Thursday, 4 October 2018

Black Tea, The Beverages That Block and Reverse the Onset of Dyspepsia, Naturally, Researchers Reveal

Kyle J. Norton 

Black and green tea may have a therapeutic and positive effect on the prevention of dyspepsia, some scientists suggested.

Dyspepsia is a digestive condition of ingestion. 

The exact causes of dyspepsia are unknown. However, researchers suggested that patients with the onset of a stomach ulcer or acid reflux disease are most susceptible to the condition. 

Certain medication such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics (metronidazole, macrolides) and diseases such as irritable bowel syndrome is associated with the increase risk of dyspepsia.

Some researchers also suggested that unhealthy choice of lifestyle such as smoking, excessive alcohol drinking also have a strong impact on the onset of the disease.

Dr. Umapati C. Baragi, the lead scientist in the study of diet and lifestyle in the etiopathogenesis of Urdhwaga Amlapitta (non-ulcer dyspepsia) said, "dietary patterns, lifestyle choices, and physical activities play an important role in the etiopathogenesis of Urdhwaga Amlapitta, and it is important for patients to have access to diet and lifestyle modifications. Currently, research in this area is minimal"

Symptoms of dyspepsia include pain in the chest, stomach burning pain, bloating, heartburn, upset stomach,.... digestive discomforts.

If you experience the above symptoms, please check with your doctor to rule out the possibility.

Black tea is a beverage with more oxidization, compared to other teas such as oolong, green, and white teas.

In the investigation of aqueous extract (BTE) and thearubigins isolated from green tea effects in sildenafnil-induced delay in gastric emptying (GE) and small intestinal transit (SIT) in total of 160 mice, randomly assigned to 20 groups with 8 in each group,  treated by different or combination of doses of BTE, thearubigins (TRs), sildenafil (SLD), metoclopramide, L-NAME (hydrochloride) and black tea extract researchers found that pretreatment of certain doses of green tea aqueous extract (BTE) and thearubigins significantly reverse motility-delaying effects caused by injection of sildenafnil.

Further differentiation also indicated that additional injection of black tea at 3% and 4.5% increases function of thearubigins (50 and 60 mg/kg) dose-dependently in promoted dyspepsia in mice in compared to the insignificant effect of the combination of BTE at 6% and thearubigins 70 mg/kg.

Moreover, combination of metoclopramide, a medicine used mainly for treatment of ingestion in people with delayed stomach emptying, BTE 4.5%, thearubigins 60 or nω -Nitro-l-arginine methyl ester hydrochloride (l-NAME) with sildenafil (5 mg/kg) reversed its motility-delaying effects,

This improvement of dyspepsia was partially blocked by application of l-NAME through reducing function nitric oxide and improving gastrointestinal smooth muscle mobility by observation of the pretreatment of l-NAME followed by application of BTE alone or combination of thearubigins 60, BTE + sildenafil, and thearubigins + sildenafil.

Dr. Murad HA, the lead author, after taking into account of confounders said, "BTE 4.5% or TRs 60 mg/kg solution could be considered a reliever therapy for the sildenafil-induced dyspepsia".

Additional investigate the role of hot water extract of black tea [Camellia sinensis (L) in normalizing the changes in the intestinal transit and gastric emptying induced by various ulcerogenic agents in experimental rats found that application of black tea extract significant promotes the intestinal transit and gastric emptying caused by glutathione (GSH) depleting agents, diethyl maleate (DEM) in decreased mucosal content in aid of digestion, indoacetamide (IDA) in reduced stomach acid secretion, gastritis, and mucus thickness on gastric transfer and N-ethyl maleimide (NEM) with function of  in significantly reduced the mucosal SH levels and the lesions.

Oral administration of black tea extract (BTE) at 20 ml/kg of a 10% solution once a day for 7 day also expressed a significantly increased the intestinal transit and gastric emptying similarly to those of conventional succimer (60 mg/kg, i.g.), the standard sulfhydryl containing an antiulcer agent
through the restoration of antioxidant of serum GSH level.

However, such increase of intestinal transit induced by BTE was reversed both by N-omega-nitro-L-arginine methyl ester (L-NAME) (25 mg/kg, i.p.) and N-omega-monomethyl-L-arginine (L-NMMA) (25 mg/kg, i.p.), in reduced levels of NO in the aided stomach in the production of gastric acid for digestive function.

Dr. Maity S, the lead author said, "restoration of intestinal nitric oxide synthase (NOS) activity was found to be associated with BTE treatment" and "These results provide evidence that nitric oxide may play a role in BTE-mediated movement of intestinal motility changes and gastric emptying induced by DEM, IDA, and NEM".

Taken together, black tea with plenty phytochemicals may be considered as functional food in reducing risk and treatment of dyspepsia.

However, intake of tea supplement should be taken with exceptional care to prevent acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Black tea extract and its thearubigins relieve the sildenafil-induced delayed gut motility in mice: a possible role of nitric oxide by Murad HA1, Abdallah HM. (PubMed)
(2) Role of reduced glutathione and nitric oxide in the black tea extract-mediated protection against ulcerogen-induced changes in motility and gastric emptying in rats by Maity S1, Vedasiromoni JR, Chaudhuri L, Ganguly DK. (PubMed)
(3) Gastrointestinal transit during endotoxemia: the role of nitric oxide by Wirthlin DJ1, Cullen JJ, Spates ST, Conklin JL, Murray J, Caropreso DK, Ephgrave KS. (PubMed)
(4) Evaluation of diet and life style in the etiopathogenesis of Urdhwaga Amlapitta (non-ulcer dyspepsia) by Umapati C. Baragi and Mahesh Kumar Vyas. (PubMed)

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