Monday, 15 October 2018

Asparagus, The Whole Food Which Stops the Spreading of Kidney Cancers Cells in Vitro

By Kyle J. Norton, Master of Nutrients

"Let foods be your medicine and let medicines be your food", using foods as the medication has been a dream of many scholars and scientists over the past many centuries.

 In order to achieve these, consumption of whole food medicine must accompany with moderate exercise, change of diet and lifestyle.

Asparagus may be a potential product used for the treatment of renal cell carcinoma caused by recurrent abnormal chromosomes in gene and reciprocal gene expression, some scientists suggested.

Kidney cancer is a medical condition characterized by irregular and disorder cell growth arose first at kidney lining tissue before invading to the deep layers of the .kidney.

At the advaced stage of kidney cancer, the malignant cells can travel a distance away from the kidney to infect other healthy tissue and organs, through blood and fluid circulation.

The exact causes of kidney cancer are unknown. Researchers also do not know why, people with the same gene inherited from the same parents, some are susceptible to the onset of the disease, while other off-springs do not.

However, researchers do not that certain risk factors such as smoking obesity, chemical exposure, gender and family history are some the prevalent risk factor that can manifest the onset of kidney cancer.

Long-term intake of certain medicines such as diuretics and analgesic pain pills, such as aspirin, acetaminophen, and ibuprofen and medical conditions such as advanced kidney disease and hypertension are associated with kidney cancer develops.

Furthermore, according to the information provided by the American Cancer Society, people born with the mutation of a gene (FH) linked to hereditary leiomyoma and the SDHB and SDHD genes are also at a higher risk to the cancer onset.

Asparagus is a flowering plant belonging to species of the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia.

The delicious plant has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.

According to the Banaras Hindu University, asparagus racemosus leaf extract inhibits growth UOK 146 renal cell carcinoma through cytotoxic activity and downgraded the process of genes responsible for proliferation of the UOK146 cell line.

Dr. Verma SP, the lead author said, " Evidence of antiproliferative effect, PRCC-TFE3(recurrent abnormal chromosomes in gene and reciprocal gene expression) fusion transcript inhibition and static anti- or pro-apoptotic regulators(BAX0 level clearly indicate that AR extract provides or elicits an apoptosis independent anticancer effect on RCC cells by some specific mechanism of regulation"

Renal cell carcinoma (Kidney cancer/renal cells) is a type of kidney cancer caused by malignant cells of the lining of the tubules in the kidney. It tends first to spread via bloodstream and the second tumor generally found in the lung, but it may also spread to lymph nodes and other organs as well.

Shatavarins (containing shatavarin IV) isolated from the roots of Asparagusracemosus exerted anti-cancer properties, in vivo against numbers of cancer cell lines, including A-498 (human kidney carcinoma) cell lines.

Oral administration of shatavarin to tumor-bearing mice at doses of 250 and 500 mg/kg body weight for 10 days,, inhibited tumor cell volume and increased non-cancer cell count, through its potent cytotoxicity, compared to the untreated mice of the EAC control group.

The herbal decode also restored the normal expression of red (RBC) and white blood cell (WBC) counts and hemoglobin (Hb) concentration which are altered in patients with renal cell cancer.

There is no doubt that Asparagus has exhibited significant anticancer activity in both in vitro and in vivo experimental models but further multi and large size studies are necessary to confirm this potency.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti-kidney cancer possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay by Medendorp K1, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG. (PubMed)
(2) Transformation capacities of the papillary renal cell carcinoma-associated PRCCTFE3 and TFE3PRCC fusion genes by Weterman MA1, van Groningen JJ, den Hartog A, Geurts van Kessel A.(PubMed)
(3) Asparagus racemosus leaf extract inhibits growth of UOK 146 renal cell carcinoma cell line: simultaneous oncogenic PRCCTFE3 fusion transcript inhibition and apoptosis independent cell death by Verma SP1, Tripathi VC, Das P.(PubMed)
(4) Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus by Mitra SK1, Prakash NS, Sundaram R.(PubMed)

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