Turmeric Promotes Myeloma Cancer Cells Apoptosis

By Kyle J. Norton

Cancer is a class of diseases characterized by irregular cell growth that starts in the tissue of specific organs.

Most cases of cancer overtime after penetrating into deeper layers of the affected organs, the oversize tumor can sometimes spread to other organs in the body via lymph or blood, leading to secondary metastasis.

Multiple myelomas (Myeloma) is a type of cancer originated from plasma cells in the bone marrow that produces the white blood cells which are normally responsible for the production of antibodies to protect our body against infection.

Over time, multiple myeloma can lead to the accumulation of cancer cells in the bone marrow, overcrowding out healthy blood cells.

According to the statistics provided by the American Cancer Society, In the US, the lifetime risk of getting multiple myeloma is 1 in 132.  In 2019, about 32,110 new cases will be diagnosed including 18,130 in men and 13,980 in women.

The causes of multiple myelomas are unidentified. However certain factors have been found to increase the risk of the conditions, inclduing

* Age
If you are between 50 and 70 years old, you are at higher risk to develop multiple myeloma.

*Gender
Men are more likely to develop multiple myeloma than women.

*Race
Cancer tends to affects blacks more often than whites.

* Previous multiple myeloma
People who previously had been treated with multiple myeloma are at a higher risk to develop it again.

*Exposed to certain chemicals
Increased risk of multiple myeloma if you are exposed to certain chemicals such as occupation.

* Family history
If a direct member of the family has multiple myeloma, the risk of the disease is increased.

* Radiation
Increased risk of cancer if you are exposed to radiation, such as radiation exposure of nuclear accident.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of multiple myeloma,, researchers examined the synergistic apoptotic effects on arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma (MM) cell line U266.

The study included U266 cells cultured with MGN-3 (50 or 100μg/ml) and curcumin (2.5-10μM) for 3 days. 

Based on the results of cells differentiation assays, MGN-3 alone or curcumin alone showed a significant anti-proliferation of U266 cells at a dose-dependent inhibition manner.

The synergistic effect was noticed at maximized at 100μg/ml MGN-3 plus 10μM curcumin, according to the analysis of post-treatment by inducing the 87% decrease in cell number and a 2.6 fold increase in the percentage of apoptotic cells.

This effect was also exhibited cell cycle arrest in the G0-G1 phase by a 53% decrease in the percentage of cells.in the G0-G1 phase.

More precisely, the combination exerted a strong activity in the stimulation of pro-apoptosis and inhibition of anti-apoptotic by the decreased and increased expression of Bcl-2 and Bax, respectively.

Collectively, researchers wrote in the final report, "MGN-3 and curcumin synergize in the induction of U266 cell apoptosis".

Taken altogether, turmeric used alone or combined with arabinoxylan rice bran may be considered supplements for the prevention and treatment of multiple myeloma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin-induced promoter hypermethylation of the mammalian target of rapamycin gene in multiple myeloma cells by Chen J1, Ying Y2, Zhu H1, Zhu T3, Qu C1, Jiang J3, Fang B. (PubMed)
(2) Synergistic apoptotic effect of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma cell line U266 in vitro by Ghoneum M1, Gollapudi S. (PubMed)