Saturday, 6 October 2018

Green Tea and Its Bioactive EGCG Which Process Anti Bacterial Activity Against the Onset of Atypical Pneumonia, Scientist Find

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in protecting the lung against bacterias that cause atypical pneumonia, some scientists suggested.

Atypical pneumonia is an infection of the lower respiratory tract. The disease is accounted for 7%‐20% of community‐acquired pneumonia (CAP).

Most cases of atypical pneumonia are caused by the Streptococcus pneumonia. However, Other bacteria such as Mycoplasma pneumonia, Chlamydia pneumonia, Chlamydia psittaci, and Legionella pneumophila are also found in some patients with atypical pneumonia.

Conventional medicine used for the treatment of typical pneumonia, such as  Macrolide antibiotics: Macrolide drugs are the preferred treatment for children and adults. Macrolides include azithromycin(Zithromax®) and clarithromycin may be effective. However, they can induce certain side effects including gastrointestinal discomforts.

The article of Popular Antibiotics May Carry Serious Side Effects BY JANE E. BRODY, in the explanation of a patient who just took on dose of antibiotic, wrote," After just one dose, he developed widespread pain and weakness." and " (He is) unable to walk uphill, climb stairs or see clearly, his symptoms included dry eyes, mouth, and skin; ringing in his ears; delayed urination; uncontrollable shaking; burning pain in his eyes and feet; occasional tingling in his hands and feet; heart palpitations; and muscle spasms in his back and around his eyes".

If you are currently taking antibiotics for the treatment of a disease, please make sure that you discuss the side effects with your doctor.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

With an aim to find the natural solution with antibacterial potential, researchers at the University of Duisburg-Essen conducted a study to examine whether green tea processes antibacterial activity against the onset of infectious diseases.

 at the final report of the experiment researcher wrote, the minimum inhibitory concentrations against bacteria were 10–100-fold higher compared to the antiviral property with the same volume. 

EGCG used alone or in combination with different antibiotics exerts a significant activity against a number of bacteria including multidrug-resistant strains such as methicillin-resistant Staphylococcus aureus Stenotrophomonas maltophilia, the group of bacteria that cause atypical pneumonia.

The additional analysis suggested that  EGCG displays the efficacy in inhibiting bacteria by binding to lipid membranes and affecting the folic acid metabolism of bacteria and fungi by inhibiting the cytoplasmic enzyme dihydrofolate reductase.

Dihydrofolate reductase, or DHFR, an enzyme that reduces hydrofolic acid to tetrahydrofolic acid, plays an essential role in the building of DNA of the cells.

Furthermore, in an aim to find a natural anti antibacterial remedy in replacing the ineffective antibiotics as well as the concerns over the toxicity of the mainstay of treatment against Stenotrophomonas maltophilia, a main cause of atypical pneumonia, researchers at the Barts & The London NHS Trust conducted a study to examine the effect of Epigallocatechin-3-gallate (EGCG), the major catechin found in green tea,against a number of bacteria.

In a total of 40 clinical isolates of S. maltophilia used in the experiment, scientists found that EGCG exerts a promising in vitro antimicrobial activity against S. maltophilia. At the dose of 512 mg/ L., EGCG inhibited bacteria in the range of 50% and 90%.

Moreover, in the examination of tea leaves organic compounds involved in the defense of the plants against invading pathogens including insects, bacteria, fungi, and viruses, researchers showed that tea flavonoids and teas exert great antimicrobial effects against foodborne and other pathogenic bacteria, virulent protein toxins produced by some of the bacteria, virulent bacteriophages, pathogenic viruses, and fungi.

Taken all together, green tea and its bioactive ingredient EGCG may be considered a functional food and supplement respectively in protecting the human body against bacteria, particularly, Streptococcus pneumonia in the initiation of the onset of bacterial infection and infectious diseases, including atypical pneumonia.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299


Sources
(1) Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea by J Steinmann,1 J Buer,1 T Pietschmann,2 and E Steinmann(PMC)
(2) Antimicrobial activity of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) against clinical isolates of Stenotrophomonas maltophilia by Gordon NC1, Wareham DW(PubMed)
(3) Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas Mendel Friedman