Sunday, 7 October 2018

#Green Tea, The Potent Functional Beverage Inhibits the Pathogens That Cause Pneumonia, Scientists Say

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of pneumonia, some scientists suggested.

Pneumonia is a lung infection caused by bacteria, viruses, or fungi. Bacterial pneumonia is the most common type in adults.

Researchers do not know why people with the same health condition, some are susceptible to the onset of the disease while others do not.

However, according to the studies, certain groups of people are at a higher prevalent to be infected, including babies and toddlers, who have an immature immune system,  people who have had a recent viral infection and people with chronic lung conditions such as asthma, bronchitis or bronchiectasis.

 Additionally, People with suppressed immune systems,  excessive alcohol drinking and smoking habit and the elderly are also associated with the increased risk of lung infection.

Most common symptoms of include fever and chill caused overexpression of inflammatory cytokines, shortness of breath and increased breathing rate, caused by reduced lung function.

Some patients with pneumonia also have serious symptoms of persistent coughing with phlegm, that does not disappear itself and chest pain.

If you experiencing some of the above symptoms, you may have pneumonia. Please check with your doctor to rule out the possibility.

Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.

In a population-based cohort study, with the follow-up from 1995 to 2006 conducted by Tohoku University Graduate School of Medicine using data of participants in National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y), researchers wrote at the end of the experiment,
* Over 12 y of follow-up, 406 deaths from pneumonia, according to the reported documents.

* According to the hazard ratios (HRs), injection of green tea demonstrated a significant reduction of death from pneumonia, (<1 cup/d, HRs

Injection of green tea <1 cup/d, with HRs of 1, 1-2 cups/d with HRs of 0.59, 3-4 cups/d, HRs of 0.55 and > or =5 cups/d with Hrs of .53, respectively in women.

Interestingly, in men, green tea injection regardless of volumes displays no significant association in risk of death from pneumonia.

These results suggested that green tea intake daily and regularly may have a strong effect in reducing risk, progression, treatment of lung infection, particularly, in the reduced rate of motility in women.


Furthermore, in the evaluate epigallocatechin gallate (EGCG) effect in influenza A virus in the induction of pneumonia in Madin-Darby canine kidney (MDCK) cells of BALB/c mice treated with EGCG (10, 20 or 40 mg·kg(-1)·d(-1), po) for 5 days. and on the 3rd day of the treatment, the mice were infected with influenza A virus., researcher indicated that
* EGCG  treatment group exerts a significant inhibition of the expression of influenza A virus in elevating production of reactive oxygen species.

* EGCG also inhibits the influenza A replication at a concentration-dependent manner (the ED(50) value of 8.71±1.11 nmol/L).

* Importantly, oral administration of green tea EGCG dramatically improves the survival rate, decreases the mean virus yields and mitigates viral pneumonia in the lungs, compared to conventional medicine at oseltamivir (40 mg·kg(-1)·d(-1)).

These results were supported by the investigation to examine, whether green tea by-products could function as an alternative to common antivirals in animals, conducted by the Konkuk University.

According to the experiment, both applications demonstrated a significantly inhibited influenza activity with green tea by-products (EC₅₀ = 6.36 µg/mL) to be equivalent to that of original green tea (EC₅₀= 6.72 µg/mL)

In against the H1N1 virus A/NWS/33, anti-influenza activity of green tea by-products (EC₅₀ = 6.36 µg/mL) is equivalent to that of original green tea (EC₅₀= 6.72 µg/mL).

However, in tested mice, oral administration of green tea by-products reduced viral titers in the lungs in the early phase of infection, but they could not protect these animals from disease and death compared to therapeutic administration of green tea by-products via feed or water supplement on a dose-dependent manner and the rate of motility at dose of 10 g/kg of feed.

These result unsurprisingly suggested that green tea bioactive compound as a single ingredient consist of a strong effect in reducing the death of pneumonia pathogens compared to the intake of green tea whole foods.

After taking into account other co and confounders, Dr. Lee HJ said, "Unidentified hexane-soluble fractions of green tea by-products possessed strong anti-influenza activity, in addition to ethyl acetate-soluble fractions, including catechins".

Taken together, green tea and its bioactive polyphenols catechin may be considered as functional foods in reducing risk, progression and treatment of pneumonia, particularly in the decrease of death ratio.

However, intake of green tea supplement should be taken with exceptional care as acute liver toxicity has been reported in numbers of the case.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and death from pneumonia in Japan: the Ohsaki cohort study by Watanabe I1, Kuriyama S, Kakizaki M, Sone T, Ohmori-Matsuda K, Nakaya N, Hozawa A, Tsuji I.(PubMed)
(2) Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea by Ling JX1, Wei F, Li N, Li JL, Chen LJ, Liu YY, Luo F, Xiong HR, Hou W, Yang ZQ.(PubMed)
(3) Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens by Lee HJ1, Lee YN, Youn HN, Lee DH, Kwak JH, Seong BL, Lee JB, Park SY, Choi IS, Song CS(PubMed).