegetables have exhibited anticancer activities, through many aspects.

Intake of cruciferous vegetables regularly is associated with reduced risk and treatment of various types of cancer.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food of cruciferous vegetables during the course of the disease will be necessary to complete the picture of cruciferous vegetables anti-cancer possibilities.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor by Popolo A1, Pinto A1, Daglia M2, Nabavi SF3, Farooqi AA4, Rastrelli L5. (PubMed)
(2) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives by Aggarwal BB1, Ichikawa H.(PubMed)
(3) Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells by Liu KC1, Shih TY1, Kuo CL2, Ma YS3,4, Yang JL2, Wu PP5, Huang YP6, Lai KC7,8, Chung JG9,10. (PubMed)
(4) Allyl nitrile: Toxicity and health effects by Tanii H1.(PubMed)