Monday, 22 October 2018

Herbal Andrographis, the Natural Liver Protective Functional Remedy, Studies Found

By Kyle J. Norton, Master of Nutrition

Scientists may have found a herbal medicine which processes strong liver protective effects, some studies suggested.

The hepatoprotective effect is the action of prevention of the liver against liver damage or toxicity. 

There is no single cause of liver diseases. Researchers suggested that virus such as hepatitis A, B, C, long-term excessive alcohol drinking and genetic mutation inherited from the parents is the major risk factors associated with the early onset of the diseases.

Some researchers suggested overweight and obesity and congenital diseases such as Hemochromatosis and Wilson’s disease also are the prevalent risk factors of liver damage and diseases.

Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol and Illegal drugs such as cocaine.

In the article on liver diseases, the 24 health also include autoimmune diseases that cause inflammation to the liver.

Sadly, according to the statistic, the mortality rate infected by viral hepatitis have increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.

Symptoms of liver diseases include persistent jaundice and gastrointestinal discomforts, abdominal pain, and swelling, leg and ankles swelling, itching, and pale color of stool.

Please check with your doctor to rule out the liver disease and damage possibility, if you are experiencing some of the above symptoms.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

The Ingredients
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients include diterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoids viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

As of today, despite enormous advances in modern medicine, conventional medicine can only focus to reduce symptoms of liver diseases. There is no completely effective medicine that can stimulate hepatic function, or offer complete protection of the organ, or help to regenerate hepatic cells.

In the finding of a natural hepatoprotective agent which can help to relieve the pressure of conventional medicine in patients with liver damage or diseases, researchers at the Vinayaka Missions University conducted a study to evaluate the liver protective activity of herbal Andrographis in liver injury in rats.

After subcutaneous injection of 50% v/v carbon tetrachloride in liquid paraffin at a dose of 3 mL/kg on alternate days for a period of 4 weeks to induce chronic liver damage, the Male Wistar rats were treated with methanol and aqueous extracts of herbal Andrographis orally at a dose of 845 mg/kg/day.

At the end of the experiment, researchers found that
* Herbal Andrographis extracts demonstrate a clinically significant activity in comparison to a standard drug.

* Hepatic steatosis, hydropic degeneration and necrosis caused by the injection of the carbon tetrachloride were completely disappeared in the standard and extract treated groups.

Further analysis also discovered, herbal Andrographis extracts exhibited hepatoprotective action against carbon tetrachloride-induced liver injury.

Dr. Sangameswaran B, the lead author at the final report wrote, "The present investigation established pharmacological evidence to support the folklore claim that it is used traditionally as a hepatoprotective agent".

Additional investigation of the liver protective effect of Andrographolide (AN), a major bioactive compound isolated from herbal Andrographis, researchers at the Dr. Hari Singh Gour Central University, formulate AN herbosomes (ANH) through complexation with naturally occurring soya-phosphatidylcholine (SPC) for enhancing absorption with carbon tetrachloride inducing hepatotoxicity rat model and compared.

The ANH showed significantly liver protective effect comparable to the standard drug (Silymarin).

Application of ANH in an animal model has better bioavailability than those of AN observed by the statistics in vitro absorption and hence improved hepatoprotection as compared to plain AN at an equivalent dose.

Taken all together, herbal Andrographis and its bioactive ingredient Andrographolide (AN)may be considered an adjunct therapy in aiding the conventional medicine in providing the extra protection of the liver and treatment of liver damage and diseases.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats.
Tatiya AU, Surana SJ, Sutar MP, Gamit NH. (PubMed)
(2) Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats. by Sangameswaran B, Reddy TC, Jayakar B.(PubMed)
(3) Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system. by Jain PK, Khurana N, Pounikar Y, Gajbhiye A, Kharya MD. (PubMed)

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