Wednesday, 10 October 2018

Green Tea and Its Bio-active Flavonoids That Process Anti Inflammatory Bowel Disease (IBD) Potency

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reducing risk and treatment of inflammatory bowel disease, some scientists suggested.

Inflammatory bowel disease (IBD) is a condition characterized by inflammation of the large intestine. The disease affects over 1.6 million American today.

The exact causes of inflammatory bowel disease are unknown. As of today, scientists do not know why, people with the same health conditions, some are susceptible to the onset of the disease, while others do not.

Some researchers suggested that the disease may be caused by the immune response failing to kill off the invasion of infectious micro-organisms in the acute phase of digestive tissue injury and damage or immune dysfunction mistakenly attacking the digestive tract, a case of autoimmune disease.

Furthermore, prolonged periods of imbalance of ratio of good and bad bacteria in the colon, long-term intake of certain medicines, age, family history, ethnicity, parasite, unhealthy diet, and smoking are some prevalent risk factors which can lead to the onset of inflammatory bowel disease.

Moreover, if you are living in the Western world, you are also at a higher risk of the onset of the disease.

For example, people who live in Western countries such as the United States and Europe have a higher IBD risk than those in other parts of the world. 

Genetic mutation inherited from the parents such as NOD2, ATG16L1and IL23R involved in innate immunity, in the autophagy, and in the inflammatory response may elevate the risk of IBD

Most common symptoms of inflammatory bowel disease are severe diarrhea, abdominal pain, fatigue, and weight loss. If you are experiencing the above symptoms, please make sure that you check with your doctor to rule the possibility.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.

According to the evaluation of the effect of tea and other sources of flavonoids in reducing inflammatory process in the development and progression of numerous pathological situations, including inflammatory bowel disease (IBD), application of the chemical compound exerted a significant effect in the decrease of  expression of the reactive oxygen species (ROS) that initiates inflammation and inflammatory process through its antioxidant and free radical scavenging activities. 

Furthermore, oral administration of flavonoid also decreased the inflammatory factors in the production of cytokines by inhibiting the synthesis and activities of different pro-inflammatory mediators.

Some researchers suggested, the result of flavonoid in reducing inflammation in the intestines may be attributed to the antioxidant activity in inhibition of tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, a cytokine or signaling protein with functions involving systemic inflammation in the response to the acute phase of infection.

The benefits of flavonoids in IDB are also found to associate with the preserving of intestinal function and the ability to interfere simultaneously every step in the inflammatory process, including the steps in the production of ROS and pro-inflammatory cytokines.

Additional differentiation of the DNA damage induced in vitro in lymphocytes from IBD patients caused by oxidative stress, plant flavonoids, quercetin and epicatechin found in green tea and other sources such as fruits, tea, and soybeans demonstrated a huge effect in inhibiting oxidative stress caused by the toxic chemical injection.

Compared to the lymphocytes from IBD patients and healthy volunteers, treatment of 50 microg/ml H(2)O(2) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in the presence of quercetin (0-250 microg/ml) or epicatechin (0-100 microg/ml) and flavonoid supplementation (250 microM quercetin or 100 microM epicatechins) displays an impressive inhibition of both oxidative substances in the induction of free radical expression.

Overall, applications of quercetin (0-250 microg/ml) or epicatechin (0-100 microg/ml) demonstrated significant effects in decreasing DNA damage by 48.6%  in the group treated with H(2)O(2) and a 43% in IQ group, compared to healthy group of 35.2 and 57.1%, respectively


However, after taking into account other confounders, researchers indicated that compared to patients from ulcerative colitis (UC) and Crohn's disease (CD), quercetin, IQ and epicatechin reduce DNA damage within lymphocytes from UC patients, compared to CD patients.

Dr. Najafzadeh M, the lead author said, " flavonoids dramatically reduced oxidative stress in vitro in lymphocytes from IBD patients and healthy individuals. Thus, flavonoids could be very effective in the treatment of oxidative stress and encouraged in the diet of IBD patients".

Taken all together, green tea with abundant bioactive flavonoids may be considered a functional food for reducing the prevalence risk factors of IBD and used combined with the standard medicine for the treatment of the disease.

Intake of green supplement should be taken with great care as toxicity was reported in some medical literature.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Flavonoids inhibit the genotoxicity of hydrogen peroxide (H(2)O(2)) and of the food mutagen 2-amino-3-methylimadazo[4,5-f]-quinoline (IQ) in lymphocytes from patients with inflammatory bowel disease (IBD) by Najafzadeh M1, Reynolds PD, Baumgartner A, Anderson D.(PubMed)
(2) Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies by Triantafillidis JK1, Triantafyllidi A1, Vagianos C2, Papalois A3. (PubMed)
(3) Studies in Natural Products Chemistry: Bioactive Natural Products (Part F) by Atta-ur-Rahman