Green Tea GTE and EGCG, The Natural Anti Chronic Fatigue Syndrome Supplements

By Kyle J. Norton, Master of  Nutrition

Scientists may have found a beverage's extract and bioactive compound for the treatment of chronic fatigue syndrome (CFS), some studies suggested.

Chronic fatigue syndrome (CFS) is a medical disorder which cannot be explained by an underlying medical condition, characterized by persistently extreme fatigue that never goes away regardless of treatment.for at least 6 months.

The exact causes of chronic fatigue syndrome are unknown. However, some researchers suggested that the conditions are the results of viral infection and chronic stress syndrome.

The University of South Florida (USF Health) in the article "Chronic fatigue syndrome: Inherited virus can cause cognitive dysfunction and fatigue" wrote, "Medveczky's team discovered that untreated CIHHV-6 patients with CFS showed signs that the HHV-6 virus was actively replicating: determined by the presence of HHV-6 messenger RNA (mRNA), a substance produced only when the virus is active".

In the psychological aspects of chronic fatigue syndrome, Dr. Takakazu Oka at the International University of Health and Welfare wrote,  " psychological stress is involved in the CFS onset, exacerbation, and/or relapse, while early life stress acts as a risk factor toward the development of CFS in later life" and "CFS patients may have disrupted stress systems, including HPA axis hypofunction and ANS alterations characterized by sympathetic overactivity and low vagal tone. Individuals with CFS respond to psychological stress". 

Some researchers also found that elimination diets, dietary restriction and the addition of nutritional supplements to habitual diet may have a beneficial effect in reducing fatigue.


The randomized control trials, including pilot studies, compared a form of nutritional supplement with a placebo control suggested, treatment of a combination of nicotinamide adenine dinucleotide hydride (NADH) and coenzyme Q10 (CoQ10) exerts a significant reduction of fatigue after 8 weeks, compared to placebo.

Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.

In the concerns of the oxidative stress in the exhibited CFS, researchers at the Panjab University launched an investigation to examine the protective effect of green tea extract (GTE) and catechin in the mouse model of CFS.

CFS animals used in the study forced swimming test session of 6 minutes every day for 7 days demonstrated a significant increase in immobility time on successive days.

Treatment with GTE (25 or 50 mg/kg, i.p.) and catechin (50 or 100 mg/kg, i.p.) for 7 days reversed the dysfunction of immobility.

Furthermore, the protection of green tea extract was correlated with the lowered levels of lipid peroxidation and restoration of reduced glutathione levels in the brains of fatigued mice.

These results suggested that oxidative stress plays a pivotal role in the pathophysiology of CFS.

Dr. Singal A, the lead scientist said, "GTE and catechin could be used as potential agents in the management of CFS and warrant the inclusion of GTE and catechin in the treatment regimen of CFS patients".

Moreover, in the evaluate pathogenesis of chronic fatigue syndrome involved increased oxido-nitrosative stress along with the generation of pro-inflammatory cytokines such as TNF-α, in chronic fatigue rats induced by a plunge of a load of 10 ± 2% body weight and forced swim inside a rectangular jar daily for 28 days, researchers found that 

* Before application of EGCG, chronic fatigue rats exhibited significant behavioral alterations along with enhanced oxido-nitrosative stress and serum TNF-α level, compared to the naive group.

* Chronic treatment with EGCG restored all the behavioral and biochemical alterations associated with chronic fatigue syndrome.

Additionally, in the study of chronic fatigue induced in mice by subjecting them to forced swim inside a rectangular jar of specific dimensions for 6 min. daily for 15 days, researchers found that Epigallocatechin gallate (EGCG; 25, 50 and 100 mg/kg, p.o.) administered daily 30 min. before forced swim session
* Increased oxidative-nitrosative stress and tumor necrosis factor-alpha levels in the brain of mice before green tea administration compared with the naive group.

* These behavioral and biochemical alterations were restored after chronic treatment with EGCG.

Taken altogether, green tea extract (GTE) and its bioactive chemicals  EGCG may have the therapeutic effect in reducing the risk and treatment of chronic fatigue syndrome

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Green tea extract and catechin ameliorate chronic fatigue-induced oxidative stress in mice by Singal A1, Kaur S, Tirkey N, Chopra K.(PubMed)
(2) Epigallocatechin gallate ameliorates behavioral and biochemical deficits in rat model of load-induced chronic fatigue syndrome by Sachdeva AK1, Kuhad A, Chopra K.(PubMed)
(3) Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome by Sachdeva AK1, Kuhad A, Tiwari V, Arora V, Chopra K.(PubMed)
(4) Chronic fatigue syndrome: Inherited virus can cause cognitive dysfunction and fatigue Date: July 26, 2013 Source: University of South Florida (USF Health)
(5) Influence of Psychological Stress on Chronic Fatigue Syndrome by Takakazu Oka