Fennel may have a therapeutic effect in reducing risk and treatment of anxiety, some scientists suggested.
In conventional medicine, an anxiolytic also known as antianxiety agent including buspirone (BuSpar), trazodone, venlafaxine and several of the benzodiazepines, is a medication used to reduce physical and psychological symptoms of anxiety disorder.
In the investigate the anxiolytic activity of ethanolic extracts of Foeniculum vulgare fruit by elevated plus maze, rotarod, open field test, and hole board models, researchers found that application of fennel extracts in the does of100-200mg/kg exerts a significant anti-anxiolytic activity, similar to those of standard anxiolytic drugs diazepam (1mg/kg) without inducing intolerable adverse effects.
This result was observed by the increased number of entries and time spent in the open arm in the elevated plus maze apparatus.
And, application the same doses also promoted a number of rearings, assisted rearing and number of square crossed viewed by an open field test.
Further analysis also discovered that of fennel extracts also processes a potent skeletal muscle relaxant effect assessed by rotarod.
Additionally, in the experiment of elevated plus maze, rotarod, open field, and hole board used in the evaluation of the psychomotor performance and emotional aspects of rodents removed from their acclimatized cage and placed in environment express anxiety and fear, application of fennel extract, researchers indicated that
* Fennel injection group decreases anxiety-related behavior to an open area.
* Treated rodents exhibit a significant increase in the number of open arm entries and rearings, time spent in the center and line crossing and head dipping.
* Fennel extract treated group also reduces numbers of time of falling through increased muscle relaxant and improved locomotor function.
These results not only are given the supports to the holistic use of fennel in the treatment of anxiety but also reconfirmed the efficacy of fennel extract in reducing levels of anxiety in tested rodents whose were placed in the environment with an expression of anxiety and fear in the first study.
Truly, the viability of above is also reaffirmed by the study conducted by the Geethanjali College of pharmacy in adult Swiss albino male mice randomly divided into six groups (n = 6).
According to the results of analysis of groups I and II received Tween 80 (5%, v/v) and diazepam (0.5 mg/kg, ip), groups III to VI received orally 50, 100, and 200 and 400 mg/kg doses of the essential oil of F. vulgare, mice groups treated with 50, 100, and 200 and 400 mg/kg displayed a significant reduction of anxiety score through expression of all tests, including elevated plus maze (EPM), staircase test (SCT) and open field test (OFT) and other various parameters in doses dependent manner.
Compared to a higher dose of 400 mg/kg and lower dose treatment group, application of 100 and 200 mg/kg dose of fennel essential oil mice demonstrated a strong decrease of anxiety through increased percent number of entries and time spent in open arms.
Compared to other doses of treatment group, administration of 200 mg/kg dose significantly increased the number of squares crossed at the center in the OFT test.
Furthermore, although the injection of 100 and 200 mg/kg doses of the essential oil-treated mice showed a significant reduction of rearing compared to another group, only the 200 mg/kg dose of the oil expressed statistically significant reduction in rearing compared with diazepam, the conventional medicine used for the treatment of anxiety.
The discovery in the study postulated that fennel essential oil may have a potential effect in reducing anxiety nonlinearly and doses dependently.
"Fennel extract may possess anxiolytic activity supporting its traditional claim about anxiolytic activity", reported in the 19th edition of Pharmacology and Pharmacotherapeutics by Sathodkar, Bhandarkar, and Rege.
Taken all together, there is no doubt that fennel extracts and essential oil may be considered a secondary therapeutic treatment compared to standard medicine in the treatment of anxiety.
However, intake of fennel supplement should be taken with extreme care in the prevention of toxicity.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE IN MICE MODEL Research Article R. NAGA KISHORE by Cheeryal (V), Keesara (M), N. ANJANEYULU, M. NAGA GANESH AND N. SRAVYA(International (Journal of Pharmacy and Pharmaceutical Sciences)
(2) Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice by Miraf Mesfin, Kaleab Asres, and Workineh Shibeshi(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)