Thursday, 11 October 2018

@Coffee, the Beverage Is Associated to the Incidence of Laryngeal Cancer, Scientists Suggest


Kyle J. Norton, Master of Nutrients

 Coffee and coffee caffeine may have potential in reducing risk and treatment of laryngeal cancer, some scientists suggested.

Laryngeal cancer is a medical condition characterized by irregular cell growth in the tissues of the larynx. The cancer cells may spread to other tissues and organs in the late stage via lymph and blood circulation.

The exact cause of laryngeal cancer is unknown. Researchers do not why people in the same family with the same health condition and gender, some are susceptible to the onset of the disease while others do not.

However, they do know that certain risk factors such as smoking, excessive alcohol drinking, unhealthy diet, family history, HPV infection and long-term exposure to some chemicals including wood dust, soot coal dust, and paint fumes can increase the risk of cancer.

Genetic mutation inherited from the parents, such as TP53, GSTM3 and NAT2 and long-term use of some medication, such as immune-suppressive drugs to fight off infection such as HIV or AID are considered the prevalent risk factors for the disease development.

According to the statistic provided by the study of  A genetic view of laryngeal cancer heterogeneity
by Dr. María José de Miguel-Luken and colleagues, Out of over 500.000 new cases squamous cell carcinoma of the head and neck (SCCHN) diagnosed in 2008 worldwide,  151.000 cases (130.000 men and 21.000 women) were laryngeal cancer.

Sadly, the world mortality rate is 2.3/100.000 for all people who are diagnosed with the cancer, causing over 82.000 deaths  in 2008.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the concerns of the effect of coffee in the risk of laryngeal cancer, researchers at the Central South University Affiliated The Third Xiangya Hospital conducted a review by searching the medical literature dadabase of Medline and EMBASE for the relevant articles published up to Oct. 2013.

A total of 2,803 cases and 503,234 controls in 10 independent studies satisfied the criteria and  guidelines set were identified.

After taking into account co and confounders the selected studies,  researchers found that incidence of laryngeal cancer was associated with coffee consumption, compared to non drinkers. 

The relative risk of coffee drinkers was 1.47 compared to baseline.

Additionally, according to genetic assay used in the study, researchers also discovered that genetic influence plays an important role in increasing the risk of laryngeal cancer in the coffee consumed population.

Dr. said, "The significant heterogeneity was detected when the association between tea and coffee consumption  and the laryngeal carcinoma".

Moreover, researchers found no statistically significant association of cancer incident difference  in comparison between moderate and low coffee drinking.

 In other word, regardless to volumes, intake of coffee is associated the to risk of the disease. 


These result suggested that there was an evidence of statistically significant association of dose of coffee consumption and risk of laryngeal cancer. 

Additional 1 pack of coffee consumption conferred a RR of 1.22.

Dr. Chen J, the lead researcher said, " A dose-response relationship between coffee intake and laryngeal carcinoma was detected" and "this meta-analysis of observational studies demonstrate that coffee consumption would increase the laryngeal cancer risk".

However,  among the 6 studies that reported the association between coffee consumption and laryngeal carcinoma, only one study was a prospective population based cohort study, while the rest 5 studies were retrospective hospital based case-control studies using observation of returned survey from participants.

The findings firmly suggested that coffee consumption would increase the laryngeal cancer risk, therefore people who are at the higher risk of laryngeal cancer incidence may want to reduce or completely withdraw from coffee consumption.

Taking all together, coffee and coffee caffeine intake may have a negative effect in increasing risk laryngeal cancer but researchers suggested that genetic and environmental factors such as alcohol intake, human papillomaviruses infection, and silica exposurem should be also taken into account. which were excluded in some studies.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tea and coffee consumption and risk of laryngeal cancer: a systematic review meta-analysis by Chen J1, Long S1.(PMC)