Thursday, 25 October 2018

Green Tea Polyphenols (GrTPs), the Anti Female Infertility Bioactive Ingredient, Scientists Find

By Kyle J. Norton, Master of Nutrition

Scientists may have found a beverage bioactive compound in improving the chance of fertility in female without inducing any side effects, some studies found,

Infertility is a condition characterized by the inability to get pregnant after 12 months of frequent and unprotected sex of a couple. Women who can carry the term of pregnancy are also considered as infertile.

According to the statistic, approximately 8 to 12 percent of couples worldwide experience fertility problemsBetween 45 and 50 percent of cases of infertility are attributed to male reproductive problems.

Most common causes of infertility in the female in the US. are aging, medical condition of endometriosis and polycystic ovarian syndrome (PCOS) which have a strong interruption of the female menstrual cycle,  sexually transmitted infections (STIs) and obesity.

Other prevalent risk factors including physical and medical condition, such as blocked fallopian tubes due to pelvic inflammatory disease, and physical problems with the uterus and diabetes, long-term intakes of a certain medicine, such as anti-inflammatory drug and hormone imbalance that affect the menstrual cycle

Genetic preposition such as The HOXA13 gene. The only one single gene disorder has been shown to affect uterine development in infertile females.
Age, smoking, use of the illicit drug, excessive alcohol drinking and long-term exposure to chemicals are the common causes of female infertility.

In term of diet, researchers at the Harvard T.H. Chan School of Public Health in the study "Diet and female fertility: doctor, what should I eat?" wrote, "According to existing data, women trying to achieve pregnancy are encouraged to increase consumption of whole grains, omega-3 fatty acids, fish, and soy and to reduce consumption of trans fats and red meat. In addition, a daily multivitamin that contains folic acid before and during pregnancy may not only prevent birth defects but also improve the chance of achieving and maintaining a pregnancy".

These results suggested that women who follow the diet with high in saturated and trans fat, intake of a large amount of red meat and processed food and less in fruits, nuts and vegetables are at the higher risk of infertility or of carrying the pregnancy to full term.

In the concerns of oxygen species (ROS), which are produced during cellular oxidation may reduce the chance of conception, researchers at the joint study led by the Uniwersytet Medyczny w Łodzi. launched an investigation to examine whether increased production of reactive oxygen species is an important factor in the etiopathogenesis of pregnancy and affects female reproduction.

Before application of green tea s (GrTPs) researchers found that oxidative stress caused by overexpression of free radicals may damage the oocytes and may impair their fertilization capacity.

The increased ROS levels probably are the results of antioxidants enzymes produced by the tested subjects being suppressed due to some unknown mechanisms.

Oxidative stress may also lead to embryo fragmentation and formation of numerous developmental abnormalities and is regarded to be one of the important reasons for spontaneous and recurrent miscarriage

Oral administered green tea polyphenols (GrTPs) inhibits the overexpression of ROS showed to restore the embryo fragmentation and formation of numerous developmental abnormalities and increase the quality of female gametes, mostly via the capability of catechins to reduce ROS production.

Further analysis also suggested that GrTPs processed antioxidant properties that only restores the health of oocytes caused by overexpression of ROS but also improves age-related decline in female fertility rate, and gamete quality.

These unique properties of green tea catechins in improving the female reproductive health suggested green tea polyphenols (GrTPs) may be considered a functional food in protecting against the damage of the oocytes and their fertilization capacity and the integrity of embryo.

Dr, Rahman SU, the lead scientist at the final report, said, "the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals".

Additionally, in the concerns of the Reactive oxygen species (ROS) that may increase the risk of female infertility, researchers launched an investigation to examine whether green tea catechins protect the female gametes over the expression of ROS.

After taking into account levels of oxidative stress before and after application of green tea catechin, researchers wrote,
* Epigallocatechin-3-gallate (EGCG), a major bioactive compound in green tea inhibited the expression of ROS in facilitating the damage of female gametes through to its strong antioxidant activity.

* Green tea catechins potentially improves the oocyte maturation and may inhibit in-vitro maturation of the oocyte

Dr. Roychoudhury S, the lead author said, " (These results furtherly confirmed) the potential roles of green tea catechins on oxidative stress in male and female reproduction and fertility".

Taken altogether, Green tea polyphenols (GrTPs) may be considered an adjunct therapy in the protection of the female gametes and oocyte maturation against the onset of infertility.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Diet and female fertility: doctor, what should I eat? by Chiu YH1, Chavarro JE2, Souter I. (PubMed)
(2) Potential role of green tea catechins in the management of oxidative stress-associated infertility by Roychoudhury S1, Agarwal A2, Virk G3, Cho CL. (PubMed)

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