Sunday, 14 October 2018

Green Tea And Its Bioactive Polyphenols Which inhibits Fibromyalgia Caused by Sleep Disturbance

By Kyle J. Norton, Master of Nutrition

Green tea may have a therapeutic and positive effect in reduced onset, progression and treatment of fibromyalgia caused by sleep disturbance, some scientists suggested.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain affecting over 10 million (3.6% of the population) people in the US alone.

Sleep disturbances are the symptoms of physical, mental, and spiritual problems. The major causes of sleeplessness and insomnia.

Insomnia, a  short-term sleep disturbance affects about 30% of adults and chronic insomnia by 10%, according to the statistic provided by the American Sleep Association.

Some researchers suggested that long-term untreated sleep disturbance is a major cause of stroke and heart disease. Dr. Dae Lim Koo, the lead author in the explanation of some risk factor of stroke, wrote, "Any causes of sleep curtailment or fragmentation such as sleep restriction, sleep apnea, insomnia, periodic limb movements during sleep, and shift work, not only impair cardiovascular restoration but also impose a stress on the cardiovascular system" and  "Sleep disturbances have been reported to play a role in the development of stroke and other cardiovascular disorders" 

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.

In the study of sleep disturbance that causes fibromyalgia, Dr. Choy EH suggested that patients with fibromyalgia demonstrated a reduced short-wave sleep and abnormal α-rhythms, suggestive of wakefulness during non-REM (rapid eye movement) sleep compared to the healthy individuals according to the observation of polysomnography.

Furthermore, in healthy participants, the study indicated that sleep deprivation can also cause fibromyalgia-like symptoms such as myalgia, tenderness, and fatigue and suggested that sleep dysfunction might be not only a consequence of pain.

These results showed a strongly correlated condition of sleep disturbance and initiation of chronic fibromyalgia if sleep disorders are left untreated for a prolonged period of time.

Moreover, according to the presentation, long time effect of sleep disturbance may influence alter the pathophysiology of the central nervous system in abnormal pain processing and central sensitization, according to the observation of the neuroimaging of patients with fibromyalgia neural activation compared to a lower pressure-pain threshold in the healthy age-matched and gender-matched individuals.

After taking into account confounders, researchers said, " Improving sleep quality can reduce pain and fatigue, further supporting the hypothesis that sleep dysfunction is a pathogenic stimulus of fibromyalgia".

Moreover, green tea bioactive polyphenols (-)-Epigallocatechin gallate (EGCG) in the evaluation of the chick brain under an acute stressful condition-induced sleep disturbance, researchers found that EGCG attenuates stress behavior with special reference to gamma-aminobutyric acid (GABA), a neurotransmitter with function in sending chemical messages through the brain and the nervous system, and involving in regulating communication between brain cells in stress environment.

Deficiency of is associated with many nervous conditions, including depression, anxiety, and sleep disorders.

Application of EGCG of doses of 50, 100 and 200 microg, intracerebroventricularly exerted a profound effect in suppressing the vocalization which normally occurs during social separation-stress, one of the risk factors of sleep disturbance.

This illustration truly suggested that EGCG reduced the time spent in active wakefulness and induced sleep-like behavior in a dose-dependent manner.

This interaction opinionated that EGCG induced sedation and hypnosis reduced stress hormone production in precipitating sleep distance probably though GABAA receptors in moderation of an acute stress response.

Some researchers suggested that green tea improved symptoms of fibromyalgia by normalizing the levels of GABA (gamma-aminobutyric acid) when came under stress, may have a therapeutic effect in reducing anxiety by relaxing the muscles and the brain. through increasing production of dopamines, serotonin, and alpha waves within the brain in orchestrated the sleep pattern.

These improvements were associated with the interaction of the brain with chemical compounds found in green tea caffeine and L-theanine, suggested by the author.

Taken all together, the findings suggested that green tea and its bioactive polyphenols EGCG and L-theanine may be considered a secondary therapy in reducing risk, progression, and treatment of fibromyalgia caused by a sleep disorder.

However, intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) The role of sleep in pain and fibromyalgia by Choy EH. (PubMed)
(2) (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain by Adachi N1, Tomonaga S, Tachibana T, Denbow DM, Furuse M.(research gate)
(3) Green Tea Health Benefits To Get You Drinking Healthy! by Abby Hannaford
(4) Sleep Disturbances as a Risk Factor for Stroke by Dae Lim Koo, Hyunwoo Nam, Robert J. Thomas, and Chang-Ho Yun(PMC)

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