Inflammatory bowel disease (IBD) is a condition characterized by inflammation of the large intestine. The disease affects over 1.6 million American today.
The exact causes of inflammatory bowel disease are unknown. As of today, scientists do not know why, people with the same health conditions, some are susceptible to the onset of the disease, while others do not.
According to the evaluation of the effect of tea and other sources of flavonoids in reducing inflammatory process in the development and progression of numerous pathological situations, including inflammatory bowel disease (IBD), application of the chemical compound exerted a significant effect in the decrease of expression of the reactive oxygen species (ROS) that initiates inflammation and inflammatory process through its antioxidant and free radical scavenging activities.
Some researchers suggested, the result of flavonoid in reducing inflammation in the intestines may be attributed to the antioxidant activity in inhibition of tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, a cytokine or signaling protein with functions involving systemic inflammation in the response to the acute phase infection.
Overall, applications of quercetin (0-250 microg/ml) or epicatechin (0-100 microg/ml) demonstrated significant effects in decreasing DNA damage by 48.6% in the group treated with H(2)O(2) and a 43% in IQ group, compared to healthy group of 35.2 and 57.1%, respectively
However, after taking into account other confounders, researchers indicated that compared to patients from ulcerative colitis (UC) and Crohn's disease (CD), both series of experiments (H(2)O(2) and quercetin, IQ and epicatechin expressed less DNA damage within lymphocytes from UC patients, compared to CD patients.
Intake of green supplement should be taken with great care as toxicity was reported in some medical literature.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Flavonoids inhibit the genotoxicity of hydrogen peroxide (H(2)O(2)) and of the food mutagen 2-amino-3-methylimadazo[4,5-f]-quinoline (IQ) in lymphocytes from patients with inflammatory bowel disease (IBD) by Najafzadeh M1, Reynolds PD, Baumgartner A, Anderson D.(PubMed)
(2) Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies by Triantafillidis JK1, Triantafyllidi A1, Vagianos C2, Papalois A3. (PubMed)
(3) Studies in Natural Products Chemistry: Bioactive Natural Products (Part F) by Atta-ur-Rahman