Free radicals are the unstable and uncharged molecule which are highly reactive by having an unpaired valence electron.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic,...
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
In the study of the effect of EtOAc soluble extract (PBet) isolated from Anise researchers found that at dose of PBet (0.5-2mg/mL), Anise extract demonstrates a protective effect of Bel-7404 cells from free radical Hydrogen peroxide H(2)O(2) and prevent free radical in inducing cell damage through scavenging of intracellular ROS.
The above illustration was supported by the study in the analysis of the antioxidant and protective effects of Pimpinella anisum (P. anisum) against gentamicin (GM) in the induction of drug
In the total of 40 male Wistar rats divided into four groups: control and sham administrated normal saline orally and intraperitoneally (i.p.), gentamicin (GM) group received 100 mg/kg bw/day i.p., GM and ethanolic extract of P. anisum with oral dose of 300 mg/kg bw/day for 8 days, researchers suggested that application of Anise reduces kidney and liver toxicity and inhibits overexpression of reactive oxygen species in initiating chain reaction in oxidative stress the facilitation, and normalizes the levels of excretion of sodium and potassium induced by free radical expression, caused by injection of gentamicin (GM).
All inhibitions were observed through the expression of levels of creatinine, associate to kidney damage and blood urea nitrogen (BUN), an indication of liver toxicity and Malondialdehyde MDA, an oxidative stress marker and the absolute excretion of sodium and potassium.
Dr. Changizi-Ashtiyani S, the lead author suggested that "potential therapeutic impact of P. anisum to attenuate GM-induced nephrotoxicity. Therefore, the simultaneous use of the ethanolic extract of P. anisum during GM administration is recommended to reduce its nephrotoxicity effects".
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Phytochemical composition and toxicity of an antioxidant extract from Pimpinellabrachycarpa (Kom.) Nakai by Lu J1, Qian W2, Xu L2, Huang G2, Cong W2, Wang Z2, Deng X3, Wang D3, Guan S4.(PubMed)
(2) Evaluation of the Antioxidant Activity of Extracts and Active Principles of Commonly Consumed Indian Spices by Patra K1, Jana S1, Mandal DP1, Bhattacharjee S1.(PubMed)
(3) Pimpinella anisum L. ethanolic extract ameliorates the gentamicin- induced nephrotoxicity in rats by Changizi-Ashtiyani S1, Seddigh A2, Najafi H3, Hossaini N4, Avan A5, Akbary A6, Manian M7, Nedaeinia R8. (PubMed)