Asparagus, The Potent Anti Liver Cancer Functional Food, Scientists Say

By Kyle J. Norton, Master of Nutrition

Asparagus May be considered an adjunct therapy combined with conventional medicine for the treatment of liver cancer, some scientists suggested.age

Liver cancer is a medical condition in which a group of cells growing and multiplying disordered and uncontrollable way in the liver tissue.

At the advanced stage, the cancerous cells can travel a distance away from the liver to infect other healthy tissue and organ via lymph or blood.

Secondary liver cancer or metastatic liver disease. are cancer started in another part of the body and spread to the liver.

Most common cancers are likely to spread to the liver including colorectal, lung and breast cancers.

The exact causes p[rimary liver cancer are unknown. Researchers also can not understand that people with the same health conditions, gender and family history, some are susceptible to the onset of liver cancer while others do not.

However, researchers do know that certain risk factors are associated with the development of the disease, such as long-term alcohol abuse, or chronic infection associated with hepatitis B and C and cirrhosis.

Some genetic mutations and liver damaged by birth defects are also elevating the risk of liver cancer.

Dr. Rao CV. the lead author in the study "Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer" wrote, "About 80-90% of liver cancers are hepatocellular carcinoma (HCC), and recent cancer genome sequencing studies have revealed frequently mutated genes in HCC".

These types of mutation are most likely are the results of oxidative stress in facilitating the accumulation of DNA damage and further mutations.

The John Hopskin Medicine, liver damage caused by birth defects includes
*Biliary atresia. A life-threatening condition in infants where the bile ducts are blocked or have developed abnormally. This blocks the flow of bile from the liver.

*Biliary (choledochal) cyst. A condition where the hepatic duct forms abnormally. This can also block the flow of bile.

*Alagille syndrome. Too few bile ducts associated with other abnormalities including heart, bone, facial features, eye, and others.

According to the statistic, in the US, every year, approximately over 40,000 adults are diagnosed with primary liver cancer, causing over 30,200 deaths.

Sadly, men are about 3 times more likely than women to be diagnosed with liver cancer.

Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia.

The plant has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.

Chemical constituents of the vegetable include essential oils, asparagine, arginine, tyrosine, flavonoids (kaempferol, quercetin, and rutin), resin, and tannin.

In the finding of natural ingredients with potential in preventing the onset of hepatocellular carcinoma (HCC), one of the most aggressive malignancies in the world, researchers conducted a study to examine the anticancer effects of the deproteinized asparagus polysaccharide on the hepatocellular carcinoma cells, using the in vitro and in vivo experimental model. 

The assessment of the experimental data suggested that the selected ingredient exert an effective inhibitor on cell growth in vitro and in vivo and potent selective cytotoxicity against human hepatocellular carcinoma Hep3B and HepG2 cells.

Further analysis showed that deproteinized asparagus polysaccharide potently induce cell apoptosis and G2/M cell cycle arrest in the more sensitive Hep3B and HepG2 cell lines.

Deproteinized asparagus polysaccharide potentiated the effects of mitomycin, a chemo drug both in vitro and in vivo.

The efficacy of the deproteinized asparagus polysaccharide was attributed to the ingredients in modulating the expression of Bax, Bcl-2, and caspase-3 apoptotic-associated pathways.

In other words, the deproteinized asparagus polysaccharide induce liver cancer cell apoptosis through numbers of cell death pathways.

Dr. Xiang J the lead scientists said, " deproteinized asparagus polysaccharide exhibited significant anticancer activity against hepatocellular carcinoma cells and could sensitize the tumoricidal effects of mitomycin".
Moreover, in the evaluation of the anti-liver cancer activity of Asparagus racemosus (Wild) through the role of dietary patterns and specific food groups, researchers launched a review of Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS), two cohort studies.

Total of 132 837 Chinese women and men, were evaluated the relationship between dietary patterns, food groups, and liver cancer risk.

Data were collected through in-person interviews and dietary information intake over the preceding year was collected by using a validated food-frequency questionnaire.

During an average follow-up of 10.9 (SWHS) or 5.5 (SMHS) years, researchers found that
* 267 incident liver cancer cases are identified after the first 2 years of study enrolment.

* A vegetable-based dietary pattern was inversely associated with liver cancer; hazard ratios (95% confidence intervals) for the lowest to highest quartiles were: 1.00; 0.98 (0.71-1.35); 0.93 (0.67-1.29); and 0.58 (0.40-0.84).

* The association was stronger among participants with a history of the chronic liver disease

* High intakes of celery, mushrooms, allium vegetables, composite vegetables (including asparagus lettuce and garland chrysanthemum), legumes and legume products were associated with reduced liver cancer risk.

The findings suggested that adding some portions of vegetables, including asparagus, are associated to reduce the risk of liver cancer, regardless of patients health condition.

Taken all together, there is no doubt that asparagus and its bioactive compound may be considered an adjunct therapy for the prevention and combined with conventional medicine for treatment of liver cancer.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti-cancer possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Chemical constituents of Asparagus J. S. Negi, P. Singh, [...], and V. K. Bisht (PubMed)
(2) Anticancer effects of deproteinized asparagus polysaccharide on hepatocellular carcinoma in vitro and in vivo. by Xiang J, Xiang Y, Lin S, Xin D, Liu X, Weng L, Chen T, Zhang M.(PubMed)
(3) Vegetable-based dietary pattern and liver cancer risk: results from the Shanghai women's and men's health studies. by Zhang W, Xiang YB, Li HL, Yang G, Cai H, Ji BT, Gao YT, Zheng W, Shu XO. (PubMed)
(4) What are congenital liver defects? by John Hopskin Medicine