Green tea may have a therapeutic and positive effect in improving microbiota imbalance in inducing of obesity and gastrointestinal diseases, some scientists suggested.
Gut microbiota is microorganisms that live in the digestive tracts in humans and animals processed functions in tandem with the host’s defenses and the immune system to protect against pathogen colonization and invasion.
According to the study by Dr. Ye Yan and colleagues in the study of microbial imbalance and intestinal pathologies, there is a complex interplay between the host, bacteria and bacterial genes that may have a strong implication in the development of these intestinal diseases.
Overexpression certain harmful bacteria in the gut such as E. coli can utilize a complex arsenal of virulence factors to colonize and persist in the intestine, leading to gut microbiota imbalance on facilitation of the early onset of gastrointestinal diseases.
The doctors continued, "Some of these virulence factors, such as the genotoxin colibactin, were found to promote colorectal cancer in experimental models".
Truly, the features of the dysbiotic states caused by large colonic bad bacteria are associated with chronic intestinal inflammation and colorectal cancer.
The exact causes of intestinal dysbiosis are unknown. However, according to the study by the Southern Cross University, a number of factors associated with modern Western living have a detrimental impact on the microflora of the gastrointestinal tract. Factors such as antibiotics, psychological and physical stress, and certain dietary components have been found to contribute to intestinal dysbiosis(4).
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
According to the evaluation of obesity-induced of C57BL/6 J male mice by feeding a high fat (HF) diet for 8 weeks, followed by treatment with oral tea saponin (0.5%) mixed in HF diet for a further 6 weeks, injection of tea saponin (0.5%) mice demonstrated an impressive activity in ameliorating endotoxemia which is caused by accumulation of endotoxins in the blood, an indication of overproduction of gram-negative rod-shaped bacteria, reduction of numbers of pro-inflammatory macrophage accumulation in the colon that exhibit colon inflammation and gut microbiota alterations and reduce expression of good bacteria, such as Bifidobacteria, Lactobacillus,... and overexpression of harmful bacteria Escherichia Coli and Enterobacter caused by HF diet.
Patients with digestive disorders have been found to associate with the imbalance of gut microbiota and dysbiosis of the gut bacteria communities that can lead to many chronic issues and diseases, including irritable bowel syndrome (IBS), coeliac disease, inflammatory bowel disease, obesity, colon cancer, and autism......,
In fact, balancing of gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet and dysfunction of the community is associated various causes the in the induction of obesity and malnutrition.
According to the study, tea saponin also improved glucose tolerance and reduced body weight gain in HF diet-induced obese mice that may be an expression of green tea extract in limiting the unfavorable gut microbiota alterations in HF diet-induced obesity.
Additional analysis of orally administration of three types of tea infusions for 13 weeks in high-fat-diet-induced obese C57BL/6J mice to examine their anti-obesity and gut microbiota modulatory effects, suggested that application of the tea infusion shows a strong effect in the prevention of the development of obesity with no significant differences and expressed a substantially increased diversity and altered the structure of gut microbiota in tested mice.
According to the high-throughput MiSeq sequencing, multivariate statistical and linear discriminant assays, Dr. Liu Z, the lead author at the Fuzhou University said, "tea infusion consumption substantially increased diversity and altered the structure of gut microbiota" and "(Some) key phylotypes (such as Alistipes, Rikenella, Lachnospiraceae, Akkermansia, Bacteroides,...) might have a close association with the obesity-related indexes of the host".
Interestingly, in male Swiss albino mice were fed with HFD (58% fat kcal) induced alterations of gut microbiota for 12 weeks, green tea extract (GTE) and isomalto-oligosaccharide (IMOs), a naturally occurring plant-based dietary injection, significantly improved liver metabolome associated with lipid metabolism and prevented imbalance of gut microbiota in damage of the lining of the small intestine (leaky gut), through reduced expression of lipopolysaccharides(LPS) in the blood stream(an indication of serve inflammation) and pro-inflammatory cytokines (e.g. resistin, TNF-α, and IL-1β).
Dr. Singh DP, the lead scientist at the University Institute of Pharmaceutical Sciences (UIPS) after differentiating above illustration said, " Combination (of GTE and IMOs restores the balance of gut microbiota through), improved beneficial gut microbiota (Lactobacillus sp., Bifidobacteria, Akkermansia muciniphila, Roseburia spp.) abundances, restored Firmicutes/Bacteriodetes and improved Prevotella/Bacteroides proportions".
Taking altogether, green tea and its phytochemical constituents expressed strongly improved beneficial effects on multiple parameters in maintaining the favorable gut microbiota ratio in reduced risk of the onset of certain diseases, including obesity, celiac disease, inflammatory bowel disease.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline in diet-induced obese mice by Wang S1,2, Huang XF3,4, Zhang P1,5, Newell KA1, Wang H1, Zheng K5, Yu Y6,7. (PubMed)
(2) The modulatory effect of infusions of green tea, oolong tea, and black tea on gut microbiota in high-fat-induced obese mice by Liu Z1, Chen Z1, Guo H1, He D1, Zhao H1, Wang Z1, Zhang W1, Liao L1, Zhang C1, Ni L1. (PubMed)
(3) Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice by Singh DP1, Singh J2, Boparai RK3, Zhu J4, Mantri S2, Khare P1, Khardori R5, Kondepudi KK6, Chopra K7, Bishnoi M8. (PubMed)
(4) The causes of intestinal dysbiosis: a review by Hawrelak JA1, Myers SP. (PubMed)