Tuesday, 16 October 2018

Strawberries, the Fruits That Kill 100% of Breast Cancer Cells in Vivo and Vitro, Scientists Say

By Kyle J. Norton, Master of Nutrition

Breast cancer (malignant breast neoplasm) is a type of irregular cell growth that starts either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk in the breast.

There are also rare cases, that breast cancer starts in other areas of the breast.

 In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone. The risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

The causes of breast cancer are unknown. Researchers do not know, people with the same health conditions and similar family history, some are more susceptible to the onset of the disease, while others do not.

However, an increase of aging, history with breast conditions, such as previous breast cancer, breast density, use of hormone estrogen therapy, overweight and obese and excessive alcohol consumption are some major risk factors which can elevate the development of breast cancer.

Furthermore, genetic mutation of certain inherited from the parent such as gene BRCA1 and BRCA2 are also the prevalent risk factors of breast cancer. There is an estimation that 33% of women who carry a harmful mutation in PALB2 will develop breast cancer by age 70 years.

According to the article posted by the National Institute of Health, " Several different tests are available. Some tests look for a specific harmful BRCA1 orBRCA2 gene mutation that has already been identified in another family member. Other tests check for all of the known harmful mutations in both genes. Multigene (panel) testing uses next-generation sequencing to look for harmful mutations in many genes that are associated with an increased risk of breast and ovarian cancer, including BRCA1 and BRCA2, at the same time".

If you have a family history of genetic mutation involved breast cancer, please make sure that you have them checked to rule out the possibility.

Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae.

The fruit has been grown all over the world with a suitable climate for commercial profits and for health benefits.

The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

Epidemiological studies strong agree that consumption of berry fruits, including strawberries have beneficial effects on human health and reduce the risk of chronic diseases, including breast cancer.

According to the Indian Institute of Science which conducted the experiment to examine whether a methanolic extract of strawberry (MESB) fruits processes anticancer activity in leukemia (CEM) and breast cancer (T47D) cell lines ex vivo, and its cancer therapeutic and chemopreventive potential in mice models, 
*  Mice bearing breast adenocarcinoma with MESB treated by the extract blocked the proliferation of tumor cells in a time-dependent manner.

* Application of the extract also increases lifespan in the cancer-bearing animal model.

* MESB treatment affected tumor cell proliferation by activating apoptosis and did not result in any side effects

* Finally, MESB treatment also induce intrinsic pathway of apoptosis by activating p73 in breast cancer cells, caused by the mutation of tumor suppressor gene p53.

These results revealed that strawberry fruits possess both cancer preventive and therapeutic values. 

Additionally, in the study to test for anti-breast cancer activity in extracts of six popularly consumed berries--blackberry, black raspberry, blueberry, cranberry, red raspberry and strawberry conducted by the University of California, researchers found that strawberry and other berry extracts exert their ability to inhibit the growth of human breast cancer cell line MCF-7 at concentrations ranging from 25 to 200 micro g/mL.

Moreover, researchers also discovered the apoptosis rate of breast cancer cells killing are increased with increasing concentration of the extract. These findings suggested that strawberry extract may have a potential to kill 100% of the breast cancer cells in a dose-dependent manner.

In compared to other extracts, black raspberry and strawberry extracts showed the most significant pro-apoptotic effects against breast cell line.

However, due to the limitation of the above studies, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of strawberry anti-breast cancer possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibit tumor progression in mice, by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC. (PubMed)
(2) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)

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