Friday, 26 October 2018

Green Tea Polyphenols (GrTPs), the Bioactive Ingredient Which Protects Sperm Quality and Integrity Against Infertility, Scientists Find

By Kyle J. Norton, Master of Nutrition

Scientists may have found a beverage bioactive compound that protects the sperm quality and integrity, without inducing any side effects, some studies found,

Infertility is a condition characterized by the inability to get pregnant after 12 months of frequent and unprotected sex of a couple. Women who cannot carry the pregnancy to term are also considered as infertile.

According to the statistic, approximately 10% of women in their reproductive years are having the difficulty of conceiving or carrying the pregnancy to term. 

Most common causes of infertility in men are low sperm count, sperm motility and abnormal sperm.
What causes the abnormal sperm production is unknown. Researchers do not know why people with the same health conditions and family history, some are having abnormal sperm production while others do not.  

However, researchers do not that certain prevalent risk factors including physical and medical condition, such as undescended testicle and diabetes long-term intakes of a certain medicine, such as anti-inflammatory drug and hormone imbalance such as testosterone deficiency are associated with abnormal sperm production.

Genetic preposition such as chromosomal conditions that affect sperm production also plays a major role in elevating the onset of abnormal sperm production.

Age, obesity, use of the illicit drug, excessive alcohol drinking and long-term exposure to chemicals are the common causes of abnormal sperm production.

In term of diet, researchers at the Harvard T.H. Chan School of Public Health in the study "Diet and men's fertility: does diet affect sperm quality?" wrote, "men may be encouraged to use antioxidant supplements and to follow dietary patterns favoring the consumption of seafood, poultry, nuts, whole grains, fruits, and vegetables. Evidence is strongest for recommending the use of antioxidant supplements to men in couples undergoing infertility treatment-although the specific antioxidants and doses remain unclear-and increasing consumption of omega-3 fatty acids from fish and nuts".

These results suggested that men who follow the diet with high in saturated and trans fat, intake of a large amount of red meat and processed food and less in fruits, nuts and vegetables are at the higher risk of sperm abnormality.

In the concerns of highly sensitive of sperm cells to reactive oxygen species (ROS), which are produced during cellular oxidation, researchers at the joint study led by the Anhui Agricultural University launched an investigation to examine the green tea polyphenols (GrTPs) effect in the protection of the integrity of the sperm.

Before application of green tea s (GrTPs) researchers found that oxidative stress has numerous effects, in the increased apoptosis, reduced motion parameters, and sperm integrity in the tested subjects with overexpression of free radicals.

The increased ROS levels probably are the results of antioxidants enzymes produced by the tested subjects being suppressed due to some unknown mechanisms.

Oral administered green tea polyphenols (GrTPs), showed to restore and increase the quality of male gametes, mostly via the capability of catechins in the reduction of ROS production.

Further analysis also suggested that GrTPs processed antioxidant properties that not only restores the abnormal sperm production caused by overexpression of ROS but also improves major semen parameters, such as sperm concentration, motility, morphology, DNA damage, fertility rate, and gamete quality.

These unique properties of green tea catechins in improving the male reproductive health suggested green tea polyphenols (GrTPs) may be considered a functional food in reducing the risk of abnormal sperm quality in many parameters.

Dr, Rahman SU, the lead scientist at the final report, said, "the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals".

Additionally, in the concerns of the reactive oxygen species (ROS) presented in high concentrations in the genital tracts of males that affects compromised vitality, increased morphological defects and decreased sperm motility, researchers launched an investigation to examine whether green tea catechins protect the sperm quality and integrity over the expression of ROS.

After taking into account levels of oxidative stress before and after application of green tea catechin, researchers wrote,
* Epigallocatechin-3-gallate (EGCG), a major bioactive compound in green tea inhibited the expression of ROS through its strong antioxidant activity.

* Green tea catechins potentially improve the sperm quality and integrity.

Dr. Roychoudhury S, the lead author said, " (These results furtherly confirmed) the potential roles of green tea catechins on oxidative stress in male and female reproduction and fertility".

Taken altogether, Green tea polyphenols (GrTPs) may be considered an adjunct therapy in the protection of the male reproductive sperm quality and integrity against the onset of infertility.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Diet and men's fertility: does diet affect sperm quality? by Nassan FL1, Chavarro JE2, Tanrikut C. (PubMed)
(2) Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review by Rahman SU1, Huang Y2, Zhu L3, Feng S4, Khan IM5, Wu J6, Li Y7, Wang X8.(PubMed)
(3) Potential role of green tea catechins in the management of oxidative stress-associated infertility by Roychoudhury S1, Agarwal A2, Virk G3, Cho CL. (PubMed)

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